20:5n-3 but not 22:6n-3 is a preferred substrate for synthesis of n-3 very-long- chain fatty acids (C24-C36) in retina.

abstract：PURPOSE:Nuclear factor-kappa B (NF-κB) has been proposed as a therapeutic target for the treatment of cataracts. The authors investigated the relationship between nuclear factor of activated T cells 5 (NFAT5) and NF-κB in ultraviolet B (UVB)-irradiated human lens epithelial (HLE) cells. METHODS:Human lens epithelial B...

journal_title：Current eye research

authors： Chung I,Hah YS,Ju S,Kim JH,Yoo WS,Cho HY,Yoo JM,Seo SW,Choi WS,Kim SJ

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To determine the effectiveness of topically applied fluoroquinolones for experimental Pseudomonas or Serratia keratitis. METHODS:Bacteria were injected intrastromally (10(3) colony forming units [CFU]). From 16 to 22 hours post-infection (PI), a single topical drop of moxifloxacin (Vigamox, 0.545%), levofloxac...

journal_title：Current eye research

authors： Thibodeaux BA,Dajcs JJ,Caballero AR,Marquart ME,Girgis DO,O'Callaghan RJ

更新日期：2004-05-01 00:00:00

abstract：:The effect of monensin on the cytotoxic effect of antitransferrin receptor immunotoxin (IT) was determined on cultured, human retinal pigment epithelial (hRPE) cells. Human RPE cells were treated with 0.1-10,000 ng/ml IT with and without 0.01-0.1 microM monensin, a lysosomotropic reagent that can influence IT activity...

journal_title：Current eye research

authors： Handa JT,Houston LL,Jaffe GJ

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To investigate the multifocal electroretinogram (mfERG) and subjective function in early age-related maculopathy (ARM). METHODS:Seventeen subjects with early ARM with visual acuity (VA) of 6/12 or better and 20 age-matched control subjects were examined. We assessed mfERGs, high and low contrast distance VA, n...

journal_title：Current eye research

authors： Feigl B,Brown B,Lovie-Kitchin J,Swann P

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:To study the effect of cataract surgery with intraocular lens (IOL) on frequency doubling perimetry (FDP). METHODS:Patients aged 40 years or above seen at our outpatient clinic with no ocular pathology except for visually significant cataract and visual acuity 6/24 or better were eligible. They underwent FDP b...

journal_title：Current eye research

authors： Arvind H,George R,Baskaran M,Raju P,Ramesh SV,Paul PG,Vijaya L

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:Membrane-associated mucins are important components of the ocular tear film. Our objective was to characterize the expression of membrane-associated mucins MUC1, MUC4, and MUC16 in healthy cornea, healthy conjunctiva, fibrovascular tissue (pannus) covering the corneal surface in limbal stem cell deficiency (LSC...

journal_title：Current eye research

authors： Pauklin M,Kakkassery V,Steuhl KP,Meller D

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:The aim of this review is to evaluate the efficacy of available Purtscher's Retinopathy treatments. MATERIALS AND METHODS:In order to collect single-case reports, electronic searches were conducted in several databases including PubMed, Embase, Web of Science, China National Knowledge Infrastructure, SinoMed...

journal_title：Current eye research

authors： Xia D,Chen X,Zhou Q,Xiao S,Yu Y,Wang Y,Du G,Huang H,Zhang W,Chen Y

更新日期：2017-06-01 00:00:00

abstract：:The selective DA2 agonist, N-0437, produced an acute reduction in intraocular pressure (IOP) and pupil diameter (PD) when applied topically to the eyes of normal monkeys. Ocular hypotension and miosis were primarily unilateral in nature, dose-related and lasted 3 to 5 hours following drug instillation. In normal monke...

journal_title：Current eye research

authors： Crosson CE,Burke JA,Chan MF,Potter DE

更新日期：1987-11-01 00:00:00

abstract：PURPOSE:This study was designed to investigate whether synthetic small interference RNA (siRNA) targeting VEGF-A could inhibit mouse corneal neovascularization or not. METHODS:First, the effect of synthetic siRNA targeting VEGF-A on the expression of VEGF in human retinal pigment epithelial line ARPE-19 cells was exam...

journal_title：Current eye research

authors： Zuo L,Fan Y,Wang F,Gu Q,Xu X

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Considerable evidence suggests that both axial and peripheral refraction play important roles in eye growth control. The large variability in peripheral refraction seen in adults and children indicates that the peripheral retina is exposed to a wide range of refractive errors. The current lack of appropriate me...

