Cytokine modulation of costimulatory molecules on human fetal retinal pigment epithelial cells.

abstract：:Purpose/Aim: Corneal abrasions and nonhealing corneal epithelial defects are common conditions that cause pain and sometimes are slow to heal. Histatins, a family of histidine-rich peptides, have been implicated in oral and skin epithelial wound healing, and have been shown to be effective in vitro in human corneal ep...

journal_title：Current eye research

authors： Oydanich M,Epstein SP,Gadaria-Rathod N,Guers JJ,Fernandez KB,Asbell PA

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:This study was undertaken in order to investigate whether the production of vasodilatory prostaglandins is increased in the retinal vasculature of the diabetic rat. METHODS:Diabetes was induced in male Sprague-Dawley rats using streptozotocin. Diabetic rats were left uncontrolled for 3-4 weeks or were treated ...

journal_title：Current eye research

authors： Johnson EI,Dunlop ME,Larkins RG

更新日期：1999-02-01 00:00:00

abstract：:Purpose: The purpose of this study was to investigate the relationship between aquaporin-1 (AQP-1) protein expression in the choroid and choroid thickness (CT) during the recovery of form-deprivation (FD) myopia in guinea pigs.Materials and Methods: Seventy-two guinea pigs were randomly assigned to the normal control ...

journal_title：Current eye research

authors： Chen W,Zhang H,Zhang Y,Wang Q,Wang Y,Li ZW

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:After corneal injury, persistent epithelial defects (PED's) may occur due to the chronic failure of the regenerating epithelium to adhere to the underlying stroma. The aim of this study was to examine the potential of epsilonaminocaproic acid (EACA) as a topical treatment for PED's. EACA inhibits the activation...

journal_title：Current eye research

authors： Williams PB,Crouch ER Jr,Crouch ER,Mazaheri M

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:To determine the role of matrix metalloproteinase 9 (MMP9) in advanced glycation end-products (AGEs) induced damage to blood-retinal barrier (BRB) and the therapeutic effects of minocycline, an MMP inhibitor, against the BRB damages. METHODS:Forty-eight Sprague Dawley rats were randomly assigned to 3 groups (1...

journal_title：Current eye research

authors： Chen YD,Xu X,Xia X,Wu H,Liu K,Zheng Z,Zhu D

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...

journal_title：Current eye research

authors： Nakazaki S,Nao-i N,Sawada A

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:To explore the roles of interleukin (IL)-17A in alkali-induced corneal neovascularization (CRNV). METHODS:Induction of CRNV by alkali injury was performed and compared in recombinant mouse IL-17A protein or anti-mouse IL-17A neutralizing antibody (Ab)-treated mice. The expression of IL-17A, IL-17A receptor (IL...

journal_title：Current eye research

authors： Liu G,Wu H,Lu P,Zhang X

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Transforming growth factor -beta2 (TGF-beta2) is a predominant isoform of TGF-betas in the eye and plasmin is a peptidase with many functions. To better understand the pathogenesis of retinal microcirculation disorders, the effects of TGF-beta2 and plasmin on cultured bovine retinal pericytes were investigated....

journal_title：Current eye research

authors： Katsura MK,Mishima HK,Minamoto A,Ishibashi F,Yamashita H

更新日期：2000-03-01 00:00:00

abstract：:Ocular aldehyde oxidase was purified for the first time from bovine ciliary body cytosol by ammonium sulfate fractionation and successive HPLC using DEAE anion-exchange and hydroxyapatite columns. The purified enzyme was homogeneous by the criterion of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The mol...

journal_title：Current eye research

authors： Shimada S,Mishima HK,Nikaido H,Kitamura S,Tatsumi K

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:Outbreaks of bacterial conjunctivitis have been linked to nontypeable strains of Streptococcus pneumoniae that lack a capsule, a key virulence factor for invasive infections. In contrast, isolates from sporadic, nonoutbreak cases of conjunctivitis were thought to be similar to invasive or nasopharyngeal isolate...

