Abstract:
PURPOSE:To examine the effects of calcitonin gene-related peptide (CGRP) on intraocular pressure (IOP). METHODS:IOP was periodically measured in rabbits treated with intravitreal injection (20 ael) of either: 1) CGRP (10(-4) approximately 10(-7) M) into one eye; 2) CGRP (10(-4) or 10(-6) M) into both eyes 30 min after intravitreal administration of CGRP-(8-37) (10( -3) M), a CGRP1 receptor antagonist, into one eye; 3) CGRP (10(-4 ) or 10(-6) M) into one eye 30 min after intravenous administration (200 mg/kg) of either Nw-nitro-L-arginine methyl ester (L-NAME), a nonselective inhibitor of nitric oxide synthase (NOS), or aminoguanidine (AG), a selective inhibitor of inducible NOS; or 4) CGRP (10(-4) or 10(-6) M) into one eye along with intraperitoneal indomethacin (50 mg/ kg at -1 and 4 h). RESULTS:CGRP (10(-4) and 10(-5) M) produced a biphasic IOP response, which consisted of an early ocular hypertensive phase and a subsequent sustained hypotensive phase. While CGRP (10(-6) M) yielded only a profound IOP reduction. CGRP-(8-37) significantly inhibited the IOP elevation induced by CGRP (10(-4) M) and completely abolished the IOP reduction induced by CGRP (10(-6) M). The IOP increase induced by CGRP (10(-4) M) was completely abolished by L-NAME, but not affected by AG. The IOP reduction induced by CGRP (10(-6) M) was not affected by L-NAME. Indomethacin did not significantly affect the IOP responses to CGRP. CONCLUSIONS:CGRP dose-dependently produces a biphasic IOP response, which is mediated by CGRP1 receptors. It is suggested that constitutive NOS is involved in the early ocular hypertensive response.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Taniguchi T,Nakai Y,Karim Z,Gu ZB,Kawase K,Kitazawa Ydoi
10.1076/ceyr.19.5.432.5291subject
Has Abstractpub_date
1999-11-01 00:00:00pages
432-8issue
5eissn
0271-3683issn
1460-2202journal_volume
19pub_type
杂志文章abstract:PURPOSE:To investigate whether retinal impairment was affected by age of rats in acute glaucoma model. METHODS:Young adult and aged rats were randomly divided into normal control, 45 mmHg, 60 mmHg and 90 mmHg groups. Intraocular pressures (IOP) of rats were acutely elevated to 45 mmHg, 60 mmHg and 90 mmHg, respectivel...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.922194
更新日期:2015-03-01 00:00:00
abstract::Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for aver...
journal_title:Current eye research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/02713688709020104
更新日期:1987-01-01 00:00:00
abstract:AIM OF THE STUDY:The similarity of many benign intrabulbar lesions to a malignant tumor requires detailed differential diagnostics. However, none of the known methods can be used as the only one to determine the type of lesions. The aim of this study was to determine color Doppler imaging (CDI) markers characteristic o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1341534
更新日期:2017-11-01 00:00:00
abstract::Ocular aldehyde oxidase was purified for the first time from bovine ciliary body cytosol by ammonium sulfate fractionation and successive HPLC using DEAE anion-exchange and hydroxyapatite columns. The purified enzyme was homogeneous by the criterion of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The mol...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909025807
更新日期:1989-07-01 00:00:00
abstract::Samples of aqueous humor from rabbits and humans were examined for growth effects on subconfluent monolayer fibroblast cultures from ocular and extraocular tissues. At a concentration of 20% aqueous by medium volume, both homologous and heterologous aqueous stimulated DNA synthesis in fibroblasts from both species. Th...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688209020019
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To evaluate changes in biometric parameters in myopic eyes. MATERIALS AND METHODS:412 eyes of 412 young myopic patients underwent ophthalmic examinations including assessments of refractive error, axial length (AL), anterior chamber depth (ACD), and central corneal thickness (CCT). By using spectral domain opt...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1130229
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To compare serum levels of chemerin in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between serum chemerin levels and diabetes retinopathy. MATERIALS AND METHODS:A total of 60 T2DM patients and 20 healthy subjects (control group) were enrolled in this study. ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1004718
更新日期:2016-01-01 00:00:00
