Abstract:
:In experimental work on retinal ischemia and its medical management, we have been disturbed by the large variations in the electroetinogram (ERG) recovery of rabbit eyes subjected to similar degrees of ischemia. We investigated whether body temperature might be one of the critical factors. We studied pigmented Dutch rabbits that had been subjected to 60 min of ocular ischemia followed by 4 h of reperfusion at different body temperatures. Ischemia was produced by cannulating the anterior chamber and raising the intraocular pressure. Scotopic ERGs and rectal temperatures were recorded at regular intervals. Rabbits with a subnormal mean temperature of 35.5-37.7 degrees C throughout the experiment showed mean a- and b-wave recoveries of 131.52% and 107.68% of preischemic values after 4 h reperfusion. At temperatures between 37.8-38.9 degrees C, the a- and b-waves only recovered to 88.43% and 32.0% respectively. Even small degrees of cooling greatly enhanced post-ischemic ERG recovery. This may explain some of the variations in ERG recovery that have been reported in the literature. We suggest that body temperature should be tightly controlled between 37.8 and 38.9 degrees C during ischemia experiments to stabilize results and minimize errors in judging therapeutic effects. Retinal cooling may be a means to protect the retina against ischemic damage in clinical situations.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Nayak MS,Marmor MFdoi
10.3109/02713689508999918subject
Has Abstractpub_date
1995-02-01 00:00:00pages
81-5issue
2eissn
0271-3683issn
1460-2202journal_volume
14pub_type
杂志文章abstract:PURPOSE:The purpose of these studies is to develop an in vitro model of corneal endothelial aging and to investigate age-related changes in morphology, mitosis, prostaglandin synthesis and prostaglandin response pathways. METHODS:First-passage rabbit corneal endothelial cells were grown in vitro for up to 30 days afte...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.5.428.7048
更新日期:1997-05-01 00:00:00
abstract:PURPOSE:In the mature retina retinoic acid (RA) biosynthesis was reported to be regulated by light. RA is of vital importance for proper function of the retina. RA activity is mediated by interaction with nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The purpose of this study was to determine ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.4.338.5307
更新日期:1999-10-01 00:00:00
abstract::We assessed the role of platelet-activating factor (PAF) in corneal allograft rejection and evaluated the effects of a PAF antagonist on corneal inflammation, cellular infiltration, vascularization, and edema. Rabbits with vascularized corneas served as recipients of allogeneic cornea grafts. Rabbits with normal corne...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409042408
更新日期:1994-02-01 00:00:00
abstract:PURPOSE:Alternative splicing of the last exon (exon 8) of vascular endothelial growth factor (VEGF) pre-mRNA is a key element in the balance of pro- and anti-angiogenic VEGF isoforms in exudative age-related macular degeneration (exAMD) and proliferative diabetic retinopathy (PDR). Three splicing factors, SRp40, ASF/SF...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.548892
更新日期:2011-04-01 00:00:00
abstract::Processing of visual information within the retina depends in large measure upon a complement of chemical neurotransmitters which are released at synaptic contacts between individual neurons. Numerous investigators have participated in the identification of many of these transmitters and their assignment to specific n...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713689609003465
更新日期:1996-07-01 00:00:00
abstract:PURPOSE:Recent studies have shown that the levels of interleukin (IL)-1beta, IL-6 and IL-8 are associated with the severity of infectious diseases. The purpose of this study was to investigate whether IL-1beta regulates the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas aeruginosa colo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.6.406.6969
更新日期:2001-12-01 00:00:00
abstract:PURPOSE:Nitric oxide production can cause either apoptotic or necrotic cell death through oxidative stress. We aimed to investigate the nitrite oxide metabolites (NOx) and nitrite levels in the aqueous humor of rabbit eyes after different methods of corneal collagen cross-linking (CXL). MATERIALS AND METHODS:Twenty-fo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2016.1139726
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To evaluate the ultrastructure of the cut edge and associated endothelial cell loss following donor cornea trephination with a standard punch, vacuum punch, and vacuum trephine and artificial anterior chamber system. MATERIALS AND METHODS:This laboratory investigation compared trephinations (8.0 mm) performed ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713680903222779
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:To study retinal neovascularization (RNV) inhibition by intravitreal injections (IVs) of ranibizumab, sTie2 fusion protein (sTie2-Fc), and a combined therapy in an oxygen-induced retinopathy (OIR) model. MATERIALS AND METHODS:An OIR mouse model was used to simulate RNV in retinopathy of prematurity (ROP); and ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1484144
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To investigate the effects of pyrrolidine dithiocarbamate (PDTC), a nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) inhibitor, on the expression of matrix metalloproteinases (MMP) and MMP-mediated apoptosis in retinal ganglion cells (RGCs) following the transection of the optic nerve (ON) in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.606591
更新日期:2011-11-01 00:00:00
abstract::This study reports on serum interleukin 2-receptor (IL-2R) levels in uveitis patients. IL-2R is the mediator protein of interleukin 2 (IL-2), a mitogenetic cytokine of primarily immune cell interaction. Stimulated T-cells readily express IL-2R on their cell surface and release a soluble form into serum. The measuremen...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999415
更新日期:1990-01-01 00:00:00
abstract::Four days after corneal inoculation of mice with herpes simplex (type 1) virus (HSV), infected trigeminal ganglion cells with and without calcitonin gene-related peptide (CGRP) antigenicity were examined by electron microscopy in sections treated with colloidal gold labeled antibodies. Cells that contain CGRP were ide...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689109020354
更新日期:1991-01-01 00:00:00
