Abstract:
PURPOSE:To determine whether the usual clinical dose of intravitreal dexamethasone can attenuate intraocular inflammation and retinal necrosis in a rabbit model of fulminant Bacillus cereus endophthalmitis induced by crude exotoxins. METHODS:Thirty-six eyes from pigmented mongrel rabbits received intravitreal injections of varying concentrations of crude B. cereus exotoxins with or without concomitant injections of 400 microg of dexamethasone sodium phosphate (0.1% solution). After ophthalmoscopic examination at 4 or 18 hr postinjection, the animals were killed and histopathologic findings graded. RESULTS:Intraocular inflammation and retinal necrosis scores in eyes receiving both exotoxins and dexamethasone did not differ significantly from eyes receiving exotoxins alone for any exotoxin dose at 4 or 18 hr. The severity of retinal necrosis increased with toxin dose and was nearly maximal after 4 hr. Intraocular inflammation also generally increased with dose, but continued to increase until 18 hr. CONCLUSIONS:Standard clinical doses of intravitreal dexamethasone do not appear to attenuate the intraocular inflammatory or tissue response to secreted B. cereus exotoxins. Other treatment modalities including vitrectomy, to decrease exotoxin load, and exotoxin inhibitors may be necessary for the effective treatment of B. cereus endophthalmitis.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Pollack JS,Beecher DJ,Pulido JS,Lee Wong ACdoi
10.1080/02713680490516701subject
Has Abstractpub_date
2004-10-01 00:00:00pages
253-9issue
4-5eissn
0271-3683issn
1460-2202pii
NU637J2HAFXW3N0Wjournal_volume
29pub_type
杂志文章abstract:PURPOSE:This study was undertaken in order to investigate whether the production of vasodilatory prostaglandins is increased in the retinal vasculature of the diabetic rat. METHODS:Diabetes was induced in male Sprague-Dawley rats using streptozotocin. Diabetic rats were left uncontrolled for 3-4 weeks or were treated ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.2.79.5386
更新日期:1999-02-01 00:00:00
abstract::Purpose/Aim: To determine the associations among socioeconomic factors, delay in management, and high-risk histopathologic features in eyes primarily enucleated for retinoblastoma. Materials and Methods: A single-site survey was conducted from January 2016 through January 2018. Eyes primarily enucleated for unilateral...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1623898
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Aqueous extract of Pleurotus tuberregium (PT) has been shown to reduce intraocular pressure (IOP) but the underlying mechanism has not been explained. PURPOSE:To investigate the effect of PT on the bovine iris in vitro in comparison with acetylcholine (ACh). METHOD:Strips of the iris were mounted in 10 ml ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.747615
更新日期:2013-03-01 00:00:00
abstract::In these experiments we characterize rabbit and bovine corneal endothelia cell cultured on microporous membrane filters (0.6cm2). Cell cultured bovine or rabbit corneal endothelial cells (subcultures 1-3) were seeded onto Millicell-HA filter inserts. Electrical resistance measured across the cultured monolayers increa...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209069168
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Due to a possible link in humans between atherosclerosis, a high-fat diet, and the development of age-related retinal degenerations, we investigated retinal changes with age and diet in high-fat-fed C57BL/6 mice, a mouse model of human atherosclerosis. METHODS:We fed C57BL/6J mice either a normal chow diet or ...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:There is limited information on region-specific gene expression in the human corneal stroma. In this study, we aimed to investigate the expression profile of the extracellular matrix and adhesion molecules in the normal corneal stroma using laser capture microdissection (LCM) and molecular techniques. METHODS:...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1200099
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:This study was designed to investigate the presence of the secretory phospholipase A2 receptor in RPE, a protein closely related to the phagocytic mannose receptor. METHODS:Proteins from cultured rat, pig, and human RPE were separated by SDS-PAGE and immunoblotted with a polyclonal guinea pig sPLA2 receptor an...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.1.1.5345
更新日期:1999-07-01 00:00:00
abstract:PURPOSE:Mechanical stimulation induces intercellular Ca(2 +) waves in the corneal endothelium. The extent of the wave propagation is dependent on the activity of gap junctions, hemichannels, and ectonucleotidases. To further establish the use of a cell culture model to investigate intercellular communication, in this s...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680902913022
