The cross-species A3 adenosine-receptor antagonist MRS 1292 inhibits adenosine-triggered human nonpigmented ciliary epithelial cell fluid release and reduces mouse intraocular pressure.

abstract：PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...

journal_title：Current eye research

authors： Nakazaki S,Nao-i N,Sawada A

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:Previous studies showed that lutein and zeaxanthin, the major human retinal carotenoids, are concentrated in the macula. In this study, the carotenoids in human macular and peripheral retina and the retinal pigment epithelium (RPE) were analyzed. They were also determined in the rod outer segments (ROS) before ...

journal_title：Current eye research

authors： Sommerburg OG,Siems WG,Hurst JS,Lewis JW,Kliger DS,van Kuijk FJ

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:To quantify the impact of posterior cornea on toric IOL calculation accuracy using Placido-topography of anterior corneal surface and Scheimpflug measurements of corneal thickness. MATERIALS AND METHODS:Three-hundred seventy-nine non-selected eyes undergoing cataract surgery with non-toric intraocular lens (IO...

journal_title：Current eye research

authors： Preussner PR,Hoffmann P,Wahl J

更新日期：2015-01-01 00:00:00

abstract：PURPOSE/AIM OF THE STUDY:Polarization-sensitive anterior-segmental optical coherence tomography (PS-OCT) is useful to evaluate the filtering blebs after trabeculectomy. However, the attenuation phenomenon of OCT signal disturbs the visibility of intra-bleb's structure and distribution of birefringence; a specific param...

journal_title：Current eye research

authors： Kosugi M,Kokubun T,Tsuda S,Yamanari M,Nakazawa T

更新日期：2020-10-04 00:00:00

abstract：:It has been suggested that the provision of HLA matched tissue for corneal transplantation would be beneficial for graft survival especially in high risk patients. In this study we report the application of a polymerase chain reaction (PCR) based tissue typing procedure to type cadaveric donor material. Using beta-glo...

journal_title：Current eye research

authors： Rakoczy P,Garlepp M,Constable I

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To facilitate studies of human retina and utilization of human retinal tissue for treatment of retinal diseases, we studied morphologic preservation in postmortem human retina. METHODS:Morphology of retinas from thirty-one human eyes was examined using light and electron microscopy. The inner and outer retina,...

journal_title：Current eye research

authors： Huang JC,Voaden MJ,Zarbin MA,Marshall J

更新日期：2000-03-01 00:00:00

abstract：:Intravitreal injection of purified human chorionic gonadotropin (hCG) in rabbits decreased intraocular pressure (IOP). A dose-dependent decrease in IOP was observed with intravitreal hCG concentrations at 30 nM and 100 nM. The onset of this effect was later than 10 hr following the injection and it lasted for more tha...

journal_title：Current eye research

authors： Liu JH,Dacus AC

更新日期：1988-10-01 00:00:00

abstract：PURPOSES:To investigate whether valproic acid (VPA) has a neuroprotective effect against ischemia/reperfusion (I/R) injury in the rat retina, and to elucidate the potential antioxidant mechanisms involved. METHODS:Adult male Wistar rats were randomly divided into four groups: sham (group A), sham plus VPA (group B), I...

journal_title：Current eye research

authors： Zhang Z,Qin X,Zhao X,Tong N,Gong Y,Zhang W,Wu X

更新日期：2012-05-01 00:00:00

abstract：:Inoculation of herpes simplex virus Type 1 into the anterior chamber of BALB/c mice induces a characteristic ocular infection involving primarily the anterior segment of virus-injected eyes and the retina of contralateral uninjected eyes. In the BALB/c strain, which is susceptible to herpetic retinitis, anti-HSV delay...

journal_title：Current eye research

authors： Whittum-Hudson JA,Pepose JS

更新日期：1988-02-01 00:00:00

abstract：PURPOSE:Chloride efflux plays an important role in aqueous humor production. Chloride currents have been described in bovine non-pigmented ciliary epithelium (NPE), in transformed cultured human NPE, and in bovine volume-activated chloride channels described in the latter. It is the basolateral membranes of the NPE of ...

journal_title：Current eye research

authors： Chen S,Sears M

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:To compare the quality of corneal endothelium of precut Descemet-stripping automated endothelial keratoplasty (DSAEK) tissue when transported with and without the anterior lamellar corneal tissue (ALCT) when organ-culture corneal storage methods are used. METHODS:After microkeratome-assisted excision of anteri...

