Abstract:
OBJECTIVES:1) To elucidate the role of collector channels in the aqueous humor outflow pathway 2) To suggest anatomic and functional methods of imaging collector channels in-vitro and in-vivo and 3) To discuss the role of such imaging modalities in the surgical management of glaucoma. METHODS:A thorough literature search was conducted on databases for studies published in English regarding the available methods to determine the role of collecting channels in normal and glaucomatous patients and to assess their patency. RESULTS:Intraocular pressure (IOP) exists as a balance between aqueous humor production and aqueous humor outflow. Collector channels are an essential anatomical constituent of the distal portion of the conventional aqueous humor outflow pathway. There are different surgical options for glaucoma management and with the recent advances in Schlemm's canal-based surgeries, collector channel's patency became a key factor in determining the optimum management for the glaucomatous eye. The advent of anatomic imaging methods has improved the ability to visualize collector channel morphology in-vitro, including swept-source optical coherence tomography (SS-OCT), spectral domain optical coherence tomography (SD-OCT), micro-computed tomography (micro CT), new immunohistochemistry techniques and scanning electron microscopy. The recent advent of real-time assessment of collector channel patency (including evaluation of episcleral venous outflow, observation of episcleral venous fluid wave, and tracer studies utilizing fluorescein, indocyanine green, and trypan blue) has been validated by the aforementioned anatomic imaging modalities. CONCLUSIONS:New modalities of in-vitro and in-vivo studies of collector channels provide promise to aid in the assessment of collector channel patency and individualization of surgical management for glaucoma patients.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
M Elhusseiny A,Jamerson EC,Menshawey R,Tam EK,El Sayed YMdoi
10.1080/02713683.2020.1773866subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1181-1187issue
10eissn
0271-3683issn
1460-2202journal_volume
45pub_type
杂志文章abstract:PURPOSE:Klotho genes are expressed in limited tissues and have been found to be a pathogenic factor of age-related diseases in mammals, but their expressions and functions in human eyes are yet to be defined. This study was performed to investigate the expression of Klotho family genes in human ocular tissues and anter...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1259421
更新日期:2017-06-01 00:00:00
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journal_title:Current eye research
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doi:10.1076/ceyr.22.3.229.5511
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abstract::Purpose: To compare four visual acuity (VA) scoring termination rules. Methods: A computer simulation generated 30,000 virtual patients who underwent 10 repetitions for each of four termination rules, on both the Snellen and ETDRS charts (2.4 million tests performed in total). Three termination rules focused on the sm...
journal_title:Current eye research
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doi:10.1080/02713683.2019.1589524
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019973
更新日期:1981-01-01 00:00:00
abstract::The possible roles of monocytes and lymphocytes in vitreous fibrosis were examined by injecting various numbers of the peripheral cell types into the rabbit vitreous. Our results indicated that the degree of vitreous fibrosis and the presence of traction retinal detachment corresponded to the number of cells injected....
journal_title:Current eye research
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doi:10.3109/02713688809033223
更新日期:1988-12-01 00:00:00
abstract::Penetrating keratoplasty was the only therapeutic choice for the treatment of corneal endothelial decompensation until the introduction of evolutional endothelial keratoplasties, namely Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK). Although now...
journal_title:Current eye research
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doi:10.1080/02713683.2019.1700529
更新日期:2020-03-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.27.2.61.15454
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:To compare the quality of corneal endothelium of precut Descemet-stripping automated endothelial keratoplasty (DSAEK) tissue when transported with and without the anterior lamellar corneal tissue (ALCT) when organ-culture corneal storage methods are used. METHODS:After microkeratome-assisted excision of anteri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.648045
更新日期:2012-02-01 00:00:00
abstract::The acyclic nucleoside phosphonate analogue PMEA [9-(2-phosphonylmethoxyethyl)adenine] is a broad spectrum antiviral agent effective against DNA viruses and retroviruses. It is particularly active against the human immunodeficiency virus and, like other phosphonylmethoxyalkyl derivatives, it also inhibits HSV-1, TK- H...
journal_title:Current eye research
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journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
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更新日期:2018-03-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1540704
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490503769
更新日期:2004-06-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000822
更新日期:1984-10-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.483312
更新日期:2010-08-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.593107
更新日期:2011-09-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713683.2015.1037924
更新日期:2016-01-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.4.396.10685
更新日期:1997-04-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600602547
更新日期:2006-04-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
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更新日期:2019-06-01 00:00:00
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journal_title:Current eye research
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journal_title:Current eye research
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更新日期:1993-03-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2011-12-01 00:00:00
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更新日期:1988-11-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209033498
更新日期:1992-10-01 00:00:00
abstract::Adult albino mice received tritiated thymidine either injected subcutaneously (333 microCi) every 6 hours for up to 36 hours, or administered in their drinking water for up to 74 days (about 45 microCi/day). Tissue sections were examined with autoradiography to determine the distribution of the label. Animals receivin...
journal_title:Current eye research
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更新日期:1988-03-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1004718
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00