journal_title：Current eye research

authors： Haas W,Hesje CK,Sanfilippo CM,Morris TW

更新日期：2011-12-01 00:00:00

abstract：:Lens epithelial cells were isolated from samples of C57BL/6 and CD-1 mice at different ages between 1 and 5 months, and assayed for the level of N-acetyl-beta-glucosaminidase and their ability to replicate in-vitro. The lens epithelial cells from C57BL/6 mice had a reduced replicative potential compared to other norma...

journal_title：Current eye research

authors： Lipman RD,Muggleton-Harris AL

更新日期：1982-01-01 00:00:00

abstract：:As it is known that chlorpromazine (CPZ) can bind to melanins as well as cause ocular phototoxicity, we investigated the cytotoxic effects of UV-visible irradiation of melanotic and amelanotic retinal pigment epithelial (RPE) cells in the presence of CPZ. At low concentrations (5 micrograms/ml) of CPZ a photosensitiza...

journal_title：Current eye research

authors： Persad S,Menon IA,Basu PK,Carre F

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous. METHODS:IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMP...

journal_title：Current eye research

authors： Plantner JJ,Smine A,Quinn TA

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To study the association of cell proliferation in uveal melanoma with the mean of the 10 largest nucleoli (MLN), microvascular prognostic factors, and survival. METHODS:Population-based, retrospective cohort study of 167 choroidal and ciliary body melanomas enucleated from 1972 to 1981. Mouse monoclonal antibo...

journal_title：Current eye research

authors： Al-Jamal RT,Kivelä T

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Pigmentation of the iris is caused by varying amounts of melanin pigment granula in a constant number of melanocytes in the superficial stroma. Melanin has been shown to act as antioxidant. We have now investigated lipid peroxidation in dependence on stromal pigmentation in isolated porcine irises. METHODS:The...

journal_title：Current eye research

authors： Nau-Staudt K,Nau WM,Haefliger IO,Flammer J

更新日期：2001-03-01 00:00:00

abstract：:Reduced glutathione (0.3 mM) stimulates the activity of sodium-potassium activated ATPase (Na+K+ATPase) by 54% in plasma membranes prepared from bovine corneal endothelial cells. Oxidized glutathione, however, has no effect on Na+K+ATPase activity in the same tissue, although it does inhibit magnesium activated ATPase...

journal_title：Current eye research

authors： Whikehart DR,Soppet DR

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the retinal expression of angiogenic chemokines/cytokines in a mouse model of oxygen-induced retinopathy. METHODS:C57BL/6 (B6) mice were exposed to 75% oxygen from postnatal day 7 (P7) to P12 and then recovered in room air. Reverse transcription-polymerase chain react...

journal_title：Current eye research

authors： Powers MR,Davies MH,Eubanks JP

更新日期：2005-04-01 00:00:00

abstract：:Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the accelerated loss of retinal ganglion cells (RGCs) and their axons. Impaired axonal transport has been implicated as a pathogenic mechanism in a number of neurodegenerative diseases, including glaucoma. The long RGC axon, with its...

journal_title：Current eye research

authors： Fahy ET,Chrysostomou V,Crowston JG

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Retinoblastoma (RB) is the most common intraocular malignancy in children. Deregulation of several miRNAs has been identified in RB, suggesting a potential role in tumorigenesis. Recent evidence suggests that many dietary components like folate, retinoids and curcumin act as potential anticancer/antiproliferati...

journal_title：Current eye research

authors： Sreenivasan S,Thirumalai K,Danda R,Krishnakumar S

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:RPE65, a retinal pigment epithelium-specific 65-kDa protein, plays a critical role in the visual cycle of the eye. Rpe65(-/-) mice develop vision loss due to a lack of 11-cis-retinal, degradation of M-opsin and mislocalization of S-opsin. Several studies have suggested that 9-cis-β-carotene, a precursor of 9-ci...

