Abstract：
:Intermittent Explosive Disorder (IED) is a relatively common disorder of impulsive aggression that typically emerges by adulthood. Maltreatment in childhood (CM) may contribute to the development of IED, but little is known about the association between CM and IED, including about how subtypes of CM may specifically relate to IED. This study aimed to test the association between CM and IED diagnosis. A second aim was to examine history of CM in suicide attempters, and to explore whether impulsivity and aggression account for the relationship between CM and suicide attempt (SA). Adults with Intermittent Explosive Disorder (IED; n = 264), with non-IED psychiatric (Axis I or II) disorders (psychiatric controls; PC; n = 199), and with no psychiatric disorder (healthy control subjects; HC; n = 185) were assessed for history of childhood maltreatment, aggression, impulsivity, and history of SA. IED subjects reported significantly greater CM compared to PC and HC subjects, and suicide attempters (n = 62) reported greater CM compared to non-attempters (n = 586). Physical abuse in childhood was independently associated with IED, while sexual abuse and emotional abuse were independently associated with SA. Impulsivity and aggression were potential mediators of the relationship between physical abuse and IED and emotional abuse and SA, but sexual abuse was associated with SA independently of aggression and impulsivity. The results suggest pathways by which environmental factors may influence impulsivity and aggression and, in turn, clinically significant self- and other-directed aggression.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Fanning JR,Meyerhoff JJ,Lee R,Coccaro EFdoi
10.1016/j.jpsychires.2014.04.012subject
Has Abstractpub_date
2014-09-01 00:00:00pages
10-7eissn
0022-3956issn
1879-1379pii
S0022-3956(14)00118-6journal_volume
56pub_type
杂志文章abstract：:Regulation of the Hypothalamus-Pituitary-Adrenal axis (HPA-axis) and its end product cortisol differs among persons with certain psychiatric disorders when compared with controls. Some reports concern Attention-Deficit/Hyperactivity Disorder (ADHD) but findings are inconclusive. In this study we collected four saliva ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.08.021
更新日期：2012-11-01 00:00:00
abstract：INTRODUCTION:Both the COVID-19 pandemic and its management have had a negative impact on mental health worldwide. There is a growing body of research on mental health as it relates to the pandemic. The objective of this study is to use bibliometric analyses to assess the mental health research output related to the COV...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.10.018
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Cognitive deficits have been identified as an important core feature of schizophrenia. Single nucleotide polymorphisms in the transcription factor 4 (TCF4) gene have been reported to be involved in the susceptibility to schizophrenia and be significantly related to cognitive deficits of schizophrenia and con...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
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abstract：:Although schizophrenia and obsessive-compulsive disorder (OCD) are distinct diagnostic entities, there are substantial areas of overlap between the two disorders in clinical characteristics, affected brain areas and pharmacotherapy. Though OCD patients apparently do not have increased risk for developing schizophrenia...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
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abstract：:Despite the fact that the majority of currently available treatment guidelines propose antidepressants as the first-line pharmacological therapy for posttraumatic stress disorder (PTSD), a substantial portion of patients fail to show an adequate response following this type of treatment. In this context, a number of s...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychires.2014.05.003
更新日期：2014-09-01 00:00:00
abstract：:Suicidal behaviour poses a significant public health concern. Research into the factors that distinguish between the emergence of suicide ideation and the enactment of a suicide attempt is crucial. This study tests central tenets of the Integrated Motivational-Volitional Model of suicidal behaviour (IMV, O'Connor and ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.07.007
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.09.012
更新日期：2010-05-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(91)90007-w
更新日期：1991-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.02.030
更新日期：2020-06-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.01.015
更新日期：2019-04-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.10.019
更新日期：2013-02-01 00:00:00
abstract：:To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnoses and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establi...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/0022-3956(87)90106-3
更新日期：1987-01-01 00:00:00
abstract：BACKGROUNDS:The present study was designed to clarify the mutual association of job burnout and insomnia and to detect the mediating effects of hair cortisol on that association. METHODS:In all, 68 female employees were recruited for the study from one secondary and one tertiary hospital between October 2018 and Novem...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.07.001
