Nona-D-arginine amide for prophylaxis and treatment of experimental Pseudomonas aeruginosa keratitis.

abstract：:Loteprednol etabonate (LE) is a new corticosteroid based on the "soft drug" concept. Contact lens-associated giant papillary conjunctivitis (GPC) was studied as a model for the anti-inflammatory effect of LE. Patients with bilateral GPC were enrolled in a multicenter, randomized, double-masked, placebo-controlled, par...

journal_title：Current eye research

authors： Bartlett JD,Howes JF,Ghormley NR,Amos JF,Laibovitz R,Horwitz B

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:To determine whether environmental factors or bacterial viability affect the binding of two strains of P. aeruginosa to mouse cornea. METHODS:Scarified corneas were placed in organ culture and inoculated with P. aeruginosa cell suspensions containing either ATCC 19660 or PAO1 bacterial strains classed as cytot...

journal_title：Current eye research

authors： Chen L,Hobden JA,Masinick SA,Hazlett LD

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:Both HSV-1 and HSV-2 express LAT during viral latency. Previous studies indicated that deletion of either LAT impairs viral reactivation from latency, but that the HSV-1 LAT confers the ability to reactivate efficiently from trigeminal ganglia onto HSV-2. We sought to determine whether the HSV-2 LAT could funct...

journal_title：Current eye research

authors： Hill J,Patel A,Bhattacharjee P,Krause P

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:Dry eye is a common condition known to have many systemic co-morbidities. We aim to report the frequency of depression and anxiety suspects in eye clinic patients and explore the association between dry eye signs and symptoms with depression and anxiety. MATERIALS AND METHODS:Adult outpatients were recruited f...

journal_title：Current eye research

authors： Liyue H,Chiang PP,Sung SC,Tong L

更新日期：2016-05-01 00:00:00

abstract：:It has been suggested that the provision of HLA matched tissue for corneal transplantation would be beneficial for graft survival especially in high risk patients. In this study we report the application of a polymerase chain reaction (PCR) based tissue typing procedure to type cadaveric donor material. Using beta-glo...

journal_title：Current eye research

authors： Rakoczy P,Garlepp M,Constable I

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To study the association of cell proliferation in uveal melanoma with the mean of the 10 largest nucleoli (MLN), microvascular prognostic factors, and survival. METHODS:Population-based, retrospective cohort study of 167 choroidal and ciliary body melanomas enucleated from 1972 to 1981. Mouse monoclonal antibo...

journal_title：Current eye research

authors： Al-Jamal RT,Kivelä T

更新日期：2006-01-01 00:00:00

abstract：:We studied the effects of a forskolin suspension on intraocular pressure (IOP) in normal albino and pigmented rabbits and in alpha-chymotrypsin induced ocular hypertensive rabbits. Experimental-induced ocular hypertensive rabbits were produced by injecting of alpha-chymotrypsin (167 units) into the posterior chamber o...

journal_title：Current eye research

authors： Shibata T,Mishima H,Kurokawa T

更新日期：1988-07-01 00:00:00

abstract：:Corneas and tendons dissected from 17-day-old chick embryos were labeled with [35S]methionine in the presence of 0.3 mM alpha,alpha'-dipyridyl. The unhydroxylated, 35S-labeled pro alpha chains and alpha chains were isolated by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. The pro alpha and alpha chains...

journal_title：Current eye research

authors： Kao WW

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:To evaluate the stability of successive applanation tonometry measurements in glaucomatous eyes. METHODS:A prospective, comparative, randomized, and evaluator-masked study was conducted in a tertiary medical center. Sixty-seven patients with glaucoma attending our glaucoma clinic underwent four successive intr...

journal_title：Current eye research

authors： Gaton DD,Ehrenberg M,Lusky M,Wussuki-Lior O,Dotan G,Weinberger D,Snir M

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To compare the efficacy and tolerability of diclofenac and bromfenac ophthalmic solutions as adjunctive therapy after cataract surgery. MATERIALS AND METHODS:This prospective randomized controlled study included 130 patients who underwent cataract surgery. One hundred patients were randomized to receive postop...

