Abstract:
:The intraocular inflammatory reaction in a murine model of herpes simplex keratouveitis was studied using immunohistochemical techniques. 5 x 10(5) PFU of HSV-1 (Stewart strain) was applied to the abraded cornea of BALB/c mice. The subsequent development of keratouveitis was documented by sequential examination, conventional histology and immunohistochemical staining of frozen sections with the following monoclonal antibodies: Thy-1, Lyt-1, Lyt-2, Ia, Mac-1 and Lyb-8.2. At one week (in the early stage) there was moderate central corneal edema with inflammatory cell infiltration, consisting of a predominance of polymorphonuclear leukocytes, with the appearance of helper/inducer T-cells(Th/i). At two weeks (in the middle stage), a geographic corneal ulcer developed and the majority of inflammatory cells were still polymorphonuclear leukocytes. However, there was a further increase in the Th/i cell population, with the first appearance of B-cells. At three weeks (in the late stage), a dense stromal corneal scar was observed and there was a decrease in the inflammatory cell population, with the predominant cell being the B-cell. Throughout the evolution of HSV-1 keratouveitis, a mild inflammatory reaction was observed in the uvea. However, the number of inflammatory cells present was too small to allow more definitive characterization. Patchy Ia staining which is noted in the normal choroid increased markedly throughout the keratouveitis.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Wang HM,Sheu MM,Stulting RD,Kaplan HJdoi
10.3109/02713688909013892subject
Has Abstractpub_date
1989-01-01 00:00:00pages
37-46issue
1eissn
0271-3683issn
1460-2202journal_volume
8pub_type
杂志文章abstract:PURPOSE:Matrix metalloproteinases (MMPs) are involved in posterior capsule opacification (PCO), but the mechanisms that promote MMP expression are yet to be determined. In this study, we investigated whether type I collagen, which is only detected in aged or cataractous lens capsules, affects the expression and activat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.853194
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:The fibroblast growth factors (FGFs) are a family of 9 heparin binding proteins which have been proposed to play key roles in angiogenesis. Basic FGF (bFGF), acidic FGF (aFGF) and FGF5 have previously been demonstrated to be expressed in the normal retina and RPE. In this study, the expression of FGF5 was explo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.4.396.10685
更新日期:1997-04-01 00:00:00
abstract::Purpose: To determine the prevalence of posterior segment manifestations among consecutive patients with pathological myopia attending our University Hospital general ophthalmology clinic and their association with age, refractive error, axial length and each other. Methods: Patients diagnosed with pathological myopia...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1606252
更新日期:2019-09-01 00:00:00
abstract:AIMS:To investigate whether tobacco smoke directly injures retinal ganglion cells (RGCs) and to evaluate the mechanisms of cell death. METHODS:Primary rat RGCs were harvested from 3- or 4-day-old newborn rats and exposed to cigarette smoke extract (CSE). Cell viability was determined by adenosine 5'-triphosphate (ATP)...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1119856
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:Membrane-associated mucins (MAMs) play important roles in barrier function and tear stability, and their expression on the ocular surface is altered in dry eye disease. Rebamipide is a mucin secretagogue that promotes the production of mucin-like glycoproteins in human corneal epithelial (HCE) cells. However, t...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.834939
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:Extracellular matrix homeostasis is dependent in part upon a family of matrix metalloproteinases and their specific inhibitors, the tissue inhibitors of metalloproteinases (TIMPs). Recently, gene defects in TIMP-3 have been identified in the affected individuals of several families with Sorsby's fundus dystroph...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.2.102.5086
更新日期:1997-02-01 00:00:00
abstract:PURPOSE:To investigate optic nerve head (ONH) pallor quantitatively in patients with primary open-angle glaucoma (POAG) and in healthy subjects, and to examine the relationship to mean deviation in perimetry (MD), cup-disk ratio (CDR), and diameters of retinal vessels. METHODS:A total of 89 POAG patients (67.6 ± 11.1 ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1307415
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To determine by immunohistochemistry the distribution of different nitric oxide synthases (NOS) isoforms in the porcine eye. METHODS:By light microscopy (immunofluorescence), porcine ocular tissues were investigated using monoclonal antibodies against neuronal NOS (nNOS; NOS I), endothelial NOS (ecNOS; NOS III...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.5.375.5355
更新日期:1999-05-01 00:00:00
abstract:AIM:To compare collared silicone punctal plugs to intracanalicular SmartPlugs for the treatment of moderate to severe dry eye. MATERIALS AND METHODS:In this prospective, randomized, single blind, clinical study, 30 patients (60 eyes) who had been diagnosed with moderate to severe dry eye syndrome were enrolled. Study ...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2013.765487
更新日期:2013-05-01 00:00:00
abstract::Corneal acidosis has been shown to reduce corneal hydration control (CHC) as measured by the rate, expressed as the percent recovery per hour (PRPH), at which the thickness of the cornea decreases exponentially after an increased hydration load. Since the effect of pH on corneal function is of scientific interest and ...
