Cryopreservation studies with porcine corneas.

abstract：:Purpose/Aim: Many genes have been associated with primary open-angle glaucoma (POAG). Knowing exactly where they are expressed in the eye helps to unravel POAG pathology and to select optimal targets for intervention. We investigated whether RNA in situ hybridization (RNA-ISH) is a convenient technique to obtain detai...

journal_title：Current eye research

authors： Hubens WHG,Breddels EM,Walid Y,Ramdas WD,Webers CAB,Gorgels TGMF

更新日期：2019-09-01 00:00:00

abstract：:To enhance efforts directed at unraveling the role and mechanisms of leukocytes in mediating injury to corneal epithelium, an isolated bovine corneal cup was developed and evaluated. Bovine peripheral leukocytes and lysates were added to the corneal epithelial surface of isolated cornea for various periods after which...

journal_title：Current eye research

authors： Elgebaly SA,Gillies C,Forouhar F,Hashem M,Baddour M,O'Rourke J,Kreutzer DL

更新日期：1985-01-01 00:00:00

abstract：:Intraocular synthesis of IgG antibodies against HSV (herpes simplex virus), CMV (cytomegalovirus) and VZV (varicella zoster virus) is considered as an indirect proof of uveoretinal infection. Paired serum and aqueous samples obtained from 16 patients with retinitis associated with AIDS, 3 patients with ARN, 8 patients...

journal_title：Current eye research

authors： Luyendijk L,vd Horn GJ,Visser OH,Suttorp-Schulten MS,vd Biesen PR,Rothova A,Kijlstra A

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To compare the differences in higher-order aberrations (HOAs) after laser subepithelial keratomileusis (LASEK) between two different laser platforms. METHODS:One hundred and seven eyes of 107 patients were included in this study. Fifty-six eyes underwent LASEK with the Triple-A profile (an ablation profile of ...

journal_title：Current eye research

authors： Liu L,Li M,Shi YH,Sun LN,Wang F,Zou J

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in the regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel p...

journal_title：Current eye research

authors： Beránek M,Kanková K,Tschöplová S,Kolár P,Vácha J

更新日期：2003-08-01 00:00:00

abstract：:Achieving the long-term goal of successful engraftment of retinal tissues into eyes blinded by endogenous retinal failure will depend, at least in part, on controlling the immune response to antigens expressed on retinal grafts. Since histoincompatible tissues will have to be used for such transplants, methods to cont...

journal_title：Current eye research

authors： Jiang LQ,Streilein JW

更新日期：1992-07-01 00:00:00

abstract：:Calmodulin has been shown to perform several important functions in the lens including regulation of the plasma membrane Ca(2+)-ATPase. This study investigated the effects of a variety of different CaM antagonists on rat lens membrane potential, membrane resistance, intracellular Na+ and Ca2+ content and transparency,...

journal_title：Current eye research

authors： Sanderson J,Gandolfi SA,Duncan G

更新日期：1994-03-01 00:00:00

abstract：:The cytoskeletal proteins of the human lens were studied by SDS-PAGE, 2-D electrophoresis and immunologically. Spectrin, vimentin and actin were identified in the superficial fiber cells of human lenses even to age 87 years. These proteins are lost from the deeper cortical and nuclear fiber cells, where a broad zone o...

journal_title：Current eye research

authors： Maisel H,Ellis M

更新日期：1984-02-01 00:00:00

abstract：:Fresh isolates of neonatal human corneal endothelial cells were maintained in tissue culture using a technique employing collagen-coated, dextran-based microcarrier beads. This method provides large yields of endothelial cells suitable for biochemical and/or transplant studies without exposing the cells to enzymatic p...

journal_title：Current eye research

authors： Insler MS,Lopez JG

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate how glutathione reductase (GR) loses its activity during cataract formation and whether it is possible to revive it back to the normal levels. METHOD:In this study, endogenous as well as synthetic reducing systems (GSH, TTase, DTT, captopril) and alpha-crystallin at dif...

journal_title：Current eye research

authors： Rachdan D,Lou MF,Harding JJ

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:Predicting the toxic potential of compounds to the ocular surface has depended on the Draize test for the past half century. Alternatives to Draize testing have recently been sought for a number of reasons. Stress gene expression has emerged as a means of quantifying cellular reaction and, thus, the toxic poten...

