当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia.

The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia.

Abstract：

:Dopaminergic and inflammatory systems have been proven to play an important role in the cognitive deficits of schizophrenia. Although increasing evidence indicates two systems have strong interaction, the relevant research on this interaction is still limited. Catechol-o-methyltransferase (COMT) and Interleukin-10 (IL-10) play critical functions in dopaminergic and inflammatory systems respectively, and their genetic polymorphisms are both associated with cognitive function. However, the interactive effect of their genetic polymorphisms has not been investigated. In this study, COMT Val158Met (rs4680) and IL-10 -592A/C (rs1800872) polymorphisms were measured in patients with chronic schizophrenia (n = 244) and healthy controls (n = 396), and their cognitive functions were assessed using the "Repeatable Battery for the Assessment of Neuropsychological Status" (RBANS). We found that IL-10 alone had no effect on cognitive function, while COMT affected language ability and interacted with the schizophrenia (case vs control) or sex in multiple RBANS indexes. Additionally, we found there was a significant interactive effect between IL-10 and COMT polymorphisms on multiple cognitive indexes of RBANS. In detail, the analysis showed that the IL-10 polymorphism had opposite effects on cognitive function in different COMT genotype carriers; meanwhile, the polymorphism of COMT only had a significant effect on cognitive function in IL-10 C carriers. And this interaction was more significant in schizophrenia than in controls. Our study discovered for the first time, there is an interactive effect between IL-10 and COMT genetic polymorphisms on cognitive function, which is valuable for further investigations and drug administrations associated with both systems.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Wang J,Xu H,Wang D,Wei G,Zhou H,Wang L,Zhou Y,Zhang X

doi

10.1016/j.jpsychires.2020.10.021

subject

Has Abstract

pub_date

2020-10-22 00:00:00

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(20)31024-4

pub_type

杂志文章

相关文献

JOURNAL OF PSYCHIATRIC RESEARCH文献大全
  • Neural correlates of emotional processing in depression: changes with cognitive behavioral therapy and predictors of treatment response.

    abstract：:Major depressive disorder (MDD) is characterized by the presence of disturbances in emotional processing. However, the neural correlates of these alterations, and how they may be affected by therapeutic interventions, remain unclear. The present study addressed these issues in a preliminary investigation using functio...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jpsychires.2010.09.007

    authors： Ritchey M,Dolcos F,Eddington KM,Strauman TJ,Cabeza R

    更新日期：2011-05-01 00:00:00

  • The effects of early life stress on reward processing.

    abstract：:Early life stress (ELS), in the form of childhood maltreatment, abuse, or neglect, increases the risk for psychiatric sequelae later in life. The neurobiology of response to early stress and of reward processing overlap substantially, leading to the prediction that reward processing may be a primary mediator of the ef...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpsychires.2018.02.002

    authors： Novick AM,Levandowski ML,Laumann LE,Philip NS,Price LH,Tyrka AR

    更新日期：2018-06-01 00:00:00

  • Suicide and hospitalization for mental disorders in Sweden: a population-based case-control study.

    abstract：:The aim of this study was to estimate suicide risk during hospitalization and in the year following discharge for patients with mental disorders. All suicide cases in Sweden 18 years and older, between 1991 and 2003 (N=20,675; 70% male), were individually matched to 10 controls from the general Swedish population. Dis...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.02.003

    authors： Reutfors J,Brandt L,Ekbom A,Isacsson G,Sparén P,Osby U

    更新日期：2010-09-01 00:00:00

  • Relationship of anxiety disorders, sleep quality, and functional impairment in a community sample.

    abstract：BACKGROUND:Anxiety disorders and insomnia are each prevalent, impairing, and highly comorbid. However, little is known about whether specific types of sleep complaints are associated with specific anxiety disorders, and whether poor sleep has an additive effect on functional impairment in anxiety disorders. METHOD:Dat...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2009.01.009

    authors： Ramsawh HJ,Stein MB,Belik SL,Jacobi F,Sareen J

    更新日期：2009-07-01 00:00:00

  • Gastrointestinal hormones in anorexia nervosa.

    abstract：:A study was undertaken of fasting and post-prandial blood levels of glucose and a number of gastrointestinal hormones in patients with anorexia nervosa. After an overnight fast their blood levels of glucose, insulin and pancreatic glucagon were significantly lower than those of age-sex matched healthy volunteers. Ther...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(85)90019-6

    authors： Alderdice JT,Dinsmore WW,Buchanan KD,Adams C

    更新日期：1985-01-01 00:00:00

  • Late-onset ADHD in adults: milder, but still dysfunctional.

