Inflammatory reaction via arachidonic acid cascade after intravitreal injection of endothelin-1.

abstract：PURPOSE:To validate the more easily applicable "flush" tear collection technique as a viable alternative to basal and reflex tear collection. MATERIALS AND METHODS:Total protein content (TPC) and immunoglobulin A (IgA) concentrations were determined in the basal, reflex, and flush tears of 16 healthy non-contact lens ...

journal_title：Current eye research

authors： Markoulli M,Papas E,Petznick A,Holden B

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis. This study, employing an experimental rabbit model of Staphylococcus aureus keratitis, investigated the effectiveness of topical taurolidine in reducing the number of bact...

journal_title：Current eye research

authors： Oguz H,Ozbilge H,Oguz E,Gurkan T

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:To investigate the efficacy of intravitreal piperacillin/tazobactam (250 microg/0.1 ml) in the treatment of experimental Pseudomonas aeruginosa endophthalmitis in rabbits. MATERIALS AND METHODS:Twenty New Zealand White albino rabbits were used in this study. The rabbits were divided into two groups (10 rabbits...

journal_title：Current eye research

authors： Ozkiris A,Evereklioglu C,Esel D,Akgün H,Göktas S,Erkiliç K

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To determine the effect of prolonged exposure to high glucose on cellular behavior of normal human corneal epithelial cells (HCEC). METHODS:HCEC were cultured in medium under normal or high glucose conditions for 14 days. Proliferation was evaluated by direct cell counting and [(3)H]thymidine incorporation. Ce...

journal_title：Current eye research

authors： Fujita H,Morita I,Takase H,Ohno-Matsui K,Mochizuki M

更新日期：2003-10-01 00:00:00

abstract：:Previous attempts to prepare monoclonal antibodies (MAbs) against S-antigen, a photoreceptor cell protein involved in the visual process and a potent autoantigen for the induction of experimental autoimmune uveitis (EAU), have yielded MAbs which define only carboxyl terminal epitopes. In this study we devised alternat...

journal_title：Current eye research

authors： Donoso LA,Gregerson DS,Smith L,Robertson S,Knospe V,Vrabec T,Kalsow CM

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:To investigate whether retinal impairment was affected by age of rats in acute glaucoma model. METHODS:Young adult and aged rats were randomly divided into normal control, 45 mmHg, 60 mmHg and 90 mmHg groups. Intraocular pressures (IOP) of rats were acutely elevated to 45 mmHg, 60 mmHg and 90 mmHg, respectivel...

journal_title：Current eye research

authors： Tan C,Hu T,Peng MC,Liu SL,Tong JB,Ouyang W,Le Y

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:To characterize the pupil light reflex (PLR), electroretinographic (ERG) and tonometric parameters in healthy rat eyes. METHODS:Brown Norway rats were used for experiments. The PLR was evaluated with a computerized pupillometer (n = 27), ERGs were recorded simultaneously from both eyes (n = 27) and IOP was mea...

journal_title：Current eye research

authors： Grozdanic S,Sakaguchi DS,Kwon YH,Kardon RH,Sonea IM

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...

journal_title：Current eye research

authors： Becker HH,Eisenberg DL,Wang N,Steinert RF,Schuman JS

更新日期：1997-12-01 00:00:00

abstract：:We assessed in vitro the antimicrobial activity of four agents (vancomycin, teicoplanin, mupirocin, and imipenem) which are effective against Gram-positive cocci causally associated with bacterial keratitis, as well as their corneal epithelial cytotoxicity. Minimal inhibitory concentrations inhibiting 90% of strains (...

journal_title：Current eye research

authors： Cutarelli PE,Lazarus HM,Jacobs MR,Lass JH

更新日期：1993-07-01 00:00:00

abstract：:In the bovine lens the gamma IV-crystallin fraction is a principal determinant of the phase separation and opacification temperature, Tc (Siezen et al, Proc. Natl. Acad. Sci. USA 82, 1985, 1701). We have now measured the effect on Tc of purified gamma IV-crystallin solutions produced by a variety of reagents which aff...

journal_title：Current eye research

authors： Siezen RJ,Benedek GB

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Diabetes has been associated with decline in accommodative function in some ethnic groups. This outcome, however, could differ since ethnic variations in accommodation have been noted. This study investigated the relationship between plasma sugar level on subjective accommodative amplitude and accommodative ...

