Abstract:
:Rainbow trout (Oncorhynchus mykiss) were used to model the solar radiation-induced cataract that occurs in hatchery-reared lake trout (Salvelinus namaycush). Rainbow trout eyes were exposed to wideband predominantly UVB radiant energy from a filtered 1000W xenon source. Lenticular damage was assessed and classified and comeal damage noted. Lenticular threshold radiant exposure was 0.48 J.cm-2 which is in the same range as the mammalian lens. Permanent lenticular damage occurred at radiant exposure levels approximately twice the threshold for lenticular radiant exposure (also similar to the mammalian response). Slit-lamp and scanning electron microscopical results support the theory of post-exposure anterior subcapsular epithelial cell damage, lens fibre swelling, and eventual rupture, leading to areas of lower refractive index in the anterior subcapsular region of the lens.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Cullen AP,Monteith-McMaster CAdoi
10.3109/02713689308999477subject
Has Abstractpub_date
1993-02-01 00:00:00pages
97-106issue
2eissn
0271-3683issn
1460-2202journal_volume
12pub_type
杂志文章abstract:PURPOSE:To evaluate the point-wise relationships between visual field sensitivity (VFS), as measured by standard automated perimetry (SAP), and macular thickness, as determined by spectral-domain optical coherence tomography (SD-OCT), in patients with glaucoma. MATERIALS AND METHODS:One hundred and six glaucoma subjec...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713683.2013.787433
更新日期:2013-08-01 00:00:00
abstract::Using phosphorus-31 nuclear magnetic resonance (P-31 NMR) spectroscopy the rat crystalline lens was evaluated as a potential animal model for the study of lens metabolic processes relevant to the human. The P-31 NMR spectra of intact rat lenses and rat lens PCA extracts provided comparable qualitative and quantitative...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019974
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:To study the mechanisms of peroxynitrite-induced photoreceptor cell damage, using retinal cultures and a peroxynitrite donor, 3-morpholinosydnonimine (SIN-1). METHODS:Retinal explants obtained from 20-day-old Lewis rat pups, were exposed to SIN-1 for varying lengths of time at varying concentrations. Apoptosis...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.1.17.23488
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To develop a standardized method for measuring from iris photographs, light and dark segments of areas and densities of iris color. METHODS:Computerized image analysis was used to measure the iris photographs. The reproducibility of this method was studied in 30 normal eyes with three different colored irides,...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.22.6.412.5490
更新日期:2001-06-01 00:00:00
abstract::In these experiments we characterize rabbit and bovine corneal endothelia cell cultured on microporous membrane filters (0.6cm2). Cell cultured bovine or rabbit corneal endothelial cells (subcultures 1-3) were seeded onto Millicell-HA filter inserts. Electrical resistance measured across the cultured monolayers increa...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209069168
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation research, the quest to understand RPE physiology, and a desire to modulate RPE in pathological states. W...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1809001
更新日期:2020-09-01 00:00:00
abstract:PURPOSE/AIM OF THE STUDY:The aim of this study is to investigate the effect of pseudoexfoliation (PEX) and PEX-induced dry eye on central corneal thickness (CCT). MATERIALS AND METHODS:This cross-sectional study consists of total 270 eyes of 135 patients (67 females, 68 males) in total. After excluding the PEX (-) 32 ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1030505
更新日期:2016-01-01 00:00:00
abstract::We previously reported that Ia+ monolayers of LEW rat corneal endothelial (CE) cells were unable to stimulate proliferation of MHC compatible T cell lines or IL-2 release from hybridomas, and inhibited [3H]-thymidine incorporation when added to conventional lymphocyte proliferation assays. Our purpose was to further a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408999891
更新日期:1994-08-01 00:00:00
abstract:PURPOSE:Retinoblastoma (RB) is the most common intraocular malignancy in children. Deregulation of several miRNAs has been identified in RB, suggesting a potential role in tumorigenesis. Recent evidence suggests that many dietary components like folate, retinoids and curcumin act as potential anticancer/antiproliferati...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.647224
更新日期:2012-05-01 00:00:00
abstract::Prorenin (PR) was localized by electron microscopic (EM) immunostaining of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunostaining. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, part...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309020401
更新日期:1993-10-01 00:00:00
abstract::Goggles that degrade the retinal image produce axial enlargement of the ocular globe and large myopic refractive errors. Many authors have assumed that visual image degradation itself leads to myopia. Hodos and co-authors have shown, however, that goggled eyes in chicks are considerably warmer than normal. Such temper...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689308999467
更新日期:1993-03-01 00:00:00
abstract:PURPOSE:Methotrexate (MTX) is the most commonly used chemotherapeutic agent to treat primary central nervous system lymphoma (PCNSL) and intraocular lymphoma (IOL). 2-methoxyestradiol (2ME2) is a potent antitumor and anti-angiogenesis agent which, unlike other cytotoxic drugs, has minimal toxicity. In this study, anti-...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680701473244
更新日期:2007-07-01 00:00:00
abstract::The effects of 4% epinephrine bitartrate and 0.5% timolol on ocular and optic nerve blood flow were studied in phakic and aphakic rabbit eyes using a radioactive microsphere (85Sr) technique. Either epinephrine or timolol was given topically as eight drops in the hour immediately preceding blood flow measurements (one...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000822
更新日期:1984-10-01 00:00:00
abstract:PURPOSE:There is limited information on region-specific gene expression in the human corneal stroma. In this study, we aimed to investigate the expression profile of the extracellular matrix and adhesion molecules in the normal corneal stroma using laser capture microdissection (LCM) and molecular techniques. METHODS:...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1200099