journal_title：Current eye research

authors： Braunstein SG,Deramaudt TG,Rosenblum DG,Dunn MG,Abraham NG

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:Phagocytosis of rod outer segments (ROS) is an important function of retinal pigment epithelial (RPE) cells. Since the details of the process are not fully known, we studied effects of cytokines produced by RPE and photoreceptor cells on phagocytosis of ROS by rat RPE cells. METHODS:RPE cells were isolated and...

journal_title：Current eye research

authors： Hayashi A,Nakae K,Naka H,Ohji M,Tano Y

更新日期：1996-05-01 00:00:00

abstract：:The goal of this study was to determine the effect of extracellular matrix components on the phagocytic function of the retinal pigment epithelial (RPE) cell. Cultured human fetal RPE cells were established in culture and plated on three commercially-prepared substrates: collagen IV, fibronectin and laminin and on thr...

journal_title：Current eye research

authors： Miceli MV,Newsome DA

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To investigate the association between corneal temperature on ocular surface and stability of tear film, and define the normal reference range of corneal surface temperature in the population of Pudong New Area, Shanghai, China. METHODS:Temperature of cornea (TOC) and tear film break-up time (BUT) were measu...

journal_title：Current eye research

authors： Yang W,Zhang L

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear production. METHODS:Patients (n = 1090) with DED of different etiologies received an extensive dry e...

journal_title：Current eye research

authors： Yazdani M,Chen X,Tashbayev B,Utheim ØA,Ræder S,Lagali N,Stojanovic A,Dartt DA,Utheim TP

更新日期：2018-12-01 00:00:00

abstract：:The reactions of lectins with dissociated and cultured epithelial cells from hyperplastic lenses of two unrelated chick strains, Hy-1 and Hy-2, characterised by hyperplasia of the lens epithelium, and lenses of a normal genotype (N) were investigated using four different lectins. Three methods of monitoring lectin-bin...

journal_title：Current eye research

authors： Odeigah PG,Clayton RM,Truman DE

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:There is a clinical need for biomimetic corneas that are as effective, preferably superior, to cadaveric donor tissue. Decellularized tissues are advantageous compared to synthetic or semi-synthetic engineered tissues in that the native matrix ultrastructure and intrinsic biological cues including growth fac...

journal_title：Current eye research

authors： Wilson SL,Sidney LE,Dunphy SE,Dua HS,Hopkinson A

更新日期：2016-06-01 00:00:00

abstract：:The present study examined the anti-herpetic effect of the glycoprotein inhibitors, hydroxynorvaline and 2-deoxyglucose, alone and in combination with trifluridine on murine ocular herpes. Following ocular inoculation with a large dose of HSV-1 RE strain (10(6) pfu), ICR mice were treated during the acute infection wi...

journal_title：Current eye research

authors： Gordon YJ,Cheng KP,Araullo-Cruz T,Romanowski E,Johnson BJ,Blough HA

更新日期：1986-02-01 00:00:00

abstract：PURPOSE/AIM:Cultured autologous oral mucosal epithelial cells (OMECs) have proven useful in the treatment of ocular surface disorders. This study is the first to investigate the potential of expanding OMEC in a xenobiotic- and serum-free medium using therapeutic contact lenses (CLs) as a substrate and carrier. MATERIA...

journal_title：Current eye research

authors： Björkblom B,Eidet JR,Utheim TP,Ulltveit-Moe HF,Raeder S

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Human beta-defensins 1 and 2 (hBD-1, -2) are antimicrobial peptides found in several epithelia including corneal epithelium. Breach of the epithelium leaves the cornea vulnerable to infection so we sought to determine if there is an increase in defensin expression after injury. METHODS:The epithelium from huma...

journal_title：Current eye research

authors： McDermott AM,Redfern RL,Zhang B

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To evaluate 24-hr intraocular pressure (IOP) and blood pressure (BP) with timolol or latanoprost/timolol fixed combination (LTFC). METHODS:Patients with primary open-angle glaucoma or ocular hypertension with normal blood pressure were randomized to LTFC, dosed each evening, or timolol dosed twice daily in a c...

