Abstract：
:Although serotonin (5-HT) genes are thought to be involved in the etiology of bulimia nervosa and binge eating, findings from molecular genetic studies are inconclusive. This may be due to limitations of past research, such as a failure to consider the influence of quantitative traits and gene-environment interactions. The current study investigated these issues by examining whether quantitative traits (i.e., impulsivity) and environmental exposure factors (i.e., dietary restraint) moderate 5-HT gene/binge eating associations in a sample of young women (N = 344). Binge eating was assessed using the Minnesota Eating Behavior Survey and the Dutch Eating Behavior Questionnaire (DEBQ). Impulsivity was assessed with the Barratt Impulsiveness Scale-Version 11. Dietary restraint was measured with a factor score derived from common restraint scales. Saliva samples were genotyped for the 5-HT2a receptor T102C polymorphism and 5-HT transporter promoter polymorphism. As expected, impulsivity and dietary restraint were associated with binge eating. Although the T allele of the 5-HT2a receptor gene and the s allele of the 5-HTT gene were associated with higher levels of impulsivity, there were no main effects of 5-HT genotypes on any binge eating measure, and interactions between genotypes, impulsivity, and dietary restraint were non-significant. In conclusion, we found no evidence to suggest that dietary restraint or impulsivity moderate associations between binge eating and these 5-HT genes. Future research should continue to explore interaction effects by examining larger samples, assessing dietary intake directly, and investigating other genes, traits, and environmental factors that may be related to binge eating and bulimia nervosa.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Racine SE,Culbert KM,Larson CL,Klump KLdoi
10.1016/j.jpsychires.2009.05.002subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1278-86issue
16eissn
0022-3956issn
1879-1379pii
S0022-3956(09)00104-6journal_volume
43pub_type
杂志文章abstract：:Immune factors may be involved in the pathophysiology of Alzheimer's disease (AD), a neurodegenerative disease. Since immune activation precedes immune-mediated processes, we measured plasma levels of four selective cytokines: interleukin-6 (IL-6), interleukin-12 (IL-12), interferon-alpha (IFN-alpha), and interferon-g...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(97)00023-x
更新日期：1997-11-01 00:00:00
abstract：:Utilizing the DSM-III-R schema, we have investigated lifetime comorbidity between panic disorder with or without agoraphobia (PD), social phobia (SP) and obsessive-compulsive disorder (OCD) on the one hand, and mood disorder on the other. Compared with PD, the results for SP and OCD showed significantly higher numbers...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(98)00044-2
更新日期：1999-01-01 00:00:00
abstract：:Major depressive disorder (MDD) is a severe mental illness leading to long-term disabilities. One of the current challenges in psychiatric research is to develop new approaches to investigate the pathophysiology of MDD and monitor drug response in order to provide better therapeutic strategies to the patients. Since t...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychires.2015.09.003
更新日期：2015-11-01 00:00:00
abstract：:Body-focused repetitive behaviors (BFRBs) and non-suicidal self-injury (NSSI) are recognized as distinct categories in the DSM-5. However, definitions and assessment of NSSI sometimes encompasses behaviors similar to BFRBs, and little data exist about their clinical differences. The current study examined clinical cha...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.02.020
更新日期：2020-05-01 00:00:00
abstract：:Patients with musculoskeletal illness often report that pain interferes with their ability to engage in activities of daily living. Catastrophic thinking is consistently depicted as an important cognitive factor that hinders adjustment to pain. Current research has also shown that pain negatively impacts an individual...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2017.04.005
更新日期：2017-08-01 00:00:00
abstract：:Sleep deprivation (SD) is an effective, however short-lived, method of treatment of depression. Preliminary findings suggest that the antidepressive effect of sleep deprivation is mediated by serotoninergic (5-HT) mechanisms. We therefore assessed serotoninergic activity before and after total SD (TSD) as well as afte...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(96)00062-3
更新日期：1997-05-01 00:00:00
abstract：:The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment. We aimed to elucidate the complement of the gut-microbiome community for individuals with bipolar disorder relative to controls; and test for relationships with ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2016.12.007
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Transcutaneous electrical acupoint stimulation (TEAS) is thought to have potential to treat obsessive-compulsive disorder (OCD). OBJECTIVE:The purpose of this study was to determine whether adding TEAS to cognitive behavioral therapy (CBT) and clomipramine would improve the efficacy of these conventional tr...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jpsychires.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:Both the COVID-19 pandemic and its management have had a negative impact on mental health worldwide. There is a growing body of research on mental health as it relates to the pandemic. The objective of this study is to use bibliometric analyses to assess the mental health research output related to the COV...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.10.018
