Measurement of iris color using computerized image analysis.


PURPOSE:To develop a standardized method for measuring from iris photographs, light and dark segments of areas and densities of iris color. METHODS:Computerized image analysis was used to measure the iris photographs. The reproducibility of this method was studied in 30 normal eyes with three different colored irides, green-brown, blue-grey brown and yellow-brown. Three photographs were taken of each iris with a slit lamp camera at three different exposures at baseline. The photographs were repeated with exposure providing for the best reproducibility at 6.5 +/- 1.7 months as a first follow-up after baseline and 3.6 +/- 0.8 months following the first follow-up visit. At least one measurement was made for each photograph. RESULTS:The mean percent coefficient of variation (standard deviation of triplicate measurements/mean x 100) ranged from 1.0 to 4.1% for area and density measurements. Furthermore, the range of mean percent differences between baseline and follow-up visits ranged from 1.2 to 6.3%. CONCLUSION:We have developed a standardized method which appears suitable for measuring changes over time in iris color.


Curr Eye Res


Current eye research


Takamoto T,Schwartz B,Cantor LB,Hoop JS,Steffens T




Has Abstract


2001-06-01 00:00:00












  • Specialized moisture retention eyewear for evaporative dry eye.

    abstract:OBJECTIVES:To evaluate the suitablity of commercially available moisture retention eyewear for treating evaporative dry eye. METHODS:Eleven patients with evaporative dry eyes were prescibed moisture retention eyewear for 3 months in addition to regular lubricant eye drops. Frequency and severity of dry eye symptoms, c...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Waduthantri S,Tan CH,Fong YW,Tong L

    更新日期:2015-05-01 00:00:00

  • Topical aminocaproic acid facilitates reepithelialization of persistent epithelial defects.

    abstract:PURPOSE:After corneal injury, persistent epithelial defects (PED's) may occur due to the chronic failure of the regenerating epithelium to adhere to the underlying stroma. The aim of this study was to examine the potential of epsilonaminocaproic acid (EACA) as a topical treatment for PED's. EACA inhibits the activation...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Williams PB,Crouch ER Jr,Crouch ER,Mazaheri M

    更新日期:1999-02-01 00:00:00

  • Prognostic significance of histopathology of primary conjunctival melanoma in Caucasians.

    abstract:PURPOSE:To assess histopathologic prognostic factors relative to clinical ones in predicting local recurrence and survival after primary conjunctival melanoma (CM). METHODS:85 patients with CM were identified in Finland between 1967 and 2000, and 70 primary tumors were available for histopathologic study. Time to firs...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Tuomaala S,Toivonen P,Al-Jamal R,Kivelä T

    更新日期:2007-11-01 00:00:00

  • Prednisolone acetate or prednisolone phosphate concurrently administered with ciprofloxacin for the therapy of experimental Pseudomonas aeruginosa keratitis.

    abstract::This study was conducted to determine the therapeutic efficacy of 3.0 mg/ml ciprofloxacin administered concurrently with one of two salts of prednisolone for the treatment of experimental pseudomonal keratitis. Rabbit corneas were injected intrastromally with Pseudomonas aeruginosa ATCC strain 27853. Sixteen hr after ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Hobden JA,Engel LS,Hill JM,Callegan MC,O'Callaghan RJ

    更新日期:1993-05-01 00:00:00

  • A platelet-activating factor antagonist reduces corneal allograft inflammation and neovascularization.

    abstract::We assessed the role of platelet-activating factor (PAF) in corneal allograft rejection and evaluated the effects of a PAF antagonist on corneal inflammation, cellular infiltration, vascularization, and edema. Rabbits with vascularized corneas served as recipients of allogeneic cornea grafts. Rabbits with normal corne...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Cohen RA,Gebhardt BM,Bazan NG

    更新日期:1994-02-01 00:00:00

  • Flicker perimetry using a luminance threshold strategy at frequencies from 5-25 Hz in glaucoma, ocular hypertension and normal controls.

    abstract::A prototype automated flicker perimeter was used to investigate flicker luminance thresholds in glaucoma patients (n = 11), ocular hypertensives (high risk n = 10, low and intermediate risk n = 21) and normal controls (n = 10). Differential light sensitivity was measured for one eye of each subject using a flickering ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Austin MW,O'Brien CJ,Wishart PK

    更新日期:1994-10-01 00:00:00

  • Cytotoxic properties of sunitinib and sorafenib on human corneal epithelial cells.

