Abstract:
:Several lines of evidence suggest a dysregulation of the adrenocortical (HPA) system with hypersecretion of CRH is associated with suicidal behavior. However, controversial results have emerged from the determination of corticotropin-releasing hormone (CRH) concentrations in the lumbar cerebrospinal fluid (CSF) of suicide attempters probably due to methodological differences. We simultaneously measured CRH concentrations in the CSF and in the plasma of 41 psychiatric in-patients with different diagnoses (affective disorder, schizophrenia, personality disorders, adjustment disorder, substance abuse) and eight neurological control subjects. We also measured plasma cortisol concentrations because data from animal experiments suggest that cortisol may influence CSF CRH concentrations. The major finding was that patients who attempted suicide prior to admission had significantly lower CSF CRH concentrations than psychiatric patients without suicidal behavior. CRH concentrations were significantly higher in the CSF than in plasma in both, psychiatric patients and neurological control subjects. There was no significant difference between suicide attempters and patients with acute suicidal ideations. The latter group showed a trend towards lower CSF CRH concentrations compared with the neurological control subjects. Patients with affective disorder alone as well as patients with multiple diagnoses, but not schizophrenic patients, showed significantly lower CSF CRH concentrations than neurological control subjects. Plasma CRH and plasma cortisol concentrations did not differ among diagnostic groups or between suicide attempters vs. non-attempters. Further studies with more homogeneous samples, drug-free patients and with simultaneous assessment of various parameters of the HPA system are warranted.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Brunner J,Stalla GK,Stalla J,Uhr M,Grabner A,Wetter TC,Bronisch Tdoi
10.1016/s0022-3956(01)00007-3subject
Has Abstractpub_date
2001-01-01 00:00:00pages
1-9issue
1eissn
0022-3956issn
1879-1379pii
S0022-3956(01)00007-3journal_volume
35pub_type
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychires.2016.01.006
更新日期:2016-04-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2015.02.006
更新日期:2015-04-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2019.01.015
更新日期:2019-04-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2015.03.016
更新日期:2015-06-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2008.12.005
更新日期:2009-06-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/s0022-3956(01)00046-2
更新日期:2002-01-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析
doi:10.1016/j.jpsychires.2019.01.013
更新日期:2019-04-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2013.03.012
更新日期:2013-07-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2017.04.003
更新日期:2017-09-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.04.005
更新日期:2012-07-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2014.12.009
更新日期:2015-02-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
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更新日期:1998-05-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2013.03.004
更新日期:2013-07-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/s0022-3956(02)00050-x
更新日期:2002-11-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/0022-3956(82)90042-5
更新日期:1982-01-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2014.03.011
更新日期:2014-07-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2017.03.008
更新日期:2017-09-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2019.01.006
更新日期:2019-04-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2013.06.006
更新日期:2013-10-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.04.019
更新日期:2012-08-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jpsychires.2015.10.006
更新日期:2015-12-01 00:00:00