Aqueous humor as a modulator of growth in fibroblast cultures.

abstract：:Antifibrosis agents have improved the success of glaucoma filtration surgery, although undesired side effects are not readily reversible and may present a major limitation in the use of these agents. Our purpose was to study the efficacy of cytosine arabinoside (Ara-C) as an adjunctive antimetabolite in glaucoma surge...

journal_title：Current eye research

authors： Chu JL,Shields SR,Netland PA

更新日期：1994-11-01 00:00:00

abstract：:In the Royal College of Surgeons rat, the migration of phagocytic cells into the subretinal space accompanies photoreceptor cell death during the early stages of retinal dystrophy. These are followed closely by cellular alterations in the retinal pigment epithelium, Müller cells, and outer retinal vessels. We have ide...

journal_title：Current eye research

authors： Roque RS,Caldwell RB

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To investigate the agreement of angular locations of retinal nerve fiber layer (RNFL) defect margins in glaucomatous eyes by using red-free fundus photographs and Cirrus high-definition optical coherence tomography (OCT) RNFL deviation and thickness maps. METHODS:We examined 380 RNFL defects that showed clear ...

journal_title：Current eye research

authors： Hwang YH,Kim YY,Kim HK,Sohn YH

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:To evaluate the length of the trabecular meshwork (TM) from the scleral spur (SS) to Schwalbe's line (SL) and assess the detectability of the SS in histopathology specimens. METHODS:This study included 158 angle images from 79 cross-sectional slides derived from eyes enucleated for melanoma. The slides were st...

journal_title：Current eye research

authors： Kasuga T,Chen YC,Bloomer MM,Hirabayashi KE,Hiratsuka Y,Murakami A,Lin SC

更新日期：2013-01-01 00:00:00

abstract：:Macrophages are invariably present in the intraocular membranes of patients with traumatic proliferative vitreoretinopathy (PVR). There are two sources from which these macrophages could be recruited: adjacent tissues and the systemic circulation. In the study described herein, the role of circulating white blood cell...

journal_title：Current eye research

authors： Gabrielian K,Wang HM,Lee M,Ogden TE,Ryan SJ

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:In tissues outside the brain, vascular endothelial growth factor-A (VEGF) causes vascular hyper-permeability by opening of inter-endothelial junctions and induction of fenestrations and vesiculo-vacuolar organelles (VVOs). In preliminary studies, we observed that in blood-retinal barrier endothelium, other cell...

journal_title：Current eye research

authors： Hofman P,Blaauwgeers HG,Tolentino MJ,Adamis AP,Nunes Cardozo BJ,Vrensen GF,Schlingemann RO

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:To determine whether environmental factors or bacterial viability affect the binding of two strains of P. aeruginosa to mouse cornea. METHODS:Scarified corneas were placed in organ culture and inoculated with P. aeruginosa cell suspensions containing either ATCC 19660 or PAO1 bacterial strains classed as cytot...

journal_title：Current eye research

authors： Chen L,Hobden JA,Masinick SA,Hazlett LD

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:To determine the relative expression of metallothionein isoforms and their differential induction by oxidative stress in cultured RPE cells and to localize the isoforms in the human chorioretinal complex. METHODS:Total RNA was isolated from cultured human retinal pigment epithelial cells using TRI-Reagent. An ...

journal_title：Current eye research

authors： Tate DJ,Miceli MV,Newsome DA

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Considerable evidence suggests that both axial and peripheral refraction play important roles in eye growth control. The large variability in peripheral refraction seen in adults and children indicates that the peripheral retina is exposed to a wide range of refractive errors. The current lack of appropriate me...

journal_title：Current eye research

authors： Schmid GF

更新日期：2003-07-01 00:00:00

abstract：:Purpose: To investigate the cytotoxic effects of fresh black carbon (FBC) particles and ozone-oxidized BC (OBC) particles on human corneal epithelial cells (HCECs), and the role of the NLRP3 inflammasome signal pathway in the process.Methods: HCECs were treated with different doses of FBC and OBC particles, the cell i...

