Expression of membrane-associated mucins in limbal stem cell deficiency and after transplantation of cultivated limbal epithelium.

abstract：PURPOSE:Nuclear factor-kappa B (NF-κB) has been proposed as a therapeutic target for the treatment of cataracts. The authors investigated the relationship between nuclear factor of activated T cells 5 (NFAT5) and NF-κB in ultraviolet B (UVB)-irradiated human lens epithelial (HLE) cells. METHODS:Human lens epithelial B...

journal_title：Current eye research

authors： Chung I,Hah YS,Ju S,Kim JH,Yoo WS,Cho HY,Yoo JM,Seo SW,Choi WS,Kim SJ

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:The purpose was to investigate the effect of the superoxide dismutase mimetic tempol on decreases in retinal blood flow that are found in diabetic mice. MATERIALS AND METHODS:Streptozotocin (STZ) was injected into male C57BL/6 mice to induce hyperglycemia. One week following the STZ injection, subsets of the m...

journal_title：Current eye research

authors： Yadav AS,Harris NR

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To measure the cell size and cell density in five layers of the central cornea in the widely used inbred C57BL/6 mouse strain using in vivo three-dimensional (3D) two-photon (2PH) imaging. METHODS:Corneas were scanned using a 2PH laser scanning fluorescence microscope after staining with plasma membrane stain ...

journal_title：Current eye research

authors： Zhang H,He S,Liu S,Xie Y,Chen G,Zhang J,Sun S,Liang D,Wang L

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Ethacrynic acid (ECA) has been shown to increase facility of aqueous outflow in whole eyes and perfused anterior segments, to open up spaces between cells in the trabecular meshwork and inner wall of Schlemm's canal, and to cause separation and retraction of trabecular meshwork and endothelial cells in culture....

journal_title：Current eye research

authors： O'Brien ET,Lee RE 3rd,Epstein DL

更新日期：1996-09-01 00:00:00

abstract：:Due to the multiple barriers imposed by the eye against the penetration of drugs, the ocular delivery and targeting are considered difficult to achieve. A major challenge in ocular drug therapy is to improve the poor bioavailability of topically applied ophthalmic drugs by overcoming the severe constraints imposed by ...

journal_title：Current eye research

authors： Souto EB,Doktorovova S,Gonzalez-Mira E,Egea MA,Garcia ML

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Choroidal neovascularization (CNV) is a major cause of vision loss in patients with age-related macular degeneration (AMD). Stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) plays a critical role in homing of bone marrow-derived cells (BMCs) to choroidal neovascularization (CNV). In this st...

journal_title：Current eye research

authors： Zhang ZX,Wang YS,Shi YY,Hou HY,Zhang C,Cai Y,Dou GR,Yao LB,Li FY

更新日期：2011-09-01 00:00:00

abstract：:Blood and lymphatic vessel proliferation into the cornea occurs after severe trauma. Whilst the events early in blood vessel growth are reasonably understood, little is known of the early events in lymphangiogenesis. In this study, a model for proliferating lymphatic vessels using tritiated-thymidine autoradiography a...

journal_title：Current eye research

authors： Junghans BM,Collin HB

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:The expression of human leukocyte antigen (HLA) class II molecules on the cell surface is necessary for the presentation of peptide antigens to helper CD4 T lymphocytes of the immune system. We studied the immunoexpression of HLA class II antigen in conjunctival precursor lesions and conjunctival squamous cell ...

journal_title：Current eye research

authors： Abhyankar D,Lakshmi SA,Pushparaj V,Biswas J,Krishnakumar S

更新日期：2003-09-01 00:00:00

abstract：:Experiments were conducted to test the influence of thapsigargin on the NaK-ATPase activity of cultured cells (ODM2) derived from human nonpigmented ciliary epithelium. The rate of ouabain-sensitive ATP hydrolysis (Na,K-ATPase activity) was diminished in cells that had been pretreated with thapsigargin then permeabili...

journal_title：Current eye research

authors： Mito T,Kuwahara S,Delamere NA

更新日期：1995-08-01 00:00:00

abstract：PURPOSE:To assess the potential impact of corneal crosslinking treatment (365 nm ultraviolet (UV)A irradiation with riboflavin) on the material properties of Intracorneal Rings Segments (ICRS). MATERIALS AND METHODS:Material properties were studied using FT-IR spectroscopy and UV-Vis spectroscopy. Rings were examined:...