    abstract:PURPOSE:To generate toxicology profiles of individual drugs on human corneal epithelial cells (HCEC) and compare their in vitro cytotoxicity. METHODS:Monolayer cultures of HCEC were harvested from two human donor eyes. Sunitinib (0.3-10 µg/mL) and Sorafenib (0.3-100 µg/mL), diluted in culture medium (CnT-BM.1, CELLnTE...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Bayyoud T,Hofmann J,Spitzer M,Bartz-Schmidt KU,Yoeruek E

    更新日期:2014-02-01 00:00:00

  • Lacrimal fluid and electrolyte secretion: a review.

    abstract::Lacrimal gland fluid is an important component of the precorneal tear film. The rate of lacrimal gland fluid secretion is controlled primarily by parasympathetic innervation, and it is, apparently, modulated by sympathetic innervation. Lacrimal gland fluid is produced in two stages, secretion of a primary fluid which ...

    journal_title:Current eye research

    pub_type: 杂志文章,评审


    authors: Mircheff AK

    更新日期:1989-06-01 00:00:00

  • Real-time confocal microscopic observations on human corneal nerves and wound healing after excimer laser photorefractive keratectomy.

    abstract:PURPOSE:Corneal wound healing after excimer laser photorefractive keratectomy (PRK) passes through a series of characteristic stages which have earlier been defined by means of histological, histochemical, and biochemical approaches. We investigated the potential of confocal microscopy to verify morphological changes i...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Linna T,Tervo T

    更新日期:1997-07-01 00:00:00

  • Intravitreal pharmacokinetics in rabbits of the foscarnet lipid prodrug: 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA).

    abstract:PURPOSE:To evaluate the intraocular distribution and metabolism of the lipid prodrug of foscarnet, 1-O-octadecyl-sn-glycerol-3- phosphonoformate (ODG-PFA), following intravitreal administration. METHODS:Twenty rabbits received ODG-[14C]PFA intravitreal injection, yielding 0.632 mM resultant intravitreal concentration....

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Cheng L,Hostetler KY,Gardner MF,Avila CP Jr,Bergeron-Lynn G,Severson GM,Freeman WR

    更新日期:1999-03-01 00:00:00

  • Cryopreservation studies with porcine corneas.

    abstract:PURPOSE:A new technique for the cryopreservation of rabbit corneas in 20% w/w dimethylsulfoxide, which has been shown to preserve significant structural and functional integrity of the endothelium, was tested in porcine corneas. METHODS:The characteristics of uptake of dimethylsulfoxide into porcine corneas were measu...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Wusteman MC,Armitage JW,Wang LH,Busza AL,Pegg DE

    更新日期:1999-09-01 00:00:00

  • Changes in diabetic retinal matrix protein mRNA levels in a common transgenic mouse strain.

    abstract::Recently, all the structural features of non-proliferative diabetic retinopathy have been demonstrated in mice fed 30% galactose for 21-26 months. To determine whether changes in retinal matrix protein mRNA levels occur early in the course of murine diabetes we used a competitive RT-PCR method to quantitate retinal mR...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Nishikawa T,Giardino I,Edelstein D,Brownlee M

    更新日期:2000-07-01 00:00:00

  • The Association of Nailfold Capillaroscopy with Systemic Matrix Metalloproteinase-9 Concentration in Normal-Tension Glaucoma.

    abstract:PURPOSE:To investigate the association of nailfold capillaroscopy, heart rate variability (HRV), and clinical characteristics of glaucoma with the plasma matrix metalloproteinase-9 (MMP-9) level in normal-tension glaucoma (NTG). MATERIALS AND METHODS:We conducted a prospective, cross-sectional study on 25 patients wit...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Lee NY,Park HY,Park SH,Park CK

    更新日期:2015-01-01 00:00:00

  • Structural changes of the retina after conventional laser photocoagulation and selective retina treatment (SRT) in spectral domain OCT.

    abstract:BACKGROUND:Spectral domain optical coherence tomography (SD-OCT) in patients can deliver retinal cross-sectional images with high resolution. This may allow the evaluation of the extent of damage to the retinal pigment epithelium (RPE) and the neurosensory retina after laser treatment. This article aims to investigate ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Framme C,Walter A,Prahs P,Regler R,Theisen-Kunde D,Alt C,Brinkmann R

