Transforming growth factor-beta stimulates collagen and fibronectin synthesis by human corneal stromal fibroblasts in vitro.

abstract：PURPOSE:Retinal pigment epithelial (RPE) cell proliferation is an important step in the pathogenesis of ocular diseases such as proliferative retinopathy. Growth factors play a major role in modulating the development and progression of these diseases. The aim of this study was to examine the effects of single growth f...

journal_title：Current eye research

authors： Kaven CW,Spraul CW,Zavazava NK,Lang GK,Lang GE

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To synthesize and characterize hydrogels with viscoelastic properties comparable to those of the natural lens. METHODS:Hydrogels were synthesized in water by free-radical polymerization of the monomer poly(ethyleneglycol)-monomethacrylate. Three different molecular weights of poly(ethyleneglycol)-dimethacrylat...

journal_title：Current eye research

authors： Murthy SK,Ravi N

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:To characterize the effect of glutamate receptor activation/inhibition on the secretion of vascular endothelial growth factor (VEGF) in retina-specific glial (Müller) cells under experimental conditions of hyperglycemia and hypoxia, two intrinsic pathologic conditions of diabetic retinopathy. METHODS:Purified ...

journal_title：Current eye research

authors： Cervantes-Villagrana AR,Garcia-Román J,González-Espinosa C,Lamas M

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:The mechanisms involved in the reported beneficial effects of Calcium dobesilate monohydrate (CaD) for the treatment of diabetic retinopathy (DR) remain to be elucidated. The main aim of the present study is to examine whether CaD prevents early events in the pathogenesis of DR such as neurodegeneration and vas...

journal_title：Current eye research

authors： Solà-Adell C,Bogdanov P,Hernández C,Sampedro J,Valeri M,Garcia-Ramirez M,Pasquali C,Simó R

更新日期：2017-09-01 00:00:00

abstract：:Penetrating keratoplasty was the only therapeutic choice for the treatment of corneal endothelial decompensation until the introduction of evolutional endothelial keratoplasties, namely Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK). Although now...

journal_title：Current eye research

authors： Okumura N,Koizumi N

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:In the limbo-corneal epithelium the stem and early precursor epithelial cell pool is confined to the limbal rim. Among the features associated with this spatial segregation is the general paucity of connexin43 (Cx43) within the limbal basal cell population and its complete absence in resident stem cells. The li...

journal_title：Current eye research

authors： Wolosin JM,Schütte M,Zieske JD,Budak MT

更新日期：2002-06-01 00:00:00

abstract：SIGNIFICANCE:Adopting a risk stratification system and appropriate listing of cases reduces the rates of intraoperative complications during phacoemulsification. Such listing would allow both safe surgery and enhance training, by ensuring an appropriately experienced surgeon is available to operate on a case or supervi...

journal_title：Current eye research

authors： Pooprasert P,Hansell J,Young-Zvandasara T,Muhtaseb M

更新日期：2020-07-30 00:00:00

abstract：PURPOSE:The present study was conducted to develop and characterize a functional primary culture of pigmented rabbit conjunctival epithelial cells on permeable support exhibiting tight barrier properties. METHODS:Conjunctival epithelial cells were isolated by 0.2% protease treatment, cultured at 0.5-1.8 x 10(6) cells/...

journal_title：Current eye research

authors： Saha P,Kim KJ,Lee VH

更新日期：1996-12-01 00:00:00

abstract：:Recent reports from this laboratory indicate that dopamine (DA2) agonists can lower intraocular pressure (IOP) in rabbits, monkeys and rats. This communication suggests that the cat nictitating membrane (CNM) preparation is a useful model for localizing the site(s) and mechanism(s) of action of dopamine (DA2) agonists...

journal_title：Current eye research

authors： Potter DE,Burke JA

更新日期：1984-11-01 00:00:00

abstract：:Purpose: To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). Materials and methods: An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure sus...