journal_title：Current eye research

authors： Sideroudi H,Labiris G,Soto-Beobide A,Voyiatzis G,Chrissanthopoulos A,Kozobolis V

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:The purpose of these studies is to develop an in vitro model of corneal endothelial aging and to investigate age-related changes in morphology, mitosis, prostaglandin synthesis and prostaglandin response pathways. METHODS:First-passage rabbit corneal endothelial cells were grown in vitro for up to 30 days afte...

journal_title：Current eye research

authors： Jumblatt MM

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:To investigate epithelial cell adhesion and proliferation on a newly developed elastin-like polymer (ELP) that mimics the functional characteristics of extracellular matrices. MATERIALS AND METHODS:A genetically engineered ELP with cell attachment sequences was adsorbed onto glass coverslips as 1, 2, or 3 mole...

journal_title：Current eye research

authors： Martínez-Osorio H,Juárez-Campo M,Diebold Y,Girotti A,Alonso M,Arias FJ,Rodríguez-Cabello JC,García-Vázquez C,Calonge M

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:We report on the use of subconjunctival bevacizumab on corneal vessel density in recurrent pterygia. METHODS:The charts of 5 patients with recurrent pterygium, who received subconjunctival injections of bevacizumab (2.5 mg/0.1 ml) were retrospectively reviewed. Ophthalmic evaluation included Snellen visual acu...

journal_title：Current eye research

authors： Bahar I,Kaiserman I,McAllum P,Rootman D,Slomovic A

更新日期：2008-01-01 00:00:00

abstract：:Membrane response to the various temperatures as one of the external factors was investigated in the lenses of the poikilothermal animal and the homothermal animal. The rainbow trout lens was used as the poikilothermal material and the rat lens as the homothermal material. The rainbow trout lens maintained in vitro it...

journal_title：Current eye research

authors： Iwata S

更新日期：1985-04-01 00:00:00

abstract：:Antifibrosis agents have improved the success of glaucoma filtration surgery, although undesired side effects are not readily reversible and may present a major limitation in the use of these agents. Our purpose was to study the efficacy of cytosine arabinoside (Ara-C) as an adjunctive antimetabolite in glaucoma surge...

journal_title：Current eye research

authors： Chu JL,Shields SR,Netland PA

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To evaluate the stability of successive applanation tonometry measurements in glaucomatous eyes. METHODS:A prospective, comparative, randomized, and evaluator-masked study was conducted in a tertiary medical center. Sixty-seven patients with glaucoma attending our glaucoma clinic underwent four successive intr...

journal_title：Current eye research

authors： Gaton DD,Ehrenberg M,Lusky M,Wussuki-Lior O,Dotan G,Weinberger D,Snir M

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Human beta-defensins 1 and 2 (hBD-1, -2) are antimicrobial peptides found in several epithelia including corneal epithelium. Breach of the epithelium leaves the cornea vulnerable to infection so we sought to determine if there is an increase in defensin expression after injury. METHODS:The epithelium from huma...

journal_title：Current eye research

authors： McDermott AM,Redfern RL,Zhang B

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF THE STUDY:To assess differences in healthy eyes in volume (CV) and choroidal thicknesses (CT) across all macular Early Treatment Diabetic Retinopathy Study (ETDRS) areas measured by swept source (SS)-OCT and spectral domain (SD)-OCT with enhanced depth imaging (EDI). MATERIALS AND METHODS:One hundred and fi...

journal_title：Current eye research

authors： Pinilla I,Sanchez-Cano A,Insa G,Bartolomé I,Perdices L,Orduna-Hospital E

更新日期：2021-02-01 00:00:00

abstract：PURPOSES:To investigate whether valproic acid (VPA) has a neuroprotective effect against ischemia/reperfusion (I/R) injury in the rat retina, and to elucidate the potential antioxidant mechanisms involved. METHODS:Adult male Wistar rats were randomly divided into four groups: sham (group A), sham plus VPA (group B), I...

journal_title：Current eye research

authors： Zhang Z,Qin X,Zhao X,Tong N,Gong Y,Zhang W,Wu X

更新日期：2012-05-01 00:00:00

abstract：:Utilizing a rapid colorimetric assay that relates cell number to cytoplasmic hexosaminidase activity, we conducted drug-induced cytotoxicity experiments on human ocular fibroblasts cultured from Tenon's capsule specimens. The effects of two different agents--dimethyl sulfoxide (DMSO) or mitomycin C--on the proliferati...