    更新日期:2009-07-01 00:00:00

  • Residual Refractive Astigmatism following Toric Intraocular Lens Implantation without Consideration of Posterior Corneal Astigmatism during Cataract Surgery with Low Anterior Keratometric Astigmatism upto 2.5 Dioptres.

    abstract::Purpose: To determine the refractive astigmatism following toric intraocular lens (tIOL) implantation without consideration of posterior keratometric astigmatism with a conventional tIOL calculator for eyes with low keratometric astigmatism (0.75D to 2.5D) and to theoretically compare the outcomes with predicted refra...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Nanavaty MA,Teeluck K,Bardan AS,Bedi KK,Ali S

    更新日期:2019-12-01 00:00:00

  • Effectiveness of topical taurolidine versus ciprofloxacin, ofloxacin, and fortified cefazolin in a rabbit Staphylococcus aureus keratitis model.

    abstract:PURPOSE:Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis. This study, employing an experimental rabbit model of Staphylococcus aureus keratitis, investigated the effectiveness of topical taurolidine in reducing the number of bact...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Oguz H,Ozbilge H,Oguz E,Gurkan T

    更新日期:2005-03-01 00:00:00

  • Detection of locally produced antibodies to herpes viruses in the aqueous of patients with acquired immune deficiency syndrome (AIDS) or acute retinal necrosis syndrome (ARN).

    abstract::Intraocular synthesis of IgG antibodies against HSV (herpes simplex virus), CMV (cytomegalovirus) and VZV (varicella zoster virus) is considered as an indirect proof of uveoretinal infection. Paired serum and aqueous samples obtained from 16 patients with retinitis associated with AIDS, 3 patients with ARN, 8 patients...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Luyendijk L,vd Horn GJ,Visser OH,Suttorp-Schulten MS,vd Biesen PR,Rothova A,Kijlstra A

    更新日期:1990-01-01 00:00:00

  • A Novel Approach to the Differentiation of Intrabulbar Tumors in Color Doppler Imaging.

    abstract:AIM OF THE STUDY:The similarity of many benign intrabulbar lesions to a malignant tumor requires detailed differential diagnostics. However, none of the known methods can be used as the only one to determine the type of lesions. The aim of this study was to determine color Doppler imaging (CDI) markers characteristic o...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Modrzejewska M,Wiącek MP

    更新日期:2017-11-01 00:00:00

  • Retinal Tissue Perfusion in Patients with Multiple Sclerosis.

    abstract::Purpose: The goal of this work was to determine whether the retinal tissue perfusion (RTP) is impaired in patients with multiple sclerosis (MS). Methods: Seventy-four patients [66 relapsing-remitting MS (RRMS) and 8 clinically isolated syndrome (CIS)] and 74 age- and gender-matched healthy controls were recruited. RTP...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Liu Y,Delgado S,Jiang H,Lin Y,Hernandez J,Deng Y,Gameiro GR,Wang J

    更新日期:2019-10-01 00:00:00

  • Murine endotoxin-induced uveitis, but not immune complex-induced uveitis, is dependent on the IL-8 receptor homolog.

    abstract:PURPOSE:To determine the roles of the murine interleukin-8 receptor homolog (mIL-8Rh, neutrophil chemokine CXC receptor 2) and macrophage inflammatory protein-1alpha (MIP-1alpha, a CC chemokine) in two eye inflammation models: endotoxin-induced uveitis (EIU) and immune complex-induced uveitis (reverse passive Arthus re...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Brito BE,O'Rourke LM,Pan Y,Huang X,Park JM,Zamora D,Cook DN,Planck SR,Rosenbaum JT

    更新日期:1999-07-01 00:00:00

  • Effect of a single-piece and a three-piece acrylic sharp-edged IOL on posterior capsule opacification.

    abstract:BACKGROUND:To compare the intensity of posterior capsule opacification (PCO) between two intraocular lenses (IOLs) of the same optic material, but with different haptic design (1-piece vs. 3-piece). METHODS:This prospective intraindividual controlled cohort study comprised eighty eyes of 40 patients with bilateral age...

    journal_title:Current eye research

    pub_type: 杂志文章,随机对照试验


    authors: Mylonas G,Prskavec M,Baradaran-Dilmaghani R,Karnik N,Buehl W,Wirtitsch M

    更新日期:2013-01-01 00:00:00

  • Chronic electrical stimulation of sympathetic nerves: effects on blood-aqueous barrier.