journal_title：Current eye research

authors： Wang X,Chen J,Kong X,Sun X

更新日期：2020-11-26 00:00:00

abstract：:The content of rhodopsin in the eyes of 15 donors (30 eyes) was determined. Both retinal and pigment epithelial fractions were collected from each globe, extracted using 1% CTAB, and the rhodopsin difference spectrum of each fraction was obtained separately. The total amount of rhodopsin, obtained by summing the amoun...

journal_title：Current eye research

authors： Fulton AB,Dodge J,Schremser JL,Armstrong A,Lanier F,Dawson WW,Williams TP

更新日期：1990-12-01 00:00:00

abstract：AIMS:To investigate whether tobacco smoke directly injures retinal ganglion cells (RGCs) and to evaluate the mechanisms of cell death. METHODS:Primary rat RGCs were harvested from 3- or 4-day-old newborn rats and exposed to cigarette smoke extract (CSE). Cell viability was determined by adenosine 5'-triphosphate (ATP)...

journal_title：Current eye research

authors： Lee K,Hong S,Seong GJ,Kim CY

更新日期：2016-10-01 00:00:00

abstract：:The initial rapid fall in tear film fluorescence after instilling a 1 microliter drop of fluorophore could be a result of stimulated tear flow or of distribution of the dye throughout the tear fluid present in the conjunctival sac. An attempt was made to decide this by comparing the fall in fluorescence of two differe...

journal_title：Current eye research

authors： Sang NM,Maurice DM

更新日期：1995-04-01 00:00:00

abstract：:Cytoskeletal and membrane proteins were isolated from respectively the urea-soluble and urea-insoluble fractions of the squid lens. The main cytoskeletal polypeptide has a molecular weight (63000) and an amino acid composition similar to those of vertebrate intermediate filament proteins, including mammalian lens vime...

journal_title：Current eye research

authors： Siezen RJ

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Histidine is an indispensable amino acid with an imidazole ring and it is a precursor of histamine, carnosine, and anserine. Histidine has been proposed to act as a neurotransmitter or neuromodulator in mammalian central nervous system (CNS), including retina. In this study, we report histidine-like immunoreact...

journal_title：Current eye research

authors： Kusakari Y,Nishikawa S,Ishiguro S,Tamai M

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:The purpose of the current study is to assess changes in the expression of Acid-Sensing Ion Channel (ASIC)1a and ASIC2 in retinal ganglion cells (RGCs) after retinal ischemia and reperfusion (I/R) injury and to test if inhibition of ASIC1a provides RGC neuroprotection. METHODS:Transient ischemia was induced in...

journal_title：Current eye research

authors： Dibas A,Millar C,Al-Farra A,Yorio T

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:NiCl(2) (15 microM) enhances the ERG b-wave amplitude of vertebrate retina, up to 1.5-fold by blocking E/R-type voltage-gated Ca(2+) channels, which is mediated by blocking the release of GABA onto ionotropic GABA-A and GABA-C receptors. In vivo, it is likely that zinc, rather than nickel ions, may be involved ...

journal_title：Current eye research

authors： Siapich SA,Wrubel H,Albanna W,Alnawaiseh M,Hescheler J,Weiergräber M,Lüke M,Schneider T

更新日期：2010-04-01 00:00:00

abstract：PURPOSE/AIM:To quantitatively analyse the evolution of TUNEL-labeling, after in vivo exposure to UVB. METHODS:Altogether, 16 Sprague Dawley rats were unilaterally exposed in vivo for 15 min to close to threshold dose, 5 kJ/m(2), of ultraviolet radiation in the 300 nm wavelength region. Animals were sacrificed in group...

journal_title：Current eye research

authors： Kronschläger M,Yu Z,Talebizadeh N,Meyer LM,Hallböök F,Söderberg PG

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:C5a anaphylatoxin is a potent inflammatory mediator that acts on polymorphonuclear cells (PMN) and monocytes via C5a receptors (C5aR). It mediates chemotaxis of both cell types and stimulates cytokine release from the latter. To investigate whether C5a can act on retinal pigment epithelial (RPE) cells, we exami...

