当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder.

DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder.

Abstract：

:The failure in the discovery of etiology of psychiatric diseases, despite extensive genetic studies, has directed the attention of neuroscientists to the contribution of epigenetic modulations, which play important roles in fine-tuning of gene expression in response to environmental factors. Previously, we analyzed 115 human post-mortem brain samples from the frontal lobe and reported DNA hypo methylation of the membrane-bound catechol-O-methyltransferase (MB-COMT) gene promoter, associated with an increased gene expression, as a risk factor for schizophrenia (SCZ) and bipolar disorder (BD). Since most epigenetic modifications are tissue specific and the availability of brain tissue to identify epigenetic aberrations in living subjects is limited, detection of epigenetic abnormalities in other tissues that represent the brain epigenetic marks is one of the critical steps to develop diagnostic and therapeutic biomarkers for mental diseases. Here, hypothesizing that; those factors that lead to the brain MB-COMT promoter DNA hypo-methylation may also cause concurrent epigenetic aberrations in peripheral tissues, we analyzed MB-COMT promoter methylation in DNA derived from the saliva in SCZ, BD and their first-degree relatives (20 cases each) as well as 25 control subjects. Using bisulfite DNA sequencing and quantitative methylation specific PCR (qMSP), we found that similar to the brain, MB-COMT promoter was hypo-methylated (∼50%) in DNA derived from the saliva in SCZ and BD compared to the control subjects (p = 0.02 and 0.037, respectively). These studies suggest that DNA methylation analysis of MB-COMT promoter in saliva can potentially be used as an available epigenetic biomarker for disease state in SCZ and BD.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Nohesara S,Ghadirivasfi M,Mostafavi S,Eskandari MR,Ahmadkhaniha H,Thiagalingam S,Abdolmaleky HM

doi

10.1016/j.jpsychires.2011.06.013

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1432-8

issue

11

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(11)00129-4

journal_volume

45

pub_type

杂志文章

相关文献

JOURNAL OF PSYCHIATRIC RESEARCH文献大全
  • Psychotic depression in hospitalized patients: Longitudinal outcomes of psychotic vs. nonpsychotic depression among inpatients.

    abstract：:Even though psychotic depression is related to worse outcomes than nonpsychotic depression, there is increasing evidence that this greater severity is not solely explained by the depressive symptoms. We evaluated the socio-demographic and clinical characteristics, as well as the differences in clinical outcomes of psy...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.06.002

    authors： Costa FBPD,Trachtenberg E,Boni A,Primo de Carvalho Alves L,Magalhães PVDS,Rocha NS

    更新日期：2020-10-01 00:00:00

  • Exploring the neurocognitive signature of poor set-shifting in anorexia and bulimia nervosa.

    abstract：:Poor set-shifting has been implicated as a risk marker, maintenance factor and candidate endophenotype of eating disorders (ED). This study aimed to add clarity to the cognitive profile of set-shifting by examining the trait across ED subtypes, assessing whether it is a state or trait marker, and whether it runs in fa...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.03.001

    authors： Roberts ME,Tchanturia K,Treasure JL

    更新日期：2010-10-01 00:00:00

  • Changes in methylation within the STK32B promoter are associated with an increased risk for generalized anxiety disorder in adolescents.

    abstract：:Generalized anxiety disorder (GAD) is highly prevalent among adolescents. An early detection of individuals at risk may prevent later psychiatric condition. Genome-wide studies investigating single nucleotide polymorphisms (SNPs) concluded that a focus on epigenetic mechanisms, which mediate the impact of environmenta...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2018.03.008

    authors： Ciuculete DM,Boström AE,Tuunainen AK,Sohrabi F,Kular L,Jagodic M,Voisin S,Mwinyi J,Schiöth HB

    更新日期：2018-07-01 00:00:00

  • Search for a gene that predisposes individuals to BPI disorder.

    abstract：:To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnoses and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establi...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/0022-3956(87)90106-3

    authors： Gerhard DS,Egeland JA,Pauls DL,Housman DE

    更新日期：1987-01-01 00:00:00

  • Risk and associated factors for a future schizophrenia diagnosis after an index diagnosis of unspecified psychotic disorder: A population-based study.

    abstract：:A significant minority of unspecified psychosis presentations progress to schizophrenia. Clinical risk factors can inform targeted referral to specialized treatment programs, but few population studies have examined this. In this study, we used health administrative data for a population-based cohort from Manitoba, Ca...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.04.019

    authors： Hensel JM,Chartier MJ,Ekuma O,MacWilliam L,Mota N,Tachere RO,McDougall C,Bolton JM