journal_title：Current eye research

authors： Long Q,Huang Y,Shang J,Liu Y,Chen C

更新日期：2020-06-01 00:00:00

abstract：AIM:To investigate microscopic changes in corneal morphology in chloroquine (CQ)-treated patients without corneal abnormalities being diagnosable by slit lamp microscopy. METHODS:Thirty-six eyes of 36 patients with rheumatoid arthritis (RA) were divided into two groups: group 1 included 26 patients receiving chloroqui...

journal_title：Current eye research

authors： Ma X,He L,He D,Xu J

更新日期：2012-04-01 00:00:00

abstract：:Steroids are widely used in the prevention of corneal neovascularization in a wide range of natural and experimental situations. However, no information is available on their effect on the growth of the individual limbal blood vascular cells or of lymphatic cells involved in corneal neovascularization. In addition, tr...

journal_title：Current eye research

authors： Boneham GC,Collin HB

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:The mechanism by which prostaglandin(PG)F2 alpha increases uveoscleral outflow and lowers intraocular pressure in primates is not known. In cultured human ciliary muscle cells, PGF2 alpha induces the expression of the protooncogene c-fos which is known to induce the transcription of genes such as matrix metallo...

journal_title：Current eye research

authors： Lindsey JD,Kashiwagi K,Boyle D,Kashiwagi F,Firestein GS,Weinreb RN

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:The mechanisms involved in the reported beneficial effects of Calcium dobesilate monohydrate (CaD) for the treatment of diabetic retinopathy (DR) remain to be elucidated. The main aim of the present study is to examine whether CaD prevents early events in the pathogenesis of DR such as neurodegeneration and vas...

journal_title：Current eye research

authors： Solà-Adell C,Bogdanov P,Hernández C,Sampedro J,Valeri M,Garcia-Ramirez M,Pasquali C,Simó R

更新日期：2017-09-01 00:00:00

abstract：:Uveal melanoma develops in one of the most capillary-rich tissues of the body and is disseminated hematogenously. Knowledge of the nature and the spatiotemporal expression of angiogenic factors in uveal melanoma is essential to the development of new treatment strategies, especially with regard to improving survival. ...

journal_title：Current eye research

authors： Notting IC,Missotten GS,Sijmons B,Boonman ZF,Keunen JE,van der Pluijm G

更新日期：2006-09-01 00:00:00

abstract：:The initial rapid fall in tear film fluorescence after instilling a 1 microliter drop of fluorophore could be a result of stimulated tear flow or of distribution of the dye throughout the tear fluid present in the conjunctival sac. An attempt was made to decide this by comparing the fall in fluorescence of two differe...

journal_title：Current eye research

authors： Sang NM,Maurice DM

更新日期：1995-04-01 00:00:00

abstract：:Severe retinopathy of prematurity (ROP) occurs in the smallest and sickest of premature infants. We hypothesized that, in a rat model of oxygen induced retinopathy, abnormal neovascularization would occur more frequently in larger litters where the pups are subject to postnatal growth retardation. Four litters of newb...

journal_title：Current eye research

authors： Holmes JM,Duffner LA

更新日期：1996-04-01 00:00:00

abstract：:The possible roles of monocytes and lymphocytes in vitreous fibrosis were examined by injecting various numbers of the peripheral cell types into the rabbit vitreous. Our results indicated that the degree of vitreous fibrosis and the presence of traction retinal detachment corresponded to the number of cells injected....

journal_title：Current eye research

authors： Raymond LA,Katakami C,Lipman MJ,Alexander DW,Spaulding AG,Choromokos E,Kao WW

更新日期：1988-12-01 00:00:00

abstract：:Corneal acidosis has been shown to reduce corneal hydration control (CHC) as measured by the rate, expressed as the percent recovery per hour (PRPH), at which the thickness of the cornea decreases exponentially after an increased hydration load. Since the effect of pH on corneal function is of scientific interest and ...

journal_title：Current eye research

authors： Cohen SR,Polse KA,Brand RJ,Bonanno JA

更新日期：1995-05-01 00:00:00

abstract：:Purpose: To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). Materials and methods: An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure sus...