abstract::Purpose: To investigate the cytotoxic effects of fresh black carbon (FBC) particles and ozone-oxidized BC (OBC) particles on human corneal epithelial cells (HCECs), and the role of the NLRP3 inflammasome signal pathway in the process.Methods: HCECs were treated with different doses of FBC and OBC particles, the cell i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1698051
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To evaluate the length of the trabecular meshwork (TM) from the scleral spur (SS) to Schwalbe's line (SL) and assess the detectability of the SS in histopathology specimens. METHODS:This study included 158 angle images from 79 cross-sectional slides derived from eyes enucleated for melanoma. The slides were st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.700757
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To establish autologous iris pigment epithelial (IPE) cell transplantation in monkey eyes. METHODS:Autologous IPE cells from three monkeys were obtained by peripheral iridectomy, and cell culture was performed with autologous serum. The cultured cells were labeled with DiI, and transplantation was performed by...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::The objective of this study was to determine if 20:5n-3 or 22:6n-3 is the primary precursor of very-long-chain fatty acids (VLCFAs; C24-C36) synthesized in retina. Rats were fed semisynthetic, nutritionally complete diet containing 20% (w/w) fat with 3% (w/w) of 22:6n-3. After 6 weeks feeding, the vitreal fluid of eac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680500246957
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To assess the effect of aging on optical quality in a normal population. METHODS:We prospectively examined 100 normal eyes of 100 healthy volunteers (50 men, 50 women; ages, 20-69 years; mean age ± standard deviation, 44.6 ± 15.5 years). We quantitatively assessed the values of MTF cutoff frequency, Strehl rat...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713683.2012.688164
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To investigate the repeatability of macular and peripapillary retinal nerve fiber layer (RNFL) thickness measurements made using swept-source optical coherence tomography (SS-OCT) and automated segmentation. Measurements were made in non-diabetic controls and in patients with diabetic retinopathy (DR) with or w...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2016.1170855
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:In the mature retina retinoic acid (RA) biosynthesis was reported to be regulated by light. RA is of vital importance for proper function of the retina. RA activity is mediated by interaction with nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The purpose of this study was to determine ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.4.338.5307
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:To determine whether the usual clinical dose of intravitreal dexamethasone can attenuate intraocular inflammation and retinal necrosis in a rabbit model of fulminant Bacillus cereus endophthalmitis induced by crude exotoxins. METHODS:Thirty-six eyes from pigmented mongrel rabbits received intravitreal injectio...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490516701
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:Both HSV-1 and HSV-2 express LAT during viral latency. Previous studies indicated that deletion of either LAT impairs viral reactivation from latency, but that the HSV-1 LAT confers the ability to reactivate efficiently from trigeminal ganglia onto HSV-2. We sought to determine whether the HSV-2 LAT could funct...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.3.219.14896
更新日期:2003-03-01 00:00:00
abstract::The cytoskeletal proteins of the human lens were studied by SDS-PAGE, 2-D electrophoresis and immunologically. Spectrin, vimentin and actin were identified in the superficial fiber cells of human lenses even to age 87 years. These proteins are lost from the deeper cortical and nuclear fiber cells, where a broad zone o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688408997222
更新日期:1984-02-01 00:00:00
abstract::Inhibition of ciliary process adenylate cyclase was studied on rabbit membrane preparations. When considered individually, epinephrine, GTP and NaCl did not inhibit adenylate cyclase activity. On the other hand, when present together, epinephrine, GTP (10(-5) M) and NaCl (200 mM) acted synergistically to cause a 27% i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809047034
更新日期:1988-03-01 00:00:00
abstract:PURPOSE:Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis. This study, employing an experimental rabbit model of Staphylococcus aureus keratitis, investigated the effectiveness of topical taurolidine in reducing the number of bact...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490908733
