Postjunctional adrenergic receptors in the rabbit eye: effects on uveal flow and intraocular pressure in isolated arterially perfused eyes.

abstract：:Purpose: The optical coherence tomography (OCT) has been used to evaluate the changes of retinal degeneration in patients with diabetic peripheral neuropathy (DPN) in recent years, but the results of previous studies were controversial. Therefore, systematic review and meta-analysis were performed to evaluate the degr...

journal_title：Current eye research

authors： Liu B,Wang W,Zhou R,Zeng X,Zhu Z

更新日期：2021-01-11 00:00:00

abstract：PURPOSE:Pigmentation of the iris is caused by varying amounts of melanin pigment granula in a constant number of melanocytes in the superficial stroma. Melanin has been shown to act as antioxidant. We have now investigated lipid peroxidation in dependence on stromal pigmentation in isolated porcine irises. METHODS:The...

journal_title：Current eye research

authors： Nau-Staudt K,Nau WM,Haefliger IO,Flammer J

更新日期：2001-03-01 00:00:00

abstract：:Inoculation of herpes simplex virus Type 1 into the anterior chamber of BALB/c mice induces a characteristic ocular infection involving primarily the anterior segment of virus-injected eyes and the retina of contralateral uninjected eyes. In the BALB/c strain, which is susceptible to herpetic retinitis, anti-HSV delay...

journal_title：Current eye research

authors： Whittum-Hudson JA,Pepose JS

更新日期：1988-02-01 00:00:00

abstract：PURPOSE:To determine by immunohistochemistry the distribution of different nitric oxide synthases (NOS) isoforms in the porcine eye. METHODS:By light microscopy (immunofluorescence), porcine ocular tissues were investigated using monoclonal antibodies against neuronal NOS (nNOS; NOS I), endothelial NOS (ecNOS; NOS III...

journal_title：Current eye research

authors： Meyer P,Champion C,Schlötzer-Schrehardt U,Flammer J,Haefliger IO

更新日期：1999-05-01 00:00:00

abstract：:The present study was aimed to demonstrate that cytochrome P-450 was induced by drug administration in particular tissues in the eye. Phenobarbital was used as an inducer. We showed immunohistochemically that cytochrome P-450 was induced in the cornea, conjunctiva and ciliary epithelium of rabbits after four days of i...

journal_title：Current eye research

authors： Matsumoto K,Kishida K,Manabe R,Sugiyama T

更新日期：1987-07-01 00:00:00

abstract：PURPOSE:Maintaining the high glutathione (GSH; tripeptide of glutamate, cysteine and glycine) levels in the lens cortex promotes lens health. The role of glutamate/aspartate (Glu/Asp) transporters and the cystine (Cys)/Glu exchanger (Xc(-) exchanger) in maintaining GSH in transformed human lens epithelial cells (SRA 01...

journal_title：Current eye research

authors： Langford MP,Redens TB,Liang C,Kavanaugh AS,Texada DE

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS:Totally, 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and cen...

journal_title：Current eye research

authors： Kwon J,Sung KR,Jo J,Yang SH

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Deficiency in Cystathionine β-synthase (CBS) leads to an abnormal accumulation of homocysteine and results in classical homocystinuria, a multi-systemic disorder that affects connective tissue, muscles, the central nervous system, and the eyes. However, the genetic players and mechanisms underlying vision alter...

journal_title：Current eye research

authors： Flores-Flores M,Moreno-García L,Castro-Martínez F,Nahmad M

更新日期：2020-09-07 00:00:00

abstract：:This study asks whether retinal adhesiveness is affected by cytochalasin D, a drug that is known to alter the apical morphology of the retinal pigment epithelium (RPE). Cytochalasin D was injected intravitreally in Dutch rabbits and retinal adhesiveness measured 0.5 to 72 h later by two methods: in vitro peeling of th...

journal_title：Current eye research

authors： Chiang RK,Yao XY,Takeuchi A,Dalal R,Marmor MF

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:To compare the abilities of balanced salt solution, BSS Plus and Hartmann's lactated Ringer's (HLR) solution to maintain the viability of retinal vascular endothelial cells (RVEC) in vitro. METHODS:Cultured retinal vascular endothelial cells were suspended in each irrigating solution for four hours. Viability ...