journal_title:Current eye research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/02713689508999932
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:To assess the effect of aging on optical quality in a normal population. METHODS:We prospectively examined 100 normal eyes of 100 healthy volunteers (50 men, 50 women; ages, 20-69 years; mean age ± standard deviation, 44.6 ± 15.5 years). We quantitatively assessed the values of MTF cutoff frequency, Strehl rat...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713683.2012.688164
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:Experiments were performed to evaluate the effect of various pro- and anti-inflammatory cytokines on the human fetal retinal pigment epithelium's (HFRPE) expression of major histocompatibility complex (MHC) and costimulatory molecules. METHODS:Pure cultures of HFRPE cells were isolated. HFRPE cells were incuba...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.4.285.5456
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. METHODS:Rats were divided into normal and KCS groups. 3% of diquafosol solutio...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1233986
更新日期:2017-05-01 00:00:00
abstract::Reduced glutathione (0.3 mM) stimulates the activity of sodium-potassium activated ATPase (Na+K+ATPase) by 54% in plasma membranes prepared from bovine corneal endothelial cells. Oxidized glutathione, however, has no effect on Na+K+ATPase activity in the same tissue, although it does inhibit magnesium activated ATPase...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019985
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:To evaluate how patient satisfaction after cataract surgery is associated with postoperative visual acuity, visual functioning, dry eye signs and symptoms, health anxiety, and depressive symptoms. PATIENTS AND METHODS:Fifty-four patients (mean age: 68.02 years) were assessed 2 months after uneventful phacoemul...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1262429
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous. METHODS:IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMP...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.2.132.5610
更新日期:1998-02-01 00:00:00
abstract::Phosphorylated proteins of the chick lens were identified following incubation of lenses in a medium containing 32P and subsequent analysis by gel electrophoresis. The acidic variant of the vimentin and both subunits of fodrin were phosphorylated, as were the 95 Kd and 49 Kd proteins associated with the beaded-chain f...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409167214
更新日期:1984-07-01 00:00:00
abstract:PURPOSE:To measure the cell size and cell density in five layers of the central cornea in the widely used inbred C57BL/6 mouse strain using in vivo three-dimensional (3D) two-photon (2PH) imaging. METHODS:Corneas were scanned using a 2PH laser scanning fluorescence microscope after staining with plasma membrane stain ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1031253
更新日期:2016-04-01 00:00:00
abstract::A reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H)-dependent hydrogen peroxide-generating activity of rat ocular tissue was investigated cytochemically utilizing the cerium method. NADPH or NADH oxidation resulted in electron-dense fine granular deposits on the corneal epithelial and endothelial plasma me...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688808997249
更新日期:1988-09-01 00:00:00
abstract::Lens epithelial cells were isolated from samples of C57BL/6 and CD-1 mice at different ages between 1 and 5 months, and assayed for the level of N-acetyl-beta-glucosaminidase and their ability to replicate in-vitro. The lens epithelial cells from C57BL/6 mice had a reduced replicative potential compared to other norma...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688208996354
更新日期:1982-01-01 00:00:00
abstract::The distribution of a steroid antagonist, RU486, that is known to reduce rabbit intraocular pressure has been examined in the eye. On an equal tissue weight basis, the corneal epithelium is the site of maximal absorption followed by conjunctival tissues (bulbar and palpebral) and the rest of the cornea. Aqueous humor ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609015138
更新日期:1986-09-01 00:00:00
abstract::Purpose: Notch signaling plays a vital role in the differentiation and proliferation of corneal epithelial cells from limbal stem cells. The temporal regulation of Notch signaling during this differentiation remains unknown. Hence, we investigated the importance of temporal activation/blockage of Notch signaling durin...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1673436
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:To evaluate the effect of the birth weight and the postconceptional age on the tear production of preterm and term newborn infants and to evaluate the changes in tear production during the first two months of life. SUBJECTS--METHODS: Both eyes of medically stable term and preterm infants were included in the st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.2.145.26235
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:Several previous studies have shown that glycoconjugates of extracellular matrix, cell membrane and nucleus play an important role in the mediation of cell proliferation, migration and differentiation. Lens epithelial cells and lens fiber cells show regional differences with regard to these parameters. If glyco...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.6.527.5083
更新日期:1997-06-01 00:00:00
abstract::Calf gamma-crystallins were separated by preparative flat-bed isoelectric focusing and characterized according to their immunological properties, molecular weights and isoelectric points. Immunologically 4 different groups of gamma-crystallins (gamma 1a-1d-crystallin) could be detected. The main immunological componen...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109001869
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:There is a substantial literature showing that the selective estrogen receptor modulator tamoxifen can block swelling-activated chloride channels, such as those in astrocytes. This study aimed to test the hypothesis that anatomic characteristics consistent with swelling may be measured within the optic nerve he...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600602547
更新日期:2006-04-01 00:00:00
abstract::Interleukin 4 (IL-4) may play a role in the development of allergic disease. We questioned whether IL-4 related phenomenon occurred on the surface of the conjunctiva during allergic conjunctivitis. Ten patients with cedar pollen-allergic conjunctivitis and 10 patients with postsurgical conjunctivitis were enrolled in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608997415
更新日期:1996-02-01 00:00:00
abstract::Intracellular binding proteins have been identified and isolated from B cells by their ability to bind to the synthetic peptide (1169-1191), the major immunodominant epitope of bovine interphotoreceptor retinoid-binding protein (IRBP) coupled to cyanogen bromide activated Sepharose 4B. After SDS-PAGE, two discrete pro...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408995790
更新日期:1994-04-01 00:00:00
abstract::Thrombospondins are a family of large multi-domain glycoproteins described as matricelluar proteins based on their ability to interact with a broad range of receptors, matrix molecules, growth factors or proteases, and to modulate array of cellular functions including intracellular signaling, proliferation and migrati...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713683.2013.877936
更新日期:2014-08-01 00:00:00
abstract:UNLABELLED:Abstract Purpose of the Study: Protein tyrosine phosphatase σ (PTPσ) acts as a neuronal receptor for chondroitin sulfate proteoglycans (CSPGs). CSPGs have inhibitory effects on experience-dependent plasticity and usually form lattice-like cell coatings that surround the parvalbumin (PV) interneurons in the v...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.803287
更新日期:2013-10-01 00:00:00