Abstract:
PURPOSE:We have previously described a metabolic acidosis-induced retinopathy in the neonatal rat, similar to retinopathy of prematurity (ROP). We also have reported exacerbation of oxygen-induced retinopathy by postnatal growth retardation, produced by raising newborn rats in 'expanded' litters. In the present study, we investigated the effect of postnatal growth retardation on the incidence and severity of acidosis-induced retinopathy. METHODS:100 newborn Sprague-Dawley rats were randomly assigned to two expanded litters of 25 pups each and five standard control litters of 10 pups each. All rats were gavaged with 10 mM/kg NH(4)Cl twice daily from days two to seven. Following five days of recovery, retinal vasculature was assessed using ADPase staining, light microscopy, and computer-assisted image analysis. The presence of neovascularization (NV), severity of NV (clock hours), and vascularized retinal areas, were evaluated in a masked manner. RESULTS:NV occurred in 52% of rats in expanded litters versus 18% of rats in standard control litters (p = 0.005). Postnatal growth retardation of pups in expanded litters was confirmed by comparing total body weight of pups raised in expanded and standard control litters (10.8g vs 13.4g on day 8, p < 0.001; 20.8g vs 25.2g on day 13, p = 0.002). CONCLUSIONS:Postnatal growth retardation increases the incidence of acidosis-induced retinopathy in the neonatal rat. Our study provides further evidence that postnatal growth retardation is a risk factor for preretinal neovascularization in immature retinae and is consistent with the clinical observation that the smallest and sickest premature infants are more likely to suffer from ROP.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Zhang S,Leske DA,Lanier WL,Holmes JMdoi
10.1076/ceyr.22.2.133.5531subject
Has Abstractpub_date
2001-02-01 00:00:00pages
133-9issue
2eissn
0271-3683issn
1460-2202journal_volume
22pub_type
杂志文章abstract:PURPOSE:Recent studies have shown that the levels of interleukin (IL)-1beta, IL-6 and IL-8 are associated with the severity of infectious diseases. The purpose of this study was to investigate whether IL-1beta regulates the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.6.406.6969
更新日期:2001-12-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713689208999510
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journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713688908995761
更新日期:1989-06-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1789664
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802337397
更新日期:2008-09-01 00:00:00
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journal_title:Current eye research
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doi:10.3109/02713680903222779
更新日期:2009-11-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.1080/02713683.2018.1501489
更新日期:2018-12-01 00:00:00
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journal_title:Current eye research
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journal_title:Current eye research
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doi:10.1080/02713683.2018.1545911
更新日期:2019-04-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709020084
更新日期:1987-01-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409047005
更新日期:1994-10-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2016.1170855
更新日期:2017-02-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.22.3.229.5511
更新日期:2001-03-01 00:00:00
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doi:10.1080/02713683.2017.1289226
更新日期:2017-08-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802416696
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508999918
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.682635
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689208999525
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journal_title:Current eye research
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doi:10.3109/02713689309020401
更新日期:1993-10-01 00:00:00
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journal_title:Current eye research
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更新日期:2018-12-01 00:00:00
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journal_title:Current eye research
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doi:10.3109/02713683.2015.1101774
更新日期:2016-09-01 00:00:00
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doi:10.3109/02713683.2014.941071
更新日期:2015-05-01 00:00:00
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journal_title:Current eye research
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更新日期:1984-08-01 00:00:00
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