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:After corneal injury, persistent epithelial defects (PED's) may occur due to the chronic failure of the regenerating epithelium to adhere to the underlying stroma. The aim of this study was to examine the potential of epsilonaminocaproic acid (EACA) as a topical treatment for PED's. EACA inhibits the activation...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.2.150.5382
更新日期:1999-02-01 00:00:00
abstract::Four groups of BALB/c mice were treated locally with different concentrations (0.1-1.0%) of retinoic acid (Etretinate) ointment for a period of one to four weeks. A fifth group was treated with the ointment base only. Ia-positive dendritic cells were identified by an indirect immunofluorescence technique which was con...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689509033511
更新日期:1995-03-01 00:00:00
abstract:PURPOSE:The experiments were designed to provide details on the characteristics of rhodopsin regeneration in the rod photoreceptors of diabetic mice and to evaluate their mechanistic basis. METHODS:A genetically-derived diabetic albino mouse was developed. An excised albino mouse eye preparation was used. The preparat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.10.979.5236
更新日期:1998-10-01 00:00:00
abstract::Posterior vitreous detachment (PVD) and epiretinal membranes occur in a number of vitreoretinal diseases. We have developed an experimental model in which we can provide the morphologic correlation of these dynamic processes. The method provides the opportunity to study epiretinal membrane formation with the scanning ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609020055
更新日期:1986-04-01 00:00:00
abstract:PURPOSE:The purpose of the current study is to assess changes in the expression of Acid-Sensing Ion Channel (ASIC)1a and ASIC2 in retinal ganglion cells (RGCs) after retinal ischemia and reperfusion (I/R) injury and to test if inhibition of ASIC1a provides RGC neuroprotection. METHODS:Transient ischemia was induced in...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1454478
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:Maintaining the high glutathione (GSH; tripeptide of glutamate, cysteine and glycine) levels in the lens cortex promotes lens health. The role of glutamate/aspartate (Glu/Asp) transporters and the cystine (Cys)/Glu exchanger (Xc(-) exchanger) in maintaining GSH in transformed human lens epithelial cells (SRA 01...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1017651
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To investigate the antiproliferative effects of the subconjunctival injection of human RAD50 (hRAD50) on fibroblasts after glaucoma filtering surgery. METHODS:After glaucoma filtering surgery in normal rabbit eye, the subconjunctival injection of hRAD50 was performed. Morphologic changes in the subconjunctival...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.3.181.26247
更新日期:2004-03-01 00:00:00
abstract::The intraocular inflammatory reaction in a murine model of herpes simplex keratouveitis was studied using immunohistochemical techniques. 5 x 10(5) PFU of HSV-1 (Stewart strain) was applied to the abraded cornea of BALB/c mice. The subsequent development of keratouveitis was documented by sequential examination, conve...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909013892
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:In keratoconus corneas, it has been shown that levels of degradative enzymes and transcription factor Sp1 are elevated and those of inhibitors are reduced, especially in the epithelial layer. This study is to determine whether the biochemical abnormalities identified in corneas also exist in conjunctival tissue...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.21.5.886.5538
更新日期:2000-11-01 00:00:00
abstract:PURPOSE:To examine the association between macular pigment optical density (MPOD) and rod-mediated dark adaptation (RMDA) in persons ≥60 years old with normal maculas as determined by an accepted color fundus photography grading system. METHODS:This cross-sectional analysis used baseline data from eyes in the Alabama ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1460380
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:Matrix metalloproteinases (MMPs) are involved in posterior capsule opacification (PCO), but the mechanisms that promote MMP expression are yet to be determined. In this study, we investigated whether type I collagen, which is only detected in aged or cataractous lens capsules, affects the expression and activat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.853194
更新日期:2014-05-01 00:00:00
abstract::A method is described for the preparation of plasma membrane enriched fractions from bovine retinal pigment epithelium (RPE) by means of differential centrifugation followed by the use of self forming gradients of Percoll. A detailed analysis of the distribution of organelle specific markers (nuclei, mitochondria, lys...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000806
更新日期:1984-09-01 00:00:00
abstract:PURPOSE:Transplantation of in vitro cultured limbal epithelial stem cells (LESCs) is a treatment widely used for LESC deficiency. However, the number of limbal tissue donors is limited, and protocols for LESC cultivation often include compounds and/or feeder layers that can induce side effects and/or increase the cost ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1250278
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:The similar and overlapping activity of VEGF and the potent corneal-derived angiogenic eicosanoid 12(R)-HETrE calls for a study of the temporal relationship in the expression of these two autocoids. Since recent evidence suggests that hypoxia induces the expression of a CYP4B1 mRNA which might be involved in th...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.1.1.5422
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:Corneal scarring is a common poor outcome of corneal trauma. Transforming growth factor β-1 plays a vital role in corneal fibrosis, inducing keratocyte transformation to myofibroblasts. Other than corneal transplantation, no other curative treatment methods for corneal scarring are currently available. Hypercap...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1820526
更新日期:2020-09-11 00:00:00
abstract:PURPOSE:Endothelial cells of different vascular systems may express site-specific adhesion molecules to attract leukocyte subsets. This study describes a method to visualize and compare leukocyte-endothelial interactions in three vascular beds within the same eye in mice. METHODS:Digital in vivo fluorescence microscop...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.24.3.214.8303
更新日期:2002-03-01 00:00:00