Pinealitis coincident with recurrent uveitis: immunohistochemical studies.


:Although experimental models of autoimmune uveitis predict pinealitis coincident with uveitis, there is no direct evidence of pineal pathology accompanying a human uveitis. Horses with naturally occurring uveitis are a potential source of eye and pineal tissues that are not available from human patients with active uveitis. We have observed pinealitis in a mare with equine recurrent uveitis. By immunohistochemistry we demonstrated immunoglobulin and MHC Class II antigen on infiltrating and resident cells of eye and pineal gland. These results support the relevance of the animal models and suggest that pinealitis may be coincident with some human uveitides.


Curr Eye Res


Current eye research


Kalsow CM,Dwyer AE,Smith AW,Nifong TP




Has Abstract


1992-01-01 00:00:00








11 Suppl


  • Mouse model of post-surgical breakdown of the blood-retinal barrier.

    abstract:PURPOSE:Post-surgical macular edema is an important clinical problem resulting from breakdown of the blood-retinal barrier (BRB) after surgery. This study was designed to develop a mouse model of post-surgical BRB breakdown. METHODS:Two 25-gauge needles, one for infusion and one for aspiration, were inserted through t...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Liu H,Demetriades AM,Xiao WH,Campochiaro PA,Vinores SA

    更新日期:2004-06-01 00:00:00

  • Prevalence and risk factors of diabetic retinopathy in subjects with suboptimal glycemic, blood pressure and lipid control. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS, Report 33).

    abstract:PURPOSE:To assess the rate of achieving optimal metabolic control among subjects with type 2 diabetes, to elucidate the influence of suboptimal control on diabetic retinopathy (DR) and to analyze the risk factors associated with DR in the subjects with suboptimal control. MATERIAL AND METHODS:A population-based, cross...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Raman R,Gupta A,Kulothungan V,Sharma T

    更新日期:2012-06-01 00:00:00

  • Effects of glaucoma on Chrna6 expression in the retina.

    abstract:PURPOSE:Recent advances in technology now provide tools capable of tracking genome-wide expression changes occurring in progressive pathological processes. The present experiments were carried out to determine if acetylcholine receptor α 6 subunit (Chrna6) is a reliable retinal ganglion cell (RGC) marker in adult mouse...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Munguba GC,Geisert EE,Williams RW,Tapia ML,Lam DK,Bhattacharya SK,Lee RK

    更新日期:2013-01-01 00:00:00

  • Aberrant Epigenetic Alterations of Glutathione-S-Transferase P1 in Age-Related Nuclear Cataract.

    abstract:PURPOSE:Oxidative damage of lens tissue contributes to the formation of age-related cataract. Pi-class glutathione-S-transferase (GSTP1) plays a role in the removal of oxidative adducts by transferring them to glutathione. To assess epigenetic regulation of GSTP1 and its potential role in age-related nuclear cataract (...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Chen J,Zhou J,Wu J,Zhang G,Kang L,Ben J,Wang Y,Qin B,Guan H

    更新日期:2017-03-01 00:00:00

  • Glaucoma Progression and its Relationship with Corrected and Uncorrected Intraocular Pressure in Eyes with History of Refractive Corneal Surgery.

    abstract:PURPOSE:To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS:Totally, 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and cen...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Kwon J,Sung KR,Jo J,Yang SH

    更新日期:2018-09-01 00:00:00

  • Cone-mediated multifocal electroretinogram in early age-related maculopathy and its relationships with subjective macular function tests.

    abstract:PURPOSE:To investigate the multifocal electroretinogram (mfERG) and subjective function in early age-related maculopathy (ARM). METHODS:Seventeen subjects with early ARM with visual acuity (VA) of 6/12 or better and 20 age-matched control subjects were examined. We assessed mfERGs, high and low contrast distance VA, n...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Feigl B,Brown B,Lovie-Kitchin J,Swann P

    更新日期:2004-10-01 00:00:00

  • Aqueous humor as a modulator of growth in fibroblast cultures.

