An intrinsic membrane glycoprotein of the lens.

abstract：:We have examined the T cell specificity of a Lewis rat T cell line (R208) specific for a pathogenic, 123 residue cyanogen bromide produced peptide of bovine S-antigen by using two independent sets of overlapping synthetic peptides representing the entire length of the 123 residue fragment. S-antigen, a 48 kDa immunopa...

journal_title：Current eye research

authors： Fling SP,Gregerson DS,Obritsch WF,Boyce-Jacino M,Merryman CF,Donoso LA

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS:Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of ...

journal_title：Current eye research

authors： Brunner M,Steger B,Romano V,Hodson M,Zheng Y,Heimann H,Kaye SB

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To investigate the tissue blood flow in the neuroretinal rim of the optic disk and macula after rhegmatogenous retinal detachment (RRD) surgery. METHODS:Tissue blood flow in the neuroretinal rim of the optic disk and macula was measured with the Heidelberg retina flowmeter in 53 eyes of 53 patients who had und...

journal_title：Current eye research

authors： Sato EA,Shinoda K,Kimura I,Ohtake Y,Inoue M

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:A new technique for the cryopreservation of rabbit corneas in 20% w/w dimethylsulfoxide, which has been shown to preserve significant structural and functional integrity of the endothelium, was tested in porcine corneas. METHODS:The characteristics of uptake of dimethylsulfoxide into porcine corneas were measu...

journal_title：Current eye research

authors： Wusteman MC,Armitage JW,Wang LH,Busza AL,Pegg DE

更新日期：1999-09-01 00:00:00

abstract：:Severe retinopathy of prematurity (ROP) occurs in the smallest and sickest of premature infants. We hypothesized that, in a rat model of oxygen induced retinopathy, abnormal neovascularization would occur more frequently in larger litters where the pups are subject to postnatal growth retardation. Four litters of newb...

journal_title：Current eye research

authors： Holmes JM,Duffner LA

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:To investigate the repeatability of macular and peripapillary retinal nerve fiber layer (RNFL) thickness measurements made using swept-source optical coherence tomography (SS-OCT) and automated segmentation. Measurements were made in non-diabetic controls and in patients with diabetic retinopathy (DR) with or w...

journal_title：Current eye research

authors： Min JK,Lee S,Kim JS,Woo JM,Yang HS

更新日期：2017-02-01 00:00:00

abstract：:This study was conducted to determine the therapeutic efficacy of 3.0 mg/ml ciprofloxacin administered concurrently with one of two salts of prednisolone for the treatment of experimental pseudomonal keratitis. Rabbit corneas were injected intrastromally with Pseudomonas aeruginosa ATCC strain 27853. Sixteen hr after ...

journal_title：Current eye research

authors： Hobden JA,Engel LS,Hill JM,Callegan MC,O'Callaghan RJ

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:To investigate whether retinal impairment was affected by age of rats in acute glaucoma model. METHODS:Young adult and aged rats were randomly divided into normal control, 45 mmHg, 60 mmHg and 90 mmHg groups. Intraocular pressures (IOP) of rats were acutely elevated to 45 mmHg, 60 mmHg and 90 mmHg, respectivel...

journal_title：Current eye research

authors： Tan C,Hu T,Peng MC,Liu SL,Tong JB,Ouyang W,Le Y

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:The similar and overlapping activity of VEGF and the potent corneal-derived angiogenic eicosanoid 12(R)-HETrE calls for a study of the temporal relationship in the expression of these two autocoids. Since recent evidence suggests that hypoxia induces the expression of a CYP4B1 mRNA which might be involved in th...

journal_title：Current eye research

authors： Mastyugin V,Mosaed S,Bonazzi A,Dunn MW,Schwartzman ML

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...

journal_title：Current eye research

authors： Nakazaki S,Nao-i N,Sawada A

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:To investigate the effects of rapamycin on the TNF-α-induced secretion of interleukin-6 (IL-6) and IL-8 in orbital fibroblasts and its possible mechanism. MATERIALS AND METHODS:Orbital fibroblasts were obtained from patients with thyroid-associated ophthalmopathy. IL-6 and IL-8 levels were measured by enzyme-l...