    更新日期：2019-07-01 00:00:00

  • Alterations of blood platelet MAO-B activity and LSD-binding in humans after sleep deprivation and recovery sleep.

    abstract：:Sleep deprivation (SD) is an effective, however short-lived, method of treatment of depression. Preliminary findings suggest that the antidepressive effect of sleep deprivation is mediated by serotoninergic (5-HT) mechanisms. We therefore assessed serotoninergic activity before and after total SD (TSD) as well as afte...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(96)00062-3

    authors： Schreiber W,Opper C,Dickhaus B,Heiser P,Wesemann W,Krieg JC

    更新日期：1997-05-01 00:00:00

  • Effects of gustatory stimulation on brain activity during hunger and satiety in females with restricting-type anorexia nervosa: an fMRI study.

    abstract：BACKGROUND:Previous research has demonstrated altered neuronal responses to visual stimulation with food in anorexia nervosa, varying with the motivational state of hunger or satiety. The aim of the present fMRI study was to assess hunger- and satiety-dependent alterations in the gustatory processing of stimulation wit...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.07.012

    authors： Vocks S,Herpertz S,Rosenberger C,Senf W,Gizewski ER

    更新日期：2011-03-01 00:00:00

  • Sluggish cognitive tempo (SCT) in an adult outpatient sample seeking an attention-deficit/hyperactivity disorder assessment: Age of onset and assessment method impact on SCT rates.

    abstract：BACKGROUND:Sluggish cognitive tempo (SCT) is associated with-but distinct from-attention-deficit/hyperactivity disorder (ADHD). This study examined SCT rates in adult outpatients seeking an ADHD assessment, differences in rates based on ADHD status, impact of assessment method (i.e., reporting source, symptom count, an...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.09.013

    authors： Mitchell JT,Davis NO,Kollins SH,Lunsford-Avery JR

    更新日期：2020-12-01 00:00:00

  • Age at onset in bipolar-related major affective illness: clinical and genetic implications.

    abstract：:Age-of-onset data were collected on 142 bipolar probands (61 males, 81 females) and 110 siblings. After correcting for demographic factors the age at illness onset did not distinguish bipolar from unipolar siblings or siblings from probands. This indicates that in a subset of pedigree data, bipolar and unipolar affect...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(82)90030-9

    authors： Baron M,Risch N,Mendlewicz J

    更新日期：1982-01-01 00:00:00

  • Resequencing and association analysis of coding regions at twenty candidate genes suggest a role for rare risk variation at AKAP9 and protective variation at NRXN1 in schizophrenia susceptibility.

    abstract：:A fraction of genetic risk to develop schizophrenia may be due to low-frequency variants. This multistep study attempted to find low-frequency variants of high effect at coding regions of eleven schizophrenia susceptibility genes supported by genome-wide association studies (GWAS) and nine genes for the DISC1 interact...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jpsychires.2015.04.013

    authors： Suárez-Rama JJ,Arrojo M,Sobrino B,Amigo J,Brenlla J,Agra S,Paz E,Brión M,Carracedo Á,Páramo M,Costas J

    更新日期：2015-07-01 00:00:00

  • The diagnostic threshold of generalized anxiety disorder in the community: a developmental perspective.

    abstract：:Discussion surrounds the question as to whether criteria for generalized anxiety disorder (GAD) should change, particularly in youth. This study examines the effects of possible criteria changes on GAD prevalence and clinical correlates. DSM-IV GAD was assessed using the M-CIDI in a community sample of adolescents and...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.12.007

    authors： Beesdo-Baum K,Winkel S,Pine DS,Hoyer J,Höfler M,Lieb R,Wittchen HU

    更新日期：2011-07-01 00:00:00

  • Relationship between induced abortion and the incidence of depression, anxiety disorder, adjustment disorder, and somatoform disorder in Germany.

    abstract：AIM:The goal of this retrospective cohort study was to analyze the relationship between induced abortion and the incidence of depression, anxiety disorder, adjustment disorder, and somatoform disorder in Germany. METHODS:Women who had undergone induced abortions for the first time in 281 gynecological practices in Ger...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.04.022

    authors： Jacob L,Kostev K,Gerhard C,Kalder M

    更新日期：2019-07-01 00:00:00

  • Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making.

    abstract：BACKGROUND:Motivational impairments are a core feature of schizophrenia and although there are numerous reports studying this feature using clinical rating scales, objective behavioural assessments are lacking. Here, we use a translational paradigm to measure incentive motivation in individuals with schizophrenia. MET...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.08.003

    authors： Fervaha G,Graff-Guerrero A,Zakzanis KK,Foussias G,Agid O,Remington G

    更新日期：2013-11-01 00:00:00

  • The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia.

