Corneal cell adhesion and proliferation on hydrogel sheets bound with cell-adhesive proteins.

abstract：PURPOSE:To examine the effects of nitric oxide synthase (NOS) inhibitors on intraocular pressure (IOP) and ocular inflammation following laser irradiation of the rabbit iris, and to investigate the involvement of nitric oxide (NO). METHODS:Thirty min after the intravenous administration of a nonselective inhibitor of ...

journal_title：Current eye research

authors： Taniguchi T,Kawakami H,Sawada A,Iwaki M,Tsuji A,Sugiyama K,Kitazawa Y

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:To evaluate "in vivo" the effect of topical travoprost on the central corneal thickness (CCT) of rabbit eyes, and the changes in the CCT after acute increases of intraocular pressure (IOP) in these eyes. MATERIALS AND METHODS:This is an interventional, prospective, case-control, masked study. Topical travopros...

journal_title：Current eye research

authors： Bolívar G,Teus M,Arranz-Marquez E

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Membrane-associated mucins are important components of the ocular tear film. Our objective was to characterize the expression of membrane-associated mucins MUC1, MUC4, and MUC16 in healthy cornea, healthy conjunctiva, fibrovascular tissue (pannus) covering the corneal surface in limbal stem cell deficiency (LSC...

journal_title：Current eye research

authors： Pauklin M,Kakkassery V,Steuhl KP,Meller D

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous. METHODS:IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMP...

journal_title：Current eye research

authors： Plantner JJ,Smine A,Quinn TA

更新日期：1998-02-01 00:00:00

abstract：:Change of urate and ascorbate levels in retinae of rat left eyes after ophthalmic artery and optic nerve ligation was studied by reversed-phase high-performance liquid chromatography with electrochemical detection. The right eyes were used for sham operation. We found that uric acid levels in the retinae of the left e...

journal_title：Current eye research

authors： Iriyama K,Yoshiura M,Iwamoto T,Kamada Y,Nozawa H,Mizuno A,Matsuzaki H

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:The pneumococcal capsule is required for pathogenesis in systemic infections, yet reports show most conjunctivitis outbreaks are caused by nonencapsulated pneumococci, while keratitis infections are caused by encapsulated strains. This study aims to determine the effect of capsule in pneumococcal keratitis and ...

journal_title：Current eye research

authors： Norcross EW,Tullos NA,Taylor SD,Sanders ME,Marquart ME

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:1) To elucidate the role of collector channels in the aqueous humor outflow pathway 2) To suggest anatomic and functional methods of imaging collector channels in-vitro and in-vivo and 3) To discuss the role of such imaging modalities in the surgical management of glaucoma. METHODS:A thorough literature sea...

journal_title：Current eye research

authors： M Elhusseiny A,Jamerson EC,Menshawey R,Tam EK,El Sayed YM

更新日期：2020-10-01 00:00:00

abstract：:Prorenin (PR) was localized by electron microscopic (EM) immunostaining of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunostaining. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, part...

journal_title：Current eye research

authors： Wallow IH,Sramek SJ,Bindley CD,Darjatmoko SR,Gange SJ

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:To evaluate the effect of the birth weight and the postconceptional age on the tear production of preterm and term newborn infants and to evaluate the changes in tear production during the first two months of life. SUBJECTS--METHODS: Both eyes of medically stable term and preterm infants were included in the st...

journal_title：Current eye research

authors： Akar Y,Cira A,Apaydin C,Erman MA,Yilmaz A

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:To generate toxicology profiles of individual drugs on human corneal epithelial cells (HCEC) and compare their in vitro cytotoxicity. METHODS:Monolayer cultures of HCEC were harvested from two human donor eyes. Sunitinib (0.3-10 µg/mL) and Sorafenib (0.3-100 µg/mL), diluted in culture medium (CnT-BM.1, CELLnTE...

journal_title：Current eye research

authors： Bayyoud T,Hofmann J,Spitzer M,Bartz-Schmidt KU,Yoeruek E

更新日期：2014-02-01 00:00:00

abstract：:Arachidonic acid metabolism via the cyclooxygenase pathway and the effects of aspirin and indomethacin were studied in whole retinas of rats with streptozotocin-induced diabetes. Diabetes was induced by intravenous injection of streptozotocin (60 mg/kg) and the animals were examined 5-6 weeks later. Whole retinas of n...

