Photosensitivity of the isolated pigment epithelium and arachidonic acid metabolism: preliminary results.

abstract：PURPOSE:Form-deprivation myopia (FDM) is believed to result principally from actions of substances that modulate information processing in the retina. We used a chick model to investigate what role nitric oxide (NO), a gaseous neuromodulator, might play in the development of FDM. METHODS:We injected different concentr...

journal_title：Current eye research

authors： Fujikado T,Kawasaki Y,Fujii J,Taniguchi N,Okada M,Suzuki A,Ohmi G,Tano Y

更新日期：1997-10-01 00:00:00

abstract：:Papavarine, cholera toxin, and isoproterenol each elevated cyclic AMP in cultured rat retinal pigment epithelium and reduced the phagocytosis of isolated rod outer segments (38-66% of controls) during a 4 hour incubation. In addition, cultured pigment epithelium was preincubated with 25 mM exogenous cyclic AMP for two...

journal_title：Current eye research

authors： Edwards RB,Flaherty PM

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To evaluate the clinical outcomes of laser in situ keratomileusis (LASIK) using a new approach for the calculation of the ablation profile based on wavefront vertexing from pupil plane to corneal. METHODS:One hundred eyes of 50 patients (age, 21-41 years) with low and moderate myopia were enrolled in this pros...

journal_title：Current eye research

authors： Uceda-Montañés A,Rogers M,Piñero DP

更新日期：2020-09-16 00:00:00

abstract：PURPOSE:To investigate the potential toxicity of the vehicle used for triamcinolone acetonide (TA) to the cornea, lens, ciliary body, and retina of pigmented rabbits. METHODS:Forty chinchilla rabbits (40 eyes) were divided into four groups: group A (control group) eyes received an intravitreal injection of 0.1 ml ster...

journal_title：Current eye research

authors： Zhengyu S,Fang W,Ying F

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Diabetes has been associated with decline in accommodative function in some ethnic groups. This outcome, however, could differ since ethnic variations in accommodation have been noted. This study investigated the relationship between plasma sugar level on subjective accommodative amplitude and accommodative ...

journal_title：Current eye research

authors： Abokyi S,Ilechie A,Asaam KA,Ntodie M

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:To evaluate choroidal thickness (CT) and retinal morphological changes in eyes with neovascular age-related macular degeneration (nAMD) following ranibizumab or aflibercept intravitreal treatment. MATERIALS AND METHODS:This was a prospective, observational, comparative study where 76 eyes of 76 consecutive pat...

journal_title：Current eye research

authors： Gharbiya M,Giustolisi R,Marchiori J,Bruscolini A,Mallone F,Fameli V,Nebbioso M,Abdolrahimzadeh S

更新日期：2018-03-01 00:00:00

abstract：AIM OF THE STUDY:The similarity of many benign intrabulbar lesions to a malignant tumor requires detailed differential diagnostics. However, none of the known methods can be used as the only one to determine the type of lesions. The aim of this study was to determine color Doppler imaging (CDI) markers characteristic o...

journal_title：Current eye research

authors： Modrzejewska M,Wiącek MP

更新日期：2017-11-01 00:00:00

abstract：:5-Fluorouracil (5-FU) and Mitomycin C (MMC) are used as adjunct chemotherapy during glaucoma filtering surgery to suppress conjunctival fibroblast proliferation. Since part of these agents may gain access to the anterior chamber and cause cytotoxicity to the corneal endothelium we set up an in vitro system to establis...

journal_title：Current eye research

authors： Nuyts RM,Pels E,Greve EL

更新日期：1992-06-01 00:00:00

abstract：:Objectives: To investigate the characteristics of margin reflex distance 1 (MRD1) asymmetry in congenital lower eyelid epiblepharon and its resolution after surgical correction of epiblepharon. Methods: Among patients who underwent lower eyelid epiblepharon surgery from November 2015 to September 2017, patients with a...

journal_title：Current eye research

authors： Yang MK,Kim N,Choung HK,Khwarg SI

更新日期：2020-12-15 00:00:00

abstract：PURPOSE:The purpose was to investigate the effect of the superoxide dismutase mimetic tempol on decreases in retinal blood flow that are found in diabetic mice. MATERIALS AND METHODS:Streptozotocin (STZ) was injected into male C57BL/6 mice to induce hyperglycemia. One week following the STZ injection, subsets of the m...

