Inhibitory Effects On Retinal Neovascularization by Ranibizumab and sTie2-Fc in An Oxygen-Induced Retinopathy Mouse Model.

abstract：PURPOSE:Corneal autofluorescence is related to advanced glycation end products formed by glucose that reaches the cornea via the aqueous humour. The aim of the study was to examine the influence on autofluorescence of changes in permeability of the blood aqueous barrier. METHODS:Corneal autofluorescence was measured i...

journal_title：Current eye research

authors： Kessel L,Moldow B,van Best JA,Sander B

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To analyze the effect of diamidines (hexamidine-diisethionat (HD), propamidin-isethionate (PD), dibromopropamidine-diisethionat (DD)), and biguanides (polyhexamethylen biguanid (PHMB), chlorhexidine (CH)) on human corneal epithelial cell, keratocyte and endothelial cell viability, proliferation, and migration, ...

journal_title：Current eye research

authors： Shi L,Stachon T,Seitz B,Wagenpfeil S,Langenbucher A,Szentmáry N

更新日期：2018-06-01 00:00:00

abstract：:Calmodulin has been shown to perform several important functions in the lens including regulation of the plasma membrane Ca(2+)-ATPase. This study investigated the effects of a variety of different CaM antagonists on rat lens membrane potential, membrane resistance, intracellular Na+ and Ca2+ content and transparency,...

journal_title：Current eye research

authors： Sanderson J,Gandolfi SA,Duncan G

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:To study the effect of cataract surgery with intraocular lens (IOL) on frequency doubling perimetry (FDP). METHODS:Patients aged 40 years or above seen at our outpatient clinic with no ocular pathology except for visually significant cataract and visual acuity 6/24 or better were eligible. They underwent FDP b...

journal_title：Current eye research

authors： Arvind H,George R,Baskaran M,Raju P,Ramesh SV,Paul PG,Vijaya L

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:Nitric oxide production can cause either apoptotic or necrotic cell death through oxidative stress. We aimed to investigate the nitrite oxide metabolites (NOx) and nitrite levels in the aqueous humor of rabbit eyes after different methods of corneal collagen cross-linking (CXL). MATERIALS AND METHODS:Twenty-fo...

journal_title：Current eye research

authors： Yuksel N,Ozel-Turkcu U,Yalinbas D,Novruzlu S,Bilgihan A,Bilgihan K

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Current standard of care for neovascular eye diseases require repeated intravitreal bolus injections of anti-vascular endothelial growth factors (anti-VEGFs). The purpose of this study was to validate a degradable microsphere-thermoresponsive hydrogel drug delivery system (DDS) capable of releasing bioactive af...

journal_title：Current eye research

authors： Liu W,Lee BS,Mieler WF,Kang-Mieler JJ

更新日期：2019-03-01 00:00:00

abstract：:Goggles that degrade the retinal image produce axial enlargement of the ocular globe and large myopic refractive errors. Many authors have assumed that visual image degradation itself leads to myopia. Hodos and co-authors have shown, however, that goggled eyes in chicks are considerably warmer than normal. Such temper...

journal_title：Current eye research

authors： Shih YF,Fitzgerald ME,Norton TT,Gamlin PD,Hodos W,Reiner A

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To evaluate the toxicity of indocyanine green (ICG) in combination with light. METHODS:Human retinal pigment epithelial cells (ARPE-19) and rat neurosensory retinal cells (R28) were treated with four different concentrations of ICG in combination with light exposure. Cell viability, mitochondrial function, and...

journal_title：Current eye research

authors： Narayanan R,Kenney MC,Kamjoo S,Trinh TH,Seigel GM,Resende GP,Kuppermann BD

更新日期：2005-06-01 00:00:00

abstract：:In experimental work on retinal ischemia and its medical management, we have been disturbed by the large variations in the electroetinogram (ERG) recovery of rabbit eyes subjected to similar degrees of ischemia. We investigated whether body temperature might be one of the critical factors. We studied pigmented Dutch r...

journal_title：Current eye research

authors： Nayak MS,Marmor MF

更新日期：1995-02-01 00:00:00

abstract：:The 'fast PIII' rod mediated photoreceptor response to flashes of monochromatic light has been investigated in isolated retinae of the RCS rat at age 30 days. A loss of both sensitivity and maximum response amplitude were found, with a concurrent slowing of the response kinetics. These observations indicate a rod abno...