更新日期:2005-03-01 00:00:00
abstract::We established growth curves for Propionibacterium acnes isolates recovered from eyes with chronic postoperative endophthalmitis. The growth curve plotted the average of the duplicate bacterial concentration against time. The generation time for P. acnes calculated from the growth curves was approximately 5.1 hours. T...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408999875
更新日期:1994-06-01 00:00:00
abstract:PURPOSE:A retrospective study was developed to evaluate risk factors in adult-onset myopia. METHODS:Subjects included were 25 to 35 years old. There were 116 non-myopic subjects in the control group and 66 myopic subjects with first lens prescription at age 17 or later. Subjects received a questionnaire about academic...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.25.5.309.13494
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To evaluate clinical outcome(s) and complication(s) of topical bevacizumab (avastin) in patients with impending recurrent pterygium. PATIENTS AND METHODS:This prospective clinical trial included 54 consecutive patients (54 eyes), who underwent pterygium surgery with bare sclera and mitomycin, and who were diag...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713680903395273
更新日期:2010-01-01 00:00:00
abstract::Processing of visual information within the retina depends in large measure upon a complement of chemical neurotransmitters which are released at synaptic contacts between individual neurons. Numerous investigators have participated in the identification of many of these transmitters and their assignment to specific n...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713689609003465
更新日期:1996-07-01 00:00:00
abstract:PURPOSE:To evaluate the toxicity of indocyanine green (ICG) in combination with light. METHODS:Human retinal pigment epithelial cells (ARPE-19) and rat neurosensory retinal cells (R28) were treated with four different concentrations of ICG in combination with light exposure. Cell viability, mitochondrial function, and...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680590959312
更新日期:2005-06-01 00:00:00
abstract::Rainbow trout (Oncorhynchus mykiss) were used to model the solar radiation-induced cataract that occurs in hatchery-reared lake trout (Salvelinus namaycush). Rainbow trout eyes were exposed to wideband predominantly UVB radiant energy from a filtered 1000W xenon source. Lenticular damage was assessed and classified an...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689308999477
更新日期:1993-02-01 00:00:00
abstract:PURPOSE:Previous studies revealed an association of tumor necrosis factor super family-15 (TNFSF15) gene polymorphisms with several autoimmune diseases, but their roles in the development of Graves' disease (GD) and Graves' ophthalmopathy (GO) remain unclear. The aim of this study was to explore the correlation between...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1705494
更新日期:2020-07-01 00:00:00
abstract::Although patients with diabetic retinopathy have been reported to have elevated vitreal IGF-I levels, it is not known whether diabetes also affects the levels of vitreal IGF binding proteins (IGFBPs) which control IGF's bioavailability. To address this issue, vitreal IGFBP levels were assayed in human diabetics, rats ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408999886
更新日期:1994-07-01 00:00:00
abstract::Posterior vitreous detachment (PVD) and epiretinal membranes occur in a number of vitreoretinal diseases. We have developed an experimental model in which we can provide the morphologic correlation of these dynamic processes. The method provides the opportunity to study epiretinal membrane formation with the scanning ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609020055
更新日期:1986-04-01 00:00:00
abstract:PURPOSE:To determine whether substance P is present in human tears. METHODS:Tear samples (1-2 microliters) were collected from one eye of each of 12 subjects. Two of the eyes had dry eye syndrome, two wore contact lenses and had dry eye syndrome, and eight were normal. Five of the eight normal eyes were scheduled to u...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.9.960.5040
更新日期:1997-09-01 00:00:00
abstract:PURPOSE:To study the effect of cataract surgery with intraocular lens (IOL) on frequency doubling perimetry (FDP). METHODS:Patients aged 40 years or above seen at our outpatient clinic with no ocular pathology except for visually significant cataract and visual acuity 6/24 or better were eligible. They underwent FDP b...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490904278
更新日期:2005-02-01 00:00:00