Abstract：
:Purpose: To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). Materials and methods: An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure suspect, 22 eyes with primary angle closure [PAC], and 25 eyes with primary angle closure glaucoma [PACG]) and 27 control eyes. OCTA was performed for all subjects to acquire a 4.5 × 4.5 mm scanning area centered on the optic discs and a 3 × 3 mm parafoveal cubes. Peripapillary and parafoveal vessel density (VD) were compared between these four groups, and the relationship between VD values and structural and functional changes was evaluated. Results: Among all four groups, the peripapillary VD of the PACG eyes was the lowest in all six sections (all P < .01), while the parafoveal VD was lower than that of the normal group only in the average, superior, and inferior areas (all P < .05). The PAC group had lower peripapillary VD than the normal group (62.6[55.2-67.4] vs. 66.7[54.7-69.3], P = .01), while their retinal nerve fiber layer (RNFL) and ganglion cell complex thickness were not significantly different than those of the control group (all P > .05). In addition, the stages of PACD, visual field mean deviation, and RNFL thickness were shown to be predictors of the peripapillary VD in the multiple linear regression analysis. Conclusions: The PAC eyes had lower peripapillary VD than normal eyes when their RNFL and GCC thickness did not differ. This suggests that a reduction in retinal VD may occur before structural loss in PAC eyes. Retinal VD measurement may be a useful tool for the assessment of PACD.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Wang X,Chen J,Kong X,Sun Xdoi
10.1080/02713683.2020.1849728subject
Has Abstractpub_date
2020-11-26 00:00:00pages
1-7eissn
0271-3683issn
1460-2202pub_type
杂志文章abstract：:In these experiments we characterize rabbit and bovine corneal endothelia cell cultured on microporous membrane filters (0.6cm2). Cell cultured bovine or rabbit corneal endothelial cells (subcultures 1-3) were seeded onto Millicell-HA filter inserts. Electrical resistance measured across the cultured monolayers increa...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713689209069168
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:To investigate the proliferative behavior of the corneal and limbal epithelia after debridement on the central region of the rabbit cornea. METHODS:After scraping a circular epithelial area, 5 mm in diameter, in the center of the cornea, ([3]) H-thymidine ( ([3]) H-TdR) was injected intravitreally, and the rab...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713680903007121
更新日期：2009-08-01 00:00:00
abstract：:Rabbits have circadian rhythms of intraocular pressure (IOP) and aqueous flow. The dark phase increases of IOP and flow are associated with increased aqueous cyclic AMP. If the daily rhythm of aqueous cyclic AMP reflects changes of tissue levels of cyclic AMP which mediate one of the mechanisms which control the rhyth...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713689209033491
更新日期：1992-09-01 00:00:00
abstract：:Levels of rhodopsin in the photoreceptors of Long-Evans rats were reduced by approximately 55% through dietary deprivation of vitamin A. The interaction of visual pigment with G-protein was examined in receptor outer segment (ROS) membranes obtained from these animals. A binding assay was used to quantitate affinity o...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688908996390
更新日期：1989-04-01 00:00:00
abstract：:Lacrimal gland fluid is an important component of the precorneal tear film. The rate of lacrimal gland fluid secretion is controlled primarily by parasympathetic innervation, and it is, apparently, modulated by sympathetic innervation. Lacrimal gland fluid is produced in two stages, secretion of a primary fluid which ...
