Abstract:
PURPOSE:The high prevalence of positive family history of keratoconus (KC) in KC patients is well-known. However, the results regarding the association between family history of KC and disease severity are controversial. The aim of this study was to evaluate the possible association between family history and severity of KC. METHOD:Clinical data of 1496 KC patients were evaluated. All participants were asked if they had had a family member with KC. Topographic and keratometric measurements of KC patients, including central corneal thickness (CCT), thinnest corneal thickness (TCT), mean, flat, and steep keratometry values (K) by the use of Pentacam, best-spectacle corrected visual acuity (BCVA), spherical equivalent (SE), and astigmatism were recorded and compared according to patients with and without a family history of KC, first- or second-degree family members, and the number of family members with KC. Severity of KC was classified according to the Amsler-Krumeich classification. RESULTS:Family history of KC was present in 292 (19.5%) patients. Of those 292 patients who had a family history of KC, 159 (54.5%) had one family member with KC and 133 (45.5%) had two or more family members with KC. There was not a significant difference between corneal pachymetry and K values of the patients with and without a family history of KC (p > 0.05). However, those with a positive family history of KC had more severe disease, according to the Amsler-Krumeich classification (p < 0.05). KC patients who had more family members with KC had significantly lower TCT and significantly higher steep K and astigmatism (p < 0.05), and had more severe disease, according to the Amsler-Krumeich classification (p < 0.05). CONCLUSION:We suggest that patients with more family members with KC should be subject to screening to identify early disease.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Naderan M,Rajabi MT,Zarrinbakhsh P,Naderan M,Bakhshi Adoi
10.3109/02713683.2015.1128553subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1414-1418issue
11eissn
0271-3683issn
1460-2202journal_volume
41pub_type
杂志文章abstract:PURPOSE:To investigate the spectral content of intraocular pressure (IOP) pulse wave by advanced spectral signal processing of continuous IOP readings obtained by dynamic contour tonometry. PATIENTS AND METHODS:A non-interventional case-control study included 20 healthy subjects, 20 previously untreated primary open a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.700755
更新日期:2012-11-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1302591
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508999913
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1007211
更新日期:2016-01-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689208999547
更新日期:1992-12-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.4.307.15433
更新日期:2003-05-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680903007121
更新日期:2009-08-01 00:00:00
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journal_title:Current eye research
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更新日期:2010-10-01 00:00:00
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更新日期:1997-10-01 00:00:00
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更新日期:2014-10-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.24.6.430.8599
更新日期:2002-06-01 00:00:00
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doi:10.1080/02713683.2018.1490772
更新日期:2018-10-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.757326
更新日期:2013-04-01 00:00:00
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更新日期:2006-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/02713683.2018.1467930
更新日期:2018-09-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689509003759
更新日期:1995-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/02713680701604749
更新日期:2007-10-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689109020340
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doi:10.3109/02713688709034868
更新日期:1987-08-01 00:00:00
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journal_title:Current eye research
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doi:10.3109/02713683.2012.683506
更新日期:2012-09-01 00:00:00
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-12-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00