Abstract:
PURPOSE:To characterize the pupil light reflex (PLR), electroretinographic (ERG) and tonometric parameters in healthy rat eyes. METHODS:Brown Norway rats were used for experiments. The PLR was evaluated with a computerized pupillometer (n = 27), ERGs were recorded simultaneously from both eyes (n = 27) and IOP was measured with a Tonopen (n = 15). RESULTS:The analysis of the PLR parameters confirmed that the consensual PLR had a significantly smaller amplitude (0.1-0.2 mm; p = 0.03) and an increased latency time (p = 0.001) compared to the direct PLR. Electroretinography revealed an a-wave amplitude of 207.2 +/- 13 microV with a latency of 25.6 +/- 0.7 ms, and a b-wave 554.3 +/- 24.5 microV with a latency of 21.4 + 1.8 ms. The flicker ERG recording revealed amplitudes of 40.6 +/- 2.4 microV. Tonometry measurements revealed that isoflurane, but not halothane, anesthesia suppressed the IOP (non-anesthetized: 25.3 +/- 1.0 mmHg; 1% halothane + 30% NO: 26.2 +/- 1.1 (p > 0.1); 1% isoflurane + 30% NO: 20.1 + 1.6 (p < 0.05)). CONCLUSIONS:Consensual PLR in rats has a relative deficit compared to the direct PLR. Isoflurane anesthesia has a suppressive effect on the IOP in healthy rat eyes.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Grozdanic S,Sakaguchi DS,Kwon YH,Kardon RH,Sonea IMdoi
10.1076/ceyr.25.2.69.10156subject
Has Abstractpub_date
2002-08-01 00:00:00pages
69-78issue
2eissn
0271-3683issn
1460-2202journal_volume
25pub_type
杂志文章abstract:PURPOSE:To evaluate the stability of successive applanation tonometry measurements in glaucomatous eyes. METHODS:A prospective, comparative, randomized, and evaluator-masked study was conducted in a tertiary medical center. Sixty-seven patients with glaucoma attending our glaucoma clinic underwent four successive intr...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
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journal_title:Current eye research
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journal_title:Current eye research
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更新日期:2015-01-01 00:00:00
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doi:10.3109/02713689109020325
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更新日期:2002-02-01 00:00:00
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更新日期:1999-03-01 00:00:00
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更新日期:2003-05-01 00:00:00
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journal_title:Current eye research
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更新日期:1996-08-01 00:00:00
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更新日期:2016-12-01 00:00:00
abstract::Levels of rhodopsin in the photoreceptors of Long-Evans rats were reduced by approximately 55% through dietary deprivation of vitamin A. The interaction of visual pigment with G-protein was examined in receptor outer segment (ROS) membranes obtained from these animals. A binding assay was used to quantitate affinity o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688908996390
更新日期:1989-04-01 00:00:00
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journal_title:Current eye research
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更新日期:2014-11-01 00:00:00