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Diabetes has been associated with decline in accommodative function in some ethnic groups. This outcome, however, could differ since ethnic variations in accommodation have been noted. This study investigated the relationship between plasma sugar level on subjective accommodative amplitude and accommodative ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1056803
更新日期:2016-06-01 00:00:00
abstract::Inoculation of herpes simplex virus Type 1 into the anterior chamber of BALB/c mice induces a characteristic ocular infection involving primarily the anterior segment of virus-injected eyes and the retina of contralateral uninjected eyes. In the BALB/c strain, which is susceptible to herpetic retinitis, anti-HSV delay...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688808995741
更新日期:1988-02-01 00:00:00
abstract:PURPOSE:To determine the roles of the murine interleukin-8 receptor homolog (mIL-8Rh, neutrophil chemokine CXC receptor 2) and macrophage inflammatory protein-1alpha (MIP-1alpha, a CC chemokine) in two eye inflammation models: endotoxin-induced uveitis (EIU) and immune complex-induced uveitis (reverse passive Arthus re...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.1.76.5339
更新日期:1999-07-01 00:00:00
abstract:PURPOSE:There is a substantial literature showing that the selective estrogen receptor modulator tamoxifen can block swelling-activated chloride channels, such as those in astrocytes. This study aimed to test the hypothesis that anatomic characteristics consistent with swelling may be measured within the optic nerve he...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600602547
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:To learn if peripheral nerve pathways are necessary for corneal expansion and anterior segment growth under a 12-hr light:dark cycle or for the inhibition of corneal expansion under constant light rearing. METHODS:Recently hatched White Leghorn chicks under anesthesia received unilateral ciliary ganglionectomy...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600738127
更新日期:2006-06-01 00:00:00
abstract::We have either introduced into the vitreous space or perfused through the anterior chamber of macaque monkey eyes two anionic tracers, anionic ferritin (AF) and horseradish peroxidase (HRP) and a cationic probe, cationic ferritin (CF). We have observed that the anionic molecules, but not the cationic one, are transpor...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688509025167
更新日期:1985-04-01 00:00:00
abstract:PURPOSE:To investigate the antiproliferative effects of the subconjunctival injection of human RAD50 (hRAD50) on fibroblasts after glaucoma filtering surgery. METHODS:After glaucoma filtering surgery in normal rabbit eye, the subconjunctival injection of hRAD50 was performed. Morphologic changes in the subconjunctival...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.3.181.26247
更新日期:2004-03-01 00:00:00
abstract::Phosphorylated proteins of the chick lens were identified following incubation of lenses in a medium containing 32P and subsequent analysis by gel electrophoresis. The acidic variant of the vimentin and both subunits of fodrin were phosphorylated, as were the 95 Kd and 49 Kd proteins associated with the beaded-chain f...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409167214
更新日期:1984-07-01 00:00:00
abstract::The new HERPCHEK (Dupont, No. Billerica, MA) enzyme immunosorbent assay (EIA) was used in a double-blind clinical study for rapid and specific detection of ocular herpes simplex virus (HSV) infection. This 4-hour assay can be used to demonstrate conclusively the presence of HSV antigen without culture and thereby rapi...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713688809033194
更新日期:1988-07-01 00:00:00
abstract:PURPOSE:To optimize cultured human corneal endothelial cell (cHCEC) sheet transplantation technique for maintenance of cHCEC viability. MATERIALS AND METHODS:cHCEC sheets cultured on a collagen scaffold were covered with or without Viscoat® and exposed to humidified air in the incubator. cHCEC sheets with or without V...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1101774
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:Pigmentation of the iris is caused by varying amounts of melanin pigment granula in a constant number of melanocytes in the superficial stroma. Melanin has been shown to act as antioxidant. We have now investigated lipid peroxidation in dependence on stromal pigmentation in isolated porcine irises. METHODS:The...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.22.3.229.5511
