Effect of gatifloxacin ophthalmic solution 0.3% on human corneal endothelial cell density and aqueous humor gatifloxacin concentration.

abstract：:Recent reports from this laboratory indicate that dopamine (DA2) agonists can lower intraocular pressure (IOP) in rabbits, monkeys and rats. This communication suggests that the cat nictitating membrane (CNM) preparation is a useful model for localizing the site(s) and mechanism(s) of action of dopamine (DA2) agonists...

journal_title：Current eye research

authors： Potter DE,Burke JA

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:Membrane-associated mucins are important components of the ocular tear film. Our objective was to characterize the expression of membrane-associated mucins MUC1, MUC4, and MUC16 in healthy cornea, healthy conjunctiva, fibrovascular tissue (pannus) covering the corneal surface in limbal stem cell deficiency (LSC...

journal_title：Current eye research

authors： Pauklin M,Kakkassery V,Steuhl KP,Meller D

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...

journal_title：Current eye research

authors： Nakazaki S,Nao-i N,Sawada A

更新日期：1998-04-01 00:00:00

abstract：:Phosphorylated proteins of the chick lens were identified following incubation of lenses in a medium containing 32P and subsequent analysis by gel electrophoresis. The acidic variant of the vimentin and both subunits of fodrin were phosphorylated, as were the 95 Kd and 49 Kd proteins associated with the beaded-chain f...

journal_title：Current eye research

authors： Ireland M,Maisel H

更新日期：1984-07-01 00:00:00

abstract：:This study was conducted to determine the therapeutic efficacy of 3.0 mg/ml ciprofloxacin administered concurrently with one of two salts of prednisolone for the treatment of experimental pseudomonal keratitis. Rabbit corneas were injected intrastromally with Pseudomonas aeruginosa ATCC strain 27853. Sixteen hr after ...

journal_title：Current eye research

authors： Hobden JA,Engel LS,Hill JM,Callegan MC,O'Callaghan RJ

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:To compare the antiviral effect of a peptide derived from human apolipoprotein E (1% apoEdp) with 1% trifluorothymidine against HSV-1 thymidine kinase (TK)-positive (HSV-1 McKrae) and with 3% foscarnet against HSV-1 TK-negative (KOS background) in the rabbit eye model of acute HSV-1 epithelial keratitis. MATER...

journal_title：Current eye research

authors： Bhattacharjee PS,Neumann DM,Hill JM

更新日期：2009-02-01 00:00:00

abstract：:A major glycoprotein of relative molecular weight of 130,000 daltons of chick lens cell membranes was identified by Concanavalin-A staining and enriched for by Con A-Sepharose chromatography. Using both Con A binding and immunological analyses with a specific polyclonal antibody, the glycoprotein was detected in chick...

journal_title：Current eye research

authors： Heslip J,Bagchi M,Zhang S,Alousi S,Maisel H

更新日期：1986-12-01 00:00:00

abstract：:Perturbations in capillary endothelial cell function are early events in the pathogenesis of diabetic retinopathy. We used tritiated thymidine autoradiography to study the turn-over rate of retinal capillary endothelial cells in retinovascular preparations from normal, untreated diabetic and diabetic mice treated with...

journal_title：Current eye research

authors： Cuthbertson RA,Mandel TE

更新日期：1989-07-01 00:00:00

abstract：:Levels of rhodopsin in the photoreceptors of Long-Evans rats were reduced by approximately 55% through dietary deprivation of vitamin A. The interaction of visual pigment with G-protein was examined in receptor outer segment (ROS) membranes obtained from these animals. A binding assay was used to quantitate affinity o...

journal_title：Current eye research

authors： Pepperberg DR,Anderson SM,Crouch R

更新日期：1989-04-01 00:00:00

abstract：:Vernier and grating acuity were measured in infants up to 6 months of age using a two-alternative forced-choice preferential looking technique. Vernier resolution was measured using a horizontal vernier grating. The grating was presented on half of the screen while the other half contained horizontal lines which were ...

