Abstract:
AIM OF THE STUDY:The similarity of many benign intrabulbar lesions to a malignant tumor requires detailed differential diagnostics. However, none of the known methods can be used as the only one to determine the type of lesions. The aim of this study was to determine color Doppler imaging (CDI) markers characteristic of choroidal melanoma and metastatic intrabulbar tumors, increasing the diagnostic value and giving a new insight into the use of this method. MATERIALS AND METHODS:CDI was performed in 44 patients with malignant tumors and in 49 patients with benign tumors. Patients with malignant tumors were divided into melanomas (n = 28) and metastatic tumors (n = 16). Univariate analysis with the logistic regression method and multivariate stepwise logistic regression analysis to create models testing tumor malignancy and differentiating melanoma from metastatic lesions were used. Model sensitivity and specificity were evaluated by the receiver-operating characteristic curve. A K-fold validation was performed. RESULTS:Arterial blood flow, regular tumor surface, and tumor location in peripheral choroid were found significant for tumor malignancy. Mixed blood flow increased the accuracy of the test (p > 0.05). Model sensitivity and specificity were 83.7% and 75.7%. A regular tumor surface and hypoechoic or isoechoic tumor mass differentiated melanoma and metastatic masses in the regression model, with a sensitivity of 85.2% and a specificity of 75.0%. The area under curve (AUC) for both the models was 0.851 SE (standard error) 0.041 and 0.853 SE 0.063, respectively. AUC in five-fold cross-validation was 0.80 SE 0.0477 and 0.743 SE 0.094, respectively. CONCLUSIONS:Arterial or mixed blood flow, regular tumor surface, and tumor location in peripheral choroid may be characteristic of malignant tumors. Regular tumor surface and echogenicity of tumor mass could differentiate melanoma from metastatic tumor.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Modrzejewska M,Wiącek MPdoi
10.1080/02713683.2017.1341534subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1482-1490issue
11eissn
0271-3683issn
1460-2202journal_volume
42pub_type
杂志文章abstract::The new HERPCHEK (Dupont, No. Billerica, MA) enzyme immunosorbent assay (EIA) was used in a double-blind clinical study for rapid and specific detection of ocular herpes simplex virus (HSV) infection. This 4-hour assay can be used to demonstrate conclusively the presence of HSV antigen without culture and thereby rapi...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713688809033194
更新日期:1988-07-01 00:00:00
abstract:PURPOSE:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in the regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.27.2.91.15954
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:To examine the association between macular pigment optical density (MPOD) and rod-mediated dark adaptation (RMDA) in persons ≥60 years old with normal maculas as determined by an accepted color fundus photography grading system. METHODS:This cross-sectional analysis used baseline data from eyes in the Alabama ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1460380
更新日期:2018-07-01 00:00:00
abstract:PURPOSE/AIM:To quantitatively analyse the evolution of TUNEL-labeling, after in vivo exposure to UVB. METHODS:Altogether, 16 Sprague Dawley rats were unilaterally exposed in vivo for 15 min to close to threshold dose, 5 kJ/m(2), of ultraviolet radiation in the 300 nm wavelength region. Animals were sacrificed in group...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.783079
更新日期:2013-08-01 00:00:00
abstract::In primates, ciliary muscle contraction causes accommodation and facilitates aqueous outflow. In living rhesus monkeys, accommodative, outflow facility, and ciliary muscle movement responses to cholinergic agonists all decline with age. We developed an apparatus to determine in vitro whether the latter is related to i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309024623
更新日期:1993-05-01 00:00:00
abstract::The cytoskeletal proteins of the human lens were studied by SDS-PAGE, 2-D electrophoresis and immunologically. Spectrin, vimentin and actin were identified in the superficial fiber cells of human lenses even to age 87 years. These proteins are lost from the deeper cortical and nuclear fiber cells, where a broad zone o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688408997222
更新日期:1984-02-01 00:00:00
abstract::Two of the major in vitro phosphorylated polypeptides of the bovine lens have been identified. Analysis by means of two-dimensional gel electrophoresis (IEF) has demonstrated that the lens phosphorylated 57,000 and 43,000 dalton polypeptides correspond in mobility to purified phosphorylated bovine lens vimentin and ch...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000838
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:There is a clinical need for biomimetic corneas that are as effective, preferably superior, to cadaveric donor tissue. Decellularized tissues are advantageous compared to synthetic or semi-synthetic engineered tissues in that the native matrix ultrastructure and intrinsic biological cues including growth fac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1062114
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Several previous studies have shown that glycoconjugates of extracellular matrix, cell membrane and nucleus play an important role in the mediation of cell proliferation, migration and differentiation. Lens epithelial cells and lens fiber cells show regional differences with regard to these parameters. If glyco...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.6.527.5083
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the suitablity of commercially available moisture retention eyewear for treating evaporative dry eye. METHODS:Eleven patients with evaporative dry eyes were prescibed moisture retention eyewear for 3 months in addition to regular lubricant eye drops. Frequency and severity of dry eye symptoms, c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.932389
更新日期:2015-05-01 00:00:00
abstract::The basement membrane of the crystalline lens of the diabetic rat was found to have a similar elasticity modulus at high stress to that of normal membrane. However, at low stress and extension Young's modulus of elasticity was 0.36 (Mean) +/- 0.15 (SD) X 10(6) Nm-2 and about 30 per cent lower than that of normal membr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688108998358
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:To optimize cultured human corneal endothelial cell (cHCEC) sheet transplantation technique for maintenance of cHCEC viability. MATERIALS AND METHODS:cHCEC sheets cultured on a collagen scaffold were covered with or without Viscoat® and exposed to humidified air in the incubator. cHCEC sheets with or without V...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1101774
更新日期:2016-09-01 00:00:00
