Abstract:
PURPOSE:The purposes of this study were to investigate the effects of topically administrated Tacrolimus and Octreotide on modulation of postoperative scarring in experimental glaucoma filtration surgery and to compare the antifibrotic properties of these agents with mitomycin-C (MMC). MATERIAL AND METHODS:A total of 28 New Zealand rabbits weighing 2.5-3 kg were randomly divided into a surgical control (SC) group and three experimental groups. Standard filtration surgeries were performed on the right eyes of all the rabbits. The rabbits in the SC group received only vehicle after the surgeries, whereas the rabbits in the three experimental groups were treated either with 0.4 mg/mL MMC during the surgery (MMC group) or with 0.3 mg/mL Tacrolimus drop four times a day (TT group) or with 10 µg/mL Octreotide drop three times a day (OT group) for 14 days. The animals were killed on day 14, eyes were enucleated and histologically and immunohistochemically analyzed. RESULTS:In SC group mean fibroblast, mononuclear cell number and fibroblast growth factor-β (FGF-β), transforming growth factor-β (TGF-β) immunostaining intensity was higher than all treatment groups. In OT group mean fibroblast number was lesser than MMC (p < 0.01) and TT (p < 0.05) group. In TT group mean fibroblast number was lesser than MMC group (p < 0.05). Mean mononuclear cell number was similar between MMC, OT and TT groups (p > 0.05). In MMC, OT and TT groups mean TGF-β and FGF-β immunostaining intensity was similar (p > 0.05). CONCLUSIONS:Topically administration of Tacrolimus and Octreotide effectively reduced the subconjuntival scarring response 2 weeks after experimental glaucoma filtration surgery.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Arslan S,Aydemir O,Güler M,Dağlı AFdoi
10.3109/02713683.2011.635404subject
Has Abstractpub_date
2012-03-01 00:00:00pages
228-33issue
3eissn
0271-3683issn
1460-2202journal_volume
37pub_type
杂志文章abstract:AIM:To test the feasibility of implanting human anterior lens capsules (HALCs) with porcine corneal endothelial cells (pCEC) in vivo in Göttingen minipigs and at the same time test the suitability of Göttingen minipig as model for endothelial keratoplasty. MATERIALS AND METHODS:Cell-carrier constructs of decellularize...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1706747
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Oxidative stress is considered a major factor in the deterioration of retinal pigment epithelium (RPE) cells in dry age-related macular degeneration (AMD). The MAPK ERK1/2 can be activated by oxidative stress, may exert both pro- and anti-apoptotic functions, and has recently been proposed as a major factor in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.961613
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:We have previously described a metabolic acidosis-induced retinopathy in the neonatal rat, similar to retinopathy of prematurity (ROP). We also have reported exacerbation of oxygen-induced retinopathy by postnatal growth retardation, produced by raising newborn rats in 'expanded' litters. In the present study, ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.22.2.133.5531
更新日期:2001-02-01 00:00:00
abstract:PURPOSE:Endothelin-1 (ET-1) is a potent vasoconstrictive and neural peptide that has been demonstrated to be present and functionally active and important in the eye. This study was undertaken to examine for the first time the cellular distribution of ET-1 in the whole human eye. METHODS:Twelve human eyes were examine...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.5.541.5187
更新日期:1998-05-01 00:00:00
abstract::We assessed in vitro the antimicrobial activity of four agents (vancomycin, teicoplanin, mupirocin, and imipenem) which are effective against Gram-positive cocci causally associated with bacterial keratitis, as well as their corneal epithelial cytotoxicity. Minimal inhibitory concentrations inhibiting 90% of strains (...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309001839
更新日期:1993-07-01 00:00:00
abstract:PURPOSE:Whether there is an interaction between eyes of individual subjects in refractive development is an important issue to guide experimental designs and help understand mechanisms involved in development of refractive errors. This study investigated whether spontaneous high myopia in one eye will affect refractive...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.568660
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:To examine the association between macular pigment optical density (MPOD) and rod-mediated dark adaptation (RMDA) in persons ≥60 years old with normal maculas as determined by an accepted color fundus photography grading system. METHODS:This cross-sectional analysis used baseline data from eyes in the Alabama ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1460380