journal_title：Current eye research

authors： Givens KT,Lee DA,Rothschiller J,Kitada S,Larian B,Cortes A

更新日期：1990-06-01 00:00:00

abstract：:Purpose: To investigate the cytotoxic effects of fresh black carbon (FBC) particles and ozone-oxidized BC (OBC) particles on human corneal epithelial cells (HCECs), and the role of the NLRP3 inflammasome signal pathway in the process.Methods: HCECs were treated with different doses of FBC and OBC particles, the cell i...

journal_title：Current eye research

authors： Long Q,Huang Y,Shang J,Liu Y,Chen C

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To assess the rate of achieving optimal metabolic control among subjects with type 2 diabetes, to elucidate the influence of suboptimal control on diabetic retinopathy (DR) and to analyze the risk factors associated with DR in the subjects with suboptimal control. MATERIAL AND METHODS:A population-based, cross...

journal_title：Current eye research

authors： Raman R,Gupta A,Kulothungan V,Sharma T

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...

journal_title：Current eye research

authors： Anitua E,Muruzabal F,de la Fuente M,Merayo J,Durán J,Orive G

更新日期：2016-07-01 00:00:00

abstract：:We established growth curves for Propionibacterium acnes isolates recovered from eyes with chronic postoperative endophthalmitis. The growth curve plotted the average of the duplicate bacterial concentration against time. The generation time for P. acnes calculated from the growth curves was approximately 5.1 hours. T...

journal_title：Current eye research

authors： Hall GS,Pratt-Rippin K,Meisler DM,Washington JA,Roussel TJ,Miller D

更新日期：1994-06-01 00:00:00

abstract：PURPOSE:Recent studies have shown that the levels of interleukin (IL)-1beta, IL-6 and IL-8 are associated with the severity of infectious diseases. The purpose of this study was to investigate whether IL-1beta regulates the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colo...

journal_title：Current eye research

authors： Xue ML,Zhu H,Willcox M,Wakefield D,Lloyd A,Thakur A

更新日期：2001-12-01 00:00:00

abstract：PURPOSE/AIM:To quantitatively analyse the evolution of TUNEL-labeling, after in vivo exposure to UVB. METHODS:Altogether, 16 Sprague Dawley rats were unilaterally exposed in vivo for 15 min to close to threshold dose, 5 kJ/m(2), of ultraviolet radiation in the 300 nm wavelength region. Animals were sacrificed in group...

journal_title：Current eye research

authors： Kronschläger M,Yu Z,Talebizadeh N,Meyer LM,Hallböök F,Söderberg PG

更新日期：2013-08-01 00:00:00

abstract：:In the bovine lens the gamma IV-crystallin fraction is a principal determinant of the phase separation and opacification temperature, Tc (Siezen et al, Proc. Natl. Acad. Sci. USA 82, 1985, 1701). We have now measured the effect on Tc of purified gamma IV-crystallin solutions produced by a variety of reagents which aff...

journal_title：Current eye research

authors： Siezen RJ,Benedek GB

更新日期：1985-10-01 00:00:00

abstract：PURPOSE:Accumulation of lipoprotein-derived lipids including esterified and unesterified cholesterol in Bruch's membrane of human eyes is a major age-related change involved in initiating and sustaining soft drusen in age-related macular degeneration (AMD). The apolipoprotein (apo) A-I mimetic peptide 4F is a small ant...

journal_title：Current eye research

authors： Rudolf M,Mir Mohi Sefat A,Miura Y,Tura A,Raasch W,Ranjbar M,Grisanti S,Aherrahrou Z,Wagner A,Messinger JD,Garber DW,Anantharamaiah GM,Curcio CA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To assess the incidence of cell proliferation and apoptosis in epiretinal membranes from eyes with proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy (PDR), and macular pucker (MP) and to further investigate the potential involvement of key executors of apoptosis. METHODS:Epiretinal memb...

journal_title：Current eye research

authors： Zhang X,Barile G,Chang S,Hays A,Pachydaki S,Schiff W,Sparrow J

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To compare the quality of corneal endothelium of precut Descemet-stripping automated endothelial keratoplasty (DSAEK) tissue when transported with and without the anterior lamellar corneal tissue (ALCT) when organ-culture corneal storage methods are used. METHODS:After microkeratome-assisted excision of anteri...

journal_title：Current eye research

authors： Jhanji V,Pollock GA,Mackey AL,Beltz J,Vajpayee RB

更新日期：2012-02-01 00:00:00