abstract::Na/K ATPase activity has been determined in normal and cataractous human lenses using labeled ATP as a substrate. The enzyme is distributed throughout the lens with approximately 1/3 of the total activity in the capsule-epithelium and 1/2 of the activity in the cortex. Furthermore, the activity of Na/K ATPase decrease...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688209000778
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the effect of vitreous reflux (VR) on the short-term effect of intravitreal ranibizumab injection. MATERIALS AND METHODS:The study included 181 eyes of 81 age-related macular degeneration (AMD) and 100 diabetic macular edema (DME) patients. Treatment response was evaluated...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1789664
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:The prospective study evaluated the effects of optical defocus on kinetic sensitivity using automated kinetic perimetry. MATERIALS AND METHODS:The 17 eyes of 17 healthy young participants were evaluated. All of the participants had myopia (≥ -5.00 D) and mild to no astigmatism (<1.00 D). Automated kinetic peri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.961614
更新日期:2015-01-01 00:00:00
abstract::Utilizing a rapid colorimetric assay that relates cell number to cytoplasmic hexosaminidase activity, we conducted drug-induced cytotoxicity experiments on human ocular fibroblasts cultured from Tenon's capsule specimens. The effects of two different agents--dimethyl sulfoxide (DMSO) or mitomycin C--on the proliferati...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999599
更新日期:1990-06-01 00:00:00
abstract:PURPOSE:The aim of the present study was to calculate the diameter of the central retinal artery from results as obtained with non-invasive techniques in healthy young subjects. METHODS:Twenty-four healthy male subjects participated in this study. Total retinal blood flow was calculated from combined bi-directional la...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.25.6.341.14231
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate how glutathione reductase (GR) loses its activity during cataract formation and whether it is possible to revive it back to the normal levels. METHOD:In this study, endogenous as well as synthetic reducing systems (GSH, TTase, DTT, captopril) and alpha-crystallin at dif...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680590953110
更新日期:2005-10-01 00:00:00
abstract::The 'fast PIII' rod mediated photoreceptor response to flashes of monochromatic light has been investigated in isolated retinae of the RCS rat at age 30 days. A loss of both sensitivity and maximum response amplitude were found, with a concurrent slowing of the response kinetics. These observations indicate a rod abno...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000805
更新日期:1984-09-01 00:00:00
abstract:PURPOSE:To evaluate central corneal thickness (CCT) and corneal volume (CV) in healthy eyes using swept source anterior segment optical coherence tomography (SS-AS-OCT) and other devices. METHODS:Thirty-three healthy right eyes of 33 subjects were investigated. CCT was measured with SS-AS-OCT, rotating Scheimpflug cam...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713683.2012.745878
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Diabetic maculopathy (DM) treated with photocoagulation may subsequently progress to proliferative diabetic retinopathy (PDR). However, there is insufficient knowledge about the incidence and risk factors for the development of PDR in patients previously treated for DM. MATERIALS AND METHODS:Survival data was ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1712729
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.12.1193.5027
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To investigate the therapeutic role of topical and oral fluconazole treatment using a rabbit model of Aspergillus fumigatus keratitis. METHODS:Aspergillus fumigatus spores were injected into the corneal stroma of the right eye of 20 rabbits. Forty-eight hours later the rabbits were randomly divided into three ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.2.113.14514
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:To determine the role of matrix metalloproteinase 9 (MMP9) in advanced glycation end-products (AGEs) induced damage to blood-retinal barrier (BRB) and the therapeutic effects of minocycline, an MMP inhibitor, against the BRB damages. METHODS:Forty-eight Sprague Dawley rats were randomly assigned to 3 groups (1...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802450984
更新日期:2008-11-01 00:00:00
abstract::Purpose: To evaluate the effect of methylphenidate on visual field testing in healthy adults with abnormal visual field results. Methods: This prospective, randomized, controlled interventional clinical trial comprised all patients who had abnormal visual field test results and normal eye examination and ophthalmic hi...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1858430
更新日期:2020-12-21 00:00:00
abstract:PURPOSE:We investigated the impact of target properties on vertical fusion amplitude (VFA) using a 3D display platform; the performance of the subjects allowed us to assess how central and peripheral retina regions interact during the fusion process. MATERIAL AND METHODS:Fourteen subjects were involved in the test. VF...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1196704
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Based on the relationship between keratoconus and dry eye, the aim of this study was to evaluate changes in signs and symptoms of dry eye in keratoconus patients before and after intrastromal corneal ring surgery. METHODS:Fifteen keratoconus patients were enrolled in Fundación Jiménez-Díaz of Madrid and Univer...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1200098
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:Current standard of care for neovascular eye diseases require repeated intravitreal bolus injections of anti-vascular endothelial growth factors (anti-VEGFs). The purpose of this study was to validate a degradable microsphere-thermoresponsive hydrogel drug delivery system (DDS) capable of releasing bioactive af...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1533983
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:The purposes of this study were to investigate the effects of topically administrated Tacrolimus and Octreotide on modulation of postoperative scarring in experimental glaucoma filtration surgery and to compare the antifibrotic properties of these agents with mitomycin-C (MMC). MATERIAL AND METHODS:A total of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.635404
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation research, the quest to understand RPE physiology, and a desire to modulate RPE in pathological states. W...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1809001
更新日期:2020-09-01 00:00:00