abstract::Uveitis can be induced by systemic or intravitreal administration of endotoxin (lipopolysaccharide, LPS). In this study we correlated the expression of class II antigens (la in rat) of the Major Histocompatibility Complex (MHC), with this experimental model of uveitis. Ia antigen was detected by immunohistochemistry u...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609029239
更新日期:1986-11-01 00:00:00
abstract::Membrane response to the various temperatures as one of the external factors was investigated in the lenses of the poikilothermal animal and the homothermal animal. The rainbow trout lens was used as the poikilothermal material and the rat lens as the homothermal material. The rainbow trout lens maintained in vitro it...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688509025158
更新日期:1985-04-01 00:00:00
abstract::The mechanism of oxidative damage to the lens through intraocular photochemical generation of superoxide and its derivatization to other oxidants such as singlet oxygen, hydroxyl radical and hydrogen peroxide has been studied. Rat lenses when organ cultured aerobically in TC 199 containing additional amounts of ribofl...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713688408997186
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:To examine the effects of calcitonin gene-related peptide (CGRP) on intraocular pressure (IOP). METHODS:IOP was periodically measured in rabbits treated with intravitreal injection (20 ael) of either: 1) CGRP (10(-4) approximately 10(-7) M) into one eye; 2) CGRP (10(-4) or 10(-6) M) into both eyes 30 min after...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.5.432.5291
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS:Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1387273
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Aqueous extract of Pleurotus tuberregium (PT) has been shown to reduce intraocular pressure (IOP) but the underlying mechanism has not been explained. PURPOSE:To investigate the effect of PT on the bovine iris in vitro in comparison with acetylcholine (ACh). METHOD:Strips of the iris were mounted in 10 ml ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.747615
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Spectral domain optical coherence tomography (SD-OCT) in patients can deliver retinal cross-sectional images with high resolution. This may allow the evaluation of the extent of damage to the retinal pigment epithelium (RPE) and the neurosensory retina after laser treatment. This article aims to investigate ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680902964892
更新日期:2009-07-01 00:00:00
abstract::Lenses from normal Wistar rats and those from a Wistar strain with X-ray-induced cataract mutation were examined electron microscopically for morphological characterization and acid phosphatase (AcPase) localization. Ocular anlages of 11 through 18 days of gestation were included in the study. A late-separating or per...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409003064
更新日期:1984-04-01 00:00:00
abstract::Lacrimal gland fluid is an important component of the precorneal tear film. The rate of lacrimal gland fluid secretion is controlled primarily by parasympathetic innervation, and it is, apparently, modulated by sympathetic innervation. Lacrimal gland fluid is produced in two stages, secretion of a primary fluid which ...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713688908995761
更新日期:1989-06-01 00:00:00
abstract:PURPOSE:Antagonists to A3 adenosine receptors (ARs) lower mouse intraocular pressure (IOP), but extension to humans is limited by species variability. We tested whether the specific A3AR antagonist MRS 1292, designed to cross species, mimicks the effects of other A3AR antagonists on cultured human nonpigmented ciliary ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680590953147
更新日期:2005-09-01 00:00:00
abstract::Arachidonic acid metabolism via the cyclooxygenase pathway and the effects of aspirin and indomethacin were studied in whole retinas of rats with streptozotocin-induced diabetes. Diabetes was induced by intravenous injection of streptozotocin (60 mg/kg) and the animals were examined 5-6 weeks later. Whole retinas of n...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000813
更新日期:1984-09-01 00:00:00
abstract:PURPOSE:This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection. METHODS:Corneal neovascularization was induced by application of a mixture of 7...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713680903429007
更新日期:2010-02-01 00:00:00
abstract::Although patients with diabetic retinopathy have been reported to have elevated vitreal IGF-I levels, it is not known whether diabetes also affects the levels of vitreal IGF binding proteins (IGFBPs) which control IGF's bioavailability. To address this issue, vitreal IGFBP levels were assayed in human diabetics, rats ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408999886
更新日期:1994-07-01 00:00:00
abstract::Due to the multiple barriers imposed by the eye against the penetration of drugs, the ocular delivery and targeting are considered difficult to achieve. A major challenge in ocular drug therapy is to improve the poor bioavailability of topically applied ophthalmic drugs by overcoming the severe constraints imposed by ...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713681003760168
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To demonstrate spectroscopic retinal oximetry measurements on arteries and veins in swine using intravitreal illumination. Retinal arterial and venous saturations are measured for a range of inspired O2 levels after pars plana vitrectomy. METHODS:Pars plana vitrectomy and intravitreal manipulations were perfor...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600760493
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To investigate the proliferative behavior of the corneal and limbal epithelia after debridement on the central region of the rabbit cornea. METHODS:After scraping a circular epithelial area, 5 mm in diameter, in the center of the cornea, ([3]) H-thymidine ( ([3]) H-TdR) was injected intravitreally, and the rab...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680903007121
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:The present study was conducted to develop and characterize a functional primary culture of pigmented rabbit conjunctival epithelial cells on permeable support exhibiting tight barrier properties. METHODS:Conjunctival epithelial cells were isolated by 0.2% protease treatment, cultured at 0.5-1.8 x 10(6) cells/...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608995151
更新日期:1996-12-01 00:00:00
abstract::Blood and lymphatic vessel proliferation into the cornea occurs after severe trauma. Whilst the events early in blood vessel growth are reasonably understood, little is known of the early events in lymphangiogenesis. In this study, a model for proliferating lymphatic vessels using tritiated-thymidine autoradiography a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909013898
更新日期:1989-01-01 00:00:00