Abstract:
PURPOSE:To investigate whether retinal impairment was affected by age of rats in acute glaucoma model. METHODS:Young adult and aged rats were randomly divided into normal control, 45 mmHg, 60 mmHg and 90 mmHg groups. Intraocular pressures (IOP) of rats were acutely elevated to 45 mmHg, 60 mmHg and 90 mmHg, respectively. Neuron loss in ganglion cell layer (GCL) and activation of retinal macrolgia and microglia 3 days after high IOP treatment were detected by immunofluorescence and further quantitatively analyzed. RESULTS:Compared with normal control, significant loss of neurons at GCL of young adult retina wasn't detected until IOP treatment of 90 mmHg. In contrast, obvious loss of neurons at GCL of aged retina was detected at IOP of 45 mmHg (p = 0.002 for central; p = 0.001 for peripheral). The loss level of neurons of aged retina was significantly higher than that of young adult retina at different IOP treatments. Compared with the young adult retina, high IOP induced more significant increase at area percentage of microglia and microglia number in inner part of aged retina. Activation of microglia and macroglia was either in parallel to or earlier than neuron loss of GCL of aged and young adult retina. CONCLUSION:Our data suggest there exists an age-related susceptibility of rat retina to the increased IOP. Therefore, the effect of ages should be considered at glaucoma study of rat models.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Tan C,Hu T,Peng MC,Liu SL,Tong JB,Ouyang W,Le Ydoi
10.3109/02713683.2014.922194subject
Has Abstractpub_date
2015-03-01 00:00:00pages
300-6issue
3eissn
0271-3683issn
1460-2202journal_volume
40pub_type
杂志文章abstract:PURPOSE:To investigate the roles of adherence and matrix metalloproteinases (MMPs) in growth patterns of major fungal pathogens in cornea. METHODS:Ninety-six eyes in 96 rabbits were equally divided into four groups receiving inoculation of fungal conidia of Aspergillus fumigatus, Candida albicans, Fusarium solani, and...
journal_title:Current eye research
pub_type: 杂志文章,收录出版
doi:10.1080/02713680590968196
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:To compare the efficacy and tolerability of diclofenac and bromfenac ophthalmic solutions as adjunctive therapy after cataract surgery. MATERIALS AND METHODS:This prospective randomized controlled study included 130 patients who underwent cataract surgery. One hundred patients were randomized to receive postop...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.1080/02713683.2018.1501489
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:It has been demonstrated that chick eye growth compensates for defocus imposed by spectacle lenses: the eye elongates in response to hyperopic defocus imposed by negative lenses and slows its elongation in response to myopic defocus imposed by positive lenses. We ask whether the synthesis of scleral extracellul...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.4.320.10697
更新日期:1997-04-01 00:00:00
abstract:PURPOSE:To investigate the relationship between meibomian gland dysfunction (MGD) and incomplete blinking caused by cranial nerve seven (CN VII) palsy. METHODS:A prospective case series of 60 consecutive patients with unilateral CN VII palsy was evaluated for MGD. According to the House-Brackmann scale, patients were ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1007211
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Current standard of care for neovascular eye diseases require repeated intravitreal bolus injections of anti-vascular endothelial growth factors (anti-VEGFs). The purpose of this study was to validate a degradable microsphere-thermoresponsive hydrogel drug delivery system (DDS) capable of releasing bioactive af...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1533983
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To evaluate clinical outcome(s) and complication(s) of topical bevacizumab (avastin) in patients with impending recurrent pterygium. PATIENTS AND METHODS:This prospective clinical trial included 54 consecutive patients (54 eyes), who underwent pterygium surgery with bare sclera and mitomycin, and who were diag...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713680903395273
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:The expression of human leukocyte antigen (HLA) class II molecules on the cell surface is necessary for the presentation of peptide antigens to helper CD4 T lymphocytes of the immune system. We studied the immunoexpression of HLA class II antigen in conjunctival precursor lesions and conjunctival squamous cell ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.27.3.151.16052
更新日期:2003-09-01 00:00:00