journal_title：Current eye research

authors： Giannaccare G,Finzi A,Sebastiani S,Greco F,Versura P,Campos EC

更新日期：2018-12-01 00:00:00

abstract：:Birefringence variations, seen as regularly spaced altering light and dark rings (bands), have been observed along the length of unfixed, freshly isolated rod outer segments (ROS) of both Rana pipiens and Xenopus laevis. In our hands, the spatial frequency of the banding pattern is from 1.3-1.6u/band in Rana pipiens a...

journal_title：Current eye research

authors： Andrews LD,Mackenzie JM Jr,Basinger SF

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:To compare the quality of corneal endothelium of precut Descemet-stripping automated endothelial keratoplasty (DSAEK) tissue when transported with and without the anterior lamellar corneal tissue (ALCT) when organ-culture corneal storage methods are used. METHODS:After microkeratome-assisted excision of anteri...

journal_title：Current eye research

authors： Jhanji V,Pollock GA,Mackey AL,Beltz J,Vajpayee RB

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:In tissues outside the brain, vascular endothelial growth factor-A (VEGF) causes vascular hyper-permeability by opening of inter-endothelial junctions and induction of fenestrations and vesiculo-vacuolar organelles (VVOs). In preliminary studies, we observed that in blood-retinal barrier endothelium, other cell...

journal_title：Current eye research

authors： Hofman P,Blaauwgeers HG,Tolentino MJ,Adamis AP,Nunes Cardozo BJ,Vrensen GF,Schlingemann RO

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:Whereas many previous studies have identified the association between sustained near work and myopia, few have assessed the influence of concomitant levels of cognitive effort. This study investigates the effect of cognitive effort on near-work induced transient myopia (NITM). METHODS:Subjects comprised of six...

journal_title：Current eye research

authors： Wolffsohn JS,Gilmartin B,Thomas R,Mallen EA

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:Retinoblastoma (RB) is the most common intraocular malignancy in children. Deregulation of several miRNAs has been identified in RB, suggesting a potential role in tumorigenesis. Recent evidence suggests that many dietary components like folate, retinoids and curcumin act as potential anticancer/antiproliferati...

journal_title：Current eye research

authors： Sreenivasan S,Thirumalai K,Danda R,Krishnakumar S

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:To determine the effect of prolonged exposure to high glucose on cellular behavior of normal human corneal epithelial cells (HCEC). METHODS:HCEC were cultured in medium under normal or high glucose conditions for 14 days. Proliferation was evaluated by direct cell counting and [(3)H]thymidine incorporation. Ce...

journal_title：Current eye research

authors： Fujita H,Morita I,Takase H,Ohno-Matsui K,Mochizuki M

更新日期：2003-10-01 00:00:00

abstract：:Calpains are calcium-activated proteinases which have been implicated in tissue differentiation and degeneration. The aims of the present study were: (1) to determine the relationship between postnatal age and calpain activity in the rat retina; (2) to test if calpain activity was aberrant in the RCS retina at differe...

journal_title：Current eye research

authors： Azarian SM,Williams DS

更新日期：1995-08-01 00:00:00

abstract：:This study was conducted to determine the therapeutic efficacy of 3.0 mg/ml ciprofloxacin administered concurrently with one of two salts of prednisolone for the treatment of experimental pseudomonal keratitis. Rabbit corneas were injected intrastromally with Pseudomonas aeruginosa ATCC strain 27853. Sixteen hr after ...

journal_title：Current eye research

authors： Hobden JA,Engel LS,Hill JM,Callegan MC,O'Callaghan RJ

更新日期：1993-05-01 00:00:00

abstract：:An experimental model of optic nerve ischemia was designed in the rabbit to determine early biochemical alterations, i.e.--changes of high energy phosphate metabolites (ATP and phosphocreatine)--in occlusive and peri-occlusive areas. Vascular occlusion provoked a rapid fall of ATP and phosphocreatine in the optic nerv...

journal_title：Current eye research

authors： Vériac S,Tissié G,Bonne C

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:To assess the potential impact of corneal crosslinking treatment (365 nm ultraviolet (UV)A irradiation with riboflavin) on the material properties of Intracorneal Rings Segments (ICRS). MATERIALS AND METHODS:Material properties were studied using FT-IR spectroscopy and UV-Vis spectroscopy. Rings were examined:...

journal_title：Current eye research

authors： Sideroudi H,Labiris G,Soto-Beobide A,Voyiatzis G,Chrissanthopoulos A,Kozobolis V