更新日期:2018-07-01 00:00:00
abstract::Purpose: To investigate to what extent the OSDI can be utilized as a discriminative test for clinical findings. Methods: One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1604972
更新日期:2019-09-01 00:00:00
abstract::Purpose: To map the time course of changes in intraocular straylight of the human eye 1 year after initial lens wearing for orthokeratology treatment using the objective double-pass technique. Materials and Methods: A total of 35 subjects (19 males and 16 females) completed the study. The mean age was 11.46 ± 2.33 yea...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1514056
更新日期:2019-01-01 00:00:00
abstract::Calmodulin has been shown to perform several important functions in the lens including regulation of the plasma membrane Ca(2+)-ATPase. This study investigated the effects of a variety of different CaM antagonists on rat lens membrane potential, membrane resistance, intracellular Na+ and Ca2+ content and transparency,...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408995780
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:To evaluate the feasibility of retinal vein bypass surgery for induced branch retinal-vein occlusion (BRVO) in the living porcine eye. METHODS:Fifteen minipigs were used in the study. Seven days before vascular surgery, hyaluronidase and plasmin were intravitreally injected for induction of posterior vitreous ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.997887
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To assess changes in retinal vascular caliber in response to short-term use of nepafenac eye drops in patients with mild diabetic macular edema. MATERIALS AND METHODS:Thirty-four patients with previously untreated bilateral mild diabetic macular edema were included in this prospective study. For each participa...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.1080/02713683.2017.1399425
更新日期:2018-03-01 00:00:00
abstract::We assessed the role of platelet-activating factor (PAF) in corneal allograft rejection and evaluated the effects of a PAF antagonist on corneal inflammation, cellular infiltration, vascularization, and edema. Rabbits with vascularized corneas served as recipients of allogeneic cornea grafts. Rabbits with normal corne...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409042408
更新日期:1994-02-01 00:00:00
abstract:PURPOSE:There is limited information on region-specific gene expression in the human corneal stroma. In this study, we aimed to investigate the expression profile of the extracellular matrix and adhesion molecules in the normal corneal stroma using laser capture microdissection (LCM) and molecular techniques. METHODS:...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1200099
更新日期:2017-04-01 00:00:00
abstract::Utilizing a rapid colorimetric assay that relates cell number to cytoplasmic hexosaminidase activity, we conducted drug-induced cytotoxicity experiments on human ocular fibroblasts cultured from Tenon's capsule specimens. The effects of two different agents--dimethyl sulfoxide (DMSO) or mitomycin C--on the proliferati...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999599
更新日期:1990-06-01 00:00:00
abstract::Macrophages are invariably present in the intraocular membranes of patients with traumatic proliferative vitreoretinopathy (PVR). There are two sources from which these macrophages could be recruited: adjacent tissues and the systemic circulation. In the study described herein, the role of circulating white blood cell...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409042392
更新日期:1994-01-01 00:00:00
abstract:PURPOSE OF THE STUDY:To assess differences in healthy eyes in volume (CV) and choroidal thicknesses (CT) across all macular Early Treatment Diabetic Retinopathy Study (ETDRS) areas measured by swept source (SS)-OCT and spectral domain (SD)-OCT with enhanced depth imaging (EDI). MATERIALS AND METHODS:One hundred and fi...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1795883
更新日期:2021-02-01 00:00:00
abstract::Intracellular binding proteins have been identified and isolated from B cells by their ability to bind to the synthetic peptide (1169-1191), the major immunodominant epitope of bovine interphotoreceptor retinoid-binding protein (IRBP) coupled to cyanogen bromide activated Sepharose 4B. After SDS-PAGE, two discrete pro...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408995790
更新日期:1994-04-01 00:00:00
abstract::The concentrations of hyaluronan (HA) and chondroitin sulfate (CS) in rabbit tears were determined using high performance liquid chromatography. The tears were taken from both normal eyes and eyes with a corneal epithelial defect. The concentration of CS was 7.61 times higher than that of HA in the tears of normal eye...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608997405
