Abstract:
:The effect of cytochalasin D (CD), an actin monomer-stabilizer, has been studied on cataract development in rat lenses. Cataractogenesis was induced by incubating the rat lenses in medium 199 (M199) containing 10(-5) M CD; by the end of 24 h, lenses first developed a visible opacity. The increased lactate dehydrogenase (LDH) activity in the culture medium, leakage of lens cytosolic proteins into the culture medium and observable development of opacity through a dissection microscope were correlated with cell damage associated with cataract formation. Non-denaturing polyacrylamide gel electrophoresis was used to separate three lens LDH isoenzymes. The effect of 1 mM vitamin C (VC) in reducing LDH leakage was also examined. The protective effect of VC on CD-initiated cataractous lenses is significant. This suggest that a portion of the opacity and lens damage may involve oxidative damage to the membrane-cytoskeleton complex which is started by CD, but partially prevented by VC
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Kilic F,Trevithick JRdoi
10.3109/02713689508995134subject
Has Abstractpub_date
1995-10-01 00:00:00pages
943-9issue
10eissn
0271-3683issn
1460-2202journal_volume
14pub_type
杂志文章abstract:PURPOSE:To compare objective optical quality, ocular scattering and aberrations of eyes implanted with an aspheric monofocal intraocular lens (IOL) or an aspheric apodized diffractive multifocal IOL three months after surgery. METHODS:Prospective consecutive nonrandomized comparative cohort study. A total of 80 eyes f...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1449220
更新日期:2018-06-01 00:00:00
abstract::In uveal vessels of isolated arterially perfused rabbit eyes there is direct evidence for the presence of post-junctional alpha 1-receptors and indirect evidence for alpha 2-receptors. Since vasoconstriction by epinephrine could not be blocked by an alpha 1-antagonist, only 30% by an alpha 2-antagonist and almost full...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688508999963
更新日期:1985-01-01 00:00:00
abstract:AIM:To compare collared silicone punctal plugs to intracanalicular SmartPlugs for the treatment of moderate to severe dry eye. MATERIALS AND METHODS:In this prospective, randomized, single blind, clinical study, 30 patients (60 eyes) who had been diagnosed with moderate to severe dry eye syndrome were enrolled. Study ...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2013.765487
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Retinoblastoma (RB) is the most common intraocular malignancy in children. Deregulation of several miRNAs has been identified in RB, suggesting a potential role in tumorigenesis. Recent evidence suggests that many dietary components like folate, retinoids and curcumin act as potential anticancer/antiproliferati...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.647224
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:To evaluate the stability of successive applanation tonometry measurements in glaucomatous eyes. METHODS:A prospective, comparative, randomized, and evaluator-masked study was conducted in a tertiary medical center. Sixty-seven patients with glaucoma attending our glaucoma clinic underwent four successive intr...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713681003678824
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.12.1193.5027
更新日期:1997-12-01 00:00:00
abstract::The goal of this study was to determine the effect of extracellular matrix components on the phagocytic function of the retinal pigment epithelial (RPE) cell. Cultured human fetal RPE cells were established in culture and plated on three commercially-prepared substrates: collagen IV, fibronectin and laminin and on thr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689609017607
更新日期:1996-01-01 00:00:00
abstract::Although experimental models of autoimmune uveitis predict pinealitis coincident with uveitis, there is no direct evidence of pineal pathology accompanying a human uveitis. Horses with naturally occurring uveitis are a potential source of eye and pineal tissues that are not available from human patients with active uv...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689208999525
更新日期:1992-01-01 00:00:00
abstract::In experimental work on retinal ischemia and its medical management, we have been disturbed by the large variations in the electroetinogram (ERG) recovery of rabbit eyes subjected to similar degrees of ischemia. We investigated whether body temperature might be one of the critical factors. We studied pigmented Dutch r...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508999918
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:To investigate retinal imaging and ablation using femtosecond laser pulses. MATERIALS AND METHODS:Two non-amplified near-infrared femtosecond lasers were used to irradiate porcine retinal specimens in vitro. The lasers were used for tissue removal as well as multiphoton laser scanning microscopy. RESULTS:Abla...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680801956452
更新日期:2008-04-01 00:00:00
abstract::Birefringence variations, seen as regularly spaced altering light and dark rings (bands), have been observed along the length of unfixed, freshly isolated rod outer segments (ROS) of both Rana pipiens and Xenopus laevis. In our hands, the spatial frequency of the banding pattern is from 1.3-1.6u/band in Rana pipiens a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409007412
更新日期:1984-11-01 00:00:00
abstract:PURPOSE:To explore the in vitro proliferative potential of human limbal epithelial cells after 31 degrees C organ-culture storage and to investigate putative factors influencing it. METHODS:185 cultures of limbal explants were carried-out either from full-thickness explants (n = 102) or from enzymatically dissociated ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600681228
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:To compare the intensity of posterior capsule opacification (PCO) between two intraocular lenses (IOLs) of the same optic material, but with different haptic design (1-piece vs. 3-piece). METHODS:This prospective intraindividual controlled cohort study comprised eighty eyes of 40 patients with bilateral age...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2012.717242
更新日期:2013-01-01 00:00:00
abstract::A method is described for the preparation of plasma membrane enriched fractions from bovine retinal pigment epithelium (RPE) by means of differential centrifugation followed by the use of self forming gradients of Percoll. A detailed analysis of the distribution of organelle specific markers (nuclei, mitochondria, lys...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000806
