Histopathological evaluation of anterior lamellar corneal tissue-on/-off storage conditions on DSAEK donor tissue after storage in organ culture.

abstract：:Uveitis can be induced by systemic or intravitreal administration of endotoxin (lipopolysaccharide, LPS). In this study we correlated the expression of class II antigens (la in rat) of the Major Histocompatibility Complex (MHC), with this experimental model of uveitis. Ia antigen was detected by immunohistochemistry u...

journal_title：Current eye research

authors： Kim MK,Palestine AG,Nussenblatt RB,Chan CC

更新日期：1986-11-01 00:00:00

abstract：PURPOSE:To evaluate changes in biometric parameters in myopic eyes. MATERIALS AND METHODS:412 eyes of 412 young myopic patients underwent ophthalmic examinations including assessments of refractive error, axial length (AL), anterior chamber depth (ACD), and central corneal thickness (CCT). By using spectral domain opt...

journal_title：Current eye research

authors： Chung HJ,Park CK

更新日期：2016-12-01 00:00:00

abstract：:Systemically administered fluorescein is converted to fluorescein glucuronide. The conjugate is fluorescent and interferes with the measurement of fluorescein in the anterior chamber. Carboxyfluorescein is a hydrophilic derivative of fluorescein. In the rabbit, carboxyfluorescein is not converted as readily to a fluor...

journal_title：Current eye research

authors： Neault TR,McLaren JW,Brubaker JH,Brubaker RF

更新日期：1986-05-01 00:00:00

abstract：:To better define the growth requirements for corneal epithelial cells, methods for serum-free culture were established. Sheets of corneal epithelium from eyes of swine and rabbits were obtained by dispase treatment of corneal buttons, and single cells and small clumps were obtained by further dissociation with trypsin...

journal_title：Current eye research

authors： Hackworth LA,Faraji-Shadan F,Schuschereba ST,Bowman PD

更新日期：1990-09-01 00:00:00

abstract：:5-Fluorouracil (5-FU) and Mitomycin C (MMC) are used as adjunct chemotherapy during glaucoma filtering surgery to suppress conjunctival fibroblast proliferation. Since part of these agents may gain access to the anterior chamber and cause cytotoxicity to the corneal endothelium we set up an in vitro system to establis...

journal_title：Current eye research

authors： Nuyts RM,Pels E,Greve EL

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:So far tear substitutes have demonstrated a limited role in restoring ocular surface damage in dry eye syndrome (DES). The aim of this study was to assess the efficacy of a new ocular surface modulator in an in vitro model of human corneal epithelium (HCE) damaged by severe osmotic stress mirroring the features...

journal_title：Current eye research

authors： Barabino S,De Servi B,Aragona S,Manenti D,Meloni M

更新日期：2017-03-01 00:00:00

abstract：:In experimental work on retinal ischemia and its medical management, we have been disturbed by the large variations in the electroetinogram (ERG) recovery of rabbit eyes subjected to similar degrees of ischemia. We investigated whether body temperature might be one of the critical factors. We studied pigmented Dutch r...

journal_title：Current eye research

authors： Nayak MS,Marmor MF

更新日期：1995-02-01 00:00:00

abstract：PURPOSE:To investigate the characteristics of anterior chamber inflammatory reaction induced by intravitreal injection of endothelin-1 (ET-1). METHODS:The time course of changes in aqueous protein concentration (APC) after intravitreal injection of 10(-4), 10(-5), 10(-6) and 10(-7) M ET-1 into rabbit eyes was measured...

journal_title：Current eye research

authors： Shoji N,Oshika T,Masuda K

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To investigate retinal imaging and ablation using femtosecond laser pulses. MATERIALS AND METHODS:Two non-amplified near-infrared femtosecond lasers were used to irradiate porcine retinal specimens in vitro. The lasers were used for tissue removal as well as multiphoton laser scanning microscopy. RESULTS:Abla...

journal_title：Current eye research

authors： Hild M,Krause M,Riemann I,Mestres P,Toropygin S,Löw U,Brückner K,Seitz B,Jonescu-Cuypers C,König K

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:We investigated the impact of target properties on vertical fusion amplitude (VFA) using a 3D display platform; the performance of the subjects allowed us to assess how central and peripheral retina regions interact during the fusion process. MATERIAL AND METHODS:Fourteen subjects were involved in the test. VF...