journal_title：Current eye research

authors： Wang X,Chen J,Kong X,Sun X

更新日期：2020-11-26 00:00:00

abstract：:DNA sequence analysis of overlapping shotgun and restriction fragments have revealed the entire sequence of the human lens fiber cell intrinsic membrane protein MP19 gene (also termed MP17, MP18, and MP20). The 8,056 bp MP19 gene contains 5 exons encoding a mature protein of 173 amino acids, which displayed a very hig...

journal_title：Current eye research

authors： Church RL,Wang JH

更新日期：1993-12-01 00:00:00

abstract：:Approximately 90% of all ophthalmic drug formulations are now applied as eyedrops. Although eyedrops are convenient and well accepted by patients, about 95% of the drug contained in the drops is lost due to absorption through the conjunctiva or through the tear drainage. A major fraction of the drug eventually enters ...

journal_title：Current eye research

authors： Gulsen D,Li CC,Chauhan A

更新日期：2005-12-01 00:00:00

abstract：:The goal of this study was to determine the effect of extracellular matrix components on the phagocytic function of the retinal pigment epithelial (RPE) cell. Cultured human fetal RPE cells were established in culture and plated on three commercially-prepared substrates: collagen IV, fibronectin and laminin and on thr...

journal_title：Current eye research

authors： Miceli MV,Newsome DA

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To evaluate serum and aqueous humor levels of fetuin-A in patients with pseudoexfoliation syndrome (PEXS) in comparison with those of age- and sex-matched healthy subjects. MATERIALS AND METHODS:This prospective study included 25 patients with PEXS and 25 control subjects who were undergoing cataract surgery w...

journal_title：Current eye research

authors： Yuksel N,Takmaz T,Ozel Turkcu U,Ergin M,Altinkaynak H,Bilgihan A

更新日期：2017-10-01 00:00:00

abstract：:Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for aver...

journal_title：Current eye research

authors： Sundmacher R,Mattes A,Neumann-Haefelin D,Adolf G,Kruss B

更新日期：1987-01-01 00:00:00

abstract：:Specimens of a cornea, conjunctiva and iris were removed at the time of penetrating keratoplasty in a case of nephropathic cystinosis. Immunohistochemical studies revealed the presence of class II antigens on the stromal keratocytes of the cornea and the vascular endothelial cells, pericytes and fibroblasts of the con...

journal_title：Current eye research

authors： Kaiser-Kupfer MI,Chan CC,Rodrigues M,Datiles MB,Gahl WA

更新日期：1987-04-01 00:00:00

abstract：PURPOSE:To evaluate differences of phagocytic capacities in rat retinal pigment epithelial (RPE) cells, iris pigment epithelial (IPE) cells, and basic fibroblast growth factor (bFGF) cDNA-transfected IPE (bFGF-IPE) cells in vitro. METHODS:The RPE cells and IPE cells were isolated from adult Long Evans rats' eyes. The ...

journal_title：Current eye research

authors： Sakuragi M,Tomita H,Abe T,Tamai M

更新日期：2001-09-01 00:00:00

abstract：:With Golgi impregnation, a simple amacrine cell type is described in the chick retina. The most relevant morphological feature of these retinal neurons is a single straight, radial trunk which dichotomizes tangentially in a rectilinear expansion in the 5th stratum of the inner plexiform layer (IPL). ...

journal_title：Current eye research

authors： Genis-Galvez JM,Chmielewski CE,Prada FA

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:Previously we established a strong association of systemic hypertension with cataract formation. In the present study, we investigated the role of nitric oxide (NO) in the development of cataract formation in CdCl2-induced hypertensive animals. MATERIALS AND METHODS:Hypertension was induced in male albino rats...

journal_title：Current eye research

authors： Yadav A,Choudhary R,Bodakhe SH

更新日期：2018-12-01 00:00:00

abstract：:In these experiments we characterize rabbit and bovine corneal endothelia cell cultured on microporous membrane filters (0.6cm2). Cell cultured bovine or rabbit corneal endothelial cells (subcultures 1-3) were seeded onto Millicell-HA filter inserts. Electrical resistance measured across the cultured monolayers increa...

journal_title：Current eye research

authors： Geroski DH,Hadley A

更新日期：1992-01-01 00:00:00