journal_title：Current eye research

authors： Lee WM,Paik JS,Cho WK,Oh EH,Lee SB,Yang SW

更新日期：2013-06-01 00:00:00

abstract：:The 'fast PIII' rod mediated photoreceptor response to flashes of monochromatic light has been investigated in isolated retinae of the RCS rat at age 30 days. A loss of both sensitivity and maximum response amplitude were found, with a concurrent slowing of the response kinetics. These observations indicate a rod abno...

journal_title：Current eye research

authors： Low JC

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:Experiments were performed to evaluate the effect of various pro- and anti-inflammatory cytokines on the human fetal retinal pigment epithelium's (HFRPE) expression of major histocompatibility complex (MHC) and costimulatory molecules. METHODS:Pure cultures of HFRPE cells were isolated. HFRPE cells were incuba...

journal_title：Current eye research

authors： Farrokh-Siar L,Rezai KA,Palmer EM,Patel SC,Ernest TJ,van Seventer GA

更新日期：2001-10-01 00:00:00

abstract：:In earlier experiments on the role of the cytolytic toxin pneumolysin in ocular infections with pneumococcus, we found that a strain carrying a deletion in the gene encoding pneumolysin was considerably less virulent than wild type when tested in an intracorneal model of keratitis in the rabbit. To confirm this result...

journal_title：Current eye research

authors： Johnson MK,Hobden JA,O'Callaghan RJ,Hill JM

更新日期：1992-12-01 00:00:00

abstract：:Langerhans cells (LC) appear to have a role in the processing of antigens presented through cutaneous surfaces. In most species LC are found in the conjunctiva and limbal epithelium but are rarely found in the central cornea. A quantitative study of corneal LC was performed in guinea pigs and rabbits with HSV-1 kerati...

journal_title：Current eye research

authors： Asbell PA,Kamenar T

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To detect the immunohistochemical changes in the main lacrimal glands of patients suffering from chronic ocular sequelae of Stevens-Johnson syndrome (SJS). METHODS:Histological sections of biopsies from the lacrimal gland of three chronic SJS patients (mean age, 33 years; 2 males) with severe dry eye disease (...

journal_title：Current eye research

authors： Singh S,Ali MJ,Mittal V,Brabletz S,Paulsen F

更新日期：2020-10-18 00:00:00

abstract：:Changes in the content of calcitonin gene-related polypeptide (CGRP) and tyrosine hydroxylase (TH) immunoreactivities in the anterior segment of the rat eye were assessed histochemically in animals subjected to sympathetic ganglionectomy or to chronic sensory denervation induced by neonatal capsaicin treatment. In the...

journal_title：Current eye research

authors： Unger WG,Terenghi G,Zhang SQ,Polak JM

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:Retinal ischemia and neovascularization (NV) are important components of many retinal disorders. To facilitate further investigation of retinal ischemia and neovascularization, we sought to develop a reproducible in vivo experimental model of venous occlusion by photodynamic thrombosis in rats. METHODS:After a...

journal_title：Current eye research

authors： Saito Y,Park L,Skolik SA,Alfaro DV,Chaudhry NA,Barnstable CJ,Liggett PE

更新日期：1997-01-01 00:00:00

abstract：:Antifibrosis agents have improved the success of glaucoma filtration surgery, although undesired side effects are not readily reversible and may present a major limitation in the use of these agents. Our purpose was to study the efficacy of cytosine arabinoside (Ara-C) as an adjunctive antimetabolite in glaucoma surge...

journal_title：Current eye research

authors： Chu JL,Shields SR,Netland PA

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To measure the cell size and cell density in five layers of the central cornea in the widely used inbred C57BL/6 mouse strain using in vivo three-dimensional (3D) two-photon (2PH) imaging. METHODS:Corneas were scanned using a 2PH laser scanning fluorescence microscope after staining with plasma membrane stain ...