    abstract：OBJECTIVE:The requirement in classificatory systems that some impairment from attention-deficit/hyperactivity disorder (ADHD) symptoms starts before 7 years of age (age of onset of impairment criteria - AOC) has been harshly criticized. Although there is evidence that late-onset ADHD is a valid diagnosis, little is kno...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.10.001

    authors： Karam RG,Bau CH,Salgado CA,Kalil KL,Victor MM,Sousa NO,Vitola ES,Picon FA,Zeni GD,Rohde LA,Belmonte-de-Abreu P,Grevet EH

    更新日期：2009-04-01 00:00:00

  • Interhemispheric differences in regional density of the normal brain.

    abstract：:In a study of regional variations in cerebral X-ray attenuation as measured by computed tomography, a relationship between bone-related beam hardening and lateralized hemispheric density differences was sought. The CT scans of 22 normal right-handed individuals were evaluated by calculating regional mean attenuation v...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(84)90017-7

    authors： Coffman JA,Bloch S

    更新日期：1984-01-01 00:00:00

  • Antisaccade performance of schizophrenia patients: evidence of reduced task-set activation and impaired error detection.

    abstract：:The antisaccade task is well suited to study the interplay between environmental stimuli and action goals in controlling behavior. It requires subjects to look to the mirror position of visual stimuli. Schizophrenia patients usually show enhanced rates of erroneous saccades toward the stimulus. The present study was d...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2005.02.007

    authors： Reuter B,Herzog E,Kathmann N

    更新日期：2006-03-01 00:00:00

  • Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.

    abstract：BACKGROUND:Previous studies indicate that negative symptoms reflect a separable domain of pathology from other symptoms of schizophrenia. However, it is currently unclear whether negative symptoms themselves are multi-faceted, and whether sub-groups of patients who display unique negative symptom profiles can be identi...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.01.015

    authors： Strauss GP,Horan WP,Kirkpatrick B,Fischer BA,Keller WR,Miski P,Buchanan RW,Green MF,Carpenter WT Jr

    更新日期：2013-06-01 00:00:00

  • Clinical and genetic analysis of children with a dual diagnosis of Tourette syndrome and autism spectrum disorder.

    abstract：:Gilles de la Tourette Syndrome (TS) is a neurodevelopmental disorder that causes children to make repeated, brief involuntary movements or sounds. TS can be co-morbid with other neurodevelopmental disorders, including autism spectrum disorder (ASD). Clusters of biologically related genes have been associated with neur...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.01.023

    authors： Carias KV,Wevrick R

    更新日期：2019-04-01 00:00:00

  • Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses' Health Study II.

    abstract：BACKGROUND:Prior cross-sectional studies have suggested that being a late chronotype is associated with depression and depressive symptoms, but prospective data are lacking. METHODS:We examined the association between chronotype and incident depression (defined as self-reported physician/clinician-diagnosed depression...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2018.05.022

    authors： Vetter C,Chang SC,Devore EE,Rohrer F,Okereke OI,Schernhammer ES

    更新日期：2018-08-01 00:00:00

  • The acute antipanic and anxiolytic activity of aerobic exercise in patients with panic disorder and healthy control subjects.

    abstract：:Regular physical activity is anxiolytic in both healthy subjects and patients with panic disorder. In contrast, acute exercise may induce acute panic attacks or increase subjective anxiety in patients with panic disorder more than in other people. The effects of quiet rest or an aerobic treadmill exercise (30 min at a...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jpsychires.2009.02.004

    authors： Ströhle A,Graetz B,Scheel M,Wittmann A,Feller C,Heinz A,Dimeo F

    更新日期：2009-08-01 00:00:00

  • Persistent mental health impacts of disaster. Five-year follow-up after the 2011 great east Japan earthquake and tsunami: Iwanuma Study.

    abstract：:Few studies have tracked the long-term mental health outcomes following major disaster. We sought to document the trajectories of depressive symptoms and post-traumatic stress symptoms (PTSS) in the aftermath of the 2011 Great East Japan earthquake and tsunami. A cohort of community-dwelling older adults were followed...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.08.016

    authors： Kino S,Aida J,Kondo K,Kawachi I

    更新日期：2020-08-23 00:00:00

  • Upregulation of A2A adenosine receptors in platelets from patients affected by bipolar disorders under treatment with typical antipsychotics.