    abstract::Samples of aqueous humor from rabbits and humans were examined for growth effects on subconfluent monolayer fibroblast cultures from ocular and extraocular tissues. At a concentration of 20% aqueous by medium volume, both homologous and heterologous aqueous stimulated DNA synthesis in fibroblasts from both species. Th...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Burke J,Foster S,Herschler J

    更新日期:1982-01-01 00:00:00

  • Incidence and Risk for Developing Proliferative Diabetic Retinopathy after Photocoagulation for Diabetic Maculopathy.

    abstract:PURPOSE:Diabetic maculopathy (DM) treated with photocoagulation may subsequently progress to proliferative diabetic retinopathy (PDR). However, there is insufficient knowledge about the incidence and risk factors for the development of PDR in patients previously treated for DM. MATERIALS AND METHODS:Survival data was ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Bek T

    更新日期:2020-08-01 00:00:00

  • The mechanism of fluid and electrolyte transport across corneal endothelium: critical revision and update of a model.

    abstract::A model for endothelial transport is updated to include recent evidence. We discuss electrolyte movements based on a Na+-K+ ATPase, a Na+-H+ exchanger, a Na+-HCO3 coupler, a Cl- -HCO-3 exchanger, a K+-Cl-coupler, and K+ and anion channels. We discuss near-isotonic transport of fluid on the basis of recent findings of ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Fischbarg J,Hernandez J,Liebovitch LS,Koniarek JP

    更新日期:1985-04-01 00:00:00

  • Mini-Review: Impaired Axonal Transport and Glaucoma.

    abstract::Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the accelerated loss of retinal ganglion cells (RGCs) and their axons. Impaired axonal transport has been implicated as a pathogenic mechanism in a number of neurodegenerative diseases, including glaucoma. The long RGC axon, with its...

    journal_title:Current eye research

    pub_type: 杂志文章,评审


    authors: Fahy ET,Chrysostomou V,Crowston JG

    更新日期:2016-01-01 00:00:00

  • Hydrogen peroxide localization in ocular tissue: an electron microscopic cytochemical study.

    abstract::A reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H)-dependent hydrogen peroxide-generating activity of rat ocular tissue was investigated cytochemically utilizing the cerium method. NADPH or NADH oxidation resulted in electron-dense fine granular deposits on the corneal epithelial and endothelial plasma me...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Atalla LR,Sevanian A,Rao NA

    更新日期:1988-09-01 00:00:00

  • Proteolytic activation of corneal matrix metalloproteinase by Pseudomonas aeruginosa elastase.

    abstract::Purified Pseudomonas aeruginosa elastase cleaved a 65 kDa gelatinase [inactive proenzyme form of matrix metalloproteinase (MMP-2)] from human corneal fibroblasts into a biologically active fragment with an approximate molecular mass of 58 kDa. However, purified pseudomonal alkaline protease did not cleave MMP-2 apprec...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Matsumoto K,Shams NB,Hanninen LA,Kenyon KR

    更新日期:1992-11-01 00:00:00

  • Detection of substance P in human tears by laser desorption mass spectrometry and immunoassay.

    abstract:PURPOSE:To determine whether substance P is present in human tears. METHODS:Tear samples (1-2 microliters) were collected from one eye of each of 12 subjects. Two of the eyes had dry eye syndrome, two wore contact lenses and had dry eye syndrome, and eight were normal. Five of the eight normal eyes were scheduled to u...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Varnell RJ,Freeman JY,Maitchouk D,Beuerman RW,Gebhardt BM

    更新日期:1997-09-01 00:00:00

  • Morphological study of epiretinal membrane following posterior penetrating injury in the monkey eye.

    abstract::Posterior vitreous detachment (PVD) and epiretinal membranes occur in a number of vitreoretinal diseases. We have developed an experimental model in which we can provide the morphologic correlation of these dynamic processes. The method provides the opportunity to study epiretinal membrane formation with the scanning ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Matsumoto B,Hsu HT,Blanks JC,Ryan SJ

    更新日期:1986-04-01 00:00:00

  • Quantitative comparison of fluoroquinolone therapies of experimental gram-negative bacterial keratitis.

