当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Resting state brain network function in major depression - Depression symptomatology, antidepressant treatment effects, future research.

Resting state brain network function in major depression - Depression symptomatology, antidepressant treatment effects, future research.

Abstract：

:The alterations of functional connectivity brain networks in major depressive disorder (MDD) have been subject of a large number of studies. Using different methodologies and focusing on diverse aspects of the disease, research shows heterogeneous results lacking integration. Disrupted network connectivity has been found in core MDD networks like the default mode network (DMN), the central executive network (CEN), and the salience network, but also in cerebellar and thalamic circuitries. Here we review literature published on resting state brain network function in MDD focusing on methodology, and clinical characteristics including symptomatology and antidepressant treatment related findings. There are relatively few investigations concerning the qualitative aspects of symptomatology of MDD, whereas most studies associate quantitative aspects with distinct resting state functional connectivity alterations. Such depression severity associated alterations are found in the DMN, frontal, cerebellar and thalamic brain regions as well as the insula and the subgenual anterior cingulate cortex. Similarly, different therapeutical options in MDD and their effects on brain function showed patchy results. Herein, pharmaceutical treatments reveal functional connectivity alterations throughout multiple brain regions notably the DMN, fronto-limbic, and parieto-temporal regions. Psychotherapeutical interventions show significant functional connectivity alterations in fronto-limbic networks, whereas electroconvulsive therapy and repetitive transcranial magnetic stimulation result in alterations of the subgenual anterior cingulate cortex, the DMN, the CEN and the dorsal lateral prefrontal cortex. While it appears clear that functional connectivity alterations are associated with the pathophysiology and treatment of MDD, future research should also generate a common strategy for data acquisition and analysis, as a least common denominator, to set the basis for comparability across studies and implementation of functional connectivity as a scientifically and clinically useful biomarker.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Brakowski J,Spinelli S,Dörig N,Bosch OG,Manoliu A,Holtforth MG,Seifritz E

doi

10.1016/j.jpsychires.2017.04.007

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

147-159

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(16)30752-X

journal_volume

pub_type

杂志文章,评审

在线工具

Resting state brain network function in major depression - Depression symptomatology, antidepressant treatment effects, future research.