journal_title：Current eye research

authors： Schmid GF

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:A quick, simple, and efficient extraction technique was developed for the removal of protein from soft hydrophilic contact lenses. METHODS:An extraction solvent consisting of a 50:50 mix of 0.2% trifluoroacetic acid and acetonitrile was used to remove protein from in vitro laboratory-deposited and human-worn c...

journal_title：Current eye research

authors： Keith D,Hong B,Christensen M

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:Mechanical stimulation induces intercellular Ca(2 +) waves in the corneal endothelium. The extent of the wave propagation is dependent on the activity of gap junctions, hemichannels, and ectonucleotidases. To further establish the use of a cell culture model to investigate intercellular communication, in this s...

journal_title：Current eye research

authors： D'hondt C,Ponsaerts R,Srinivas SP,Vereecke J,Himpens B

更新日期：2009-06-01 00:00:00

abstract：UNLABELLED:Abstract Purpose of the Study: Protein tyrosine phosphatase σ (PTPσ) acts as a neuronal receptor for chondroitin sulfate proteoglycans (CSPGs). CSPGs have inhibitory effects on experience-dependent plasticity and usually form lattice-like cell coatings that surround the parvalbumin (PV) interneurons in the v...

journal_title：Current eye research

authors： Liu H,Xu H,Yu T,Yao J,Zhao C,Yin ZQ

更新日期：2013-10-01 00:00:00

abstract：:Purified Pseudomonas aeruginosa elastase cleaved a 65 kDa gelatinase [inactive proenzyme form of matrix metalloproteinase (MMP-2)] from human corneal fibroblasts into a biologically active fragment with an approximate molecular mass of 58 kDa. However, purified pseudomonal alkaline protease did not cleave MMP-2 apprec...

journal_title：Current eye research

authors： Matsumoto K,Shams NB,Hanninen LA,Kenyon KR

更新日期：1992-11-01 00:00:00

abstract：:A method is described for the preparation of plasma membrane enriched fractions from bovine retinal pigment epithelium (RPE) by means of differential centrifugation followed by the use of self forming gradients of Percoll. A detailed analysis of the distribution of organelle specific markers (nuclei, mitochondria, lys...

journal_title：Current eye research

authors： Ottonello S,Maraini G

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:There is a clinical need for biomimetic corneas that are as effective, preferably superior, to cadaveric donor tissue. Decellularized tissues are advantageous compared to synthetic or semi-synthetic engineered tissues in that the native matrix ultrastructure and intrinsic biological cues including growth fac...

journal_title：Current eye research

authors： Wilson SL,Sidney LE,Dunphy SE,Dua HS,Hopkinson A

更新日期：2016-06-01 00:00:00

abstract：:Changes in the content of calcitonin gene-related polypeptide (CGRP) and tyrosine hydroxylase (TH) immunoreactivities in the anterior segment of the rat eye were assessed histochemically in animals subjected to sympathetic ganglionectomy or to chronic sensory denervation induced by neonatal capsaicin treatment. In the...

journal_title：Current eye research

authors： Unger WG,Terenghi G,Zhang SQ,Polak JM

更新日期：1988-08-01 00:00:00

abstract：:Retinal pigment epithelia (RPE) and retinal neurons (RN) arise from the same underlying precursor cell population. It is worthwhile to explore the transdifferentiation potential of RPE cells, given the benefits that could accrue from turning RPE into neural retina containing all its normal cellular subpopulations. Fac...

journal_title：Current eye research

authors： Khera S,Tiwari A,Srinivasan R,Gupta A,Luthra-Guptasarma M

更新日期：2012-07-01 00:00:00

abstract：:Intracellular binding proteins have been identified and isolated from B cells by their ability to bind to the synthetic peptide (1169-1191), the major immunodominant epitope of bovine interphotoreceptor retinoid-binding protein (IRBP) coupled to cyanogen bromide activated Sepharose 4B. After SDS-PAGE, two discrete pro...

journal_title：Current eye research

authors： Rengarajan K,de Smet MD,Chader GJ,Wiggert B

更新日期：1994-04-01 00:00:00

abstract：:Cultured retinal glial cells from the rat are responsive to modulation by vasoactive intestinal peptide (VIP). VIP (1 X 10(-6) M) elevated the intracellular cyclic AMP concentration from the basal level of (4.4-11.1) p mole/mg protein to (354-440) p mole/mg protein in three minutes at 25 degrees C. The half-maximal co...

