Mini-Review: Impaired Axonal Transport and Glaucoma.

abstract：PURPOSE:Most studies of cell growth of the RPE employ cultures which have been previously passaged, but here we investigated freshly-explanted RPE cells, which may have been growth-quiescent for years, within the eye to determine whether co-culture affects initial outgrowth in primary culture. METHODS:Bovine or human ...

journal_title：Current eye research

authors： McKay BS,Burke JM

更新日期：1997-09-01 00:00:00

abstract：:It has been shown that illumination of rod outer segment suspension in the presence of photosensitizers (methylene blue lambda greater than or equal to 620 nm; retinal 370 less than or equal to lambda less than or equal to 390 nm) results in chemical modification of the lipid and protein components of the photo-recept...

journal_title：Current eye research

authors： Shvedova AA,Alekseeva OM,Kuliev IYa,Muranov KO,Kozlov YuP,Kagan VE

更新日期：1982-01-01 00:00:00

abstract：:The aim of this study was to determine whether or not alpha neoprotein formation can occur in the lens in response to a photolytic process. Alpha crystallin from young calf and aged bovine lenses was irradiated for up to 22 hours with UV light. After cortical alpha crystallin had been irradiated, it completely preserv...

journal_title：Current eye research

authors： Hibino K,Du J,Dillon J,Malinowski K

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:To investigate the relationship between retinal fractal dimensions (Dfs) and retinal circulation, which is impaired in early-stage diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). METHODS:Using a laser Doppler velocimetry system, we measured the retinal vessel diameter (D) and blood ve...

journal_title：Current eye research

authors： Nagaoka T,Yoshida A

更新日期：2013-11-01 00:00:00

abstract：:Loteprednol etabonate (LE) is a new corticosteroid based on the "soft drug" concept. Contact lens-associated giant papillary conjunctivitis (GPC) was studied as a model for the anti-inflammatory effect of LE. Patients with bilateral GPC were enrolled in a multicenter, randomized, double-masked, placebo-controlled, par...

journal_title：Current eye research

authors： Bartlett JD,Howes JF,Ghormley NR,Amos JF,Laibovitz R,Horwitz B

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:Deficiency in Cystathionine β-synthase (CBS) leads to an abnormal accumulation of homocysteine and results in classical homocystinuria, a multi-systemic disorder that affects connective tissue, muscles, the central nervous system, and the eyes. However, the genetic players and mechanisms underlying vision alter...

journal_title：Current eye research

authors： Flores-Flores M,Moreno-García L,Castro-Martínez F,Nahmad M

更新日期：2020-09-07 00:00:00

abstract：:The effects of repeated exposures to UV-A (335 nm) and UV-B (305 nm) radiation on the crystalline lens were studied by treating cultured bovine lenses daily or weekly. The effects of irradiation on lens optical quality were monitored using an automated scanning laser system that records both relative transmittance and...

journal_title：Current eye research

authors： Stuart DD,Cullen AP,Sivak JG,Doughty MJ

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:We located immunohistochemically the matrix metalloproteinases (MMP) -1, -2, -3 and -9 and the tissue inhibitors of matrix metalloproteinases (TIMP) -1 and -2 in the fibrous capsule of patients with intraocular lenses (IOLs). METHODS:During vitreoretinal surgery in 10 patients we obtained post-cataract surgery...

journal_title：Current eye research

authors： Kawashima Y,Saika S,Miyamoto T,Yamanaka O,Okada Y,Tanaka S,Ohnishi Y

更新日期：2000-12-01 00:00:00

abstract：:The objective of this study was to determine if 20:5n-3 or 22:6n-3 is the primary precursor of very-long-chain fatty acids (VLCFAs; C24-C36) synthesized in retina. Rats were fed semisynthetic, nutritionally complete diet containing 20% (w/w) fat with 3% (w/w) of 22:6n-3. After 6 weeks feeding, the vitreal fluid of eac...