journal_title：Current eye research

authors： Manny RE,Klein SA

更新日期：1984-03-01 00:00:00

abstract：:The ocular penetration pathways of three alpha 2-adrenergic agents (p-aminoclonidine, AGN 190342, and clonidine) were investigated in rabbits both in vitro and in vivo. The corneal permeabilities of the compounds correlated positively with their octanol/water distribution coefficients. The ocular drug absorption via c...

journal_title：Current eye research

authors： Chien DS,Homsy JJ,Gluchowski C,Tang-Liu DD

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:To compare the intensity of posterior capsule opacification (PCO) between two intraocular lenses (IOLs) of the same optic material, but with different haptic design (1-piece vs. 3-piece). METHODS:This prospective intraindividual controlled cohort study comprised eighty eyes of 40 patients with bilateral age...

journal_title：Current eye research

authors： Mylonas G,Prskavec M,Baradaran-Dilmaghani R,Karnik N,Buehl W,Wirtitsch M

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To determine the plasma levels of the sulfur-containing amino-acids homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione, and taurine in patients with central retinal vein occlusion (CRVO) and in healthy subjects and to ascertain whether there are statistically significant differences between...

journal_title：Current eye research

authors： Pinna A,Zinellu A,Franconi F,Carru C

更新日期：2010-07-01 00:00:00

abstract：:Purpose: To investigate to what extent the OSDI can be utilized as a discriminative test for clinical findings. Methods: One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface st...

journal_title：Current eye research

authors： Yazdani M,Chen X,Tashbayev B,Utheim ØA,Ræder S,Hua Y,Eidet JR,Stojanovic A,Dartt DA,Utheim TP

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Raman spectroscopy could potentially be used as a diagnostic tool for the detection of meibomian gland dysfunction by measuring the composition, conformation, and amount of meibum lipid on the lid margin. Toward this goal and to test our studies of meibum lipid using infrared spectroscopy, we measured the Raman...

journal_title：Current eye research

authors： Oshima Y,Sato H,Zaghloul A,Foulks GN,Yappert MC,Borchman D

更新日期：2009-10-01 00:00:00

abstract：:Posterior vitreous detachment (PVD) and epiretinal membranes occur in a number of vitreoretinal diseases. We have developed an experimental model in which we can provide the morphologic correlation of these dynamic processes. The method provides the opportunity to study epiretinal membrane formation with the scanning ...

journal_title：Current eye research

authors： Matsumoto B,Hsu HT,Blanks JC,Ryan SJ

更新日期：1986-04-01 00:00:00

abstract：PURPOSE:To validate the more easily applicable "flush" tear collection technique as a viable alternative to basal and reflex tear collection. MATERIALS AND METHODS:Total protein content (TPC) and immunoglobulin A (IgA) concentrations were determined in the basal, reflex, and flush tears of 16 healthy non-contact lens ...

journal_title：Current eye research

authors： Markoulli M,Papas E,Petznick A,Holden B

更新日期：2011-03-01 00:00:00

abstract：:The changes in mouse corneal inflammatory cell population and the phagocytic capability of these cells were studied quantitatively at 24 and 48 hours after eliciting inflammatory cells into the cornea by Pseudomonas aeruginosa inoculation. Mice were selected for study according to their ability (young adult Swiss-Webs...

journal_title：Current eye research

authors： Hazlett LD,Kreindler FB,Berk RS,Barrett R

更新日期：1990-02-01 00:00:00

abstract：:A model system for retinal adhesion, consisting of interacting bovine pigment, epithelium (PE) cells and photoreceptor outer segments, was utilized to examine any adhesive role of the interphotoreceptor matrix. PE cells were dissociated by trypsin treatment of the eyecup, and were allowed to replenish their surface pr...

journal_title：Current eye research

authors： Adler AJ,Klucznik KM

更新日期：1981-01-01 00:00:00

abstract：:Spontaneous ocular shedding and adrenergic induction of ocular shedding were examined in rabbits infected with ten strains of herpes simplex virus type 1 (HSV-1): McKrae, KOS, F, Rodanus, 17 Syn+, RE, E-43, SC-16, MacIntyre, and CGA-3. All ocular inoculations were with 50 microliter of HSV-1 with titers between 1-10 X...