    abstract::The effect of electrical stimulation of the sympathetic nerves on the blood-aqueous barrier was investigated in rabbits. The permeability of the barrier was assessed during either acute, chronic or following chronic nerve stimulation. During acute and chronic stimulation of the sympathetic nerves, fluorescein entered ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Bartels SP,Pawlowski AM

    更新日期:1990-10-01 00:00:00

  • ApoA-I Mimetic Peptide 4F Reduces Age-Related Lipid Deposition in Murine Bruch's Membrane and Causes Its Structural Remodeling.

    abstract:PURPOSE:Accumulation of lipoprotein-derived lipids including esterified and unesterified cholesterol in Bruch's membrane of human eyes is a major age-related change involved in initiating and sustaining soft drusen in age-related macular degeneration (AMD). The apolipoprotein (apo) A-I mimetic peptide 4F is a small ant...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Rudolf M,Mir Mohi Sefat A,Miura Y,Tura A,Raasch W,Ranjbar M,Grisanti S,Aherrahrou Z,Wagner A,Messinger JD,Garber DW,Anantharamaiah GM,Curcio CA

    更新日期:2018-01-01 00:00:00

  • Postjunctional adrenergic receptors in the rabbit eye: effects on uveal flow and intraocular pressure in isolated arterially perfused eyes.

    abstract::In uveal vessels of isolated arterially perfused rabbit eyes there is direct evidence for the presence of post-junctional alpha 1-receptors and indirect evidence for alpha 2-receptors. Since vasoconstriction by epinephrine could not be blocked by an alpha 1-antagonist, only 30% by an alpha 2-antagonist and almost full...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: van Pinxteren PC,van Alphen GW

    更新日期:1985-01-01 00:00:00

  • Altered rhodopsin regeneration in diabetic mice caused by acid conditions within the rod photoreceptors.

    abstract:PURPOSE:The experiments were designed to provide details on the characteristics of rhodopsin regeneration in the rod photoreceptors of diabetic mice and to evaluate their mechanistic basis. METHODS:A genetically-derived diabetic albino mouse was developed. An excised albino mouse eye preparation was used. The preparat...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Ostroy SE

    更新日期:1998-10-01 00:00:00

  • S-antigen: preparation and characterization of site-specific monoclonal antibodies.

    abstract::Previous attempts to prepare monoclonal antibodies (MAbs) against S-antigen, a photoreceptor cell protein involved in the visual process and a potent autoantigen for the induction of experimental autoimmune uveitis (EAU), have yielded MAbs which define only carboxyl terminal epitopes. In this study we devised alternat...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Donoso LA,Gregerson DS,Smith L,Robertson S,Knospe V,Vrabec T,Kalsow CM

    更新日期:1990-04-01 00:00:00

  • Circular RNAs: Potential Star Molecules Involved in Diabetic Retinopathy.

    abstract::Purpose: To summarize the research status on the function and mechanism of circRNAs in regulating the occurrence of diabetic retinopathy (DR). Methods: We systematically searched PubMed,, and ARVO Abstracts website and reviewed relevant studies. Results: Thousands of circRNAs were found to be aberrantly exp...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: He M,Zhou R,Liu S,Cheng W,Wang W

    更新日期:2020-08-30 00:00:00

  • Inhibitory effect of oral doxycycline on neovascularization in a rat corneal alkali burn model of angiogenesis.

    abstract:PURPOSE:To examine the efficacy of oral doxycycline treatment (as compared to oral and topical dexamethasone) for inhibiting corneal neovascularization (CNV). METHODS:Following corneal alkali burn, rats were treated daily with oral doxycycline, oral dexamethasone, or topical dexamethasone for 14 days. Control rats wer...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Dan L,Shi-long Y,Miao-li L,Yong-ping L,Hong-jie M,Ying Z,Xiang-gui W

    更新日期:2008-08-01 00:00:00

  • Identification of Feeder Vessels in Ocular Surface Neoplasia Using Indocyanine Green Angiography.

    abstract:PURPOSE:To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS:Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Brunner M,Steger B,Romano V,Hodson M,Zheng Y,Heimann H,Kaye SB

    更新日期:2018-02-01 00:00:00

  • Radial keratotomy increases outflow facility in the porcine eye in vitro.

    abstract:PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Becker HH,Eisenberg DL,Wang N,Steinert RF,Schuman JS

    更新日期:1997-12-01 00:00:00