MMP9 is involved in glycation end-products induced increase of retinal vascular permeability in rats and the therapeutic effect of minocycline.

abstract：PURPOSE:In the mature retina retinoic acid (RA) biosynthesis was reported to be regulated by light. RA is of vital importance for proper function of the retina. RA activity is mediated by interaction with nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The purpose of this study was to determine ...

journal_title：Current eye research

authors： Janssen JJ,Kuhlmann ED,van Vugt AH,Winkens HJ,Janssen BP,Deutman AF,Driessen CA

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Whereas many previous studies have identified the association between sustained near work and myopia, few have assessed the influence of concomitant levels of cognitive effort. This study investigates the effect of cognitive effort on near-work induced transient myopia (NITM). METHODS:Subjects comprised of six...

journal_title：Current eye research

authors： Wolffsohn JS,Gilmartin B,Thomas R,Mallen EA

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:Antagonists to A3 adenosine receptors (ARs) lower mouse intraocular pressure (IOP), but extension to humans is limited by species variability. We tested whether the specific A3AR antagonist MRS 1292, designed to cross species, mimicks the effects of other A3AR antagonists on cultured human nonpigmented ciliary ...

journal_title：Current eye research

authors： Yang H,Avila MY,Peterson-Yantorno K,Coca-Prados M,Stone RA,Jacobson KA,Civan MM

更新日期：2005-09-01 00:00:00

abstract：:Rabbits have circadian rhythms of intraocular pressure (IOP) and aqueous flow. The dark phase increases of IOP and flow are associated with increased aqueous cyclic AMP. If the daily rhythm of aqueous cyclic AMP reflects changes of tissue levels of cyclic AMP which mediate one of the mechanisms which control the rhyth...

journal_title：Current eye research

authors： Kiuchi Y,Gregory DS

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:A new technique for the cryopreservation of rabbit corneas in 20% w/w dimethylsulfoxide, which has been shown to preserve significant structural and functional integrity of the endothelium, was tested in porcine corneas. METHODS:The characteristics of uptake of dimethylsulfoxide into porcine corneas were measu...

journal_title：Current eye research

authors： Wusteman MC,Armitage JW,Wang LH,Busza AL,Pegg DE

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:To study retinal neovascularization (RNV) inhibition by intravitreal injections (IVs) of ranibizumab, sTie2 fusion protein (sTie2-Fc), and a combined therapy in an oxygen-induced retinopathy (OIR) model. MATERIALS AND METHODS:An OIR mouse model was used to simulate RNV in retinopathy of prematurity (ROP); and ...

journal_title：Current eye research

authors： Jiang C,Ruan L,Zhang J,Huang X

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To quantify levels of matricellular proteins in aqueous humor samples from acute primary angle closure (APAC) and non-glaucomatous cataract eyes and investigate their correlation with intraocular pressure (IOP) fluctuation. MATERIALS AND METHODS:Aqueous humor samples were collected from 63 eyes including 29 cu...

journal_title：Current eye research

authors： Wang J,Fu M,Liu K,Wang N,Zhang Z,Zhou M,Xu X

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To detect the immunohistochemical changes in the main lacrimal glands of patients suffering from chronic ocular sequelae of Stevens-Johnson syndrome (SJS). METHODS:Histological sections of biopsies from the lacrimal gland of three chronic SJS patients (mean age, 33 years; 2 males) with severe dry eye disease (...

journal_title：Current eye research

authors： Singh S,Ali MJ,Mittal V,Brabletz S,Paulsen F

更新日期：2020-10-18 00:00:00

abstract：PURPOSE:To facilitate studies of human retina and utilization of human retinal tissue for treatment of retinal diseases, we studied morphologic preservation in postmortem human retina. METHODS:Morphology of retinas from thirty-one human eyes was examined using light and electron microscopy. The inner and outer retina,...

journal_title：Current eye research

authors： Huang JC,Voaden MJ,Zarbin MA,Marshall J

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:Previously we established a strong association of systemic hypertension with cataract formation. In the present study, we investigated the role of nitric oxide (NO) in the development of cataract formation in CdCl2-induced hypertensive animals. MATERIALS AND METHODS:Hypertension was induced in male albino rats...