journal_title：Current eye research

authors： Mourad KM,Edelhauser HF,Capone A Jr,Lynn MJ,Geroski DH

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:The mechanisms involved in the reported beneficial effects of Calcium dobesilate monohydrate (CaD) for the treatment of diabetic retinopathy (DR) remain to be elucidated. The main aim of the present study is to examine whether CaD prevents early events in the pathogenesis of DR such as neurodegeneration and vas...

journal_title：Current eye research

authors： Solà-Adell C,Bogdanov P,Hernández C,Sampedro J,Valeri M,Garcia-Ramirez M,Pasquali C,Simó R

更新日期：2017-09-01 00:00:00

abstract：AIM:To compare collared silicone punctal plugs to intracanalicular SmartPlugs for the treatment of moderate to severe dry eye. MATERIALS AND METHODS:In this prospective, randomized, single blind, clinical study, 30 patients (60 eyes) who had been diagnosed with moderate to severe dry eye syndrome were enrolled. Study ...

journal_title：Current eye research

authors： Rabensteiner DF,Boldin I,Klein A,Horwath-Winter J

更新日期：2013-05-01 00:00:00

abstract：UNLABELLED:Purpose. To develop a rapid and accurate method for the quantification of reduced glutathione (GSH) and oxidized glutathione (GSSG) using micro-quantities of ocular lens. Methods. The epithelium, cortex and nucleus of the lens were separated and also the whole lens was homogenized in 3% metaphosphoric acid. ...

journal_title：Current eye research

authors： Liu S,Ansari NH,Wang C,Wang L,Srivastava SK

更新日期：1996-07-01 00:00:00

abstract：:Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for aver...

journal_title：Current eye research

authors： Sundmacher R,Mattes A,Neumann-Haefelin D,Adolf G,Kruss B

更新日期：1987-01-01 00:00:00

abstract：:Utilizing a rapid colorimetric assay that relates cell number to cytoplasmic hexosaminidase activity, we conducted drug-induced cytotoxicity experiments on human ocular fibroblasts cultured from Tenon's capsule specimens. The effects of two different agents--dimethyl sulfoxide (DMSO) or mitomycin C--on the proliferati...

journal_title：Current eye research

authors： Givens KT,Lee DA,Rothschiller J,Kitada S,Larian B,Cortes A

更新日期：1990-06-01 00:00:00

abstract：PURPOSE:To evaluate how corneal deturgescence after Descemet membrane endothelial keratoplasty (DMEK) influences the posterior corneal surface area and the endothelial cell density (ECD) measurements. MATERIALS AND METHODS:A mathematical model was formulated to estimate the increase in posterior corneal surface area a...

journal_title：Current eye research

authors： Quilendrino R,Höhn H,Tse WH,Chi H,Dapena I,Ham L,Oellerich S,Melles GR

更新日期：2013-02-01 00:00:00

abstract：:The interfibrillar spacing of collagen fibrils was measured at twenty different positions across a macular dystrophy cornea using synchrotron X-ray diffraction. Unlike previous work of this type the cornea had not been frozen for storage. The spacings were all significantly lower than the spacings which existed at sim...

journal_title：Current eye research

authors： Quantock AJ,Meek KM,Ridgway AE,Bron AJ,Thonar EJ

更新日期：1990-04-01 00:00:00

abstract：:Retinal pigment epithelia (RPE) and retinal neurons (RN) arise from the same underlying precursor cell population. It is worthwhile to explore the transdifferentiation potential of RPE cells, given the benefits that could accrue from turning RPE into neural retina containing all its normal cellular subpopulations. Fac...

journal_title：Current eye research

authors： Khera S,Tiwari A,Srinivasan R,Gupta A,Luthra-Guptasarma M

更新日期：2012-07-01 00:00:00

abstract：:Ocular aldehyde oxidase was purified for the first time from bovine ciliary body cytosol by ammonium sulfate fractionation and successive HPLC using DEAE anion-exchange and hydroxyapatite columns. The purified enzyme was homogeneous by the criterion of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The mol...

journal_title：Current eye research

authors： Shimada S,Mishima HK,Nikaido H,Kitamura S,Tatsumi K

更新日期：1989-07-01 00:00:00

abstract：:Free radicals and oxidative damage play roles in aging and age-related ocular diseases such as cataracts, so defensive mechanisms become important factors for protection. Because N-acetylation is involved in a wide variety of detoxification processes, this study was conducted to examine the relationship between the ac...

journal_title：Current eye research

authors： Tamer L,Yilmaz A,Yildirim H,Ayaz L,Ates NA,Karakas S,Oz O,Yildirim O,Atik U