    abstract:PURPOSE:To determine the effectiveness of topically applied fluoroquinolones for experimental Pseudomonas or Serratia keratitis. METHODS:Bacteria were injected intrastromally (10(3) colony forming units [CFU]). From 16 to 22 hours post-infection (PI), a single topical drop of moxifloxacin (Vigamox, 0.545%), levofloxac...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Thibodeaux BA,Dajcs JJ,Caballero AR,Marquart ME,Girgis DO,O'Callaghan RJ

    更新日期:2004-05-01 00:00:00

  • Dispersion of DMPC liposomes in contact lenses for ophthalmic drug delivery.

    abstract::Approximately 90% of all ophthalmic drug formulations are now applied as eyedrops. Although eyedrops are convenient and well accepted by patients, about 95% of the drug contained in the drops is lost due to absorption through the conjunctiva or through the tear drainage. A major fraction of the drug eventually enters ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Gulsen D,Li CC,Chauhan A

    更新日期:2005-12-01 00:00:00

  • The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes.

    abstract::The compound 2-mercaptoacetyl-L-phenylalanyl-L-leucine (HS-Ac-Phe-Leu) is a potent and specific inhibitor of Pseudomonas aeruginosa elastase, effectively inhibiting the elastase activity both, in vitro and within the rabbit cornea. This inhibitor was therefore evaluated as an adjunct to antibiotics (gentamicin) treatm...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Spierer A,Kessler E

    更新日期:1984-04-01 00:00:00

  • Dark-light change of iris parameters and related factors among American Caucasians, American Chinese, and Mainland Chinese.

    abstract:PURPOSE:To assess the distribution of dark-light changes in iris features and associated factors amongst American Caucasians, American Chinese and mainland Chinese aged 40 years and over. METHODS:Four gender- and age-matched cohorts: Caucasians, American Chinese, Southern Chinese and Northern Chinese comprised the stu...

    journal_title:Current eye research

    pub_type: 杂志文章,多中心研究


    authors: Wang D,He M,Wu L,Kao A,Pekmezci M,Singh K,Lin S

    更新日期:2012-07-01 00:00:00

  • Intramuscular Distribution of the Abducens Nerve in the Lateral Rectus Muscle for the Management of Strabismus.

    abstract:AIMS:To elucidate the intramuscular distribution and branching patterns of the abducens nerve in the lateral rectus (LR) muscle so as to provide anatomical confirmation of the presence of compartmentalization, including for use in clinical applications such as botulinum toxin injections. METHODS:Thirty whole-mount hum...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Shin HJ,Lee SH,Shin KJ,Koh KS,Song WC

    更新日期:2018-06-01 00:00:00

  • The effect of elevated extracellular glucose on migration, adhesion and proliferation of SV40 transformed human corneal epithelial cells.

    abstract:PURPOSE:To examine the effect of elevated extracellular glucose, thus simulating diabetes, on migration, adhesion and proliferation of SV40 transformed human corneal epithelial (HCE) cells. METHODS:HCE cells were maintained in serum supplemented media containing 5 mM, 17.5 mM or 38 mM D-glucose. Cell migration was det...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: McDermott AM,Kern TS,Murphy CJ

    更新日期:1998-09-01 00:00:00

  • The predicted structure of chick lens CP49 and a variant thereof, CP49ins, the first vertebrate cytoplasmic intermediate filament protein with a lamin-like insertion in helix 1B.

    abstract::The full length cDNA sequence for the lens-specific intermediate filament protein, CP49, from chicken is presented. The sequence contains features typical of the other intermediate filament proteins, including two major alpha-helical regions, helix I and II and appropriate linker regions. CP49 lacks a C-terminal non-a...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Sawada K,Agata J,Eguchi G,Quinlan R,Maisel H

    更新日期:1995-07-01 00:00:00

  • Plasma Rich in Growth Factors for the Treatment of Ocular Surface Diseases.

    abstract:PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...

    journal_title:Current eye research

    pub_type: 杂志文章,评审


    authors: Anitua E,Muruzabal F,de la Fuente M,Merayo J,Durán J,Orive G

    更新日期:2016-07-01 00:00:00

  • Quantifying retinal irradiance levels in light damage experiments.