    abstract：:Dopaminergic and inflammatory systems have been proven to play an important role in the cognitive deficits of schizophrenia. Although increasing evidence indicates two systems have strong interaction, the relevant research on this interaction is still limited. Catechol-o-methyltransferase (COMT) and Interleukin-10 (IL...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.10.021

    authors： Wang J,Xu H,Wang D,Wei G,Zhou H,Wang L,Zhou Y,Zhang X

    更新日期：2020-10-22 00:00:00

  • A caution on the use of cut-points applied to screening instruments or diagnostic criteria.

    abstract：:Although cut-points or threshold scores are commonly used in screening instruments as well as in psychiatric diagnostic practice, much is still to be learned about their functional characteristics. This study demonstrates that, for a cut-off of y items on a screening instrument, there is great variability in the ident...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(94)90029-9

    authors： Clarke DM,McKenzie DP

    更新日期：1994-03-01 00:00:00

  • A comparison of the Cohen-Mansfield agitation inventory with the CERAD behavioral rating scale for dementia in community-dwelling persons with Alzheimer's disease.

    abstract：:In a group of 242 community-dwelling patients with Alzheimer's disease (AD), a longitudinal comparison was made of two caregiver-administered instruments for assessment of behavioral disturbance; the Cohen-Mansfield Agitation Inventory (CMAI) and the CERAD Behavioral Rating Scale for Dementia (BRSD). We examined recor...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-3956(98)00027-2

    authors： Weiner MF,Koss E,Patterson M,Jin S,Teri L,Thomas R,Thal LJ,Whitehouse P

    更新日期：1998-11-01 00:00:00

  • Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: informing future studies of antidepressant treatments.

    abstract：:Exposure to early life stress (ELS) is strongly associated with poor treatment outcomes, particularly for trauma-associated disorders such as depression. Little research to date, however, has examined the potential effects of ELS on outcomes with newer treatments, such as repetitive transcranial magnetic stimulation (...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.01.014

    authors： Philip NS,Valentine TR,Sweet LH,Tyrka AR,Price LH,Carpenter LL

    更新日期：2014-05-01 00:00:00

  • Validity of depression rating scales during pregnancy and the postpartum period: impact of trimester and parity.

    abstract：:The objective of the current study was to delineate the optimal cutpoints for depression rating scales during pregnancy and the postpartum period and to assess the perinatal factors influencing these scores. Women participating in prospective investigations of maternal mental illness were enrolled prior to 28 weeks ge...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.05.017

    authors： Ji S,Long Q,Newport DJ,Na H,Knight B,Zach EB,Morris NJ,Kutner M,Stowe ZN

    更新日期：2011-02-01 00:00:00

  • A new type of scale for determining remission from depression: the Remission from Depression Questionnaire.

    abstract：:Current standards for treating major depressive disorder (MDD) recommend that achieving remission should be considered the principal goal of treatment. Recent research suggests that the symptom-based definitions of remission used in efficacy studies do not adequately reflect the perspective of depressed patients recei...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.09.006

    authors： Zimmerman M,Martinez JH,Attiullah N,Friedman M,Toba C,Boerescu DA,Ragheb M

    更新日期：2013-01-01 00:00:00

  • Interhemispheric differences in regional density of the normal brain.

    abstract：:In a study of regional variations in cerebral X-ray attenuation as measured by computed tomography, a relationship between bone-related beam hardening and lateralized hemispheric density differences was sought. The CT scans of 22 normal right-handed individuals were evaluated by calculating regional mean attenuation v...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(84)90017-7

    authors： Coffman JA,Bloch S

    更新日期：1984-01-01 00:00:00

  • HLA in psychiatric and control subjects. A comparative study of HLA antigen frequencies in schizophrenic, schizoaffective and control subjects.

    abstract：:HLA antigens were typed among 24 schizophrenic, 13 schizoaffective and 246 control subjects. Schizoaffective patients showed significantly decreased incidence of A2 compared with schizophrenic patients or controls. ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(85)90076-7

    authors： Adler S,Vasile RG,Yunis E,Shapiro R

    更新日期：1985-01-01 00:00:00

  • Implicit and explicit memory in patients with obsessive-compulsive disorder: an event-related potential study.

    abstract：:The implicit and explicit memory in patients with obsessive-compulsive disorder (OCD) was investigated using the event-related potential (ERP). For the assessment of implicit memory, a lexical decision task was administered. Among a total of 320 words and 140 non-words, 200 words were repeated, while the remaining 120...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2005.05.007

    authors： Kim MS,Kim YY,Kim EN,Lee KJ,Ha TH,Kwon JS

    更新日期：2006-09-01 00:00:00

  • Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism.