journal_title：Current eye research

authors： Fukuoka Y,Medof EM

更新日期：2001-11-01 00:00:00

abstract：:Achieving the long-term goal of successful engraftment of retinal tissues into eyes blinded by endogenous retinal failure will depend, at least in part, on controlling the immune response to antigens expressed on retinal grafts. Since histoincompatible tissues will have to be used for such transplants, methods to cont...

journal_title：Current eye research

authors： Jiang LQ,Streilein JW

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:To evaluate the anatomical correlation between fellow eyes for bilateral second-line anti-VEGF treatment in eyes with bilateral diabetic macular edema (DME) with incomplete response to first-line bevacizumab therapy. METHODS:Seventy-four eyes (n = 37 patients) with bilateral-DME having incomplete response to f...

journal_title：Current eye research

authors： Tiosano L,Ayalon A,Banin E,Averbukh E,Jaouni T,Chowers I

更新日期：2020-08-30 00:00:00

abstract：:Goggles that degrade the retinal image produce axial enlargement of the ocular globe and large myopic refractive errors. Many authors have assumed that visual image degradation itself leads to myopia. Hodos and co-authors have shown, however, that goggled eyes in chicks are considerably warmer than normal. Such temper...

journal_title：Current eye research

authors： Shih YF,Fitzgerald ME,Norton TT,Gamlin PD,Hodos W,Reiner A

更新日期：1993-03-01 00:00:00

abstract：:Using an animal model of retinoblastoma in inbred rats and cultured human adenovirus type 12-induced retinoblastoma-like tumor cells (RAO 188), complement-dependent cytotoxicity was determined by measuring release of 3H-uridine labelled RNA. Sera from rats in which tumors did not grow after adenovirus type 12 inoculat...

journal_title：Current eye research

authors： Nishida T,Mukai N,Solish SP

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix (ECM) proteins in the retina. Breakdown of ECM proteins results in neovascularization and tractional retinal detachment, which eventually lead to the symptoms of proliferative diabetic retinopathy. Müller cells ar...

journal_title：Current eye research

authors： Miyata Y,Kase M,Sugita Y,Shimada A,Nagase T,Katsura Y,Kosano H

更新日期：2012-09-01 00:00:00

abstract：:The maximal velocity (Vmax) and the apparent dissociation constant (K0.5) of Na+K+-ATPase have each been estimated with respect to sodium and potassium ion activation. These estimations were made from the enzymatic activity of plasma membrane preparations derived from bovine corneal endothelial cells. The determinatio...

journal_title：Current eye research

authors： Whikehart DR,Montgomery B,Hafer LM

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...

journal_title：Current eye research

authors： Nakazaki S,Nao-i N,Sawada A

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:To determine the plasma levels of the sulfur-containing amino-acids homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione, and taurine in patients with central retinal vein occlusion (CRVO) and in healthy subjects and to ascertain whether there are statistically significant differences between...

journal_title：Current eye research

authors： Pinna A,Zinellu A,Franconi F,Carru C

更新日期：2010-07-01 00:00:00

abstract：:Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for aver...

journal_title：Current eye research

authors： Sundmacher R,Mattes A,Neumann-Haefelin D,Adolf G,Kruss B

更新日期：1987-01-01 00:00:00

abstract：:The distribution of vasoactive intestinal polypeptide (VIP)- and neurotensin (NT)-like immunoreactivities in the chicken retina was investigated by immunohistochemistry. VIP- and NT-positive cells were found throughout the chicken retina. The majority of them were located in the proximal portion of the inner nuclear l...

journal_title：Current eye research

authors： Fukuda M,Kuwayama Y,Shiosaka S,Inagaki S,Ishimoto I,Shimizu Y,Takagi H,Sakanaka M,Takatsuki K,Senba E,Tohyama M

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection. METHODS:Corneal neovascularization was induced by application of a mixture of 7...

journal_title：Current eye research

authors： Avisar I,Weinberger D,Kremer I

更新日期：2010-02-01 00:00:00