journal_title：Current eye research

authors： Abokyi S,Ilechie A,Asaam KA,Ntodie M

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Corneal autofluorescence is related to advanced glycation end products formed by glucose that reaches the cornea via the aqueous humour. The aim of the study was to examine the influence on autofluorescence of changes in permeability of the blood aqueous barrier. METHODS:Corneal autofluorescence was measured i...

journal_title：Current eye research

authors： Kessel L,Moldow B,van Best JA,Sander B

更新日期：2003-05-01 00:00:00

abstract：:The present study was aimed to demonstrate that cytochrome P-450 was induced by drug administration in particular tissues in the eye. Phenobarbital was used as an inducer. We showed immunohistochemically that cytochrome P-450 was induced in the cornea, conjunctiva and ciliary epithelium of rabbits after four days of i...

journal_title：Current eye research

authors： Matsumoto K,Kishida K,Manabe R,Sugiyama T

更新日期：1987-07-01 00:00:00

abstract：:The initial rapid fall in tear film fluorescence after instilling a 1 microliter drop of fluorophore could be a result of stimulated tear flow or of distribution of the dye throughout the tear fluid present in the conjunctival sac. An attempt was made to decide this by comparing the fall in fluorescence of two differe...

journal_title：Current eye research

authors： Sang NM,Maurice DM

更新日期：1995-04-01 00:00:00

abstract：:Serum zinc and copper levels were analyzed in 26 retinitis pigmentosa patients and compared with serum zinc levels of a control group. Serum zinc levels were documented to be decreased with a mean concentration of 0.735 +/- 0.167 micrograms/ml (p less than 0.001). Serum copper levels, on the other hand, were found to ...

journal_title：Current eye research

authors： Karcioglu ZA,Stout R,Hahn HJ

更新日期：1984-08-01 00:00:00

abstract：:Spontaneous ocular shedding and adrenergic induction of ocular shedding were examined in rabbits infected with ten strains of herpes simplex virus type 1 (HSV-1): McKrae, KOS, F, Rodanus, 17 Syn+, RE, E-43, SC-16, MacIntyre, and CGA-3. All ocular inoculations were with 50 microliter of HSV-1 with titers between 1-10 X...

journal_title：Current eye research

authors： Hill JM,Rayfield MA,Haruta Y

更新日期：1987-01-01 00:00:00

abstract：:This study asks whether retinal adhesiveness is affected by cytochalasin D, a drug that is known to alter the apical morphology of the retinal pigment epithelium (RPE). Cytochalasin D was injected intravitreally in Dutch rabbits and retinal adhesiveness measured 0.5 to 72 h later by two methods: in vitro peeling of th...

journal_title：Current eye research

authors： Chiang RK,Yao XY,Takeuchi A,Dalal R,Marmor MF

更新日期：1995-12-01 00:00:00

abstract：:To investigate the role of lymphocytes in the pathogenesis of uveitis, we analyzed the expression of memory markers, CD29 and CD45RO antigens, and apoptosis-related Fas antigen on T lymphocytes in the aqueous humor (AH) and peripheral blood (PB) from patients with uveitis. Using three-color flow cytometry, we assessed...

journal_title：Current eye research

authors： Ohta K,Norose K,Wang XC,Ito S,Yano A,Segawa K

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:To evaluate "in vivo" the effect of topical travoprost on the central corneal thickness (CCT) of rabbit eyes, and the changes in the CCT after acute increases of intraocular pressure (IOP) in these eyes. MATERIALS AND METHODS:This is an interventional, prospective, case-control, masked study. Topical travopros...

journal_title：Current eye research

authors： Bolívar G,Teus M,Arranz-Marquez E

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Extracellular matrix (ECM) plays an important role in the regulation of cell function. The aging process may involve chemical modifications to ECM proteins, which may contribute to the aging of the Bruch membrane and pathogenesis of age-related macular degeneration (AMD). The purpose of this study is to investi...

journal_title：Current eye research

authors： Wang Z,Paik DC,Del Priore LV,Burch RL,Gaillard ER

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:The effects of repeated topical administration of the selective beta 2-adrenergic agonist fenoterol on the intraocular pressure and on the adenylyl cyclase activity in ciliary processes in rabbit were examined in order to detect their possible causal relationship. METHODS:Intraocular pressure was measured by p...