更新日期：2019-10-01 00:00:00
abstract：:One important target in the treatment of major depressive disorder (MDD) is the serotonin (5-hydroxytryptamine, 5-HT) system. Selective serotonin reuptake inhibitors (SSRI) are used to treat MDD. Yet, the mode of action of these drugs is not completely understood. There is evolving evidence for a role of glutamate in ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.06.005
更新日期：2011-02-01 00:00:00
abstract：:Pilot studies represent a fundamental phase of the research process. The purpose of conducting a pilot study is to examine the feasibility of an approach that is intended to be used in a larger scale study. The roles and limitations of pilot studies are described here using a clinical trial as an example. A pilot stud...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.10.008
更新日期：2011-05-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2012.08.009
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:In attention-deficit/hyperactivity disorder (ADHD) not only deficits in dopamine-related cognitive functioning have been found but also a lower dopamine-sensitive olfactory threshold. The aim of the present study was to proof that only olfactory but not trigeminal sensitivity is increased in ADHD. Structural...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2016.02.007
更新日期：2016-05-01 00:00:00
abstract：:Analysis of the distribution of diagnoses in families (segregation analysis) has not, so far, advanced us toward the goal of resolving the inheritance of the major psychiatric disorders. Recent advances in genetics, particularly the development of new molecular genetic linkage methods, have made it, at least theoretic...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/0022-3956(87)90103-8
更新日期：1987-01-01 00:00:00
abstract：:A childhood history of attention deficit hyperactivity disorder (ADHD) is common in psychotic disorders, yet prescription stimulants may interact adversely with the physiology of these disorders. Specifically, exposure to stimulants leads to long-term increases in dopamine release. We therefore hypothesized that indiv...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2015.09.012
更新日期：2015-12-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.04.014
更新日期：2010-12-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.12.042
更新日期：2020-12-21 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2003.11.009
更新日期：2004-07-01 00:00:00
abstract：:The effects of lithium treatment on serotonin (5-HT) binding sites in the rat brain were investigated. Oral administration of lithium carbonate for 3 weeks did not influence 5-HT2 binding sites in the cerebral cortex. On the other hand, the number of 5-HT1 binding sites labeled with [3H]5-HT was decreased significantl...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(90)90016-j
更新日期：1990-01-01 00:00:00
abstract：:During the evening of 13 November 2015, the deadliest terror attacks in France in recent times occurred in the Paris area. Overall, 130 people were killed, 643 were physically injured and several thousands were psychologically impacted. Thousands of first responders, including health professionals, firefighters, affil...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.11.018
更新日期：2020-02-01 00:00:00
abstract：:Depression and anxiety are prevalent in patients with heart failure (HF). Reduced ejection fraction (EF) and increased N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) have been shown to be independently associated with depressive symptoms and may therefore increase HF disease progression and mortality. Th...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2018.06.010
更新日期：2018-09-01 00:00:00
abstract：:The auditory evoked field (AEF) component N100m represents the most prominent and stable peak of the AEF, and its alterations in patients with schizophrenia are an extensive topic of neuropsychiatric research. In our current study, the degree of N100m habituation was investigated in 20 male schizophrenics and 19 healt...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(00)00007-8
更新日期：2000-05-01 00:00:00
abstract：:Aggressive behavior is controlled at multiple anatomical levels within the human brain. To illustrate hierarchical neural controls over aggression, we compare and contrast the roles of the hypothalamus, amygdaloid complex, and orbital prefrontal cortex in terms of their distinctive sensory inputs, effector channels, a...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/0022-3956(88)90073-8
更新日期：1988-01-01 00:00:00
abstract：:The aim of this work is to investigate the impact of placebo response rates on the relative risk of response to drug versus placebo in randomized, double-blind, placebo-controlled clinical trials of pharmacological therapy in Bipolar Depression (BPD). Medline/PubMed publication databases were searched for randomized, ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析
doi：10.1016/j.jpsychires.2015.12.016
更新日期：2016-03-01 00:00:00
abstract：:Mobile phone short messaging service (SMS) reminders may be a low-cost method for promoting medication adherence. Our objective was to determine whether text SMS reminders improve medication adherence in patients with bipolar I disorder even after discontinuation of the intervention. Participants were stable adult bip...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2018.07.013
更新日期：2018-09-01 00:00:00