journal_title：Current eye research
pub_type： 杂志文章,评审
doi：10.3109/02713688908995761
更新日期：1989-06-01 00:00:00
abstract：PURPOSES:To investigate whether valproic acid (VPA) has a neuroprotective effect against ischemia/reperfusion (I/R) injury in the rat retina, and to elucidate the potential antioxidant mechanisms involved. METHODS:Adult male Wistar rats were randomly divided into four groups: sham (group A), sham plus VPA (group B), I...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713683.2011.653616
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:To test if nicotine counteracts the dampening effect of human cytomegalovirus (HCMV) infection of NF-kappaB in retinal pigment epithelial (RPE) cells, thereby increasing the permissiveness of RPE cells for HCMV replication. METHODS:Human ARPE-19 cells were transfected with NF-kappaB luciferase DNA, inoculated ...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713680500514651
更新日期：2006-02-01 00:00:00
abstract：PURPOSE:Diabetic maculopathy (DM) treated with photocoagulation may subsequently progress to proliferative diabetic retinopathy (PDR). However, there is insufficient knowledge about the incidence and risk factors for the development of PDR in patients previously treated for DM. MATERIALS AND METHODS:Survival data was ...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2020.1712729
更新日期：2020-08-01 00:00:00
abstract：AIM OF THE STUDY:The similarity of many benign intrabulbar lesions to a malignant tumor requires detailed differential diagnostics. However, none of the known methods can be used as the only one to determine the type of lesions. The aim of this study was to determine color Doppler imaging (CDI) markers characteristic o...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2017.1341534
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:To demonstrate spectroscopic retinal oximetry measurements on arteries and veins in swine using intravitreal illumination. Retinal arterial and venous saturations are measured for a range of inspired O2 levels after pars plana vitrectomy. METHODS:Pars plana vitrectomy and intravitreal manipulations were perfor...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713680600760493
更新日期：2006-07-01 00:00:00
abstract：:We adapted a previously described procedure to quantitate collagen in corneal tissue sections prepared from paraffin-embedded samples. The method entailed staining the deparaffinized tissue sections with Sirius red, eluting the bound dye with NaOH-methanol, and estimating the color in a spectrophotometer as an indicat...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688609015119
更新日期：1986-08-01 00:00:00
abstract：PURPOSE:To evaluate the clinical outcomes of laser in situ keratomileusis (LASIK) using a new approach for the calculation of the ablation profile based on wavefront vertexing from pupil plane to corneal. METHODS:One hundred eyes of 50 patients (age, 21-41 years) with low and moderate myopia were enrolled in this pros...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2020.1822418
更新日期：2020-09-16 00:00:00
abstract：:Serum zinc and copper levels were analyzed in 26 retinitis pigmentosa patients and compared with serum zinc levels of a control group. Serum zinc levels were documented to be decreased with a mean concentration of 0.735 +/- 0.167 micrograms/ml (p less than 0.001). Serum copper levels, on the other hand, were found to ...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688409011750
更新日期：1984-08-01 00:00:00
abstract：PURPOSE:The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization. METHODS:Immunohistochemistry was used to study the expression of purinergic P2Y2 and P2X2 receptors in the neonatal mouse retina during normal vascular development and after oxygen...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713680701885470
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:To determine the effects of a subconjunctival injection of mitomycin-C (MMC) on iridial circulation in rabbits. METHODS:Dutch rabbits anesthetized with pentobarbital received a 0.2-ml subconjunctival injection of 0.4 mg/ml or 0.1 mg/ml MMC; the contralateral eye received 0.2 ml physiological saline. Intraocula...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.19.2.197.5327
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in the regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel p...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.27.2.91.15954
更新日期：2003-08-01 00:00:00
abstract：PURPOSE:To compare the clinical outcomes following Descemet's membrane endothelial keratoplasty (DMEK) with 100% air tamponade versus 10% sulfur hexafluoride (SF6) tamponade. METHODS:Retrospective analysis of 108 consecutive DMEK cases subdivided by anterior chamber tamponade with 54 eyes receiving 10% SF6 and 54 eyes...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2018.1431286
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection. METHODS:Corneal neovascularization was induced by application of a mixture of 7...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713680903429007
更新日期：2010-02-01 00:00:00