abstract::Thrombospondins are a family of large multi-domain glycoproteins described as matricelluar proteins based on their ability to interact with a broad range of receptors, matrix molecules, growth factors or proteases, and to modulate array of cellular functions including intracellular signaling, proliferation and migrati...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713683.2013.877936
更新日期:2014-08-01 00:00:00
abstract::Two of the major in vitro phosphorylated polypeptides of the bovine lens have been identified. Analysis by means of two-dimensional gel electrophoresis (IEF) has demonstrated that the lens phosphorylated 57,000 and 43,000 dalton polypeptides correspond in mobility to purified phosphorylated bovine lens vimentin and ch...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000838
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:To investigate the association between corneal temperature on ocular surface and stability of tear film, and define the normal reference range of corneal surface temperature in the population of Pudong New Area, Shanghai, China. METHODS:Temperature of cornea (TOC) and tear film break-up time (BUT) were measu...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2016.1167920
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:Proliferative vitreoretinopathy is a serious complication of retinal detachment surgery in which retinal pigment epithelial cells abnormally proliferate within the vitreous cavity and under the retinal surface. Octreotide acetate, a somatostatin analog, has been shown to inhibit the cellular proliferation of a ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689609017634
更新日期:1996-09-01 00:00:00
abstract::In an earlier study we isolated three cyanogen bromide cleavage fragments of bovine IRBP that exhibited high levels of immunopathogenicity, producing inflammatory changes in the eyes (EAU) and pineal gland (EAP) of Lewis rats. These fragments have been localized within the IRBP sequence. In order to identify these put...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809033202
更新日期:1988-07-01 00:00:00
abstract::Lens epithelial cells were isolated from samples of C57BL/6 and CD-1 mice at different ages between 1 and 5 months, and assayed for the level of N-acetyl-beta-glucosaminidase and their ability to replicate in-vitro. The lens epithelial cells from C57BL/6 mice had a reduced replicative potential compared to other norma...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688208996354
更新日期:1982-01-01 00:00:00
abstract::Purpose: Dual wavelength retinal oximetry allows the quantification of oxygen saturation in the larger retinal vessels. However, the technique might be refined further by identifying factors that are responsible for the different oxygen saturations in first order arterioles from the same eye shortly after their branch...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1524015
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To examine the effects of calcitonin gene-related peptide (CGRP) on intraocular pressure (IOP). METHODS:IOP was periodically measured in rabbits treated with intravitreal injection (20 ael) of either: 1) CGRP (10(-4) approximately 10(-7) M) into one eye; 2) CGRP (10(-4) or 10(-6) M) into both eyes 30 min after...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.5.432.5291
更新日期:1999-11-01 00:00:00
abstract::Previous studies have reported the expression of acidic fibroblast growth factor (aFGF) by rat, bovine, and human retinal pigment epithelium (RPE) in vivo. To critically examine the expression of aFGF by RPE cells, we studied the density dependence of steady-state levels of mRNA and protein expression in vitro. Northe...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309029225
更新日期:1993-11-01 00:00:00
abstract:PURPOSE:Investigated the effect of N-3-aminomethylbenzylacetamidine (1400 W), a highly selective inhibitor of inducible nitric oxide synthase (iNOS), on the effector phase of EAU. METHODS:Sixteen Lewis rats were sensitized with bovine retinal S-antigen; ten of them injected subcutaneously with 1400 W (20 mg/kg) three ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.1.1.14250
更新日期:2003-01-01 00:00:00
abstract::An experimental model of optic nerve ischemia was designed in the rabbit to determine early biochemical alterations, i.e.--changes of high energy phosphate metabolites (ATP and phosphocreatine)--in occlusive and peri-occlusive areas. Vascular occlusion provoked a rapid fall of ATP and phosphocreatine in the optic nerv...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209001779
更新日期:1992-03-01 00:00:00
