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Frequency-specific alterations in functional connectivity in treatment-resistant and -sensitive major depressive disorder.

Abstract：

:Major depressive disorder (MDD) may involve alterations in brain functional connectivity in multiple neural circuits and present large-scale network dysfunction. Patients with treatment-resistant depression (TRD) and treatment-sensitive depression (TSD) show different responses to antidepressants and aberrant brain functions. This study aims to investigate functional connectivity patterns of TRD and TSD at the whole brain resting state. Seventeen patients with TRD, 17 patients with TSD, and 17 healthy controls matched with age, gender, and years of education were recruited in this study. The brain was divided using an automated anatomical labeling atlas into 90 regions of interest, which were used to construct the entire brain functional networks. An analysis method called network-based statistic was used to explore the dysconnected subnetworks of TRD and TSD at different frequency bands. At resting state, TSD and TRD present characteristic patterns of network dysfunction at special frequency bands. The dysconnected subnetwork of TSD mainly lies in the fronto-parietal top-down control network. Moreover, the abnormal neural circuits of TRD are extensive and complex. These circuits not only depend on the abnormal affective network but also involve other networks, including salience network, auditory network, visual network, and language processing cortex. Our findings reflect that the pathological mechanism of TSD may refer to impairment in cognitive control, whereas TRD mainly triggers the dysfunction of emotion processing and affective cognition. This study reveals that differences in brain functional connectivity at resting state reflect distinct pathophysiological mechanisms in TSD and TRD. These findings may be helpful in differentiating two types of MDD and predicting treatment responses.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

He Z,Cui Q,Zheng J,Duan X,Pang Y,Gao Q,Han S,Long Z,Wang Y,Li J,Wang X,Zhao J,Chen H

doi

10.1016/j.jpsychires.2016.07.011

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

30-9

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(16)30142-X

journal_volume

pub_type

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Frequency-specific alterations in functional connectivity in treatment-resistant and -sensitive major depressive disorder.