journal_title：Current eye research

authors： Low JC

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:The aim of this study is to determine age-related morphological changes in the corneal subbasal nerve plexus (SNP) in two inbred mouse strains. MATERIALS AND METHODS:The corneal SNP was investigated by in vivo confocal laser scanning microscopy (CLSM) in 0.5-, 1-, 1.5-, and 2-year-old C57BL/6J mice and in 0.5-...

journal_title：Current eye research

authors： Reichard M,Weiss H,Poletti E,Ruggeri A,Guthoff RF,Stachs O,Baltrusch S

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:This work compares the concentration of active ingredients and preservatives in commonly used brand name versus generic glaucoma medications. MATERIALS AND METHODS:Active ingredient and benzalkonium chloride (BAK) concentrations in brand name latanoprost and dorzolamide-timolol were each compared to two gen...

journal_title：Current eye research

authors： Kahook MY,Fechtner RD,Katz LJ,Noecker RJ,Ammar DA

更新日期：2012-02-01 00:00:00

abstract：:In the Royal College of Surgeons rat, the migration of phagocytic cells into the subretinal space accompanies photoreceptor cell death during the early stages of retinal dystrophy. These are followed closely by cellular alterations in the retinal pigment epithelium, Müller cells, and outer retinal vessels. We have ide...

journal_title：Current eye research

authors： Roque RS,Caldwell RB

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To compare the retinal sensitivity, using Microperimeter and the morphological changes in retinal layers, using Spectral Domain Optical Coherence Tomography (SD-OCT), between myopes and age-matched emmetropes. METHODS:Twenty-nine myopic eyes and 29 emmetropic eyes were enrolled in this prospective case control...

journal_title：Current eye research

authors： Gella L,Raman R,Sharma T

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Increases in matrix proteins, such as type I collagen and fibronectin, are observed with aging in the retinal pigment epithelium (RPE) basement membrane. However, little is known about altered gene expression profiles of RPE associated with increases in matrix proteins. We investigated changes in gene expressio...

journal_title：Current eye research

authors： Imai H,Honda S,Kondo N,Ishibashi K,Tsukahara Y,Negi A

更新日期：2007-10-01 00:00:00

abstract：:In an earlier study we isolated three cyanogen bromide cleavage fragments of bovine IRBP that exhibited high levels of immunopathogenicity, producing inflammatory changes in the eyes (EAU) and pineal gland (EAP) of Lewis rats. These fragments have been localized within the IRBP sequence. In order to identify these put...

journal_title：Current eye research

authors： Sanui H,Redmond TM,Hu LH,Kuwabara T,Margalit H,Cornette JL,Wiggert B,Chader GJ,Gery I

更新日期：1988-07-01 00:00:00

abstract：:It has been hypothesized that an activator of Ca-ATPase co-exists with Ca-ATPase in the mouse lens. Though the Ca-ATPase activity could be measured from mouse lens homogenate, its activity could not be determined in individual soluble and insoluble fractions. The Ca-ATPase activity, however, could be detected when an ...

journal_title：Current eye research

authors： Iwata S,Shirasawa E,Takehana M

更新日期：1984-05-01 00:00:00

abstract：PURPOSE:Hypercarbia has been suggested as a risk factor for retinopathy of prematurity (ROP). We investigated the effect of hypercarbia on the retinal vasculature of the neonatal rat to determine whether hypercarbia alone could induce preretinal neovascularization analogous to ROP. METHODS:In a preliminary blood gas s...

journal_title：Current eye research

authors： Holmes JM,Zhang S,Leske DA,Lanier WL

更新日期：1998-06-01 00:00:00

abstract：PURPOSE/AIM OF THE STUDY:The aim of this study is to investigate the effect of pseudoexfoliation (PEX) and PEX-induced dry eye on central corneal thickness (CCT). MATERIALS AND METHODS:This cross-sectional study consists of total 270 eyes of 135 patients (67 females, 68 males) in total. After excluding the PEX (-) 32 ...

journal_title：Current eye research

authors： Akdemir MO,Kirgiz A,Ayar O,Kaldirim H,Mert M,Cabuk KS,Taskapili M

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Previously we established a strong association of systemic hypertension with cataract formation. In the present study, we investigated the role of nitric oxide (NO) in the development of cataract formation in CdCl2-induced hypertensive animals. MATERIALS AND METHODS:Hypertension was induced in male albino rats...