journal_title：Current eye research

authors： Ozaki T,Nakazawa M,Kudo T,Hirano S,Suzuki K,Ishiguro S

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Klotho genes are expressed in limited tissues and have been found to be a pathogenic factor of age-related diseases in mammals, but their expressions and functions in human eyes are yet to be defined. This study was performed to investigate the expression of Klotho family genes in human ocular tissues and anter...

journal_title：Current eye research

authors： Zhang Y,Wang L,Wu Z,Yu X,Du X,Li X

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To evaluate the intraocular distribution and metabolism of the lipid prodrug of foscarnet, 1-O-octadecyl-sn-glycerol-3- phosphonoformate (ODG-PFA), following intravitreal administration. METHODS:Twenty rabbits received ODG-[14C]PFA intravitreal injection, yielding 0.632 mM resultant intravitreal concentration....

journal_title：Current eye research

authors： Cheng L,Hostetler KY,Gardner MF,Avila CP Jr,Bergeron-Lynn G,Severson GM,Freeman WR

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...

journal_title：Current eye research

authors： Anitua E,Muruzabal F,de la Fuente M,Merayo J,Durán J,Orive G

更新日期：2016-07-01 00:00:00

abstract：:The compound 2-mercaptoacetyl-L-phenylalanyl-L-leucine (HS-Ac-Phe-Leu) is a potent and specific inhibitor of Pseudomonas aeruginosa elastase, effectively inhibiting the elastase activity both, in vitro and within the rabbit cornea. This inhibitor was therefore evaluated as an adjunct to antibiotics (gentamicin) treatm...

journal_title：Current eye research

authors： Spierer A,Kessler E

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Diabetes has been associated with decline in accommodative function in some ethnic groups. This outcome, however, could differ since ethnic variations in accommodation have been noted. This study investigated the relationship between plasma sugar level on subjective accommodative amplitude and accommodative ...

journal_title：Current eye research

authors： Abokyi S,Ilechie A,Asaam KA,Ntodie M

更新日期：2016-06-01 00:00:00

abstract：:Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for aver...

journal_title：Current eye research

authors： Sundmacher R,Mattes A,Neumann-Haefelin D,Adolf G,Kruss B

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Human beta-defensins 1 and 2 (hBD-1, -2) are antimicrobial peptides found in several epithelia including corneal epithelium. Breach of the epithelium leaves the cornea vulnerable to infection so we sought to determine if there is an increase in defensin expression after injury. METHODS:The epithelium from huma...

journal_title：Current eye research

authors： McDermott AM,Redfern RL,Zhang B

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Psychiatric conditions and not just the treatments themselves might be involved in the pathophysiology of dry eye disease (DED). The aim of our study was to evaluate the association between depression and DED using objective and subjective tests in patients with newly diagnosed depressive disorder who were not ...

journal_title：Current eye research

authors： Tiskaoglu NS,Yazıcı A,Karlıdere T,Sari E,Oguz EY,Musaoglu M,Aslan S,Samet Ermiş S

更新日期：2017-05-01 00:00:00

abstract：:Objectives: To investigate the characteristics of margin reflex distance 1 (MRD1) asymmetry in congenital lower eyelid epiblepharon and its resolution after surgical correction of epiblepharon. Methods: Among patients who underwent lower eyelid epiblepharon surgery from November 2015 to September 2017, patients with a...

journal_title：Current eye research

authors： Yang MK,Kim N,Choung HK,Khwarg SI

更新日期：2020-12-15 00:00:00

abstract：:Purified Pseudomonas aeruginosa elastase cleaved a 65 kDa gelatinase [inactive proenzyme form of matrix metalloproteinase (MMP-2)] from human corneal fibroblasts into a biologically active fragment with an approximate molecular mass of 58 kDa. However, purified pseudomonal alkaline protease did not cleave MMP-2 apprec...

journal_title：Current eye research

authors： Matsumoto K,Shams NB,Hanninen LA,Kenyon KR

更新日期：1992-11-01 00:00:00