journal_title：Current eye research

authors： Cepelík J,Hynie S

更新日期：1997-10-01 00:00:00

abstract：PURPOSE OF THE STUDY:To assess differences in healthy eyes in volume (CV) and choroidal thicknesses (CT) across all macular Early Treatment Diabetic Retinopathy Study (ETDRS) areas measured by swept source (SS)-OCT and spectral domain (SD)-OCT with enhanced depth imaging (EDI). MATERIALS AND METHODS:One hundred and fi...

journal_title：Current eye research

authors： Pinilla I,Sanchez-Cano A,Insa G,Bartolomé I,Perdices L,Orduna-Hospital E

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:To explore the roles of interleukin (IL)-17A in alkali-induced corneal neovascularization (CRNV). METHODS:Induction of CRNV by alkali injury was performed and compared in recombinant mouse IL-17A protein or anti-mouse IL-17A neutralizing antibody (Ab)-treated mice. The expression of IL-17A, IL-17A receptor (IL...

journal_title：Current eye research

authors： Liu G,Wu H,Lu P,Zhang X

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Pseudoexfoliation (PXF) is a microfibrillopathy involving disordered elastogenesis. Abnormal extracellular matrix (ECM) production underlies the pathophysiology of PXF. The enzyme Lysyl oxidase (LOX) and its isoforms are known to cross-link the elastin and collagen. Though the etiopathogensis of PXF is not well...

journal_title：Current eye research

authors： Gayathri R,Coral K,Sharmila F,Sripriya S,Sripriya K,Manish P,Shantha B,Ronnie G,Vijaya L,Narayanasamy A

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:The present study was conducted to develop and characterize a functional primary culture of pigmented rabbit conjunctival epithelial cells on permeable support exhibiting tight barrier properties. METHODS:Conjunctival epithelial cells were isolated by 0.2% protease treatment, cultured at 0.5-1.8 x 10(6) cells/...

journal_title：Current eye research

authors： Saha P,Kim KJ,Lee VH

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:The prospective study evaluated the effects of optical defocus on kinetic sensitivity using automated kinetic perimetry. MATERIALS AND METHODS:The 17 eyes of 17 healthy young participants were evaluated. All of the participants had myopia (≥ -5.00 D) and mild to no astigmatism (<1.00 D). Automated kinetic peri...

journal_title：Current eye research

authors： Hirasawa K,Shoji N

更新日期：2015-01-01 00:00:00

abstract：:Purpose: To determine the prevalence of posterior segment manifestations among consecutive patients with pathological myopia attending our University Hospital general ophthalmology clinic and their association with age, refractive error, axial length and each other. Methods: Patients diagnosed with pathological myopia...

journal_title：Current eye research

authors： Elnahry AG,Khafagy MM,Esmat SM,Mortada HA

更新日期：2019-09-01 00:00:00

abstract：:Endothelin-1 (ET-1) affects intraocular pressure (IOP) in rabbits. First, we studied IOP responses to the intravitreal injection of various doses of ET-1 ranging from 5 ng to 5 micrograms in unanesthetized rabbits, and observed a transient rise in IOP, from 0.5 to 2 h in duration, invariably followed by a prolonged IO...

journal_title：Current eye research

authors： Sugiyama K,Haque MS,Okada K,Taniguchi T,Kitazawa Y

更新日期：1995-06-01 00:00:00

abstract：:Cornea endothelial cells sensitized with rose bengal and exposed to light demonstrated a wavelength dependent alteration in physiological response. Corneas exposed to 549 millimicron swelled at rates similar to controls exposed to identical energy levels of incandescent light. Corneas exposed to 451, 500, 612, and 651...

journal_title：Current eye research

authors： Hull DS,Csukas S,Green K

更新日期：1981-01-01 00:00:00

abstract：:VIP markedly stimulates intracellular cAMP accumulation in the human retinoblastoma Y-79 cell line. cAMP increased about 5-fold above the basal level with 10(-8)M VIP and reached a maximum level (about 70-fold increase) with 2 X 10(-6)M VIP. Glucagon at 6 X 10(-8)M significantly increased cAMP accumulation with a maxi...

journal_title：Current eye research

authors： Kyritsis A,Koh SW,Chader GJ

更新日期：1984-02-01 00:00:00