journal_title：Current eye research

authors： Suh M,Clandinin MT

更新日期：2005-11-01 00:00:00

abstract：:The effect of electrical stimulation of the sympathetic nerves on the blood-aqueous barrier was investigated in rabbits. The permeability of the barrier was assessed during either acute, chronic or following chronic nerve stimulation. During acute and chronic stimulation of the sympathetic nerves, fluorescein entered ...

journal_title：Current eye research

authors： Bartels SP,Pawlowski AM

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS:Totally, 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and cen...

journal_title：Current eye research

authors： Kwon J,Sung KR,Jo J,Yang SH

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To determine the relative expression of metallothionein isoforms and their differential induction by oxidative stress in cultured RPE cells and to localize the isoforms in the human chorioretinal complex. METHODS:Total RNA was isolated from cultured human retinal pigment epithelial cells using TRI-Reagent. An ...

journal_title：Current eye research

authors： Tate DJ,Miceli MV,Newsome DA

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To identify vitreous proteins that were differentially expressed in patients suffering from proliferative diabetic retinopathy with active neovascularization. METHODS:The vitreous samples of 15 active proliferative diabetic retinopathy patients were analyzed by two-dimensional gel electrophoresis and mass spec...

journal_title：Current eye research

authors： Kim SJ,Kim S,Park J,Lee HK,Park KS,Yu HG,Kim Y

更新日期：2006-03-01 00:00:00

abstract：:Two alternative methods for the study of the lens cytoskeleton are described which serve to overcome some of the difficulties imparted by the unique biology of the lens. The first technique involves rapid freezing, thick sectioning, and selective extraction and/or fixation of the lens section. This approach offers sev...

journal_title：Current eye research

authors： FitzGerald PG

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Statins have been shown to reduce ocular inflammation in animal models of uveitis and to prevent development of uveitis in observational studies. There have been no experimental human studies evaluating statins' efficacy and safety in uveitis. In this study, we aimed to investigate efficacy and safety of simvas...

journal_title：Current eye research

authors： Shirinsky IV,Biryukova AA,Shirinsky VS

更新日期：2017-12-01 00:00:00

abstract：:Recently, growth factors are known to phosphorylate tyrosine residues of proteins to regulate cellular functions. We investigated growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial (RPE) cells. The phosphorylation experiments were done in membrane preparations of ...

journal_title：Current eye research

authors： Yoshimura N,Kuriyama S,Iwaki M,Honda Y

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate how glutathione reductase (GR) loses its activity during cataract formation and whether it is possible to revive it back to the normal levels. METHOD:In this study, endogenous as well as synthetic reducing systems (GSH, TTase, DTT, captopril) and alpha-crystallin at dif...

journal_title：Current eye research

authors： Rachdan D,Lou MF,Harding JJ

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To evaluate the point-wise relationships between visual field sensitivity (VFS), as measured by standard automated perimetry (SAP), and macular thickness, as determined by spectral-domain optical coherence tomography (SD-OCT), in patients with glaucoma. MATERIALS AND METHODS:One hundred and six glaucoma subjec...

journal_title：Current eye research

authors： Kim JM,Sung KR,Yoo YC,Kim CY

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Avascular tissues can be used to identify antilymph- or antihemangiogenic factors. The human sclera-the outer covering layer of the eye, lacks lymphatic vessels and contains only a superficial network of blood vessels and was used here to identify endogenous antiangiogenic factors. METHODS:Expression levels of...

journal_title：Current eye research

authors： Schlereth SL,Karlstetter M,Hos D,Matthaei M,Cursiefen C,Heindl LM

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Previous studies have suggested that corneal fibrosis controlled by a TGFbeta-mediated cytocrine pathway underlies the development of clinical corneal haze and associated regression of photoablative effect following excimer laser PRK. Using a unique blocking antibody, we evaluated the role of TGFbeta in post-PR...

journal_title：Current eye research

authors： Møller-Pedersen T,Cavanagh HD,Petroll WM,Jester JV

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:Histidine is an indispensable amino acid with an imidazole ring and it is a precursor of histamine, carnosine, and anserine. Histidine has been proposed to act as a neurotransmitter or neuromodulator in mammalian central nervous system (CNS), including retina. In this study, we report histidine-like immunoreact...