journal_title：Current eye research

authors： Zhang H,He S,Liu S,Xie Y,Chen G,Zhang J,Sun S,Liang D,Wang L

更新日期：2016-04-01 00:00:00

abstract：:This study asks whether retinal adhesiveness is affected by cytochalasin D, a drug that is known to alter the apical morphology of the retinal pigment epithelium (RPE). Cytochalasin D was injected intravitreally in Dutch rabbits and retinal adhesiveness measured 0.5 to 72 h later by two methods: in vitro peeling of th...

journal_title：Current eye research

authors： Chiang RK,Yao XY,Takeuchi A,Dalal R,Marmor MF

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation research, the quest to understand RPE physiology, and a desire to modulate RPE in pathological states. W...

journal_title：Current eye research

authors： Khan AZ,Utheim TP,Moe MC,Aass HCD,Sapkota D,Vallenari EM,Eidet JR

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To investigate the agreement of angular locations of retinal nerve fiber layer (RNFL) defect margins in glaucomatous eyes by using red-free fundus photographs and Cirrus high-definition optical coherence tomography (OCT) RNFL deviation and thickness maps. METHODS:We examined 380 RNFL defects that showed clear ...

journal_title：Current eye research

authors： Hwang YH,Kim YY,Kim HK,Sohn YH

更新日期：2014-11-01 00:00:00

abstract：:Human endothelial morphologic changes were quantitated by specular microscopy and computer-assisted morphometry to establish normal baselines of various morphologic parameters. Cellular polymegethism and cellular pleomorphism increases with age, and normal baseline parameters are detailed. Furthermore, no significant ...

journal_title：Current eye research

authors： Yee RW,Matsuda M,Schultz RO,Edelhauser HF

更新日期：1985-06-01 00:00:00

abstract：:Recently, all the structural features of non-proliferative diabetic retinopathy have been demonstrated in mice fed 30% galactose for 21-26 months. To determine whether changes in retinal matrix protein mRNA levels occur early in the course of murine diabetes we used a competitive RT-PCR method to quantitate retinal mR...

journal_title：Current eye research

authors： Nishikawa T,Giardino I,Edelstein D,Brownlee M

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To evaluate changes in biometric parameters in myopic eyes. MATERIALS AND METHODS:412 eyes of 412 young myopic patients underwent ophthalmic examinations including assessments of refractive error, axial length (AL), anterior chamber depth (ACD), and central corneal thickness (CCT). By using spectral domain opt...

journal_title：Current eye research

authors： Chung HJ,Park CK

更新日期：2016-12-01 00:00:00

abstract：:Cytoskeletal and membrane proteins were isolated from respectively the urea-soluble and urea-insoluble fractions of the squid lens. The main cytoskeletal polypeptide has a molecular weight (63000) and an amino acid composition similar to those of vertebrate intermediate filament proteins, including mammalian lens vime...

journal_title：Current eye research

authors： Siezen RJ

更新日期：1982-01-01 00:00:00

abstract：:Recent reports from this laboratory indicate that dopamine (DA2) agonists can lower intraocular pressure (IOP) in rabbits, monkeys and rats. This communication suggests that the cat nictitating membrane (CNM) preparation is a useful model for localizing the site(s) and mechanism(s) of action of dopamine (DA2) agonists...

journal_title：Current eye research

authors： Potter DE,Burke JA

更新日期：1984-11-01 00:00:00

abstract：:Thrombospondins are a family of large multi-domain glycoproteins described as matricelluar proteins based on their ability to interact with a broad range of receptors, matrix molecules, growth factors or proteases, and to modulate array of cellular functions including intracellular signaling, proliferation and migrati...

journal_title：Current eye research

authors： Masli S,Sheibani N,Cursiefen C,Zieske J

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:To assess the potential impact of corneal crosslinking treatment (365 nm ultraviolet (UV)A irradiation with riboflavin) on the material properties of Intracorneal Rings Segments (ICRS). MATERIALS AND METHODS:Material properties were studied using FT-IR spectroscopy and UV-Vis spectroscopy. Rings were examined:...

journal_title：Current eye research

authors： Sideroudi H,Labiris G,Soto-Beobide A,Voyiatzis G,Chrissanthopoulos A,Kozobolis V

更新日期：2015-05-01 00:00:00