Abstract：
:Aggressive behavior is controlled at multiple anatomical levels within the human brain. To illustrate hierarchical neural controls over aggression, we compare and contrast the roles of the hypothalamus, amygdaloid complex, and orbital prefrontal cortex in terms of their distinctive sensory inputs, effector channels, and principles of integration as deduced from observations in animals and man. We illustrate characteristic syndromes of human aggression resulting from hypothalamic, temporolimbic, or frontal cortical lesions. The application of this perspective to research on criminal violence is discussed.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Weiger WA,Bear DMdoi
10.1016/0022-3956(88)90073-8subject
Has Abstractpub_date
1988-01-01 00:00:00pages
85-98issue
2eissn
0022-3956issn
1879-1379journal_volume
22pub_type
杂志文章,评审abstract：:Antipsychotic drugs, potent dopamine receptor antagonists, are commonly used in the treatment of psychotic and affective illness. The discovery of antagonistic interactions between A2A adenosine receptors (ARs) and D2 dopamine receptors (DRs) in the central nervous system suggests that the adenosine system may be invo...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2004.12.008
更新日期：2006-02-01 00:00:00
abstract：:Cholesterol (CHL) and phospholipid (PL) levels in synaptosomal membranes in particular can have an impact on cell signalling. Alterations in peripheral CHL measures have been consistently reported in suicidal behaviour. As CHL and PL turnover in the brain are important in synapse maintenance and function, the objectiv...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.10.019
更新日期：2013-02-01 00:00:00
abstract：:The relationship of Narcissistic Personality Disorder (NPD) to suicidal behavior is understudied. The modest body of existing research suggests that NPD is protective against low-lethality suicide attempts, but is associated with high lethality attempts. Mood-disordered patients (N = 657) received structured interview...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2016.10.020
更新日期：2017-02-01 00:00:00
abstract：:Narcissistic personality disorder is the subject of extensive discussion in the literature. Yet, the validity of this diagnostic category remains questionable. This is owed, in large part, to the relative absence of empirical work that has examined narcissism in clinical samples. Descriptions and findings from studies...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.12.005
更新日期：2009-06-01 00:00:00
abstract：:Impairments in social cognition have been documented in severe alcohol use disorder (SAUD) over the past two decades. They have been linked with lower social functioning and poor treatment outcomes, illustrating their key role in the disorder. However, studies investigating social cognition in SAUD have largely focuse...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.06.031
更新日期：2020-10-01 00:00:00
abstract：:Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.04.012
更新日期：2013-10-01 00:00:00
abstract：:Childhood maltreatment is associated with posttraumatic stress disorder (PTSD) and elevated rates of adolescent and adult psychopathology including major depression, bipolar disorder, substance use disorders, and other medical comorbidities. Gray matter volume changes have been found in maltreated youth with (versus w...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpsychires.2017.12.015
更新日期：2018-03-01 00:00:00
abstract：:In the last couple of years, non-coding (nc) RNAs like micro-RNAs (miRNAs), small interference RNAs (siRNAs) and long ncRNAs (lncRNAs) have emerged as promising candidates for biomarkers and drug-targets in a variety of psychiatric disorders. In contrast to reports on ncRNAs in affective disorders, schizophrenia and a...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychires.2015.03.014
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Transcutaneous electrical acupoint stimulation (TEAS) is thought to have potential to treat obsessive-compulsive disorder (OCD). OBJECTIVE:The purpose of this study was to determine whether adding TEAS to cognitive behavioral therapy (CBT) and clomipramine would improve the efficacy of these conventional tr...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jpsychires.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：:The post-partum period is a time of extreme vulnerability for a whole spectrum of psychiatric disorders. Delivery may be considered an important risk factor in genetically susceptible women. Five hundred and eight SNPs in 44 genes at candidate pathways putatively related to mood changes after delivery were genotyped i...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpsychires.2009.12.012
更新日期：2010-08-01 00:00:00
abstract：:The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD. Hippocampal Cholinergic Neurostimulating Peptide (HCNP) regulates acetylcholine synthesis. The aim of the present work was to investigate expression lev...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2015.02.006
更新日期：2015-04-01 00:00:00
abstract：:Previously our study has shown that the DNA methylation (DNAm) levels at CpG sites in the pro-inflammatory cytokine gene, TNF-alpha, decrease along with aging, suggesting the potential role of DNAm in aging and heightened inflammatory process leading to increased risk for delirium. However, DNAm differences between de...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.06.005
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Previous studies indicate that negative symptoms reflect a separable domain of pathology from other symptoms of schizophrenia. However, it is currently unclear whether negative symptoms themselves are multi-faceted, and whether sub-groups of patients who display unique negative symptom profiles can be identi...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.01.015
更新日期：2013-06-01 00:00:00
abstract：:Although cut-points or threshold scores are commonly used in screening instruments as well as in psychiatric diagnostic practice, much is still to be learned about their functional characteristics. This study demonstrates that, for a cut-off of y items on a screening instrument, there is great variability in the ident...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(94)90029-9
更新日期：1994-03-01 00:00:00