    abstract::From knowledge of the optical parameters of experimental animal eyes and radiometric parameters of the light source, it is possible to provide accurate retinal irradiances (dose rates). Examples are given for the rat, cat, monkey and other animals of interest. Fluorescent lamps and incandescent lamp radiances are prov...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Sliney DH

    更新日期:1984-01-01 00:00:00

  • Characterization of alpha 2-adrenergic receptors, negatively coupled to adenylate cyclase, in rabbit ciliary processes.

    abstract::Inhibition of ciliary process adenylate cyclase was studied on rabbit membrane preparations. When considered individually, epinephrine, GTP and NaCl did not inhibit adenylate cyclase activity. On the other hand, when present together, epinephrine, GTP (10(-5) M) and NaCl (200 mM) acted synergistically to cause a 27% i...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Kintz P,Himber J,de Burlet G,Andermann G

    更新日期:1988-03-01 00:00:00

  • Prolonged exposure to high glucose impaired cellular behavior of normal human corneal epithelial cells.

    abstract:PURPOSE:To determine the effect of prolonged exposure to high glucose on cellular behavior of normal human corneal epithelial cells (HCEC). METHODS:HCEC were cultured in medium under normal or high glucose conditions for 14 days. Proliferation was evaluated by direct cell counting and [(3)H]thymidine incorporation. Ce...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Fujita H,Morita I,Takase H,Ohno-Matsui K,Mochizuki M

    更新日期:2003-10-01 00:00:00

  • Diffuse luminance flicker increases retinal vessel diameter in humans.

    abstract:PURPOSE:To determine retinal vessel diameter variations in response to neuronal activity induced by diffuse luminance flicker. METHODS:The diameter of retinal arteries and veins was measured in 9 normal subjects by computer analysis of fundus pictures taken in monochromatic light under normal conditions of illuminatio...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Formaz F,Riva CE,Geiser M

    更新日期:1997-12-01 00:00:00

  • Distribution of a steroid antagonist in the eye following topical administration.

    abstract::The distribution of a steroid antagonist, RU486, that is known to reduce rabbit intraocular pressure has been examined in the eye. On an equal tissue weight basis, the corneal epithelium is the site of maximal absorption followed by conjunctival tissues (bulbar and palpebral) and the rest of the cornea. Aqueous humor ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Cheeks L,Green K

    更新日期:1986-09-01 00:00:00

  • An in vivo model for dissociating alpha 2-and DA2-adrenoceptor activity in an ocular adnexa: utility of the cat nictitating membrane preparation.

    abstract::Recent reports from this laboratory indicate that dopamine (DA2) agonists can lower intraocular pressure (IOP) in rabbits, monkeys and rats. This communication suggests that the cat nictitating membrane (CNM) preparation is a useful model for localizing the site(s) and mechanism(s) of action of dopamine (DA2) agonists...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Potter DE,Burke JA

    更新日期:1984-11-01 00:00:00

  • Assessment of Streptococcus pneumoniae capsule in conjunctivitis and keratitis in vivo neuraminidase activity increases in nonencapsulated pneumococci following conjunctival infection.

    abstract:PURPOSE:The pneumococcal capsule is required for pathogenesis in systemic infections, yet reports show most conjunctivitis outbreaks are caused by nonencapsulated pneumococci, while keratitis infections are caused by encapsulated strains. This study aims to determine the effect of capsule in pneumococcal keratitis and ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Norcross EW,Tullos NA,Taylor SD,Sanders ME,Marquart ME

    更新日期:2010-09-01 00:00:00

  • Ultrastructural, histochemical and biochemical studies of the melanin metabolism in pallid mouse eye.

    abstract::In an attempt to determine the factors involved in ocular pigment variation, the eyes of pallid mice (c57BL/6J-Pa/Pa), and those of littermate black mice (C57BL/6J-+/Pa) were examined ultrastructurally, histochemically, and biochemically. As controls, the eyes of black and congenic albino mice (C57BL/6J +/C2J and -C2J...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Ito M,Hashimoto K,Organisciak DT

    更新日期:1982-01-01 00:00:00