journal_title：Current eye research

authors： Yadav A,Choudhary R,Bodakhe SH

更新日期：2018-12-01 00:00:00

abstract：:Purpose/Aim: Corneal abrasions and nonhealing corneal epithelial defects are common conditions that cause pain and sometimes are slow to heal. Histatins, a family of histidine-rich peptides, have been implicated in oral and skin epithelial wound healing, and have been shown to be effective in vitro in human corneal ep...

journal_title：Current eye research

authors： Oydanich M,Epstein SP,Gadaria-Rathod N,Guers JJ,Fernandez KB,Asbell PA

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Extracellular matrix (ECM) plays an important role in the regulation of cell function. The aging process may involve chemical modifications to ECM proteins, which may contribute to the aging of the Bruch membrane and pathogenesis of age-related macular degeneration (AMD). The purpose of this study is to investi...

journal_title：Current eye research

authors： Wang Z,Paik DC,Del Priore LV,Burch RL,Gaillard ER

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Aqueous extract of Pleurotus tuberregium (PT) has been shown to reduce intraocular pressure (IOP) but the underlying mechanism has not been explained. PURPOSE:To investigate the effect of PT on the bovine iris in vitro in comparison with acetylcholine (ACh). METHOD:Strips of the iris were mounted in 10 ml ...

journal_title：Current eye research

authors： Akinlabi GA,Asowata OE,Ozolua RI,Akpaja OO,Iyawe V

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:To assess the upper eyelid kinematics during spontaneous blinking in unilateral paralytic lagophthalmos before and after upper eyelid load with gold weight (GW) or autogenous temporalis fascia (TF) sling. DESIGN:Comparative case series. SUBJECTS:Patients with long-standing unresolved unilateral facial palsy w...

journal_title：Current eye research

authors： Wambier SP,Garcia DM,Cruz AA,Messias A

更新日期：2016-04-01 00:00:00

abstract：:The present study was aimed to demonstrate that cytochrome P-450 was induced by drug administration in particular tissues in the eye. Phenobarbital was used as an inducer. We showed immunohistochemically that cytochrome P-450 was induced in the cornea, conjunctiva and ciliary epithelium of rabbits after four days of i...

journal_title：Current eye research

authors： Matsumoto K,Kishida K,Manabe R,Sugiyama T

更新日期：1987-07-01 00:00:00

abstract：PURPOSE:To determine whether substance P is present in human tears. METHODS:Tear samples (1-2 microliters) were collected from one eye of each of 12 subjects. Two of the eyes had dry eye syndrome, two wore contact lenses and had dry eye syndrome, and eight were normal. Five of the eight normal eyes were scheduled to u...

journal_title：Current eye research

authors： Varnell RJ,Freeman JY,Maitchouk D,Beuerman RW,Gebhardt BM

更新日期：1997-09-01 00:00:00

abstract：:Corneal acidosis has been shown to reduce corneal hydration control (CHC) as measured by the rate, expressed as the percent recovery per hour (PRPH), at which the thickness of the cornea decreases exponentially after an increased hydration load. Since the effect of pH on corneal function is of scientific interest and ...

journal_title：Current eye research

authors： Cohen SR,Polse KA,Brand RJ,Bonanno JA

更新日期：1995-05-01 00:00:00

abstract：:Papavarine, cholera toxin, and isoproterenol each elevated cyclic AMP in cultured rat retinal pigment epithelium and reduced the phagocytosis of isolated rod outer segments (38-66% of controls) during a 4 hour incubation. In addition, cultured pigment epithelium was preincubated with 25 mM exogenous cyclic AMP for two...

journal_title：Current eye research

authors： Edwards RB,Flaherty PM

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...

journal_title：Current eye research

authors： Anitua E,Muruzabal F,de la Fuente M,Merayo J,Durán J,Orive G

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Matrix metalloproteinases (MMPs) are involved in posterior capsule opacification (PCO), but the mechanisms that promote MMP expression are yet to be determined. In this study, we investigated whether type I collagen, which is only detected in aged or cataractous lens capsules, affects the expression and activat...

journal_title：Current eye research

authors： Shimada A,Miyata Y,Kosano H

更新日期：2014-05-01 00:00:00