abstract::The ocular penetration pathways of three alpha 2-adrenergic agents (p-aminoclonidine, AGN 190342, and clonidine) were investigated in rabbits both in vitro and in vivo. The corneal permeabilities of the compounds correlated positively with their octanol/water distribution coefficients. The ocular drug absorption via c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008997579
更新日期:1990-11-01 00:00:00
abstract:PURPOSE:To detect the immunohistochemical changes in the main lacrimal glands of patients suffering from chronic ocular sequelae of Stevens-Johnson syndrome (SJS). METHODS:Histological sections of biopsies from the lacrimal gland of three chronic SJS patients (mean age, 33 years; 2 males) with severe dry eye disease (...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1836227
更新日期:2020-10-18 00:00:00
abstract::We assessed in vitro the antimicrobial activity of four agents (vancomycin, teicoplanin, mupirocin, and imipenem) which are effective against Gram-positive cocci causally associated with bacterial keratitis, as well as their corneal epithelial cytotoxicity. Minimal inhibitory concentrations inhibiting 90% of strains (...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309001839
更新日期:1993-07-01 00:00:00
abstract::Purpose: The purpose of this study is to present the study design and one month's preliminary results of a 2-year randomized trial, Combined Atropine with Orthokeratology (AOK), for myopia control study. Methods: Children aged 6 to <11 years and with 1.00-4.00 D myopia were randomly assigned to AOK group or ortho-k al...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.1080/02713683.2019.1568501
更新日期:2019-06-01 00:00:00
abstract::Penetrating keratoplasty was the only therapeutic choice for the treatment of corneal endothelial decompensation until the introduction of evolutional endothelial keratoplasties, namely Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK). Although now...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1700529
更新日期:2020-03-01 00:00:00
abstract::The present study was aimed to demonstrate that cytochrome P-450 was induced by drug administration in particular tissues in the eye. Phenobarbital was used as an inducer. We showed immunohistochemically that cytochrome P-450 was induced in the cornea, conjunctiva and ciliary epithelium of rabbits after four days of i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709034854
更新日期:1987-07-01 00:00:00
abstract:PURPOSE:This study identifies the prevalence and risk factors of sensorineural hearing loss and primary open-angle glaucoma (POAG). MATERIALS AND METHODS:Patients aged 19 years or older who had undergone both ophthalmologic examination and audiometry as part of the Korea National Health and Nutrition Examination Surve...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1712424
更新日期:2020-08-01 00:00:00
abstract::Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the accelerated loss of retinal ganglion cells (RGCs) and their axons. Impaired axonal transport has been implicated as a pathogenic mechanism in a number of neurodegenerative diseases, including glaucoma. The long RGC axon, with its...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713683.2015.1037924
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Transforming growth factor -beta2 (TGF-beta2) is a predominant isoform of TGF-betas in the eye and plasmin is a peptidase with many functions. To better understand the pathogenesis of retinal microcirculation disorders, the effects of TGF-beta2 and plasmin on cultured bovine retinal pericytes were investigated....
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:PURPOSE:To review the microbiological spectrum and antibiotic sensitivities of the pathogens that cause culture-proven endophthalmitis and to understand the status and trends of antibiotic susceptibility at a public hospital over a 10-year period. METHODS:The data of 577 culture-proven endophthalmitis isolates collect...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1188118
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Experiments were performed to evaluate the effect of various pro- and anti-inflammatory cytokines on the human fetal retinal pigment epithelium's (HFRPE) expression of major histocompatibility complex (MHC) and costimulatory molecules. METHODS:Pure cultures of HFRPE cells were isolated. HFRPE cells were incuba...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.4.285.5456
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:Whether there is an interaction between eyes of individual subjects in refractive development is an important issue to guide experimental designs and help understand mechanisms involved in development of refractive errors. This study investigated whether spontaneous high myopia in one eye will affect refractive...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.568660
更新日期:2011-06-01 00:00:00