Abstract:
PURPOSE:To detect the immunohistochemical changes in the main lacrimal glands of patients suffering from chronic ocular sequelae of Stevens-Johnson syndrome (SJS). METHODS:Histological sections of biopsies from the lacrimal gland of three chronic SJS patients (mean age, 33 years; 2 males) with severe dry eye disease (Schirmer = 0 mm) were assessed using double immunofluorescence techniques. Changes in the expression of secretory proteins lactoferrin (Lf), lysozyme (Ly), aquaporin 5 (AQP5), S-100, and early apoptosis marker (Annexin V) were studied. RESULTS:Different morphological expressions of secretory proteins were present in the three samples. One sample had maintained the immunoreactivity for Lf, Ly, S-100, similar to healthy controls. Two samples had significantly reduced immunoreactivity for anti-Lf, anti-Ly, and S-100, the weakest being in the sample with distorted lobular architecture and mild interlobular fibrosis. AQP5 had a distinct vesicular intracytoplasmic immunoreactivity suggesting defective trafficking and integration of the protein to the apical membrane. There was no S-100 immunostaining in the acinar or ductal epithelium, whereas interstitial nerve fibers scattered in the periacinar region showed reduced immunoreactivity for S-100. There was strong Annexin V immunoreactivity in the nuclei of epithelial cells in the majority of acinar and ductal epithelia of all the samples, with distorted nuclear morphology in one sample. CONCLUSION:Defective trafficking of AQP5 and variable expression of Ly, Lf, S-100 are the notable findings in the lacrimal glands of chronic SJS patients along with signs of early apoptosis. It suggests that the palpebral lobe of the lacrimal gland is involved in the pathological processes occurring in the conjunctiva of SJS patients.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Singh S,Ali MJ,Mittal V,Brabletz S,Paulsen Fdoi
10.1080/02713683.2020.1836227subject
Has Abstractpub_date
2020-10-18 00:00:00pages
1-7eissn
0271-3683issn
1460-2202pub_type
杂志文章abstract:PURPOSE:Acanthamoeba keratitis is a sight-threatening corneal infection. It is known that: (i) more amoebae bind to the surface of injured corneas than to the normal corneal surface and (ii) mannose-containing glycoproteins (GPs) possess binding sites for Acanthamoeba. The present study was undertaken to determine whet...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:PURPOSE:To investigate the roles of adherence and matrix metalloproteinases (MMPs) in growth patterns of major fungal pathogens in cornea. METHODS:Ninety-six eyes in 96 rabbits were equally divided into four groups receiving inoculation of fungal conidia of Aspergillus fumigatus, Candida albicans, Fusarium solani, and...
journal_title:Current eye research
pub_type: 杂志文章,收录出版
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journal_title:Current eye research
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journal_title:Current eye research
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doi:
更新日期:2000-01-01 00:00:00
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journal_title:Current eye research
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更新日期:2013-10-01 00:00:00
abstract:PURPOSE:The pneumococcal capsule is required for pathogenesis in systemic infections, yet reports show most conjunctivitis outbreaks are caused by nonencapsulated pneumococci, while keratitis infections are caused by encapsulated strains. This study aims to determine the effect of capsule in pneumococcal keratitis and ...
journal_title:Current eye research
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abstract:PURPOSE:We identified a novel mutation in Paired Box gene 6 (PAX6) and characterized its associated clinical features of severe ocular malformation in a Chinese family with congenital aniridia. METHODS:We studied two patients with aniridia from a Chinese family. All patients and noncarriers in this family underwent fu...
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abstract::Phosphorylated proteins of the chick lens were identified following incubation of lenses in a medium containing 32P and subsequent analysis by gel electrophoresis. The acidic variant of the vimentin and both subunits of fodrin were phosphorylated, as were the 95 Kd and 49 Kd proteins associated with the beaded-chain f...
journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688808995741
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journal_title:Current eye research
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doi:10.3109/02713688509000845
更新日期:1985-03-01 00:00:00
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journal_title:Current eye research
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journal_title:Current eye research
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doi:10.3109/02713683.2015.1056803
更新日期:2016-06-01 00:00:00
abstract::Hybridomas producing monoclonal antibodies to the retinal S antigen were obtained by fusion of spleen cells from a BALB/c mouse immunized with purified bovine S antigen and NS-1 myeloma cells. Six cloned hybridomas were selected and expanded as large scale cultures and as ascites in mice. The specificity of the antibo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000800
更新日期:1984-06-01 00:00:00
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journal_title:Current eye research
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doi:10.3109/02713683.2012.658488
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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更新日期:1984-03-01 00:00:00
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journal_title:Current eye research
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更新日期:1985-06-01 00:00:00