journal_title：Current eye research

authors： Hill JM,Rayfield MA,Haruta Y

更新日期：1987-01-01 00:00:00

abstract：:Intraocular inflammation of exogenous origin, which may lead to the loss of visual function in both eyes, i.e. SO confronts ophthalmologists much less rarely than might be expected. Epidemiological studies comprising ergophthalmological aspects underscore this. Questions with regard to therapy should consider the fact...

journal_title：Current eye research

authors： Kraus-Mackiw E

更新日期：1990-01-01 00:00:00

abstract：:A method is described for the preparation of plasma membrane enriched fractions from bovine retinal pigment epithelium (RPE) by means of differential centrifugation followed by the use of self forming gradients of Percoll. A detailed analysis of the distribution of organelle specific markers (nuclei, mitochondria, lys...

journal_title：Current eye research

authors： Ottonello S,Maraini G

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:Statins have been shown to reduce ocular inflammation in animal models of uveitis and to prevent development of uveitis in observational studies. There have been no experimental human studies evaluating statins' efficacy and safety in uveitis. In this study, we aimed to investigate efficacy and safety of simvas...

journal_title：Current eye research

authors： Shirinsky IV,Biryukova AA,Shirinsky VS

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:This study identifies the prevalence and risk factors of sensorineural hearing loss and primary open-angle glaucoma (POAG). MATERIALS AND METHODS:Patients aged 19 years or older who had undergone both ophthalmologic examination and audiometry as part of the Korea National Health and Nutrition Examination Surve...

journal_title：Current eye research

authors： Kim JM,Lee MY,Kim JW,Lee J,Kim HJ,Cha SC,Kim NR

更新日期：2020-08-01 00:00:00

abstract：:Na/K ATPase activity has been determined in normal and cataractous human lenses using labeled ATP as a substrate. The enzyme is distributed throughout the lens with approximately 1/3 of the total activity in the capsule-epithelium and 1/2 of the activity in the cortex. Furthermore, the activity of Na/K ATPase decrease...

journal_title：Current eye research

authors： Kobatashi S,Roy D,Spector A

更新日期：1982-01-01 00:00:00

abstract：PURPOSE/AIM:Cultured autologous oral mucosal epithelial cells (OMECs) have proven useful in the treatment of ocular surface disorders. This study is the first to investigate the potential of expanding OMEC in a xenobiotic- and serum-free medium using therapeutic contact lenses (CLs) as a substrate and carrier. MATERIA...

journal_title：Current eye research

authors： Björkblom B,Eidet JR,Utheim TP,Ulltveit-Moe HF,Raeder S

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:The aim of this pilot study was to determine the presence of complement activation products in tears from pre- and postkeratoplasty eyes and the fellow eyes in order to investigate the activation of the classical and alternative pathways of the complement system in the early postkeratoplasty period. METHODS:Te...

journal_title：Current eye research

authors： Kerényi A,Nagy G,Veres A,Varga L,Füst A,Nagymihány A,Czumbel N,Süveges I,Füst G

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation research, the quest to understand RPE physiology, and a desire to modulate RPE in pathological states. W...

journal_title：Current eye research

authors： Khan AZ,Utheim TP,Moe MC,Aass HCD,Sapkota D,Vallenari EM,Eidet JR

更新日期：2020-09-01 00:00:00

abstract：:Systemically administered fluorescein is converted to fluorescein glucuronide. The conjugate is fluorescent and interferes with the measurement of fluorescein in the anterior chamber. Carboxyfluorescein is a hydrophilic derivative of fluorescein. In the rabbit, carboxyfluorescein is not converted as readily to a fluor...

journal_title：Current eye research

authors： Neault TR,McLaren JW,Brubaker JH,Brubaker RF

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:A new technique for the cryopreservation of rabbit corneas in 20% w/w dimethylsulfoxide, which has been shown to preserve significant structural and functional integrity of the endothelium, was tested in porcine corneas. METHODS:The characteristics of uptake of dimethylsulfoxide into porcine corneas were measu...

journal_title：Current eye research

authors： Wusteman MC,Armitage JW,Wang LH,Busza AL,Pegg DE

更新日期：1999-09-01 00:00:00