journal_title：Current eye research

authors： Koh SW,Roberge FG

更新日期：1989-11-01 00:00:00

abstract：:Purpose: To evaluate the long-term efficacy and safety of the modified canaloplasty technique with additional suprachoroidal drainage in patients with pseudoexfoliation glaucoma. Methods: This retrospective clinical trial included 131 patients with pseudoexfoliation glaucoma who underwent canaloplasty with suprachoroi...

journal_title：Current eye research

authors： Seuthe AM,Szurman P,Januschowski K

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD) is the most common cause of visual loss. The dry AMD is characterized by retinal pigment epithelium (RPE) death and changes in AMD lead to severe loss of vision. Coumarin-derived esculetin has a number of therapeutic and pharmacological effects such as anti-inflammatory an...

journal_title：Current eye research

authors： Ozal SA,Turkekul K,Gurlu V,Guclu H,Erdogan S

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To evaluate "in vivo" the effect of topical travoprost on the central corneal thickness (CCT) of rabbit eyes, and the changes in the CCT after acute increases of intraocular pressure (IOP) in these eyes. MATERIALS AND METHODS:This is an interventional, prospective, case-control, masked study. Topical travopros...

journal_title：Current eye research

authors： Bolívar G,Teus M,Arranz-Marquez E

更新日期：2011-11-01 00:00:00

abstract：:Systemically administered fluorescein is converted to fluorescein glucuronide. The conjugate is fluorescent and interferes with the measurement of fluorescein in the anterior chamber. Carboxyfluorescein is a hydrophilic derivative of fluorescein. In the rabbit, carboxyfluorescein is not converted as readily to a fluor...

journal_title：Current eye research

authors： Neault TR,McLaren JW,Brubaker JH,Brubaker RF

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to examine the functional connectivity between the primary visual cortex and other cortical areas during rest in normal subjects and patients with comitant strabismus using functional magnetic resonance imaging (fMRI). METHODS:A prospective, observational study was conducted. Ten pati...

journal_title：Current eye research

authors： Yan X,Wang Y,Xu L,Liu Y,Song S,Ding K,Zhou Y,Jiang T,Lin X

更新日期：2019-03-01 00:00:00

abstract：:With Golgi impregnation, a simple amacrine cell type is described in the chick retina. The most relevant morphological feature of these retinal neurons is a single straight, radial trunk which dichotomizes tangentially in a rectilinear expansion in the 5th stratum of the inner plexiform layer (IPL). ...

journal_title：Current eye research

authors： Genis-Galvez JM,Chmielewski CE,Prada FA

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:To evaluate the anatomical correlation between fellow eyes for bilateral second-line anti-VEGF treatment in eyes with bilateral diabetic macular edema (DME) with incomplete response to first-line bevacizumab therapy. METHODS:Seventy-four eyes (n = 37 patients) with bilateral-DME having incomplete response to f...

journal_title：Current eye research

authors： Tiosano L,Ayalon A,Banin E,Averbukh E,Jaouni T,Chowers I

更新日期：2020-08-30 00:00:00

abstract：PURPOSE:The aim of the present study was to calculate the diameter of the central retinal artery from results as obtained with non-invasive techniques in healthy young subjects. METHODS:Twenty-four healthy male subjects participated in this study. Total retinal blood flow was calculated from combined bi-directional la...

journal_title：Current eye research

authors： Dorner GT,Polska E,Garhöfer G,Zawinka C,Frank B,Schmetterer L

更新日期：2002-12-01 00:00:00

abstract：:Rainbow trout (Oncorhynchus mykiss) were used to model the solar radiation-induced cataract that occurs in hatchery-reared lake trout (Salvelinus namaycush). Rainbow trout eyes were exposed to wideband predominantly UVB radiant energy from a filtered 1000W xenon source. Lenticular damage was assessed and classified an...

journal_title：Current eye research

authors： Cullen AP,Monteith-McMaster CA

更新日期：1993-02-01 00:00:00

abstract：PURPOSE:We have previously described a metabolic acidosis-induced retinopathy in the neonatal rat, similar to retinopathy of prematurity (ROP). We also have reported exacerbation of oxygen-induced retinopathy by postnatal growth retardation, produced by raising newborn rats in 'expanded' litters. In the present study, ...

journal_title：Current eye research

authors： Zhang S,Leske DA,Lanier WL,Holmes JM

更新日期：2001-02-01 00:00:00