journal_title：Current eye research

authors： Konstas AG,Pikilidou MI,Tsironi S,Mikropoulos D,Kozobolis VP,Sarafidis PA,Lasaridis AN,Nelson LA,Stewart WC

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To assess the potential impact of corneal crosslinking treatment (365 nm ultraviolet (UV)A irradiation with riboflavin) on the material properties of Intracorneal Rings Segments (ICRS). MATERIALS AND METHODS:Material properties were studied using FT-IR spectroscopy and UV-Vis spectroscopy. Rings were examined:...

journal_title：Current eye research

authors： Sideroudi H,Labiris G,Soto-Beobide A,Voyiatzis G,Chrissanthopoulos A,Kozobolis V

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To test if nicotine counteracts the dampening effect of human cytomegalovirus (HCMV) infection of NF-kappaB in retinal pigment epithelial (RPE) cells, thereby increasing the permissiveness of RPE cells for HCMV replication. METHODS:Human ARPE-19 cells were transfected with NF-kappaB luciferase DNA, inoculated ...

journal_title：Current eye research

authors： Buckner AE,Dix RD

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Frequent steroid drops represent a challenge in patient compliance. This study evaluated the safety and efficacy of 5 minute topical dexamethasone sodium phosphate-Visulex (DSP-Visulex) treatment regimen (two applications on the first week then weekly after) compared to daily prednisolone acetate 1% (PA) for no...

journal_title：Current eye research

authors： Papangkorn K,Truett KR,Vitale AT,Jhaveri C,Scales DK,Foster CS,Montieth A,Higuchi JW,Brar B,Higuchi WI

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:We performed nailfold capillary microscopy to explore microvasculature abnormalities in uveitis overall and uveitis stratified in various ways. METHODS:This was a cross-sectional, case-control, observational study. One hundred and seven uveitis patients and 130 control subjects were included. We used a JH-1004...

journal_title：Current eye research

authors： Chen X,Yao X,Chi Y,Guo C,Zhang J,Li J,Zhang S,Rong X,Pasquale LR,Yang L

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Previous studies revealed an association of tumor necrosis factor super family-15 (TNFSF15) gene polymorphisms with several autoimmune diseases, but their roles in the development of Graves' disease (GD) and Graves' ophthalmopathy (GO) remain unclear. The aim of this study was to explore the correlation between...

journal_title：Current eye research

authors： Zhang M,Liu S,Xu J,Lv S,Fan Y,Zhang Y,Zhang Y,Wu Y,Su Y,Yu H,Song S,He J,Li H

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To compare objective optical quality, ocular scattering and aberrations of eyes implanted with an aspheric monofocal intraocular lens (IOL) or an aspheric apodized diffractive multifocal IOL three months after surgery. METHODS:Prospective consecutive nonrandomized comparative cohort study. A total of 80 eyes f...

journal_title：Current eye research

authors： Liao X,Lin J,Tian J,Wen B,Tan Q,Lan C

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To determine the role of apoptosis in the pathogenesis of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. METHODS:Forty-three eyes from patients with cytomegalovirus retinitis treated before the introduction of highly active anti-retroviral therapy were examined by routine hi...

journal_title：Current eye research

authors： Buggage RR,Chan CC,Matteson DM,Reed GF,Whitcup SM

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization. METHODS:Immunohistochemistry was used to study the expression of purinergic P2Y2 and P2X2 receptors in the neonatal mouse retina during normal vascular development and after oxygen...

journal_title：Current eye research

authors： Sarman S,Mancini J,van der Ploeg I,Croxatto JO,Kvanta A,Gallo JE

更新日期：2008-03-01 00:00:00

abstract：:The variation of central corneal thickness with age was measured weekly at 10am by ultrasound pachometry in 10 normal (5 to 19 weeks of age) and 10 alloxan-induced diabetic (9 to 19 weeks of age) rabbits. The diurnal variation of corneal thickness was also measured at 2 hour intervals for a period of 24 hours on both ...

journal_title：Current eye research

authors： Herse PR

更新日期：1990-05-01 00:00:00