journal_title：Current eye research

authors： Jhanji V,Pollock GA,Mackey AL,Beltz J,Vajpayee RB

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:To characterize the possible cytotoxic effects of oxysterols (7beta-hydroxycholesterol (7beta-OH), 25-hydroxycholesterol (25-OH)) in human retinal pigment epithelial cells (ARPE-19) and to detail the relationships between some of these effects. METHODS:ARPE-19 cells were treated with 7beta-OH and 25-OH. Cell v...

journal_title：Current eye research

authors： Malvitte L,Montange T,Vejux A,Joffre C,Bron A,Creuzot-Garcher C,Lizard G

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To investigate the association between corneal temperature on ocular surface and stability of tear film, and define the normal reference range of corneal surface temperature in the population of Pudong New Area, Shanghai, China. METHODS:Temperature of cornea (TOC) and tear film break-up time (BUT) were measu...

journal_title：Current eye research

authors： Yang W,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:Purpose/aim of the study: To observe and analyze the weekly changes in morphology and size of vacuoles, so called Wedl cells, in eyes with posterior subcapsular cataract (PSC). MATERIALS AND METHODS:Thirty-six eyes of 36 patients with pronounced PSC were included in this prospective study. High-resolution retroillumi...

journal_title：Current eye research

authors： Neumayer T,Hirnschall N,Georgopoulos M,Findl O

更新日期：2017-12-01 00:00:00

abstract：SIGNIFICANCE:Adopting a risk stratification system and appropriate listing of cases reduces the rates of intraoperative complications during phacoemulsification. Such listing would allow both safe surgery and enhance training, by ensuring an appropriately experienced surgeon is available to operate on a case or supervi...

journal_title：Current eye research

authors： Pooprasert P,Hansell J,Young-Zvandasara T,Muhtaseb M

更新日期：2020-07-30 00:00:00

abstract：:The ocular penetration pathways of three alpha 2-adrenergic agents (p-aminoclonidine, AGN 190342, and clonidine) were investigated in rabbits both in vitro and in vivo. The corneal permeabilities of the compounds correlated positively with their octanol/water distribution coefficients. The ocular drug absorption via c...

journal_title：Current eye research

authors： Chien DS,Homsy JJ,Gluchowski C,Tang-Liu DD

更新日期：1990-11-01 00:00:00

abstract：:The compound 2-mercaptoacetyl-L-phenylalanyl-L-leucine (HS-Ac-Phe-Leu) is a potent and specific inhibitor of Pseudomonas aeruginosa elastase, effectively inhibiting the elastase activity both, in vitro and within the rabbit cornea. This inhibitor was therefore evaluated as an adjunct to antibiotics (gentamicin) treatm...

journal_title：Current eye research

authors： Spierer A,Kessler E

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:To study changes in the morphometric characteristics of the whole brain visual-related cortex in various stages of primary open angle glaucoma (POAG) in vivo. MATERIALS AND METHODS:Thirty POAG patients (nine early stage cases and 21 advanced-late stage cases) and 30 gender-, education-, and age-matched healthy...

journal_title：Current eye research

authors： Li C,Cai P,Shi L,Lin Y,Zhang J,Liu S,Xie B,Shi Y,Yang H,Li S,Du H,Wang J

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:We investigated the impact of target properties on vertical fusion amplitude (VFA) using a 3D display platform; the performance of the subjects allowed us to assess how central and peripheral retina regions interact during the fusion process. MATERIAL AND METHODS:Fourteen subjects were involved in the test. VF...

journal_title：Current eye research

authors： Zhang D,Neveu P,Fattakhova Y,Ferragut S,Lamard M,Cochener B,de Bougrenet de la Tocnaye JL

更新日期：2017-03-01 00:00:00

abstract：:Retinal degeneration is a leading cause of untreatable blindness in the industrialised world. It is typically irreversible and there are few curative treatments available. The use of stem cells to generate new retinal neurons for transplantation purposes has received significant interest in recent years and is beginni...

journal_title：Current eye research

authors： Langhe R,Pearson RA

更新日期：2020-03-01 00:00:00

abstract：:Purpose: To map the time course of changes in intraocular straylight of the human eye 1 year after initial lens wearing for orthokeratology treatment using the objective double-pass technique. Materials and Methods: A total of 35 subjects (19 males and 16 females) completed the study. The mean age was 11.46 ± 2.33 yea...