    abstract：:Antipsychotic drugs, potent dopamine receptor antagonists, are commonly used in the treatment of psychotic and affective illness. The discovery of antagonistic interactions between A2A adenosine receptors (ARs) and D2 dopamine receptors (DRs) in the central nervous system suggests that the adenosine system may be invo...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2004.12.008

    authors： Martini C,Tuscano D,Trincavelli ML,Cerrai E,Bianchi M,Ciapparelli A,Alessio L,Novelli L,Catena M,Lucacchini A,Cassano GB,Dell'Osso L

    更新日期：2006-02-01 00:00:00

  • Relationship between ethnicity and sleep patterns in normal controls: implications for psychopathology and treatment.

    abstract：:The purpose of the study was to examine ethnic influences on sleep regulation. Seventy-three normal volunteers from four ethnic groups (17 African-Americans, 10 Asians, 30 Caucasians and 16 Hispanics) were studied for two consecutive nights with sleep polysomnography recordings in the laboratory. The subjects were in ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(99)00019-9

    authors： Rao U,Poland RE,Lutchmansingh P,Ott GE,McCracken JT,Lin KM

    更新日期：1999-09-01 00:00:00

  • Panic disorder: the role of the balance system.

    abstract：:Experimental evidences suggest that Panic Disorder (PD) is characterized by abnormalities in respiratory and vestibular functions. We studied balance system function in patients with PD and its relationships with CO(2) reactivity and clinical characteristics. Nineteen patients with PD with/without agoraphobia underwen...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(01)00031-0

    authors： Perna G,Dario A,Caldirola D,Stefania B,Cesarani A,Bellodi L

    更新日期：2001-09-01 00:00:00

  • Reduced amygdala volume in newly admitted psychiatric in-patients with unipolar major depression.

    abstract：:Structural neuroimaging studies investigating amygdala volumes in patients suffering from major depression have yielded variable results. Discrepant findings across studies may be attributable in part to heterogeneity with respect to antidepressant medication and to lack of adequate control for the effects of total br...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2009.03.007

    authors： Kronenberg G,Tebartz van Elst L,Regen F,Deuschle M,Heuser I,Colla M

    更新日期：2009-09-01 00:00:00

  • Distinct neural responses used to gain insight into hallucinatory perception in patients with schizophrenia.

    abstract：OBJECTIVE:Most patients with schizophrenia suffer from various types of hallucinations, which commonly produce distress, functional disability or behavioral dyscontrol. The neural process of adapting to hallucinations in patients with schizophrenia remains unknown. METHODS:Functional magnetic resonance imaging (MRI) r...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.06.012

    authors： Kim JJ,Ku J,Lee H,Choi SH,Kim IY

    更新日期：2012-10-01 00:00:00

  • Measurement and predictors of resilience among community-dwelling older women.

    abstract：BACKGROUND:Resilience, the ability to adapt positively to adversity, may be an important factor in successful aging. However, the assessment and correlates of resilience in elderly individuals have not received adequate attention. METHOD:A total of 1395 community-dwelling women over age 60 who were participants at the...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.03.007

    authors： Lamond AJ,Depp CA,Allison M,Langer R,Reichstadt J,Moore DJ,Golshan S,Ganiats TG,Jeste DV

    更新日期：2008-12-01 00:00:00

  • Neuregulin-1 haplotype HAP(ICE) is associated with lower hippocampal volumes in schizophrenic patients and in non-affected family members.

    abstract：:The neuregulin-1 (NRG1) gene on chromosome 8p has been suggested as a potential susceptibility gene for schizophrenia. The exact way in which genetic variation in NRG1 might impact on this susceptibility for the disorder is a focus of current research. The present study aimed at investigating the possible relationship...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.01.009

    authors： Gruber O,Falkai P,Schneider-Axmann T,Schwab SG,Wagner M,Maier W

    更新日期：2008-11-01 00:00:00

  • Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain.

    abstract：:Weight gain and metabolic syndrome are the most common deleterious side effects following treatment with second generation antipsychotic drugs such as clozapine and olanzapine. However, the mechanisms underlying these negative effects of second generation antipsychotic drugs are not fully understood. In this study we ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.01.010

    authors： Souza RP,Tiwari AK,Chowdhury NI,Ceddia RB,Lieberman JA,Meltzer HY,Kennedy JL,Müller DJ

    更新日期：2012-04-01 00:00:00

  • Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia.