journal_title：Current eye research

authors： Naveh-Floman N,Weissman C,Belkin M

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:A pilot study was conducted to evaluate human corneal epithelial cell shedding in response to wearing a silicone hydrogel contact lens/solution combination inducing corneal staining. The nature of ex vivo collected cells staining with fluorescein was also examined. METHODS:A contralateral eye study was conduct...

journal_title：Current eye research

authors： Gorbet M,Peterson R,McCanna D,Woods C,Jones L,Fonn D

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:Intrastromal epithelial migration occurs following deep excimer annular keratectomy. Our purpose is to determine the localization of gelatinase B expression and its relationship to migrating intrastromal epithelial cells following deep annular excimer keratectomy. METHODS:Rabbit corneas were treated with deep ...

journal_title：Current eye research

authors： Maeda M,Vanlandingham BD,Ye H,Lu PC,Azar DT

更新日期：1998-08-01 00:00:00

abstract：:In uveal vessels of isolated arterially perfused rabbit eyes there is direct evidence for the presence of post-junctional alpha 1-receptors and indirect evidence for alpha 2-receptors. Since vasoconstriction by epinephrine could not be blocked by an alpha 1-antagonist, only 30% by an alpha 2-antagonist and almost full...

journal_title：Current eye research

authors： van Pinxteren PC,van Alphen GW

更新日期：1985-01-01 00:00:00

abstract：:The clinical impression that pre-existing diabetes exacerbates radiation injury to the retinal vasculature was studied in STZ diabetic rats. Half of 2 groups of streptozotocin (STZ)-induced diabetic rats and 1 group of normal animals had their right eyes irradiated with 1000 cGy of 90 KVP x-rays. The prevalence of ace...

journal_title：Current eye research

authors： Gardiner TA,Amoaku WM,Archer DB

更新日期：1993-11-01 00:00:00

abstract：:Purpose: To determine the prevalence of posterior segment manifestations among consecutive patients with pathological myopia attending our University Hospital general ophthalmology clinic and their association with age, refractive error, axial length and each other. Methods: Patients diagnosed with pathological myopia...

journal_title：Current eye research

authors： Elnahry AG,Khafagy MM,Esmat SM,Mortada HA

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:To establish autologous iris pigment epithelial (IPE) cell transplantation in monkey eyes. METHODS:Autologous IPE cells from three monkeys were obtained by peripheral iridectomy, and cell culture was performed with autologous serum. The cultured cells were labeled with DiI, and transplantation was performed by...

journal_title：Current eye research

authors： Abe T,Tomita H,Kano T,Yoshida M,Ohashi T,Nakamura Y,Nishikawa S,Tamai M

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:Both HSV-1 and HSV-2 express LAT during viral latency. Previous studies indicated that deletion of either LAT impairs viral reactivation from latency, but that the HSV-1 LAT confers the ability to reactivate efficiently from trigeminal ganglia onto HSV-2. We sought to determine whether the HSV-2 LAT could funct...

journal_title：Current eye research

authors： Hill J,Patel A,Bhattacharjee P,Krause P

更新日期：2003-03-01 00:00:00

abstract：:In the unsutured partial thickness penetrating wounds of the cornea, the epithelium migrates over the wounded stromal surface prior to the onset of stromal regeneration. To determine the possible affects of the epithelial ingrowth on the organization of the stromal scar tissues, the healing of unsutured and sutured wo...

journal_title：Current eye research

authors： Melles GR,SundarRaj N,Binder PS,van der Weiden MM,Wijdh RH,Beekhuis WH,Anderson JA

更新日期：1995-09-01 00:00:00

abstract：:The effect of cytochalasin D (CD), an actin monomer-stabilizer, has been studied on cataract development in rat lenses. Cataractogenesis was induced by incubating the rat lenses in medium 199 (M199) containing 10(-5) M CD; by the end of 24 h, lenses first developed a visible opacity. The increased lactate dehydrogenas...