journal_title：Current eye research

authors： Yadav AS,Harris NR

更新日期：2011-05-01 00:00:00

abstract：:Rainbow trout (Oncorhynchus mykiss) were used to model the solar radiation-induced cataract that occurs in hatchery-reared lake trout (Salvelinus namaycush). Rainbow trout eyes were exposed to wideband predominantly UVB radiant energy from a filtered 1000W xenon source. Lenticular damage was assessed and classified an...

journal_title：Current eye research

authors： Cullen AP,Monteith-McMaster CA

更新日期：1993-02-01 00:00:00

abstract：:Uveitis can be induced by systemic or intravitreal administration of endotoxin (lipopolysaccharide, LPS). In this study we correlated the expression of class II antigens (la in rat) of the Major Histocompatibility Complex (MHC), with this experimental model of uveitis. Ia antigen was detected by immunohistochemistry u...

journal_title：Current eye research

authors： Kim MK,Palestine AG,Nussenblatt RB,Chan CC

更新日期：1986-11-01 00:00:00

abstract：PURPOSE:Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis. This study, employing an experimental rabbit model of Staphylococcus aureus keratitis, investigated the effectiveness of topical taurolidine in reducing the number of bact...

journal_title：Current eye research

authors： Oguz H,Ozbilge H,Oguz E,Gurkan T

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Previous studies revealed an association of tumor necrosis factor super family-15 (TNFSF15) gene polymorphisms with several autoimmune diseases, but their roles in the development of Graves' disease (GD) and Graves' ophthalmopathy (GO) remain unclear. The aim of this study was to explore the correlation between...

journal_title：Current eye research

authors： Zhang M,Liu S,Xu J,Lv S,Fan Y,Zhang Y,Zhang Y,Wu Y,Su Y,Yu H,Song S,He J,Li H

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:The effects of several serotonergic agonists on aqueous humor formation (AHF), total outflow facility (OF) and intraocular pressure (IOP) were investigated in living cynomolgus monkeys. METHODS:We determined the effect of a single topical unilateral 300 microg or 3 mg dose of the 5-HT agonists serotonin, 5-car...

journal_title：Current eye research

authors： Gabelt BT,Millar CJ,Kiland JA,Peterson JA,Seeman JL,Kaufman PL

更新日期：2001-08-01 00:00:00

abstract：:It has been hypothesized that an activator of Ca-ATPase co-exists with Ca-ATPase in the mouse lens. Though the Ca-ATPase activity could be measured from mouse lens homogenate, its activity could not be determined in individual soluble and insoluble fractions. The Ca-ATPase activity, however, could be detected when an ...

journal_title：Current eye research

authors： Iwata S,Shirasawa E,Takehana M

更新日期：1984-05-01 00:00:00

abstract：PURPOSE:To examine the effects of external modulation of epithelial-mesenchymal interaction on conjunctival epithelial cell differentiation characteristics. METHODS:Keratin K4 and laminin beta2 chain protein localization was examined in an organotypic model which facilitates the comparison of differentiation character...

journal_title：Current eye research

authors： Kurpakus MA,Lin L

更新日期：1999-01-01 00:00:00

abstract：:In these experiments we characterize rabbit and bovine corneal endothelia cell cultured on microporous membrane filters (0.6cm2). Cell cultured bovine or rabbit corneal endothelial cells (subcultures 1-3) were seeded onto Millicell-HA filter inserts. Electrical resistance measured across the cultured monolayers increa...

journal_title：Current eye research

authors： Geroski DH,Hadley A

更新日期：1992-01-01 00:00:00

abstract：:About 55% of the acyl groups of dog and human vitreous are unsaturated fatty acids. The major components are oleate (18:1, n-9) and arachidonate (20:4, n-6) with moderate amounts of linoleate (18:2, n-6) and docosahexaenoate (22:6, n-3). Palmitate (16:0) and stearate (18:0) are the major saturated fatty acids. There a...

journal_title：Current eye research

authors： Reddy TS,Birkle DL,Packer AJ,Dobard P,Bazan NG

更新日期：1986-06-01 00:00:00

abstract：PURPOSE:Acanthamoeba keratitis is a sight-threatening corneal infection. It is known that: (i) more amoebae bind to the surface of injured corneas than to the normal corneal surface and (ii) mannose-containing glycoproteins (GPs) possess binding sites for Acanthamoeba. The present study was undertaken to determine whet...

