Abstract:
:Purpose: To evaluate the long-term efficacy and safety of the modified canaloplasty technique with additional suprachoroidal drainage in patients with pseudoexfoliation glaucoma. Methods: This retrospective clinical trial included 131 patients with pseudoexfoliation glaucoma who underwent canaloplasty with suprachoroidal drainage (scD). One hundred and eleven of 131 patients underwent the follow-up examination after 48 months. Primary endpoints were the pressure-lowering and drug-sparing effect as well as the success rates. Secondary endpoints were intra- and postoperative complications and the occurrence of secondary surgical interventions. Results: The IOP was reduced by 45.8% after 12 months (from baseline 23.4 ± 5.1 mmHg to 12.7 ± 2.2 mmHg) and by 45.1% after four years (12.8 ± 2.2 mmHg) (p < .001). The mean number of IOP-lowering medication decreased significantly from 3.4 at baseline to 0.6 after 12 months and to 1.0 after four years. The IOP-reducing effect was even stronger in those cases in whom canaloplasty+ scD was combined with cataract surgery (49.4% after 12 months and 47.6% after four years). No serious complications were observed. Conclusions: The modified surgery technique of canaloplasty with suprachoroidal drainage is a safe and effective way of reducing IOP in patients with pseudoexfoliation glaucoma.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Seuthe AM,Szurman P,Januschowski Kdoi
10.1080/02713683.2020.1795203subject
Has Abstractpub_date
2021-02-01 00:00:00pages
217-223issue
2eissn
0271-3683issn
1460-2202journal_volume
46pub_type
杂志文章abstract::Purpose: To determine the refractive astigmatism following toric intraocular lens (tIOL) implantation without consideration of posterior keratometric astigmatism with a conventional tIOL calculator for eyes with low keratometric astigmatism (0.75D to 2.5D) and to theoretically compare the outcomes with predicted refra...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1638418
更新日期:2019-12-01 00:00:00
abstract:UNLABELLED:Abstract Purpose of the Study: Protein tyrosine phosphatase σ (PTPσ) acts as a neuronal receptor for chondroitin sulfate proteoglycans (CSPGs). CSPGs have inhibitory effects on experience-dependent plasticity and usually form lattice-like cell coatings that surround the parvalbumin (PV) interneurons in the v...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.803287
更新日期:2013-10-01 00:00:00
abstract::The selective DA2 agonist, N-0437, produced an acute reduction in intraocular pressure (IOP) and pupil diameter (PD) when applied topically to the eyes of normal monkeys. Ocular hypotension and miosis were primarily unilateral in nature, dose-related and lasted 3 to 5 hours following drug instillation. In normal monke...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688708997557
更新日期:1987-11-01 00:00:00
abstract:PURPOSE:Corneal scarring is a common poor outcome of corneal trauma. Transforming growth factor β-1 plays a vital role in corneal fibrosis, inducing keratocyte transformation to myofibroblasts. Other than corneal transplantation, no other curative treatment methods for corneal scarring are currently available. Hypercap...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1820526
更新日期:2020-09-11 00:00:00
abstract::The administration of 0.1-0.5% of ethanol produces a slow increase in the transepithelial potential (TEP) of about 2 mV in the bovine pigment epithelium (RPE) under ordinary room lighting. However, virtually no response could be observed when ethanol was administered in the dark. Because of this apparent light sensiti...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408999905
更新日期:1994-09-01 00:00:00
abstract:PURPOSE:To investigate the tissue blood flow in the neuroretinal rim of the optic disk and macula after rhegmatogenous retinal detachment (RRD) surgery. METHODS:Tissue blood flow in the neuroretinal rim of the optic disk and macula was measured with the Heidelberg retina flowmeter in 53 eyes of 53 patients who had und...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680701531108
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To determine the effectiveness of topically applied fluoroquinolones for experimental Pseudomonas or Serratia keratitis. METHODS:Bacteria were injected intrastromally (10(3) colony forming units [CFU]). From 16 to 22 hours post-infection (PI), a single topical drop of moxifloxacin (Vigamox, 0.545%), levofloxac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.5.337.28676
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:To evaluate the effect of the birth weight and the postconceptional age on the tear production of preterm and term newborn infants and to evaluate the changes in tear production during the first two months of life. SUBJECTS--METHODS: Both eyes of medically stable term and preterm infants were included in the st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.2.145.26235
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:To investigate the morphological or functional differences of retina in amblyopia. MATERIALS AND METHODS:Forty-one patients with unilateral strabismic, anisometropic or combined amblyopia were included in the study. A control group was composed of 16 normal children. All participants were tested with optical c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.779721
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:To investigate the association of nailfold capillaroscopy, heart rate variability (HRV), and clinical characteristics of glaucoma with the plasma matrix metalloproteinase-9 (MMP-9) level in normal-tension glaucoma (NTG). MATERIALS AND METHODS:We conducted a prospective, cross-sectional study on 25 patients wit...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.971937
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:There is limited information on region-specific gene expression in the human corneal stroma. In this study, we aimed to investigate the expression profile of the extracellular matrix and adhesion molecules in the normal corneal stroma using laser capture microdissection (LCM) and molecular techniques. METHODS:...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1200099
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To study the mechanisms of peroxynitrite-induced photoreceptor cell damage, using retinal cultures and a peroxynitrite donor, 3-morpholinosydnonimine (SIN-1). METHODS:Retinal explants obtained from 20-day-old Lewis rat pups, were exposed to SIN-1 for varying lengths of time at varying concentrations. Apoptosis...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.1.17.23488
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To investigate the spectral content of intraocular pressure (IOP) pulse wave by advanced spectral signal processing of continuous IOP readings obtained by dynamic contour tonometry. PATIENTS AND METHODS:A non-interventional case-control study included 20 healthy subjects, 20 previously untreated primary open a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.700755
更新日期:2012-11-01 00:00:00