journal_title：Current eye research

authors： Liu G,Jin N,Bi H,Du B,Gu T,Zhang B,Wei R

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Pigmentation of the iris is caused by varying amounts of melanin pigment granula in a constant number of melanocytes in the superficial stroma. Melanin has been shown to act as antioxidant. We have now investigated lipid peroxidation in dependence on stromal pigmentation in isolated porcine irises. METHODS:The...

journal_title：Current eye research

authors： Nau-Staudt K,Nau WM,Haefliger IO,Flammer J

更新日期：2001-03-01 00:00:00

abstract：:The effect of electrical stimulation of the sympathetic nerves on the blood-aqueous barrier was investigated in rabbits. The permeability of the barrier was assessed during either acute, chronic or following chronic nerve stimulation. During acute and chronic stimulation of the sympathetic nerves, fluorescein entered ...

journal_title：Current eye research

authors： Bartels SP,Pawlowski AM

更新日期：1990-10-01 00:00:00

abstract：:In the bovine lens the gamma IV-crystallin fraction is a principal determinant of the phase separation and opacification temperature, Tc (Siezen et al, Proc. Natl. Acad. Sci. USA 82, 1985, 1701). We have now measured the effect on Tc of purified gamma IV-crystallin solutions produced by a variety of reagents which aff...

journal_title：Current eye research

authors： Siezen RJ,Benedek GB

更新日期：1985-10-01 00:00:00

abstract：PURPOSE:Disulfiram (DSF) exhibits a wide variety of biological activities, including an anti-inflammatory action, on which we focused our attention. The aim of the present study was to investigate the effect of oral DSF on endotoxin-induced uveitis (EIU) in rats. METHODS:We investigated its effect upon cellular infilt...

journal_title：Current eye research

authors： Kanai K,Itoh N,Yoshioka K,Yonezawa T,Ikadai H,Hori Y,Ito Y,Nagai N,Chikazawa S,Hoshi F,Higuchi S

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:To assess the effect of aging on optical quality in a normal population. METHODS:We prospectively examined 100 normal eyes of 100 healthy volunteers (50 men, 50 women; ages, 20-69 years; mean age ± standard deviation, 44.6 ± 15.5 years). We quantitatively assessed the values of MTF cutoff frequency, Strehl rat...

journal_title：Current eye research

authors： Kamiya K,Umeda K,Kobashi H,Shimizu K,Kawamorita T,Uozato H

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:We report on the use of subconjunctival bevacizumab on corneal vessel density in recurrent pterygia. METHODS:The charts of 5 patients with recurrent pterygium, who received subconjunctival injections of bevacizumab (2.5 mg/0.1 ml) were retrospectively reviewed. Ophthalmic evaluation included Snellen visual acu...

journal_title：Current eye research

authors： Bahar I,Kaiserman I,McAllum P,Rootman D,Slomovic A

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To assess histopathologic prognostic factors relative to clinical ones in predicting local recurrence and survival after primary conjunctival melanoma (CM). METHODS:85 patients with CM were identified in Finland between 1967 and 2000, and 70 primary tumors were available for histopathologic study. Time to firs...

journal_title：Current eye research

authors： Tuomaala S,Toivonen P,Al-Jamal R,Kivelä T

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To quantitatively measure the flow, nonflow, density, and foveal avascular zone (FAZ) assessment tool parameters of optical coherence tomography angiography (OCTA) in patients with nonocular Behcet's Disease (BD), and to compare the results with those obtained in healthy controls. METHODS:FAZ parameters, flow ...

journal_title：Current eye research

authors： Goker YS,Yılmaz S,Kızıltoprak H,Tekin K,Demir G

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:To investigate whether zeaxanthin, the predominant carotenoid pigment of the macular pigments in human retina, provides neuroprotection against retinal cell damage. METHODS:We used in vitro cultured retinal ganglion cells (RGCs), specifically RGC-5, an E1A virus-transformed rat cell line. Cell damage was induc...

journal_title：Current eye research

authors： Nakajima Y,Shimazawa M,Otsubo K,Ishibashi T,Hara H

更新日期：2009-04-01 00:00:00