Abstract:
UNLABELLED:Both decrease in bone mineral density and increase in bone turnover had been reported in patients with major depression compared to healthy controls. But the effect of antidepressant treatment on markers of bone turnover is not studied. The aim of this study was to investigate the effect of treatment of a major depressive episode with an SSRI antidepressant on bone turnover in premenopausal women. METHODS:Fifty premenopausal female patients with newly diagnosed major depression according to DSM IV-R criteria were included into the study. Before starting antidepressant therapy (escitalopram 10 mg/day) and three months later, blood samples were collected for the measurement of serum calcium, phosphorus, osteocalcin, β-CTX and iPTH. Depressive status was determined with Hamilton Depression Scale. RESULTS:Treatment of depression did not create any change in laboratory levels of either calcium or phosphorus. Basal iPTH level was significantly decreased with the treatment. Treatment resulted in an increase in serum osteocalcin and decrease in β-CTX levels. HAMD score was significantly correlated with both osteocalcin and β-CTX. The decrease in β-CTX and increase in osteocalcin levels were more prominent in patients with a HAMD score that remained below 15 than above 15 at the end of the study period. In conclusion, this study shows that with the treatment of depression bone formation increases and bone resorption decreases in premenopausal women with major depression.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Aydin H,Mutlu N,Akbas NBdoi
10.1016/j.jpsychires.2011.04.005subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1316-20issue
10eissn
0022-3956issn
1879-1379pii
S0022-3956(11)00072-0journal_volume
45pub_type
杂志文章abstract::The failure in the discovery of etiology of psychiatric diseases, despite extensive genetic studies, has directed the attention of neuroscientists to the contribution of epigenetic modulations, which play important roles in fine-tuning of gene expression in response to environmental factors. Previously, we analyzed 11...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2011.06.013
更新日期:2011-11-01 00:00:00
abstract::Deep transcranial magnetic stimulation (DTMS) is a non-invasive brain stimulation method mostly utilised in the treatment of major depression. The aim of the current study was to systematically review the literature on the cognitive effects of DTMS applied with the H-coil system in major psychiatric disorders. Followi...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jpsychires.2010.05.016
更新日期:2011-02-01 00:00:00
abstract::Depression and anxiety are prevalent in patients with heart failure (HF). Reduced ejection fraction (EF) and increased N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) have been shown to be independently associated with depressive symptoms and may therefore increase HF disease progression and mortality. Th...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2018.06.010
更新日期:2018-09-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jpsychires.2011.02.005
更新日期:2011-08-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2014.03.022
更新日期:2014-08-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.09.002
更新日期:2012-12-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/s0022-3956(98)00015-6
更新日期:1998-09-01 00:00:00
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journal_title:Journal of psychiatric research
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doi:10.1016/j.jpsychires.2015.08.004
更新日期:2015-10-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析
doi:10.1016/j.jpsychires.2018.02.001
更新日期:2018-04-01 00:00:00
abstract::We have previously demonstrated an impairment of intraplatelet L-arginine-nitric oxide-cGMP pathway in major depression (MD) associated to platelet dysfunction. Here, we evaluated arginase pathway and phosphodiesterase 5 (PDE5) expression in platelets, systemic and intraplatelet oxidative status in untreated MD patien...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2014.12.009
更新日期:2015-02-01 00:00:00
abstract:UNLABELLED:This prospective study aimed to assess symptomatic evolution of patients diagnosed with Upper Airway Resistance Syndrome (UARS) four and half years after the initial UARS diagnosis. For this purpose, 138 UARS patients were contacted by mail between 43 and 69 months after the initial evaluation; 105 responded...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2005.03.007
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Methadone maintenance therapy (MMT) is provided to patients with opioid use disorder (OUD). However, as with all opioids, methadone impacts negatively on sexual function. To counter this, Rosa Damascena oil (RDO) has been used successfully for opioid-dependent male patients under MMT and with methadone-relat...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jpsychires.2017.08.011
更新日期:2017-12-01 00:00:00
abstract::Major depressive disorder (MDD) is characterized by the presence of disturbances in emotional processing. However, the neural correlates of these alterations, and how they may be affected by therapeutic interventions, remain unclear. The present study addressed these issues in a preliminary investigation using functio...
journal_title:Journal of psychiatric research
pub_type: 临床试验,杂志文章
doi:10.1016/j.jpsychires.2010.09.007
更新日期:2011-05-01 00:00:00
abstract::The impact of co-morbid substance use on mortality is not well studied in psychotic disorders. The objective of this study was to examine the impact of substance use on mortality in people with psychotic disorders and alcohol and/or drug use. We examined the rate of substance use and the risk of substance use on morta...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.04.019
更新日期:2012-08-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2019.12.005
更新日期:2020-02-01 00:00:00
abstract::The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment. We aimed to elucidate the complement of the gut-microbiome community for individuals with bipolar disorder relative to controls; and test for relationships with ...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2016.12.007
更新日期:2017-04-01 00:00:00
abstract::Early life stress (ELS), in the form of childhood maltreatment, abuse, or neglect, increases the risk for psychiatric sequelae later in life. The neurobiology of response to early stress and of reward processing overlap substantially, leading to the prediction that reward processing may be a primary mediator of the ef...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychires.2018.02.002
更新日期:2018-06-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2005.04.014
更新日期:2006-04-01 00:00:00
abstract::Research investigating patterns of familial aggregation of psychiatric disorders has used the family history method in which a single family member reports on the psychiatric history of their relatives. This method is more efficient and less costly than the family study method, in which direct interviews are performed...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/0022-3956(92)90005-9
更新日期:1992-04-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2016.10.022
更新日期:2017-02-01 00:00:00
abstract::Major depressed patients show increased bacterial translocation with elevated plasma levels of lipopolysaccharide (LPS), which may trigger immune-inflammatory and neuro-oxidative responses. Recently, an animal model based on chronic LPS administration was developed which was associated with long-lasting depressive-lik...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2018.10.003
更新日期:2018-12-01 00:00:00
abstract::Many individuals who die by suicide or attempt suicide have no pre-existing psychiatric record. In these cases determination of the presence of mental illness at the time of the suicidal act depends on diagnostic interviews with different informants, but the reliability of such interviews is unknown. To address this i...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2017.12.003
更新日期:2018-03-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jpsychires.2010.05.009
更新日期:2011-01-01 00:00:00
abstract::The goal of this article is to highlight the significant potential benefits of applying computational mathematical models to the field of psychiatry, specifically in relation to diagnostic conceptualization. The purpose of these models is to augment the current diagnostic categories that utilize a "snapshot" approach ...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychires.2011.10.013
更新日期:2012-04-01 00:00:00
abstract::The present study examines the association between subjective age and risk of incident dementia in a large longitudinal sample of older adults. Participants were adults aged 65 years and older from the National Health and Aging Trends Study (NHATS). Subjective age, covariates, and cognitive status were assessed in 201...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2018.02.008
更新日期:2018-05-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2010.11.003
更新日期:2011-06-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2009.08.003
更新日期:2010-03-01 00:00:00
abstract::Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, ...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2008.10.013
更新日期:2009-05-01 00:00:00