更新日期:1996-02-01 00:00:00
abstract:PURPOSE:Folic acid (FA) is an essential nutrient for normal embryonic development. FA deficiency (FAD) in maternal diet increases the risk of several defects among the progeny, especially, neural tube defects. The eye begins its development from the neural tube; however, the relationship between FAD and ocular developm...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1545911
更新日期:2019-04-01 00:00:00
abstract::Due to the multiple barriers imposed by the eye against the penetration of drugs, the ocular delivery and targeting are considered difficult to achieve. A major challenge in ocular drug therapy is to improve the poor bioavailability of topically applied ophthalmic drugs by overcoming the severe constraints imposed by ...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713681003760168
更新日期:2010-07-01 00:00:00
abstract::Two alternative methods for the study of the lens cytoskeleton are described which serve to overcome some of the difficulties imparted by the unique biology of the lens. The first technique involves rapid freezing, thick sectioning, and selective extraction and/or fixation of the lens section. This approach offers sev...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008997582
更新日期:1990-11-01 00:00:00
abstract::Rabbits have circadian rhythms of intraocular pressure (IOP) and aqueous flow. The dark phase increases of IOP and flow are associated with increased aqueous cyclic AMP. If the daily rhythm of aqueous cyclic AMP reflects changes of tissue levels of cyclic AMP which mediate one of the mechanisms which control the rhyth...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209033491
更新日期:1992-09-01 00:00:00
abstract::The pigmented epithelium of the vertebrate retina phagocytizes the discarded tips of photoreceptors and it is likely that a specific cellular recognition process is involved in this phenomenon. The apical surface of retinal pigmented epithelium (RPE) contains microvilli which interdigitate with the outer segment regio...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709034868
更新日期:1987-08-01 00:00:00
abstract::It has been hypothesized that an activator of Ca-ATPase co-exists with Ca-ATPase in the mouse lens. Though the Ca-ATPase activity could be measured from mouse lens homogenate, its activity could not be determined in individual soluble and insoluble fractions. The Ca-ATPase activity, however, could be detected when an ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409065593
更新日期:1984-05-01 00:00:00
abstract::DNA sequence analysis of overlapping shotgun and restriction fragments have revealed the entire sequence of the human lens fiber cell intrinsic membrane protein MP19 gene (also termed MP17, MP18, and MP20). The 8,056 bp MP19 gene contains 5 exons encoding a mature protein of 173 amino acids, which displayed a very hig...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309033503
更新日期:1993-12-01 00:00:00
abstract:PURPOSE:To compare the retinal sensitivity, using Microperimeter and the morphological changes in retinal layers, using Spectral Domain Optical Coherence Tomography (SD-OCT), between myopes and age-matched emmetropes. METHODS:Twenty-nine myopic eyes and 29 emmetropic eyes were enrolled in this prospective case control...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.599105
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To investigate the expression in the mouse retina and the function in a retinal cell of cullin5 that is known as a protein that is associated with ubiquitilation. METHODS:The retinal sites of expressing cullin5 were determined by immunohistochemistry with a specific antibody for cullin5. Retinal cells were tra...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.514658
更新日期:2011-01-01 00:00:00
abstract::Change of urate and ascorbate levels in retinae of rat left eyes after ophthalmic artery and optic nerve ligation was studied by reversed-phase high-performance liquid chromatography with electrochemical detection. The right eyes were used for sham operation. We found that uric acid levels in the retinae of the left e...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688608996369
更新日期:1986-07-01 00:00:00
abstract:PURPOSE:To identify vitreous proteins that were differentially expressed in patients suffering from proliferative diabetic retinopathy with active neovascularization. METHODS:The vitreous samples of 15 active proliferative diabetic retinopathy patients were analyzed by two-dimensional gel electrophoresis and mass spec...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600557030
更新日期:2006-03-01 00:00:00