Abstract:
PURPOSE:To evaluate serum and aqueous humor levels of fetuin-A in patients with pseudoexfoliation syndrome (PEXS) in comparison with those of age- and sex-matched healthy subjects. MATERIALS AND METHODS:This prospective study included 25 patients with PEXS and 25 control subjects who were undergoing cataract surgery without any systemic or ocular disease. Aqueous humor and serum fetuin-A levels were measured with enzyme-linked immunosorbent assay method. RESULTS:The mean age of the PEXS group (14 males, 11 females, n = 25) was 57.7 ± 6.9 years, and the control group (13 males, 12 females, n = 25) was 58.1 ± 5.7 years. There was no difference between the groups in terms of age (p = 0.77) and sex (p = 0.83). The mean serum fetuin-A level of the PEXS group did not differ from that of the control group (p = 0.53). The mean aqueous humor level of the PEXS group was significantly higher than that of the control group (p = 0.032). There were no significant correlations between aqueous humor and serum fetuin-A levels among patients with PEXS and control group (p > 0.05). CONCLUSIONS:Increased levels of fetuin-A in aqueous humor of patients with PEXS may show the local effect of fetuin-A on the anterior segment. With considering the wide range of possible biological functions of fetuin-A in the pathogenesis of PEXS, further studies are needed to clarify the clinical relevance of these findings.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Yuksel N,Takmaz T,Ozel Turkcu U,Ergin M,Altinkaynak H,Bilgihan Adoi
10.1080/02713683.2017.1324629subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1378-1381issue
10eissn
0271-3683issn
1460-2202journal_volume
42pub_type
杂志文章abstract:PURPOSE:To examine whether transforming growth factor-beta 2 (TGF-beta 2) induces the expression of alpha-smooth muscle actin (SMA), a biochemical marker of myofibroblasts, in cultured bovine retinal pigment epithelial (RPE) cells. METHODS:Bovine RPE cells were cultured in F-12 nutrient mixture supplemented with 5% fe...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608995147
更新日期:1996-11-01 00:00:00
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doi:10.1080/02713683.2020.1812085
更新日期:2020-08-30 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689609000760
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802245772
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journal_title:Current eye research
pub_type: 杂志文章,评审
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更新日期:1996-07-01 00:00:00
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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更新日期:1981-01-01 00:00:00
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journal_title:Current eye research
pub_type: 临床试验,杂志文章
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更新日期:1988-07-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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journal_title:Current eye research
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更新日期:2007-10-01 00:00:00
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更新日期:2009-10-01 00:00:00
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journal_title:Current eye research
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更新日期:1986-05-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508999918
更新日期:1995-02-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
abstract::The effect of cytochalasin D (CD), an actin monomer-stabilizer, has been studied on cataract development in rat lenses. Cataractogenesis was induced by incubating the rat lenses in medium 199 (M199) containing 10(-5) M CD; by the end of 24 h, lenses first developed a visible opacity. The increased lactate dehydrogenas...
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doi:
更新日期:2000-04-01 00:00:00
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更新日期:2015-05-01 00:00:00
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更新日期:2001-04-01 00:00:00
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更新日期:2021-02-01 00:00:00
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更新日期:2015-03-01 00:00:00
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journal_title:Current eye research
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更新日期:2005-10-01 00:00:00
abstract::The effects of transforming growth factor-beta (TGF beta) and epidermal growth factor (EGF) on the synthesis of collagen and fibronectin, and on the proliferation of human corneal stromal fibroblasts in vitro, were evaluated. Human corneal stromal fibroblasts in culture were incubated for 48 hours with TGF beta or EGF...
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更新日期:1993-08-01 00:00:00
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更新日期:2014-02-01 00:00:00
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更新日期:2020-10-01 00:00:00
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journal_title:Current eye research
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更新日期:1984-05-01 00:00:00