abstract：:High pressure liquid chromatography was used to measure alpha-tocopherol in the retinas of rats reared in a cyclic light or dark environment. These measurements were performed on extracts of whole retinas during the developmental period, 18-60 days, and on isolated ROS from adult animals. Similar alpha-tocopherol dete...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688409007414
更新日期：1984-11-01 00:00:00
abstract：:Endothelin-1 (ET-1) affects intraocular pressure (IOP) in rabbits. First, we studied IOP responses to the intravitreal injection of various doses of ET-1 ranging from 5 ng to 5 micrograms in unanesthetized rabbits, and observed a transient rise in IOP, from 0.5 to 2 h in duration, invariably followed by a prolonged IO...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713689509003759
更新日期：1995-06-01 00:00:00
abstract：PURPOSE:Experiments were performed to evaluate the effect of various pro- and anti-inflammatory cytokines on the human fetal retinal pigment epithelium's (HFRPE) expression of major histocompatibility complex (MHC) and costimulatory molecules. METHODS:Pure cultures of HFRPE cells were isolated. HFRPE cells were incuba...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.23.4.285.5456
更新日期：2001-10-01 00:00:00
abstract：:Spontaneous ocular shedding and adrenergic induction of ocular shedding were examined in rabbits infected with ten strains of herpes simplex virus type 1 (HSV-1): McKrae, KOS, F, Rodanus, 17 Syn+, RE, E-43, SC-16, MacIntyre, and CGA-3. All ocular inoculations were with 50 microliter of HSV-1 with titers between 1-10 X...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688709020074
更新日期：1987-01-01 00:00:00
abstract：:Changes in the content of calcitonin gene-related polypeptide (CGRP) and tyrosine hydroxylase (TH) immunoreactivities in the anterior segment of the rat eye were assessed histochemically in animals subjected to sympathetic ganglionectomy or to chronic sensory denervation induced by neonatal capsaicin treatment. In the...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688809033207
更新日期：1988-08-01 00:00:00
abstract：PURPOSE:In tissues outside the brain, vascular endothelial growth factor-A (VEGF) causes vascular hyper-permeability by opening of inter-endothelial junctions and induction of fenestrations and vesiculo-vacuolar organelles (VVOs). In preliminary studies, we observed that in blood-retinal barrier endothelium, other cell...
journal_title：Current eye research
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：PURPOSE:To assess the effect of aging on optical quality in a normal population. METHODS:We prospectively examined 100 normal eyes of 100 healthy volunteers (50 men, 50 women; ages, 20-69 years; mean age ± standard deviation, 44.6 ± 15.5 years). We quantitatively assessed the values of MTF cutoff frequency, Strehl rat...
journal_title：Current eye research
pub_type： 临床试验,杂志文章
doi：10.3109/02713683.2012.688164
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:To evaluate the effect of the birth weight and the postconceptional age on the tear production of preterm and term newborn infants and to evaluate the changes in tear production during the first two months of life. SUBJECTS--METHODS: Both eyes of medically stable term and preterm infants were included in the st...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.28.2.145.26235
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:The expression of human leukocyte antigen (HLA) class II molecules on the cell surface is necessary for the presentation of peptide antigens to helper CD4 T lymphocytes of the immune system. We studied the immunoexpression of HLA class II antigen in conjunctival precursor lesions and conjunctival squamous cell ...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.27.3.151.16052
更新日期：2003-09-01 00:00:00
abstract：:Purpose/Aim: Corneal abrasions and nonhealing corneal epithelial defects are common conditions that cause pain and sometimes are slow to heal. Histatins, a family of histidine-rich peptides, have been implicated in oral and skin epithelial wound healing, and have been shown to be effective in vitro in human corneal ep...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2018.1490772
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Retinal pigment epithelial (RPE) cell proliferation is an important step in the pathogenesis of ocular diseases such as proliferative retinopathy. Growth factors play a major role in modulating the development and progression of these diseases. The aim of this study was to examine the effects of single growth f...
journal_title：Current eye research
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Rainbow trout (Oncorhynchus mykiss) were used to model the solar radiation-induced cataract that occurs in hatchery-reared lake trout (Salvelinus namaycush). Rainbow trout eyes were exposed to wideband predominantly UVB radiant energy from a filtered 1000W xenon source. Lenticular damage was assessed and classified an...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713689308999477
更新日期：1993-02-01 00:00:00