journal_title：Current eye research

authors： Kusakari Y,Nishikawa S,Ishiguro S,Tamai M

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:To study whether there exists a relationship between retinal nerve fiber layer thickness and oxygen saturation and to identify whether perivascular thickness (pRNFL) or quadrant thickness (qRNFL) has a stronger correlation. METHODS:Patients without any detectable ocular abnormality on complete ophthalmic evalu...

journal_title：Current eye research

authors： Mohan A,Dabir S,Kurian M,Shetty R,Chidambara L,Kumar RS

更新日期：2016-09-01 00:00:00

abstract：AIM:To investigate microscopic changes in corneal morphology in chloroquine (CQ)-treated patients without corneal abnormalities being diagnosable by slit lamp microscopy. METHODS:Thirty-six eyes of 36 patients with rheumatoid arthritis (RA) were divided into two groups: group 1 included 26 patients receiving chloroqui...

journal_title：Current eye research

authors： Ma X,He L,He D,Xu J

更新日期：2012-04-01 00:00:00

abstract：:Purpose: The goal of this work was to determine whether the retinal tissue perfusion (RTP) is impaired in patients with multiple sclerosis (MS). Methods: Seventy-four patients [66 relapsing-remitting MS (RRMS) and 8 clinically isolated syndrome (CIS)] and 74 age- and gender-matched healthy controls were recruited. RTP...

journal_title：Current eye research

authors： Liu Y,Delgado S,Jiang H,Lin Y,Hernandez J,Deng Y,Gameiro GR,Wang J

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous. METHODS:IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMP...

journal_title：Current eye research

authors： Plantner JJ,Smine A,Quinn TA

更新日期：1998-02-01 00:00:00

abstract：AIMS:To investigate whether tobacco smoke directly injures retinal ganglion cells (RGCs) and to evaluate the mechanisms of cell death. METHODS:Primary rat RGCs were harvested from 3- or 4-day-old newborn rats and exposed to cigarette smoke extract (CSE). Cell viability was determined by adenosine 5'-triphosphate (ATP)...

journal_title：Current eye research

authors： Lee K,Hong S,Seong GJ,Kim CY

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To compare the clinical outcomes following Descemet's membrane endothelial keratoplasty (DMEK) with 100% air tamponade versus 10% sulfur hexafluoride (SF6) tamponade. METHODS:Retrospective analysis of 108 consecutive DMEK cases subdivided by anterior chamber tamponade with 54 eyes receiving 10% SF6 and 54 eyes...

journal_title：Current eye research

authors： Rickmann A,Szurman P,Jung S,Boden KT,Wahl S,Haus A,Boden K,Januschowski K

更新日期：2018-04-01 00:00:00

abstract：:Free radicals and oxidative damage play roles in aging and age-related ocular diseases such as cataracts, so defensive mechanisms become important factors for protection. Because N-acetylation is involved in a wide variety of detoxification processes, this study was conducted to examine the relationship between the ac...

journal_title：Current eye research

authors： Tamer L,Yilmaz A,Yildirim H,Ayaz L,Ates NA,Karakas S,Oz O,Yildirim O,Atik U

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To evaluate the length of the trabecular meshwork (TM) from the scleral spur (SS) to Schwalbe's line (SL) and assess the detectability of the SS in histopathology specimens. METHODS:This study included 158 angle images from 79 cross-sectional slides derived from eyes enucleated for melanoma. The slides were st...

journal_title：Current eye research

authors： Kasuga T,Chen YC,Bloomer MM,Hirabayashi KE,Hiratsuka Y,Murakami A,Lin SC

更新日期：2013-01-01 00:00:00

abstract：:Posterior vitreous detachment (PVD) and epiretinal membranes occur in a number of vitreoretinal diseases. We have developed an experimental model in which we can provide the morphologic correlation of these dynamic processes. The method provides the opportunity to study epiretinal membrane formation with the scanning ...

journal_title：Current eye research

authors： Matsumoto B,Hsu HT,Blanks JC,Ryan SJ

更新日期：1986-04-01 00:00:00