abstract::Birefringence variations, seen as regularly spaced altering light and dark rings (bands), have been observed along the length of unfixed, freshly isolated rod outer segments (ROS) of both Rana pipiens and Xenopus laevis. In our hands, the spatial frequency of the banding pattern is from 1.3-1.6u/band in Rana pipiens a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409007412
更新日期:1984-11-01 00:00:00
abstract:PURPOSE:To explore the in vitro proliferative potential of human limbal epithelial cells after 31 degrees C organ-culture storage and to investigate putative factors influencing it. METHODS:185 cultures of limbal explants were carried-out either from full-thickness explants (n = 102) or from enzymatically dissociated ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600681228
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To study the association of cell proliferation in uveal melanoma with the mean of the 10 largest nucleoli (MLN), microvascular prognostic factors, and survival. METHODS:Population-based, retrospective cohort study of 167 choroidal and ciliary body melanomas enucleated from 1972 to 1981. Mouse monoclonal antibo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680500478535
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To quantify the impact of posterior cornea on toric IOL calculation accuracy using Placido-topography of anterior corneal surface and Scheimpflug measurements of corneal thickness. MATERIALS AND METHODS:Three-hundred seventy-nine non-selected eyes undergoing cataract surgery with non-toric intraocular lens (IO...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.959708
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To investigate epithelial cell adhesion and proliferation on a newly developed elastin-like polymer (ELP) that mimics the functional characteristics of extracellular matrices. MATERIALS AND METHODS:A genetically engineered ELP with cell attachment sequences was adsorbed onto glass coverslips as 1, 2, or 3 mole...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802542053
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Corneal autofluorescence is related to advanced glycation end products formed by glucose that reaches the cornea via the aqueous humour. The aim of the study was to examine the influence on autofluorescence of changes in permeability of the blood aqueous barrier. METHODS:Corneal autofluorescence was measured i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.4.307.15433
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:Deficiency in Cystathionine β-synthase (CBS) leads to an abnormal accumulation of homocysteine and results in classical homocystinuria, a multi-systemic disorder that affects connective tissue, muscles, the central nervous system, and the eyes. However, the genetic players and mechanisms underlying vision alter...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1818262
更新日期:2020-09-07 00:00:00
abstract:PURPOSE:To investigate the relationship between retinal fractal dimensions (Dfs) and retinal circulation, which is impaired in early-stage diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). METHODS:Using a laser Doppler velocimetry system, we measured the retinal vessel diameter (D) and blood ve...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.805232
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:Outbreaks of bacterial conjunctivitis have been linked to nontypeable strains of Streptococcus pneumoniae that lack a capsule, a key virulence factor for invasive infections. In contrast, isolates from sporadic, nonoutbreak cases of conjunctivitis were thought to be similar to invasive or nasopharyngeal isolate...
journal_title:Current eye research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/02713683.2011.624670
更新日期:2011-12-01 00:00:00
abstract::Two alternative methods for the study of the lens cytoskeleton are described which serve to overcome some of the difficulties imparted by the unique biology of the lens. The first technique involves rapid freezing, thick sectioning, and selective extraction and/or fixation of the lens section. This approach offers sev...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008997582
更新日期:1990-11-01 00:00:00
abstract::Recently, growth factors are known to phosphorylate tyrosine residues of proteins to regulate cellular functions. We investigated growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial (RPE) cells. The phosphorylation experiments were done in membrane preparations of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209033498
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:To establish autologous iris pigment epithelial (IPE) cell transplantation in monkey eyes. METHODS:Autologous IPE cells from three monkeys were obtained by peripheral iridectomy, and cell culture was performed with autologous serum. The cultured cells were labeled with DiI, and transplantation was performed by...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:To compare objective optical quality, ocular scattering and aberrations of eyes implanted with an aspheric monofocal intraocular lens (IOL) or an aspheric apodized diffractive multifocal IOL three months after surgery. METHODS:Prospective consecutive nonrandomized comparative cohort study. A total of 80 eyes f...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1449220
更新日期:2018-06-01 00:00:00
abstract::This study reports on serum interleukin 2-receptor (IL-2R) levels in uveitis patients. IL-2R is the mediator protein of interleukin 2 (IL-2), a mitogenetic cytokine of primarily immune cell interaction. Stimulated T-cells readily express IL-2R on their cell surface and release a soluble form into serum. The measuremen...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999415
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To evaluate the stability of successive applanation tonometry measurements in glaucomatous eyes. METHODS:A prospective, comparative, randomized, and evaluator-masked study was conducted in a tertiary medical center. Sixty-seven patients with glaucoma attending our glaucoma clinic underwent four successive intr...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713681003678824
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to characterize swelling pressure-thickness, swelling pressure-hydration and hydration-thickness relations of porcine cornea. METHODS:Mechanical compression tests and free swelling experiments were performed on porcine cornea. A rheometer (DHR-2, TA Instruments) with a thermally contr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.809769
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:In the limbo-corneal epithelium the stem and early precursor epithelial cell pool is confined to the limbal rim. Among the features associated with this spatial segregation is the general paucity of connexin43 (Cx43) within the limbal basal cell population and its complete absence in resident stem cells. The li...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.24.6.430.8599
更新日期:2002-06-01 00:00:00