    abstract：BACKGROUND:Gray matter reduction and ventricular enlargement belong to the best replicated findings in schizophrenia. Brain morphologic changes were also found in non-schizophrenic family members (FM). The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic cha...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2005.04.009

    authors： Schneider-Axmann T,Kamer T,Moroni M,Maric N,Tepest R,Dani I,Honer WG,Scherk H,Rietschel M,Schulze TG,Müller DJ,Cordes J,Schönell H,Steinmetz H,Gaebel W,Vogeley K,Kühn KU,Wagner M,Maier W,Träber F,Block W,Schild

    更新日期：2006-10-01 00:00:00

  • Cognitive impairment among children at-risk for schizophrenia.

    abstract：:Adults with schizophrenia present cognitive impairments, as do individuals at ultra-high risk for the disorder, youth with relatives with schizophrenia spectrum disorders, and children with antecedents of schizophrenia. The present study aimed to determine if impairments in childhood differed depending on the definiti...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.12.003

    authors： Dickson H,Cullen AE,Reichenberg A,Hodgins S,Campbell DD,Morris RG,Laurens KR

    更新日期：2014-03-01 00:00:00

  • Association between psychological morbidities and information provision, reliability, and satisfaction among disaster victims: A cross-sectional study.

    abstract：:Providing information about disaster relief services and recovery processes reduces the damage from disasters and enables disaster victims to respond to disasters effectively. The present study aimed to clarify the associations between provision, reliability, satisfaction of information and satisfaction with media cov...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.08.010

    authors： Kang E

    更新日期：2020-11-01 00:00:00

  • An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder.

    abstract：OBJECTIVES:Dysfunctions in stress biology are hypothesized to contribute to anxiety disorders, and to be ameliorated during successful treatment, but limited clinical data exist to support this hypothesis. We evaluated whether increases in morning cortisol and the diurnal cortisol slope, markers of stress biology, are ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2017.10.011

    authors： Keefe JR,Guo W,Li QS,Amsterdam JD,Mao JJ

    更新日期：2018-01-01 00:00:00

  • Migraine: temperament and character.

    abstract：:The personality profile of 26 adult migraine patients from a large Swedish family with migraine and 87 controls were studied by means of Cloninger's seven-factor model of Temperament and Character (TCI; Temperament and Character Inventory). For the diagnosis of migraine, a questionnaire, slightly modified to fit the c...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(96)00009-x

    authors： Nylander PO,Schlette P,Brändström S,Nilsson M,Forsgren T,Forsgren L,Adolfsson R

    更新日期：1996-09-01 00:00:00

  • Revised diagnostic criteria and a new structured interview for diagnosing anxiety disorders.

    abstract：:In recent years there has been a growing interest in the diagnosis and treatment of Anxiety Disorders. A fundamental assumption of the newer treatments is the identification of specific subtypes of Anxiety Disorders. Although the DSM-III classification of Anxiety Disorders is widely accepted, research experience since...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(88)90069-6

    authors： Spitzer RL,Williams JB

    更新日期：1988-01-01 00:00:00

  • Gender differences in depression: an ethological study of nonverbal behavior during interviews.

    abstract：:Previous studies of gender differences in the phenomenology of depression have focused mostly on symptoms as measured by self-report questionnaires or clinician-rated scales. In this study, we examined gender differences in the interpersonal behavior of depressed patients by using ethological techniques which involve ...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-3956(98)00064-8

    authors： Troisi A,Moles A

    更新日期：1999-05-01 00:00:00

  • Self-harm history predicts resistance to inpatient treatment of body shape aversion in women with eating disorders: The role of negative affect.

    abstract：:Although self-harm has been observed among patients with eating disorders, the effects of such tendencies on treatment outcomes are unclear. The current study employed structural equation modeling to (a) evaluate the relationship between self-harm and changes in body dissatisfaction and drive for thinness in a large s...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2015.03.016

    authors： Olatunji BO,Cox R,Ebesutani C,Wall D

    更新日期：2015-06-01 00:00:00

  • Temporal sequencing of nicotine dependence and bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).

    abstract：:Bipolar disorder (BD) and nicotine dependence (ND) often co-occur. However, the mechanisms underlying this association remain unclear. We aimed to examine, for the first time in a national and representative sample, the magnitude and direction of the temporal relationship between BD and ND; and to compare, among indiv...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.03.012

    authors： Martínez-Ortega JM,Goldstein BI,Gutiérrez-Rojas L,Sala R,Wang S,Blanco C

    更新日期：2013-07-01 00:00:00