Ocular manifestation of simian immunodeficiency syndrome (SAIDS).

Abstract:

:The management of opportunistic infections is a significant problem in acquired immunodeficiency syndrome (AIDS) and the development of more effective chemotherapeutic agents is needed. We present the ocular manifestations of an AIDS-like disease in rhesus monkeys experimentally infected with simian immunodeficiency virus (SIV) at the Delta Regional Primate Research Center. These findings consisted of rubeosis in the anterior segment and retinitis, optic neuritis, choroiditis and panophthalmitis in the posterior segment of the eye. Investigation of the retinas by electron microscopy revealed SIV in both eyes of one animal and a herpes virus in two animals. Serology confirmed cytomegalovirus (CMV) as the likely agent. This primate model will prove useful for both further investigations of the possible interaction between immunosuppressive lentiviruses and CMV in ocular disease and antiviral drug testing.

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Conway MD,Didier P,Fairburn B,Soike KF,Martin L,Murphey-Corb M,Meiners N,Insler MS

doi

10.3109/02713689008999571

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

759-70

issue

8

eissn

0271-3683

issn

1460-2202

journal_volume

9

pub_type

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