    abstract：:Polyunsaturated fatty acids (PUFA) profiles associate with risk for mood disorders. This poses the hypothesis of metabolic differences between patients and unaffected healthy controls that relate to the primary illness or are secondary to medication use or dietary intake. However, dietary manipulation or supplementati...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.06.001

    authors： Evans SJ,Ringrose RN,Harrington GJ,Mancuso P,Burant CF,McInnis MG

    更新日期：2014-10-01 00:00:00

  • Intramuscular olanzapine for agitated patients: A systematic review and meta-analysis of randomized controlled trials.

    abstract：:We performed an updated systematic review and meta-analysis of randomized controlled trials (RCTs) of intramuscular (IM)-olanzapine (OLA-IM) versus controls in agitated patients. The risk ratio, number-needed-to-treat/harm, and standardized mean difference based on a random effects model were calculated. We identified...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jpsychires.2015.07.005

    authors： Kishi T,Matsunaga S,Iwata N

    更新日期：2015-09-01 00:00:00

  • Frequency and correlates of anxiety symptoms during the COVID-19 pandemic in low- and middle-income countries: A multinational study.

    abstract：OBJECTIVE:Studies have documented the significant direct and indirect psychological, social, and economic consequences of the Coronavirus disease 2019 (COVID-19) in many countries but little is known on its impact in low- and middle-income countries (LMICs) already facing difficult living conditions and having vulnerab...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jpsychires.2020.09.031

    authors： Cénat JM,Dalexis RD,Guerrier M,Noorishad PG,Derivois D,Bukaka J,Birangui JP,Adansikou K,Clorméus LA,Kokou-Kpolou CK,Ndengeyingoma A,Sezibera V,Auguste RE,Rousseau C

    更新日期：2021-01-01 00:00:00

  • Major depression induces oxidative stress and platelet hyperaggregability.

    abstract：:We have previously demonstrated an impairment of intraplatelet L-arginine-nitric oxide-cGMP pathway in major depression (MD) associated to platelet dysfunction. Here, we evaluated arginase pathway and phosphodiesterase 5 (PDE5) expression in platelets, systemic and intraplatelet oxidative status in untreated MD patien...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.12.009

    authors： Ormonde do Carmo MB,Mendes-Ribeiro AC,Matsuura C,Pinto VL,Mury WV,Pinto NO,Moss MB,Ferraz MR,Brunini TM

    更新日期：2015-02-01 00:00:00

  • Alcohol and cannabis use and mortality in people with schizophrenia and related psychotic disorders.

    abstract：:The impact of co-morbid substance use on mortality is not well studied in psychotic disorders. The objective of this study was to examine the impact of substance use on mortality in people with psychotic disorders and alcohol and/or drug use. We examined the rate of substance use and the risk of substance use on morta...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.04.019

    authors： Koola MM,McMahon RP,Wehring HJ,Liu F,Mackowick KM,Warren KR,Feldman S,Shim JC,Love RC,Kelly DL

    更新日期：2012-08-01 00:00:00

  • Satiety responses in eating disorders.

    abstract：:Appetite and satiety responses in a test meal paradigm were studied in six anorexia nervosa patients (four had bingeing and purging behaviors) and in nine normal control women. The anorexic patients were distinguished from normal controls by the amounts of food taken and by the pattern of the hunger and fullness respo...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(85)90029-9

    authors： Owen WP,Halmi KA,Gibbs J,Smith GP

    更新日期：1985-01-01 00:00:00

  • A systematic review and network meta-analysis of carbon dioxide provocation in psychiatric disorders.

    abstract：BACKGROUND:False suffocation alarm hypothesis has been widely used to explain carbon dioxide hypersensitivity in panic disorder (PD). However, hypersensitivity to carbon dioxide has been observed in other psychiatric disorders. We explored the specificity of carbon dioxide inhalation as a panic provocation test among p...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.11.032

    authors： Tural U,Iosifescu DV

    更新日期：2020-11-19 00:00:00

  • Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring.

    abstract：:An increased incidence of schizophrenia has been associated with several perinatal insults, most notably maternal infection during pregnancy and perinatal hypoxia. This study used a rat model to directly test if maternal exposure to bacterial endotoxin (lipopolysaccharide, LPS) during pregnancy alters behaviors releva...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2003.10.001

    authors： Fortier ME,Joober R,Luheshi GN,Boksa P

    更新日期：2004-05-01 00:00:00