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To investigate whether retinal impairment was affected by age of rats in acute glaucoma model. METHODS:Young adult and aged rats were randomly divided into normal control, 45 mmHg, 60 mmHg and 90 mmHg groups. Intraocular pressures (IOP) of rats were acutely elevated to 45 mmHg, 60 mmHg and 90 mmHg, respectivel...

journal_title：Current eye research

authors： Tan C,Hu T,Peng MC,Liu SL,Tong JB,Ouyang W,Le Y

更新日期：2015-03-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta), a multifunctional cytokine which has been identified in normal and inflamed ocular fluids, may play a role in the evolution of inflammatory ocular lesions. In this study we utilized a rabbit model of LPS-induced uveitis to determine if exogenous TGF-beta 2 could alter its co...

journal_title：Current eye research

authors： Allen JB,McGahan MC,Ogawa Y,Sellon DC,Clark BD,Fleisher LN

更新日期：1996-01-01 00:00:00

abstract：:We studied the effects of a forskolin suspension on intraocular pressure (IOP) in normal albino and pigmented rabbits and in alpha-chymotrypsin induced ocular hypertensive rabbits. Experimental-induced ocular hypertensive rabbits were produced by injecting of alpha-chymotrypsin (167 units) into the posterior chamber o...

journal_title：Current eye research

authors： Shibata T,Mishima H,Kurokawa T

更新日期：1988-07-01 00:00:00

abstract：PURPOSE/AIM:Cultured autologous oral mucosal epithelial cells (OMECs) have proven useful in the treatment of ocular surface disorders. This study is the first to investigate the potential of expanding OMEC in a xenobiotic- and serum-free medium using therapeutic contact lenses (CLs) as a substrate and carrier. MATERIA...

journal_title：Current eye research

authors： Björkblom B,Eidet JR,Utheim TP,Ulltveit-Moe HF,Raeder S

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Phagocytosis of rod outer segments (ROS) is an important function of retinal pigment epithelial (RPE) cells. Since the details of the process are not fully known, we studied effects of cytokines produced by RPE and photoreceptor cells on phagocytosis of ROS by rat RPE cells. METHODS:RPE cells were isolated and...

journal_title：Current eye research

authors： Hayashi A,Nakae K,Naka H,Ohji M,Tano Y

更新日期：1996-05-01 00:00:00

abstract：:Hybridomas producing monoclonal antibodies to the retinal S antigen were obtained by fusion of spleen cells from a BALB/c mouse immunized with purified bovine S antigen and NS-1 myeloma cells. Six cloned hybridomas were selected and expanded as large scale cultures and as ascites in mice. The specificity of the antibo...

journal_title：Current eye research

authors： Faure JP,Mirshahi M,Dorey C,Thillaye B,de Kozak Y,Boucheix C

更新日期：1984-06-01 00:00:00

abstract：PURPOSE:To evaluate the effect of gatifloxacin ophthalmic solution 0.3% (Zymar, Allergan, Inc., Irvine, CA, USA) on corneal endothelial cell density and morphology and to measure gatifloxacin penetration into aqueous humor. METHODS:This was a single-center, open-label clinical study. Ten patients undergoing standard c...

journal_title：Current eye research

authors： Price MO,Quillin C,Price FW Jr

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To investigate the spectral content of intraocular pressure (IOP) pulse wave by advanced spectral signal processing of continuous IOP readings obtained by dynamic contour tonometry. PATIENTS AND METHODS:A non-interventional case-control study included 20 healthy subjects, 20 previously untreated primary open a...

journal_title：Current eye research

authors： Božić M,Dukić ML,Stojković M

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:To assess the rate of achieving optimal metabolic control among subjects with type 2 diabetes, to elucidate the influence of suboptimal control on diabetic retinopathy (DR) and to analyze the risk factors associated with DR in the subjects with suboptimal control. MATERIAL AND METHODS:A population-based, cross...

journal_title：Current eye research

authors： Raman R,Gupta A,Kulothungan V,Sharma T

更新日期：2012-06-01 00:00:00

abstract：:It has been suggested that the provision of HLA matched tissue for corneal transplantation would be beneficial for graft survival especially in high risk patients. In this study we report the application of a polymerase chain reaction (PCR) based tissue typing procedure to type cadaveric donor material. Using beta-glo...

journal_title：Current eye research

authors： Rakoczy P,Garlepp M,Constable I

更新日期：1992-05-01 00:00:00