journal_title：Current eye research

authors： Yadav A,Choudhary R,Bodakhe SH

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix (ECM) proteins in the retina. Breakdown of ECM proteins results in neovascularization and tractional retinal detachment, which eventually lead to the symptoms of proliferative diabetic retinopathy. Müller cells ar...

journal_title：Current eye research

authors： Miyata Y,Kase M,Sugita Y,Shimada A,Nagase T,Katsura Y,Kosano H

更新日期：2012-09-01 00:00:00

abstract：:Recently, growth factors are known to phosphorylate tyrosine residues of proteins to regulate cellular functions. We investigated growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial (RPE) cells. The phosphorylation experiments were done in membrane preparations of ...

journal_title：Current eye research

authors： Yoshimura N,Kuriyama S,Iwaki M,Honda Y

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:To quantify the impact of posterior cornea on toric IOL calculation accuracy using Placido-topography of anterior corneal surface and Scheimpflug measurements of corneal thickness. MATERIALS AND METHODS:Three-hundred seventy-nine non-selected eyes undergoing cataract surgery with non-toric intraocular lens (IO...

journal_title：Current eye research

authors： Preussner PR,Hoffmann P,Wahl J

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The aim of this study is to determine age-related morphological changes in the corneal subbasal nerve plexus (SNP) in two inbred mouse strains. MATERIALS AND METHODS:The corneal SNP was investigated by in vivo confocal laser scanning microscopy (CLSM) in 0.5-, 1-, 1.5-, and 2-year-old C57BL/6J mice and in 0.5-...

journal_title：Current eye research

authors： Reichard M,Weiss H,Poletti E,Ruggeri A,Guthoff RF,Stachs O,Baltrusch S

更新日期：2016-08-01 00:00:00

abstract：:Two different measures of response to therapy were evaluated in a model of keratitis caused by Aspergillus fumigatus in Dutch-belted rabbits. Combined pre and post-inoculation treatment with oral fluconazole 37.5 mg/kg bid or itraconazole 40 mg/kg bid was compared to post-inoculation treatment only and untreated contr...

journal_title：Current eye research

authors： O'Day DM,Head WS,Robinson RD,Williams TE,Gedde S

更新日期：1992-01-01 00:00:00

abstract：:Recent reports from this laboratory indicate that dopamine (DA2) agonists can lower intraocular pressure (IOP) in rabbits, monkeys and rats. This communication suggests that the cat nictitating membrane (CNM) preparation is a useful model for localizing the site(s) and mechanism(s) of action of dopamine (DA2) agonists...

journal_title：Current eye research

authors： Potter DE,Burke JA

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. METHODS:Rats were divided into normal and KCS groups. 3% of diquafosol solutio...

journal_title：Current eye research

authors： Choi KE,Song JS,Kang B,Eom Y,Kim HM

更新日期：2017-05-01 00:00:00

abstract：AIMS:To elucidate the intramuscular distribution and branching patterns of the abducens nerve in the lateral rectus (LR) muscle so as to provide anatomical confirmation of the presence of compartmentalization, including for use in clinical applications such as botulinum toxin injections. METHODS:Thirty whole-mount hum...

journal_title：Current eye research

authors： Shin HJ,Lee SH,Shin KJ,Koh KS,Song WC

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:We report on the use of subconjunctival bevacizumab on corneal vessel density in recurrent pterygia. METHODS:The charts of 5 patients with recurrent pterygium, who received subconjunctival injections of bevacizumab (2.5 mg/0.1 ml) were retrospectively reviewed. Ophthalmic evaluation included Snellen visual acu...

journal_title：Current eye research

authors： Bahar I,Kaiserman I,McAllum P,Rootman D,Slomovic A

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To study the mechanisms of peroxynitrite-induced photoreceptor cell damage, using retinal cultures and a peroxynitrite donor, 3-morpholinosydnonimine (SIN-1). METHODS:Retinal explants obtained from 20-day-old Lewis rat pups, were exposed to SIN-1 for varying lengths of time at varying concentrations. Apoptosis...