journal_title：Current eye research

authors： Zhang D,Neveu P,Fattakhova Y,Ferragut S,Lamard M,Cochener B,de Bougrenet de la Tocnaye JL

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Most studies of cell growth of the RPE employ cultures which have been previously passaged, but here we investigated freshly-explanted RPE cells, which may have been growth-quiescent for years, within the eye to determine whether co-culture affects initial outgrowth in primary culture. METHODS:Bovine or human ...

journal_title：Current eye research

authors： McKay BS,Burke JM

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:To study the effect of Na-K pump and K(ATP) channel inhibition on the diameter and the adenosine-induced vasodilation of small retinal arterioles. METHODS:Thirty isolated porcine arterioles with a diameter of approximately 70 microm were mounted in a double-barrelled pipette system placed in an organ bath, and...

journal_title：Current eye research

authors： Jeppesen P,Aalkjaer C,Bek T

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Previous studies have suggested that corneal fibrosis controlled by a TGFbeta-mediated cytocrine pathway underlies the development of clinical corneal haze and associated regression of photoablative effect following excimer laser PRK. Using a unique blocking antibody, we evaluated the role of TGFbeta in post-PR...

journal_title：Current eye research

authors： Møller-Pedersen T,Cavanagh HD,Petroll WM,Jester JV

更新日期：1998-07-01 00:00:00

abstract：:Recently, all the structural features of non-proliferative diabetic retinopathy have been demonstrated in mice fed 30% galactose for 21-26 months. To determine whether changes in retinal matrix protein mRNA levels occur early in the course of murine diabetes we used a competitive RT-PCR method to quantitate retinal mR...

journal_title：Current eye research

authors： Nishikawa T,Giardino I,Edelstein D,Brownlee M

更新日期：2000-07-01 00:00:00

abstract：:Serum zinc and copper levels were analyzed in 26 retinitis pigmentosa patients and compared with serum zinc levels of a control group. Serum zinc levels were documented to be decreased with a mean concentration of 0.735 +/- 0.167 micrograms/ml (p less than 0.001). Serum copper levels, on the other hand, were found to ...

journal_title：Current eye research

authors： Karcioglu ZA,Stout R,Hahn HJ

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:To investigate the agreement of angular locations of retinal nerve fiber layer (RNFL) defect margins in glaucomatous eyes by using red-free fundus photographs and Cirrus high-definition optical coherence tomography (OCT) RNFL deviation and thickness maps. METHODS:We examined 380 RNFL defects that showed clear ...

journal_title：Current eye research

authors： Hwang YH,Kim YY,Kim HK,Sohn YH

更新日期：2014-11-01 00:00:00

abstract：:Posterior vitreous detachment (PVD) and epiretinal membranes occur in a number of vitreoretinal diseases. We have developed an experimental model in which we can provide the morphologic correlation of these dynamic processes. The method provides the opportunity to study epiretinal membrane formation with the scanning ...

journal_title：Current eye research

authors： Matsumoto B,Hsu HT,Blanks JC,Ryan SJ

更新日期：1986-04-01 00:00:00

abstract：:An initial characterization of the lenticular ionic permeabilities of the isolated Sprague-Dawley rat lens utilizing short-circuiting techniques was carried out to provide the basis for further studies of mechanisms underlying cataractogenesis associated with salt-sensitive genetic hypertension in the rat. Both active...

journal_title：Current eye research

authors： Estapé ES,Rodríguez-Sargent C,Candia OA

更新日期：1992-02-01 00:00:00

abstract：:We have examined the T cell specificity of a Lewis rat T cell line (R208) specific for a pathogenic, 123 residue cyanogen bromide produced peptide of bovine S-antigen by using two independent sets of overlapping synthetic peptides representing the entire length of the 123 residue fragment. S-antigen, a 48 kDa immunopa...

journal_title：Current eye research

authors： Fling SP,Gregerson DS,Obritsch WF,Boyce-Jacino M,Merryman CF,Donoso LA

更新日期：1990-01-01 00:00:00

abstract：:The interfibrillar spacing of collagen fibrils was measured at twenty different positions across a macular dystrophy cornea using synchrotron X-ray diffraction. Unlike previous work of this type the cornea had not been frozen for storage. The spacings were all significantly lower than the spacings which existed at sim...