更新日期:2001-03-01 00:00:00
abstract::A major glycoprotein of relative molecular weight of 130,000 daltons of chick lens cell membranes was identified by Concanavalin-A staining and enriched for by Con A-Sepharose chromatography. Using both Con A binding and immunological analyses with a specific polyclonal antibody, the glycoprotein was detected in chick...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688608995176
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:This work compares the concentration of active ingredients and preservatives in commonly used brand name versus generic glaucoma medications. MATERIALS AND METHODS:Active ingredient and benzalkonium chloride (BAK) concentrations in brand name latanoprost and dorzolamide-timolol were each compared to two gen...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.631722
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:The aim of this review is to evaluate the efficacy of available Purtscher's Retinopathy treatments. MATERIALS AND METHODS:In order to collect single-case reports, electronic searches were conducted in several databases including PubMed, Embase, Web of Science, China National Knowledge Infrastructure, SinoMed...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.1080/02713683.2016.1255335
更新日期:2017-06-01 00:00:00
abstract::Purpose: The purpose of this study is to present the study design and one month's preliminary results of a 2-year randomized trial, Combined Atropine with Orthokeratology (AOK), for myopia control study. Methods: Children aged 6 to <11 years and with 1.00-4.00 D myopia were randomly assigned to AOK group or ortho-k al...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.1080/02713683.2019.1568501
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Membrane-associated mucins are important components of the ocular tear film. Our objective was to characterize the expression of membrane-associated mucins MUC1, MUC4, and MUC16 in healthy cornea, healthy conjunctiva, fibrovascular tissue (pannus) covering the corneal surface in limbal stem cell deficiency (LSC...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802699408
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To assess the upper eyelid kinematics during spontaneous blinking in unilateral paralytic lagophthalmos before and after upper eyelid load with gold weight (GW) or autogenous temporalis fascia (TF) sling. DESIGN:Comparative case series. SUBJECTS:Patients with long-standing unresolved unilateral facial palsy w...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2015.1031252
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Predicting the toxic potential of compounds to the ocular surface has depended on the Draize test for the past half century. Alternatives to Draize testing have recently been sought for a number of reasons. Stress gene expression has emerged as a means of quantifying cellular reaction and, thus, the toxic poten...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.2.115.5325
更新日期:1999-08-01 00:00:00
abstract::From knowledge of the optical parameters of experimental animal eyes and radiometric parameters of the light source, it is possible to provide accurate retinal irradiances (dose rates). Examples are given for the rat, cat, monkey and other animals of interest. Fluorescent lamps and incandescent lamp radiances are prov...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688408997199
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:Post-surgical macular edema is an important clinical problem resulting from breakdown of the blood-retinal barrier (BRB) after surgery. This study was designed to develop a mouse model of post-surgical BRB breakdown. METHODS:Two 25-gauge needles, one for infusion and one for aspiration, were inserted through t...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490503769
更新日期:2004-06-01 00:00:00
abstract::We studied the protective effects of passive immunization with virus specific antibody in newborn rabbits inoculated subcutaneously with type 2 herpes simplex virus (HSV-2). Newborn rabbits given anti-HSV-2 antibody intraperitoneally (IP) on days 0, 2 and 4 post infection had smaller herpetic skin lesions and reduced ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709020084
更新日期:1987-01-01 00:00:00
abstract::The variation of central corneal thickness with age was measured weekly at 10am by ultrasound pachometry in 10 normal (5 to 19 weeks of age) and 10 alloxan-induced diabetic (9 to 19 weeks of age) rabbits. The diurnal variation of corneal thickness was also measured at 2 hour intervals for a period of 24 hours on both ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999611
更新日期:1990-05-01 00:00:00