Reduction in choroidal blood flow occurs in chicks wearing goggles that induce eye growth toward myopia.

Abstract:

:Goggles that degrade the retinal image produce axial enlargement of the ocular globe and large myopic refractive errors. Many authors have assumed that visual image degradation itself leads to myopia. Hodos and co-authors have shown, however, that goggled eyes in chicks are considerably warmer than normal. Such temperature changes may either underlie or be a consequence of alterations in choroidal blood flow (CBF). Since alterations in CBF could affect eye growth, we explored the effect of monocular goggling on CBF in chicks. Plastic goggles were glued over one eye in four-day old chicks and the goggles were left in place for 12 or 14 days. Fourteen days after the goggling, CBF was measured using laser Doppler velocimetry. Three groups of chicks were studied: 1) chicks with goggles for 14 days; 2) chicks with goggles for 12 days followed by no goggles for the two days; 3) age matched non-goggled chicks. A -scan ultrasonography confirmed that the visual deprivation produced vitreous chamber elongation in the goggled eye and that the degree of elongation for the goggled eye was the same for the two goggled groups. The results were: 1) blood flow in non-goggled chicks was similar in both eyes; 2) blood flow was significantly reduced in the goggled eye in chicks wearing goggles for 14 days- 37% of control; and 3) blood flow was still significantly reduced in the goggled eye in chicks whose goggles were removed two days before measurement- 51% of control. These results show that CBF is reduced by goggles that result in myopic eye growth.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Shih YF,Fitzgerald ME,Norton TT,Gamlin PD,Hodos W,Reiner A

doi

10.3109/02713689308999467

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

219-27

issue

3

eissn

0271-3683

issn

1460-2202

journal_volume

12

pub_type

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