更新日期：2015-05-01 00:00:00

abstract：:Bovine vitreous body and aorta contain extractable leukocyte elastase inhibitors, which were purified by gel filtration and affinity chromatography on agarose-pancreatic elastase. The purified inhibitor preparation from aorta was resolved by polyacrylamide gel electrophoresis into a main band migrating slightly faster...

journal_title：Current eye research

authors： Arsenis C,Kuettner KE,Eisenstein R

更新日期：1988-02-01 00:00:00

abstract：:In experimental work on retinal ischemia and its medical management, we have been disturbed by the large variations in the electroetinogram (ERG) recovery of rabbit eyes subjected to similar degrees of ischemia. We investigated whether body temperature might be one of the critical factors. We studied pigmented Dutch r...

journal_title：Current eye research

authors： Nayak MS,Marmor MF

更新日期：1995-02-01 00:00:00

abstract：:EDGF, a growth factor purified from bovine retina is able to increase the rate of wound healing of rabbit corneal epithelium in a dose dependent way. Two applications a day are enough to obtain the maximum rate. The most purified preparation of EDGF is as effective as EGF or pFGF in promoting this phenomenon and allow...

journal_title：Current eye research

authors： Petroutsos G,Courty J,Guimaraes R,Pouliquen Y,Barritault D,Plouët J,Courtois Y

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:To investigate the tissue blood flow in the neuroretinal rim of the optic disk and macula after rhegmatogenous retinal detachment (RRD) surgery. METHODS:Tissue blood flow in the neuroretinal rim of the optic disk and macula was measured with the Heidelberg retina flowmeter in 53 eyes of 53 patients who had und...

journal_title：Current eye research

authors： Sato EA,Shinoda K,Kimura I,Ohtake Y,Inoue M

更新日期：2007-09-01 00:00:00

abstract：:Purified Pseudomonas aeruginosa elastase cleaved a 65 kDa gelatinase [inactive proenzyme form of matrix metalloproteinase (MMP-2)] from human corneal fibroblasts into a biologically active fragment with an approximate molecular mass of 58 kDa. However, purified pseudomonal alkaline protease did not cleave MMP-2 apprec...

journal_title：Current eye research

authors： Matsumoto K,Shams NB,Hanninen LA,Kenyon KR

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:To assess the upper eyelid kinematics during spontaneous blinking in unilateral paralytic lagophthalmos before and after upper eyelid load with gold weight (GW) or autogenous temporalis fascia (TF) sling. DESIGN:Comparative case series. SUBJECTS:Patients with long-standing unresolved unilateral facial palsy w...

journal_title：Current eye research

authors： Wambier SP,Garcia DM,Cruz AA,Messias A

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Androgens are thought to play a role in the regulation of the human lacrimal gland. Androgen receptor mRNA has been isolated from human lacrimal tissue; however, it is not known which cell(s) in human lacrimal tissue may contain androgen receptors. This study is an immunohistochemical investigation of the locat...

journal_title：Current eye research

authors： Smith RE,Taylor CR,Rao NA,Young LL,Rife LL

更新日期：1999-04-01 00:00:00

abstract：:Adult albino mice received tritiated thymidine either injected subcutaneously (333 microCi) every 6 hours for up to 36 hours, or administered in their drinking water for up to 74 days (about 45 microCi/day). Tissue sections were examined with autoradiography to determine the distribution of the label. Animals receivin...

journal_title：Current eye research

authors： McDonald TF,Green K

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:The effects of repeated topical administration of the selective beta 2-adrenergic agonist fenoterol on the intraocular pressure and on the adenylyl cyclase activity in ciliary processes in rabbit were examined in order to detect their possible causal relationship. METHODS:Intraocular pressure was measured by p...

journal_title：Current eye research

authors： Cepelík J,Hynie S

更新日期：1997-10-01 00:00:00

abstract：:Na/K ATPase activity has been determined in normal and cataractous human lenses using labeled ATP as a substrate. The enzyme is distributed throughout the lens with approximately 1/3 of the total activity in the capsule-epithelium and 1/2 of the activity in the cortex. Furthermore, the activity of Na/K ATPase decrease...

journal_title：Current eye research

authors： Kobatashi S,Roy D,Spector A

更新日期：1982-01-01 00:00:00