journal_title：Current eye research

authors： Quantock AJ,Meek KM,Ridgway AE,Bron AJ,Thonar EJ

更新日期：1990-04-01 00:00:00

abstract：:The cytoskeletal proteins of the human lens were studied by SDS-PAGE, 2-D electrophoresis and immunologically. Spectrin, vimentin and actin were identified in the superficial fiber cells of human lenses even to age 87 years. These proteins are lost from the deeper cortical and nuclear fiber cells, where a broad zone o...

journal_title：Current eye research

authors： Maisel H,Ellis M

更新日期：1984-02-01 00:00:00

abstract：PURPOSE:To evaluate the intraocular distribution and metabolism of the lipid prodrug of foscarnet, 1-O-octadecyl-sn-glycerol-3- phosphonoformate (ODG-PFA), following intravitreal administration. METHODS:Twenty rabbits received ODG-[14C]PFA intravitreal injection, yielding 0.632 mM resultant intravitreal concentration....

journal_title：Current eye research

authors： Cheng L,Hostetler KY,Gardner MF,Avila CP Jr,Bergeron-Lynn G,Severson GM,Freeman WR

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS:Totally, 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and cen...

journal_title：Current eye research

authors： Kwon J,Sung KR,Jo J,Yang SH

更新日期：2018-09-01 00:00:00

abstract：:Levels of rhodopsin in the photoreceptors of Long-Evans rats were reduced by approximately 55% through dietary deprivation of vitamin A. The interaction of visual pigment with G-protein was examined in receptor outer segment (ROS) membranes obtained from these animals. A binding assay was used to quantitate affinity o...

journal_title：Current eye research

authors： Pepperberg DR,Anderson SM,Crouch R

更新日期：1989-04-01 00:00:00

abstract：:Change of urate and ascorbate levels in retinae of rat left eyes after ophthalmic artery and optic nerve ligation was studied by reversed-phase high-performance liquid chromatography with electrochemical detection. The right eyes were used for sham operation. We found that uric acid levels in the retinae of the left e...

journal_title：Current eye research

authors： Iriyama K,Yoshiura M,Iwamoto T,Kamada Y,Nozawa H,Mizuno A,Matsuzaki H

更新日期：1986-07-01 00:00:00

abstract：:Corneal acidosis has been shown to reduce corneal hydration control (CHC) as measured by the rate, expressed as the percent recovery per hour (PRPH), at which the thickness of the cornea decreases exponentially after an increased hydration load. Since the effect of pH on corneal function is of scientific interest and ...

journal_title：Current eye research

authors： Cohen SR,Polse KA,Brand RJ,Bonanno JA

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:The mechanism by which prostaglandin(PG)F2 alpha increases uveoscleral outflow and lowers intraocular pressure in primates is not known. In cultured human ciliary muscle cells, PGF2 alpha induces the expression of the protooncogene c-fos which is known to induce the transcription of genes such as matrix metallo...

journal_title：Current eye research

authors： Lindsey JD,Kashiwagi K,Boyle D,Kashiwagi F,Firestein GS,Weinreb RN

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:To evaluate differences of phagocytic capacities in rat retinal pigment epithelial (RPE) cells, iris pigment epithelial (IPE) cells, and basic fibroblast growth factor (bFGF) cDNA-transfected IPE (bFGF-IPE) cells in vitro. METHODS:The RPE cells and IPE cells were isolated from adult Long Evans rats' eyes. The ...

journal_title：Current eye research

authors： Sakuragi M,Tomita H,Abe T,Tamai M

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:Experiments were performed to evaluate the effect of various pro- and anti-inflammatory cytokines on the human fetal retinal pigment epithelium's (HFRPE) expression of major histocompatibility complex (MHC) and costimulatory molecules. METHODS:Pure cultures of HFRPE cells were isolated. HFRPE cells were incuba...

journal_title：Current eye research

authors： Farrokh-Siar L,Rezai KA,Palmer EM,Patel SC,Ernest TJ,van Seventer GA

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Folic acid (FA) is an essential nutrient for normal embryonic development. FA deficiency (FAD) in maternal diet increases the risk of several defects among the progeny, especially, neural tube defects. The eye begins its development from the neural tube; however, the relationship between FAD and ocular developm...

journal_title：Current eye research

authors： Sijilmassi O,López-Alonso JM,Del Río Sevilla A,Murillo González J,Barrio Asensio MDC

更新日期：2019-04-01 00:00:00