abstract：UNLABELLED:Both decrease in bone mineral density and increase in bone turnover had been reported in patients with major depression compared to healthy controls. But the effect of antidepressant treatment on markers of bone turnover is not studied. The aim of this study was to investigate the effect of treatment of a ma...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2011.04.005
更新日期：2011-10-01 00:00:00
abstract：:Elevated rates of cigarette smoking are observed prior to the onset of psychosis and remain stable early in the illness. Cannabis use frequently co-occurs with cigarette smoking and is independently associated with distinct clinical outcomes. However, past research has not controlled for cannabis use in cigarette smok...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2016.10.022
更新日期：2017-02-01 00:00:00
abstract：:Estimating the prevalence rates of mental disorders is important for developing prevention, treatment, and research plans. Given that survey-based and registry-based prevalence rates of mental disorders each have pros and cons yet complement one another, it is important to consider both assessments when investigating ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.07.047
更新日期：2020-11-01 00:00:00
abstract：:Research investigating patterns of familial aggregation of psychiatric disorders has used the family history method in which a single family member reports on the psychiatric history of their relatives. This method is more efficient and less costly than the family study method, in which direct interviews are performed...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(92)90005-9
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:Quality of life (QOL) is now recognised as an important measure of outcome that could potentially influence clinical decision-making for those with a first-episode psychosis (FEP). A number of QOL instruments are available however; many differ in their conceptual orientation which may have serious implicatio...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.06.001
更新日期：2013-10-01 00:00:00
abstract：:The objective of the current study was to delineate the optimal cutpoints for depression rating scales during pregnancy and the postpartum period and to assess the perinatal factors influencing these scores. Women participating in prospective investigations of maternal mental illness were enrolled prior to 28 weeks ge...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.05.017
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Chronic users of cannabis often report withdrawal symptoms after abstinence from use, but little is known about cannabis withdrawal in people with schizophrenia. METHODS:Cannabis use patterns and withdrawal symptoms in adults with schizophrenia who had at least weekly cannabis use before attempting to quit ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.10.010
更新日期：2013-02-01 00:00:00
abstract：:In acute psychotic schizophrenia patients we investigated if the combination of triiodothyronine (T3) plus risperidone was more effective when compared to risperidone monotherapy. Thirty-two in-patients meeting the DSM-IV-TR diagnostic criteria for schizophrenia and without thyroid disease received risperidone (flexib...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2015.11.007
更新日期：2016-02-01 00:00:00
abstract：:This study examined dispositional emotion-, personality/temperament-, and reward-related variables in relation to post-surgery eating pathology and weight-change among 107 adults who underwent Roux-en-Y gastric bypass (RYGB) or laparoscopic adjustable gastric banding (LAGB). As part of a prospective cohort study, annu...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.10.014
更新日期：2020-01-01 00:00:00
abstract：:Blood-injury-injection (BII) phobia presents with a unique anxiety response that often involves blood pressure drops and pronounced bradycardia, which can culminate in fainting. The current recommended treatment for BII phobia is Applied Tension (AT), a tension technique that includes in vivo exposure. However, surpri...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychires.2009.04.008
更新日期：2009-10-01 00:00:00
abstract：:Ghrelin showed antidepressant-like effects in mice. Furthermore, ghrelin influences sleep and the activity of hypothalamic-pituitary-adrenal (HPA) and somatotropic axis in healthy humans as indicated by increased cortisol and growth hormone (GH) plasma levels. Both sleep and the activity of these endocrine axes are di...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2010.09.002
更新日期：2011-03-01 00:00:00
abstract：:The purpose of the study was to examine ethnic influences on sleep regulation. Seventy-three normal volunteers from four ethnic groups (17 African-Americans, 10 Asians, 30 Caucasians and 16 Hispanics) were studied for two consecutive nights with sleep polysomnography recordings in the laboratory. The subjects were in ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(99)00019-9
更新日期：1999-09-01 00:00:00
abstract：:Cognitive-behavioral therapy (CBT) constitutes an empirically based treatment for tic disorders (TD), but much remains to be learned about its impact at the neural level. Therefore, we examined the electrophysiological correlates of CBT in TD patients, and we evaluated the utility of event-related potentials (ERP) as ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2018.08.020
更新日期：2018-10-01 00:00:00
abstract：:Cannabis is commonly used recreationally for its euphoric and relaxing effects, while its medical use is permitted in several jurisdictions. With only low-quality evidence suggesting anxiolytic effects of cannabis and strong public sentiment surrounding such purported effects, the purpose of this study was to examine ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.01.024
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Regulatory T cells (Tregs, CD4(+)CD25(hi)) are specialized in steering the immune response and cytokine release to maintain tolerance to self-antigens. As cytokines such as interleukin (IL)-1β, IL-6 and interferon (IFN)-α have been shown to be involved in the pathophysiology of depression and cytokine levels...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.03.005
更新日期：2010-11-01 00:00:00
abstract：:Major depressive disorder (MDD) is a severe mental illness leading to long-term disabilities. One of the current challenges in psychiatric research is to develop new approaches to investigate the pathophysiology of MDD and monitor drug response in order to provide better therapeutic strategies to the patients. Since t...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychires.2015.09.003
更新日期：2015-11-01 00:00:00