更新日期:1984-09-01 00:00:00
abstract::Purpose: To evaluate the efficacy of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing sustained-release thalidomide for delayed adjustable strabismus surgery. Methods: This is a prospective, masked-observer, controlled study using 50 eyes of 25 rabbits. After superior rectus muscle (SRM...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1591461
更新日期:2019-07-01 00:00:00
abstract::Posterior subcapsular cataracts (PSC) are associated with hereditary retinal dystrophy in the Royal College of Surgeons (RCS) rat model and with human retinitis pigmentosa. The relationship of lens and retinal pathology has never been explained. Previous studies of pink-eyed RCS rats aged 2.5 to 11 months had shown an...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688209011629
更新日期:1982-01-01 00:00:00
abstract:PURPOSE/AIM OF THE STUDY:Polarization-sensitive anterior-segmental optical coherence tomography (PS-OCT) is useful to evaluate the filtering blebs after trabeculectomy. However, the attenuation phenomenon of OCT signal disturbs the visibility of intra-bleb's structure and distribution of birefringence; a specific param...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1825749
更新日期:2020-10-04 00:00:00
abstract:PURPOSE:To compare the retinal sensitivity, using Microperimeter and the morphological changes in retinal layers, using Spectral Domain Optical Coherence Tomography (SD-OCT), between myopes and age-matched emmetropes. METHODS:Twenty-nine myopic eyes and 29 emmetropic eyes were enrolled in this prospective case control...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.599105
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To investigate the antiproliferative effects of the subconjunctival injection of human RAD50 (hRAD50) on fibroblasts after glaucoma filtering surgery. METHODS:After glaucoma filtering surgery in normal rabbit eye, the subconjunctival injection of hRAD50 was performed. Morphologic changes in the subconjunctival...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.3.181.26247
更新日期:2004-03-01 00:00:00
abstract:PURPOSE/AIM OF THE STUDY:The aim of this study is to investigate the effect of pseudoexfoliation (PEX) and PEX-induced dry eye on central corneal thickness (CCT). MATERIALS AND METHODS:This cross-sectional study consists of total 270 eyes of 135 patients (67 females, 68 males) in total. After excluding the PEX (-) 32 ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1030505
更新日期:2016-01-01 00:00:00
abstract:AIM OF THE STUDY:The similarity of many benign intrabulbar lesions to a malignant tumor requires detailed differential diagnostics. However, none of the known methods can be used as the only one to determine the type of lesions. The aim of this study was to determine color Doppler imaging (CDI) markers characteristic o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1341534
更新日期:2017-11-01 00:00:00
abstract::Experiments were conducted to test the influence of thapsigargin on the NaK-ATPase activity of cultured cells (ODM2) derived from human nonpigmented ciliary epithelium. The rate of ouabain-sensitive ATP hydrolysis (Na,K-ATPase activity) was diminished in cells that had been pretreated with thapsigargin then permeabili...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508998492
更新日期:1995-08-01 00:00:00
abstract:PURPOSE:Corneal wound healing after excimer laser photorefractive keratectomy (PRK) passes through a series of characteristic stages which have earlier been defined by means of histological, histochemical, and biochemical approaches. We investigated the potential of confocal microscopy to verify morphological changes i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.7.640.5058
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Aqueous extract of Pleurotus tuberregium (PT) has been shown to reduce intraocular pressure (IOP) but the underlying mechanism has not been explained. PURPOSE:To investigate the effect of PT on the bovine iris in vitro in comparison with acetylcholine (ACh). METHOD:Strips of the iris were mounted in 10 ml ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.747615
更新日期:2013-03-01 00:00:00
abstract::The changes in mouse corneal inflammatory cell population and the phagocytic capability of these cells were studied quantitatively at 24 and 48 hours after eliciting inflammatory cells into the cornea by Pseudomonas aeruginosa inoculation. Mice were selected for study according to their ability (young adult Swiss-Webs...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008995199
更新日期:1990-02-01 00:00:00
abstract:PURPOSE/AIMS:To evaluate the prognostic factors for the best corrected visual acuity (BCVA) and central subfield macular thickness (CSMT) after vitrectomy with internal limiting membrane (ILM) peeling for diabetic macular edema. MATERIALS AND METHODS:A total of 44 eyes of 35 patients who had undergone vitrectomy with ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.820327
更新日期:2013-12-01 00:00:00
abstract::Purpose: To investigate the cytotoxic effects of fresh black carbon (FBC) particles and ozone-oxidized BC (OBC) particles on human corneal epithelial cells (HCECs), and the role of the NLRP3 inflammasome signal pathway in the process.Methods: HCECs were treated with different doses of FBC and OBC particles, the cell i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1698051
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To study the mechanisms of peroxynitrite-induced photoreceptor cell damage, using retinal cultures and a peroxynitrite donor, 3-morpholinosydnonimine (SIN-1). METHODS:Retinal explants obtained from 20-day-old Lewis rat pups, were exposed to SIN-1 for varying lengths of time at varying concentrations. Apoptosis...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.1.17.23488
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:C5a anaphylatoxin is a potent inflammatory mediator that acts on polymorphonuclear cells (PMN) and monocytes via C5a receptors (C5aR). It mediates chemotaxis of both cell types and stimulates cytokine release from the latter. To investigate whether C5a can act on retinal pigment epithelial (RPE) cells, we exami...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.5.320.5437
更新日期:2001-11-01 00:00:00
abstract::We studied the effects of a forskolin suspension on intraocular pressure (IOP) in normal albino and pigmented rabbits and in alpha-chymotrypsin induced ocular hypertensive rabbits. Experimental-induced ocular hypertensive rabbits were produced by injecting of alpha-chymotrypsin (167 units) into the posterior chamber o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809033195
更新日期:1988-07-01 00:00:00