Abstract:
PURPOSE:To determine by immunohistochemistry the distribution of different nitric oxide synthases (NOS) isoforms in the porcine eye. METHODS:By light microscopy (immunofluorescence), porcine ocular tissues were investigated using monoclonal antibodies against neuronal NOS (nNOS; NOS I), endothelial NOS (ecNOS; NOS III), and macrophage NOS (macNOS; NOS II). RESULTS:Specific nNOS immunoreactivity was detected along the apical cytoplasmic portions of the non-pigmented and pigmented ciliary epithelial cells, in the endothelial lining of the corneoscleral meshwork and the uveal cords of the iridocorneal angle tissue, as well as in the photoreceptor layer of the sensory retina. Immunoreactivity for ecNOS was confined to the vascular endothelium of the vessels of the conjunctiva, iris, ciliary body, retina, choroid and optic nerve. A mild immunostaining for macNOS was present in the cytoplasm of some non-pigmented ciliary epithelial cells. CONCLUSIONS:The predominant localization of nNOS in ciliary epithelial and trabecular endothelial cells suggests a possible involvement of nNOS in both the production and outflow of aqueous humor in porcine eyes.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Meyer P,Champion C,Schlötzer-Schrehardt U,Flammer J,Haefliger IOdoi
10.1076/ceyr.18.5.375.5355subject
Has Abstractpub_date
1999-05-01 00:00:00pages
375-80issue
5eissn
0271-3683issn
1460-2202journal_volume
18pub_type
杂志文章abstract::In primates, ciliary muscle contraction causes accommodation and facilitates aqueous outflow. In living rhesus monkeys, accommodative, outflow facility, and ciliary muscle movement responses to cholinergic agonists all decline with age. We developed an apparatus to determine in vitro whether the latter is related to i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309024623
更新日期:1993-05-01 00:00:00
abstract:PURPOSE:To examine the morphological changes in the meibomian glands of eyes of patients with dry eye disease using the non-contact infrared meibography system and to assess their relationship with meibomian dropout, signs, and tear-film function. METHODS:Subjects included 264 randomly selected patients (528 eyes) suf...
journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688408997233
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709020084
更新日期:1987-01-01 00:00:00
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journal_title:Current eye research
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doi:10.1080/02713683.2018.1540642
更新日期:2019-03-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:1984-05-01 00:00:00
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更新日期:2019-07-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:2006-06-01 00:00:00
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journal_title:Current eye research
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journal_title:Current eye research
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更新日期:2009-06-01 00:00:00
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journal_title:Current eye research
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doi:10.1076/ceyr.23.3.185.5465
更新日期:2001-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1056804
更新日期:2016-05-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.891750
更新日期:2014-10-01 00:00:00
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journal_title:Current eye research
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journal_title:Current eye research
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更新日期:2016-12-01 00:00:00
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journal_title:Current eye research
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更新日期:2020-10-01 00:00:00
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journal_title:Current eye research
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更新日期:2004-08-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.3.308.5225
更新日期:1998-03-01 00:00:00
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journal_title:Current eye research
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更新日期:1987-05-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.5.320.5437
更新日期:2001-11-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689308999466
更新日期:1993-03-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Current eye research
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更新日期:2010-03-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.2.102.5086
更新日期:1997-02-01 00:00:00
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journal_title:Current eye research
pub_type: 临床试验,杂志文章
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更新日期:2013-05-01 00:00:00