journal_title：Current eye research

authors： Kilic F,Trevithick JR

更新日期：1995-10-01 00:00:00

abstract：PURPOSE:Oxidative damage of lens tissue contributes to the formation of age-related cataract. Pi-class glutathione-S-transferase (GSTP1) plays a role in the removal of oxidative adducts by transferring them to glutathione. To assess epigenetic regulation of GSTP1 and its potential role in age-related nuclear cataract (...

journal_title：Current eye research

authors： Chen J,Zhou J,Wu J,Zhang G,Kang L,Ben J,Wang Y,Qin B,Guan H

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To determine the role of apoptosis in the pathogenesis of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. METHODS:Forty-three eyes from patients with cytomegalovirus retinitis treated before the introduction of highly active anti-retroviral therapy were examined by routine hi...

journal_title：Current eye research

authors： Buggage RR,Chan CC,Matteson DM,Reed GF,Whitcup SM

更新日期：2000-09-01 00:00:00

abstract：:To better define the growth requirements for corneal epithelial cells, methods for serum-free culture were established. Sheets of corneal epithelium from eyes of swine and rabbits were obtained by dispase treatment of corneal buttons, and single cells and small clumps were obtained by further dissociation with trypsin...

journal_title：Current eye research

authors： Hackworth LA,Faraji-Shadan F,Schuschereba ST,Bowman PD

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:Psychiatric conditions and not just the treatments themselves might be involved in the pathophysiology of dry eye disease (DED). The aim of our study was to evaluate the association between depression and DED using objective and subjective tests in patients with newly diagnosed depressive disorder who were not ...

journal_title：Current eye research

authors： Tiskaoglu NS,Yazıcı A,Karlıdere T,Sari E,Oguz EY,Musaoglu M,Aslan S,Samet Ermiş S

更新日期：2017-05-01 00:00:00

abstract：:Calpains are calcium-activated proteinases which have been implicated in tissue differentiation and degeneration. The aims of the present study were: (1) to determine the relationship between postnatal age and calpain activity in the rat retina; (2) to test if calpain activity was aberrant in the RCS retina at differe...

journal_title：Current eye research

authors： Azarian SM,Williams DS

更新日期：1995-08-01 00:00:00

abstract：:The effects of repeated exposures to UV-A (335 nm) and UV-B (305 nm) radiation on the crystalline lens were studied by treating cultured bovine lenses daily or weekly. The effects of irradiation on lens optical quality were monitored using an automated scanning laser system that records both relative transmittance and...

journal_title：Current eye research

authors： Stuart DD,Cullen AP,Sivak JG,Doughty MJ

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:We identified a novel mutation in Paired Box gene 6 (PAX6) and characterized its associated clinical features of severe ocular malformation in a Chinese family with congenital aniridia. METHODS:We studied two patients with aniridia from a Chinese family. All patients and noncarriers in this family underwent fu...

journal_title：Current eye research

authors： He Y,Pan Z,Luo F

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To compare the retinal sensitivity, using Microperimeter and the morphological changes in retinal layers, using Spectral Domain Optical Coherence Tomography (SD-OCT), between myopes and age-matched emmetropes. METHODS:Twenty-nine myopic eyes and 29 emmetropic eyes were enrolled in this prospective case control...

journal_title：Current eye research

authors： Gella L,Raman R,Sharma T

更新日期：2011-10-01 00:00:00

abstract：:The management of opportunistic infections is a significant problem in acquired immunodeficiency syndrome (AIDS) and the development of more effective chemotherapeutic agents is needed. We present the ocular manifestations of an AIDS-like disease in rhesus monkeys experimentally infected with simian immunodeficiency v...

journal_title：Current eye research

authors： Conway MD,Didier P,Fairburn B,Soike KF,Martin L,Murphey-Corb M,Meiners N,Insler MS

更新日期：1990-08-01 00:00:00

abstract：:Experiments were conducted to test the influence of thapsigargin on the NaK-ATPase activity of cultured cells (ODM2) derived from human nonpigmented ciliary epithelium. The rate of ouabain-sensitive ATP hydrolysis (Na,K-ATPase activity) was diminished in cells that had been pretreated with thapsigargin then permeabili...

journal_title：Current eye research

authors： Mito T,Kuwahara S,Delamere NA

更新日期：1995-08-01 00:00:00