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:Dysfunctions in stress biology are hypothesized to contribute to anxiety disorders, and to be ameliorated during successful treatment, but limited clinical data exist to support this hypothesis. We evaluated whether increases in morning cortisol and the diurnal cortisol slope, markers of stress biology, are ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2017.10.011
更新日期：2018-01-01 00:00:00
abstract：:In acute psychotic schizophrenia patients we investigated if the combination of triiodothyronine (T3) plus risperidone was more effective when compared to risperidone monotherapy. Thirty-two in-patients meeting the DSM-IV-TR diagnostic criteria for schizophrenia and without thyroid disease received risperidone (flexib...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2015.11.007
更新日期：2016-02-01 00:00:00
abstract：:Suicide is a serious worldwide health problem of critical consequences. Nowadays genetic factors are considered to be an important cause of suicide. The association between Val66Met (rs6265) polymorphism of the BDNF gene and suicide behavior has been increasingly studied. The aim of this study was to perform a meta-an...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychires.2017.07.020
更新日期：2017-11-01 00:00:00
abstract：INTRODUCTION:Doublecortin (DCX) and polysialilated neural cell adhesion molecule (PSA-NCAM), two proteins associated with immature neuronal phenotypes and elevated neuroplasticity in the adult brain, have recently been identified in the mammalian amygdala, and evidence from rodent studies suggests that stress may modif...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.11.013
更新日期：2013-03-01 00:00:00
abstract：:The auditory evoked field (AEF) component N100m represents the most prominent and stable peak of the AEF, and its alterations in patients with schizophrenia are an extensive topic of neuropsychiatric research. In our current study, the degree of N100m habituation was investigated in 20 male schizophrenics and 19 healt...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(00)00007-8
更新日期：2000-05-01 00:00:00
abstract：:Although sleep disturbance has been shown to be associated with psychological distress and the hypothalamic-pituitary-adrenal (HPA) axis function, the simultaneous relationship between sleep, distress and HPA axis function is less clear. Here we examined the relationship between sleep quality as assessed with the Pitt...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2011.04.001
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Prior cross-sectional studies have suggested that being a late chronotype is associated with depression and depressive symptoms, but prospective data are lacking. METHODS:We examined the association between chronotype and incident depression (defined as self-reported physician/clinician-diagnosed depression...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2018.05.022
更新日期：2018-08-01 00:00:00
abstract：:There is a body of evidence suggesting that BDNF is involved in bipolar disorder (BD) pathogenesis. Intracerebroventricular (ICV) injection of ouabain (OUA), a specific Na(+)/K(+) ATPase inhibitor, induces hyperlocomotion in rats, and has been used as an animal model of mania. The present study aims to investigate the...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.11.002
更新日期：2010-06-01 00:00:00
abstract：:Recent evidence suggests that peripheral markers related to oxidative stress, inflammation and neurotrophins may be altered during mood episodes in bipolar disorder. These can be seen as proxies of peripheral toxicity or markers of illness activity. Here we report an en bloc assessment of a set of previously described...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.05.015
更新日期：2011-02-01 00:00:00
abstract：:We performed a systematic review and meta-analysis of the efficacy and safety of second generation (SG) long-acting antipsychotics (LAIAs) versus first generation (FG) LAIAs in schizophrenia. We conducted a comprehensive search in PubMed, MEDLINE, EMBASE and PsycINFO until May 2019. Inclusion criteria for randomized t...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychires.2020.06.013
更新日期：2020-10-01 00:00:00
abstract：:Recent theoretical and empirical evidence highlights associations between attention-deficit/hyperactivity disorder (ADHD) symptoms and task-unrelated thought, including mind-wandering and rumination. However, it has been hypothesized that sluggish cognitive tempo (SCT), characterized by daydreaming and staring behavio...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.01.016
更新日期：2020-04-01 00:00:00
abstract：:Patients with major depressive disorder (MDD) usually suffer from altered cognitive functions of episodic memory, working memory, mental processing speed and motor response. Diverse studies suggest that different antidepressant agents may improve cognitive functions in patients with MDD. The aim of this work is to stu...
journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章
doi：10.1016/j.jpsychires.2008.10.015
更新日期：2009-06-01 00:00:00
abstract：:Suicide plans are a major risk factor for suicide, which is a devastating outcome of depression. While structural and functional brain changes have been demonstrated in relation to suicidal thoughts and behaviour, brain mechanisms underlying suicide plans have not yet been studied. Here, we studied changes in regional...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2016.10.011
更新日期：2017-01-01 00:00:00
abstract：:The use of activity which is carefully planned so as to facilitate change in the patient is a unique characteristic of occupational therapy. Occupational therapy closely resembles the actual living situation more so than any other treatment setting and therefore provides a realistic environment in which the patient ca...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(85)90054-8
更新日期：1985-01-01 00:00:00
abstract：:Depression has a chronic and recurrent course often with early onset and is the leading cause of disability worldwide. In contrast to diagnoses for other conditions which rely on precise medical tests, the diagnosis of depression still focuses exclusively on symptom reports. As a result, heterogeneous patient groups a...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.12.004
更新日期：2020-03-01 00:00:00
abstract：:The anterior cingulate cortex (ACC) plays a major role in modulating executive control of attention. Here, 15 medication-nai ve patients with attention deficit/hyperactivity disorder (ADHD) and 10 carefully matched healthy controls were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [B...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2007.06.006
更新日期：2008-06-01 00:00:00
abstract：:Alterations in the density and size of pyramidal neurons in the prefrontal cortex have been described in schizophrenia and mood disorder. However, the changes are generally modest and have not always been replicated. We investigated the possibility that specific pyramidal neuron sub-populations, defined by their immun...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(03)00075-x
更新日期：2003-11-01 00:00:00
abstract：:In a study of regional variations in cerebral X-ray attenuation as measured by computed tomography, a relationship between bone-related beam hardening and lateralized hemispheric density differences was sought. The CT scans of 22 normal right-handed individuals were evaluated by calculating regional mean attenuation v...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(84)90017-7
更新日期：1984-01-01 00:00:00
abstract：:Bipolar disorder (BD) is characterized by frequent recurrence, incomplete recovery, cognitive dysfunction and poor functioning. Impairment lingers in the interepisodic period and mechanisms leading to this dysfunctional state are not fully comprehended. To our knowledge the association of biological rhythm dysfunction...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.08.003
更新日期：2010-03-01 00:00:00
abstract：:Dysfunction of the N-methyl-d-aspartate receptor, which is modulated by excitatory amino acids (EAA), is involved in the pathophysiology of schizophrenia. The effects of antipsychotics on EAA metabolism are uncertain. Positive clinical effects of treatment with antipsychotics were not always associated with changes in...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.03.015
更新日期：2012-06-01 00:00:00
abstract：:Although considerable empirical work has been devoted to identifying risk factors for suicide attempts, most longitudinal research has studied recurrent attempts rather than first lifetime attempts. The present study sought to examine prospective predictors of first lifetime suicide attempts among adults receiving tre...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpsychires.2016.09.020
更新日期：2017-01-01 00:00:00