journal_title：Current eye research

authors： Ito S,Wu GS,Kimoto T,Hisatomi T,Ishibashi T,Rao NA

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:The mechanism by which prostaglandin(PG)F2 alpha increases uveoscleral outflow and lowers intraocular pressure in primates is not known. In cultured human ciliary muscle cells, PGF2 alpha induces the expression of the protooncogene c-fos which is known to induce the transcription of genes such as matrix metallo...

journal_title：Current eye research

authors： Lindsey JD,Kashiwagi K,Boyle D,Kashiwagi F,Firestein GS,Weinreb RN

更新日期：1996-08-01 00:00:00

abstract：:Achieving the long-term goal of successful engraftment of retinal tissues into eyes blinded by endogenous retinal failure will depend, at least in part, on controlling the immune response to antigens expressed on retinal grafts. Since histoincompatible tissues will have to be used for such transplants, methods to cont...

journal_title：Current eye research

authors： Jiang LQ,Streilein JW

更新日期：1992-07-01 00:00:00

abstract：:Penetrating keratoplasty was the only therapeutic choice for the treatment of corneal endothelial decompensation until the introduction of evolutional endothelial keratoplasties, namely Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK). Although now...

journal_title：Current eye research

authors： Okumura N,Koizumi N

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To investigate the repeatability of macular and peripapillary retinal nerve fiber layer (RNFL) thickness measurements made using swept-source optical coherence tomography (SS-OCT) and automated segmentation. Measurements were made in non-diabetic controls and in patients with diabetic retinopathy (DR) with or w...

journal_title：Current eye research

authors： Min JK,Lee S,Kim JS,Woo JM,Yang HS

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To demonstrate spectroscopic retinal oximetry measurements on arteries and veins in swine using intravitreal illumination. Retinal arterial and venous saturations are measured for a range of inspired O2 levels after pars plana vitrectomy. METHODS:Pars plana vitrectomy and intravitreal manipulations were perfor...

journal_title：Current eye research

authors： Salyer DA,Beaudry N,Basavanthappa S,Twietmeyer K,Eskandari M,Denninghoff KR,Chipman RA,Park RI

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:Disulfiram (DSF) exhibits a wide variety of biological activities, including an anti-inflammatory action, on which we focused our attention. The aim of the present study was to investigate the effect of oral DSF on endotoxin-induced uveitis (EIU) in rats. METHODS:We investigated its effect upon cellular infilt...

journal_title：Current eye research

authors： Kanai K,Itoh N,Yoshioka K,Yonezawa T,Ikadai H,Hori Y,Ito Y,Nagai N,Chikazawa S,Hoshi F,Higuchi S

更新日期：2010-10-01 00:00:00

abstract：:The cytoskeletal proteins of the human lens were studied by SDS-PAGE, 2-D electrophoresis and immunologically. Spectrin, vimentin and actin were identified in the superficial fiber cells of human lenses even to age 87 years. These proteins are lost from the deeper cortical and nuclear fiber cells, where a broad zone o...

journal_title：Current eye research

authors： Maisel H,Ellis M

更新日期：1984-02-01 00:00:00

abstract：PURPOSE:To investigate optic nerve head (ONH) pallor quantitatively in patients with primary open-angle glaucoma (POAG) and in healthy subjects, and to examine the relationship to mean deviation in perimetry (MD), cup-disk ratio (CDR), and diameters of retinal vessels. METHODS:A total of 89 POAG patients (67.6 ± 11.1 ...

journal_title：Current eye research

authors： Ramm L,Schwab B,Stodtmeister R,Hammer M,Sauer L,Spörl E,Pillunat LE,Terai N

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Corneal wound healing after excimer laser photorefractive keratectomy (PRK) passes through a series of characteristic stages which have earlier been defined by means of histological, histochemical, and biochemical approaches. We investigated the potential of confocal microscopy to verify morphological changes i...

journal_title：Current eye research

authors： Linna T,Tervo T

更新日期：1997-07-01 00:00:00

abstract：:Lenses from normal Wistar rats and those from a Wistar strain with X-ray-induced cataract mutation were examined electron microscopically for morphological characterization and acid phosphatase (AcPase) localization. Ocular anlages of 11 through 18 days of gestation were included in the study. A late-separating or per...

journal_title：Current eye research

authors： Anderson JW,Gorthy WC

更新日期：1984-04-01 00:00:00