journal_title：Current eye research

authors： Jaison PL,Cao Z,Panjwani N

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:The purposes of this study were to investigate the effects of topically administrated Tacrolimus and Octreotide on modulation of postoperative scarring in experimental glaucoma filtration surgery and to compare the antifibrotic properties of these agents with mitomycin-C (MMC). MATERIAL AND METHODS:A total of ...

journal_title：Current eye research

authors： Arslan S,Aydemir O,Güler M,Dağlı AF

更新日期：2012-03-01 00:00:00

abstract：:Cytoskeletal and membrane proteins were isolated from respectively the urea-soluble and urea-insoluble fractions of the squid lens. The main cytoskeletal polypeptide has a molecular weight (63000) and an amino acid composition similar to those of vertebrate intermediate filament proteins, including mammalian lens vime...

journal_title：Current eye research

authors： Siezen RJ

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to characterize a standardized porcine ex-vivo testing system for intraocular pressure (IOP) monitoring after vitrectomy with different endotamponades. METHODS:Twenty-four pig eyes, six per endotamponade group were obtained immediately postmortem. After pars plana vitrectomy, vitreous...

journal_title：Current eye research

authors： Ebner M,Mariacher S,Hurst J,Szurman P,Schnichels S,Spitzer MS,Januschowski K

更新日期：2017-08-01 00:00:00

abstract：:Phosphorylated proteins of the chick lens were identified following incubation of lenses in a medium containing 32P and subsequent analysis by gel electrophoresis. The acidic variant of the vimentin and both subunits of fodrin were phosphorylated, as were the 95 Kd and 49 Kd proteins associated with the beaded-chain f...

journal_title：Current eye research

authors： Ireland M,Maisel H

更新日期：1984-07-01 00:00:00

abstract：:Human endothelial morphologic changes were quantitated by specular microscopy and computer-assisted morphometry to establish normal baselines of various morphologic parameters. Cellular polymegethism and cellular pleomorphism increases with age, and normal baseline parameters are detailed. Furthermore, no significant ...

journal_title：Current eye research

authors： Yee RW,Matsuda M,Schultz RO,Edelhauser HF

更新日期：1985-06-01 00:00:00

abstract：:Calmodulin has been shown to perform several important functions in the lens including regulation of the plasma membrane Ca(2+)-ATPase. This study investigated the effects of a variety of different CaM antagonists on rat lens membrane potential, membrane resistance, intracellular Na+ and Ca2+ content and transparency,...

journal_title：Current eye research

authors： Sanderson J,Gandolfi SA,Duncan G

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Corneal scarring is a common poor outcome of corneal trauma. Transforming growth factor β-1 plays a vital role in corneal fibrosis, inducing keratocyte transformation to myofibroblasts. Other than corneal transplantation, no other curative treatment methods for corneal scarring are currently available. Hypercap...

journal_title：Current eye research

authors： Chang YM,Cian AA,Weng TH,Liang CM,Pao SI,Chen YJ

更新日期：2020-09-11 00:00:00

abstract：PURPOSE:To compare the antiviral effect of a peptide derived from human apolipoprotein E (1% apoEdp) with 1% trifluorothymidine against HSV-1 thymidine kinase (TK)-positive (HSV-1 McKrae) and with 3% foscarnet against HSV-1 TK-negative (KOS background) in the rabbit eye model of acute HSV-1 epithelial keratitis. MATER...

journal_title：Current eye research

authors： Bhattacharjee PS,Neumann DM,Hill JM

更新日期：2009-02-01 00:00:00

abstract：:Experiments were conducted to test the influence of thapsigargin on the NaK-ATPase activity of cultured cells (ODM2) derived from human nonpigmented ciliary epithelium. The rate of ouabain-sensitive ATP hydrolysis (Na,K-ATPase activity) was diminished in cells that had been pretreated with thapsigargin then permeabili...

journal_title：Current eye research

authors： Mito T,Kuwahara S,Delamere NA

更新日期：1995-08-01 00:00:00

abstract：:Purpose: To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). Materials and methods: An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure sus...

journal_title：Current eye research

authors： Wang X,Chen J,Kong X,Sun X

更新日期：2020-11-26 00:00:00