Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study.

abstract：PURPOSE:To determine the role of matrix metalloproteinase 9 (MMP9) in advanced glycation end-products (AGEs) induced damage to blood-retinal barrier (BRB) and the therapeutic effects of minocycline, an MMP inhibitor, against the BRB damages. METHODS:Forty-eight Sprague Dawley rats were randomly assigned to 3 groups (1...

journal_title：Current eye research

authors： Chen YD,Xu X,Xia X,Wu H,Liu K,Zheng Z,Zhu D

更新日期：2008-11-01 00:00:00

abstract：:A major glycoprotein of relative molecular weight of 130,000 daltons of chick lens cell membranes was identified by Concanavalin-A staining and enriched for by Con A-Sepharose chromatography. Using both Con A binding and immunological analyses with a specific polyclonal antibody, the glycoprotein was detected in chick...

journal_title：Current eye research

authors： Heslip J,Bagchi M,Zhang S,Alousi S,Maisel H

更新日期：1986-12-01 00:00:00

abstract：PURPOSE:There is a substantial literature showing that the selective estrogen receptor modulator tamoxifen can block swelling-activated chloride channels, such as those in astrocytes. This study aimed to test the hypothesis that anatomic characteristics consistent with swelling may be measured within the optic nerve he...

journal_title：Current eye research

authors： Eisner A,O'Malley JP,Incognito LJ,Toomey MD,Samples JR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:To compare the intensity of posterior capsule opacification (PCO) between two intraocular lenses (IOLs) of the same optic material, but with different haptic design (1-piece vs. 3-piece). METHODS:This prospective intraindividual controlled cohort study comprised eighty eyes of 40 patients with bilateral age...

journal_title：Current eye research

authors： Mylonas G,Prskavec M,Baradaran-Dilmaghani R,Karnik N,Buehl W,Wirtitsch M

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Membrane-associated mucins are important components of the ocular tear film. Our objective was to characterize the expression of membrane-associated mucins MUC1, MUC4, and MUC16 in healthy cornea, healthy conjunctiva, fibrovascular tissue (pannus) covering the corneal surface in limbal stem cell deficiency (LSC...

journal_title：Current eye research

authors： Pauklin M,Kakkassery V,Steuhl KP,Meller D

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Maintaining the high glutathione (GSH; tripeptide of glutamate, cysteine and glycine) levels in the lens cortex promotes lens health. The role of glutamate/aspartate (Glu/Asp) transporters and the cystine (Cys)/Glu exchanger (Xc(-) exchanger) in maintaining GSH in transformed human lens epithelial cells (SRA 01...

journal_title：Current eye research

authors： Langford MP,Redens TB,Liang C,Kavanaugh AS,Texada DE

更新日期：2016-01-01 00:00:00

abstract：PURPOSE/AIM:Cultured autologous oral mucosal epithelial cells (OMECs) have proven useful in the treatment of ocular surface disorders. This study is the first to investigate the potential of expanding OMEC in a xenobiotic- and serum-free medium using therapeutic contact lenses (CLs) as a substrate and carrier. MATERIA...

journal_title：Current eye research

authors： Björkblom B,Eidet JR,Utheim TP,Ulltveit-Moe HF,Raeder S

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Retinal ischemia and neovascularization (NV) are important components of many retinal disorders. To facilitate further investigation of retinal ischemia and neovascularization, we sought to develop a reproducible in vivo experimental model of venous occlusion by photodynamic thrombosis in rats. METHODS:After a...

journal_title：Current eye research

authors： Saito Y,Park L,Skolik SA,Alfaro DV,Chaudhry NA,Barnstable CJ,Liggett PE

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Androgens are thought to play a role in the regulation of the human lacrimal gland. Androgen receptor mRNA has been isolated from human lacrimal tissue; however, it is not known which cell(s) in human lacrimal tissue may contain androgen receptors. This study is an immunohistochemical investigation of the locat...

journal_title：Current eye research

authors： Smith RE,Taylor CR,Rao NA,Young LL,Rife LL

更新日期：1999-04-01 00:00:00

abstract：PURPOSE/AIMS:To evaluate the prognostic factors for the best corrected visual acuity (BCVA) and central subfield macular thickness (CSMT) after vitrectomy with internal limiting membrane (ILM) peeling for diabetic macular edema. MATERIALS AND METHODS:A total of 44 eyes of 35 patients who had undergone vitrectomy with ...

journal_title：Current eye research

authors： Yamada Y,Suzuma K,Ryu M,Tsuiki E,Fujikawa A,Kitaoka T

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Proliferative vitreoretinopathy is a serious complication of retinal detachment surgery in which retinal pigment epithelial cells abnormally proliferate within the vitreous cavity and under the retinal surface. Octreotide acetate, a somatostatin analog, has been shown to inhibit the cellular proliferation of a ...

journal_title：Current eye research

authors： Luo Q,Peyman GA,Conway MD,Woltering EA

更新日期：1996-09-01 00:00:00

abstract：:Calf gamma-crystallins were separated by preparative flat-bed isoelectric focusing and characterized according to their immunological properties, molecular weights and isoelectric points. Immunologically 4 different groups of gamma-crystallins (gamma 1a-1d-crystallin) could be detected. The main immunological componen...

journal_title：Current eye research

authors： Bours J,Vornhagen R,Herlt M,Rink H

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To characterize the effect of glutamate receptor activation/inhibition on the secretion of vascular endothelial growth factor (VEGF) in retina-specific glial (Müller) cells under experimental conditions of hyperglycemia and hypoxia, two intrinsic pathologic conditions of diabetic retinopathy. METHODS:Purified ...

journal_title：Current eye research

authors： Cervantes-Villagrana AR,Garcia-Román J,González-Espinosa C,Lamas M

更新日期：2010-08-01 00:00:00

abstract：:The variation of central corneal thickness with age was measured weekly at 10am by ultrasound pachometry in 10 normal (5 to 19 weeks of age) and 10 alloxan-induced diabetic (9 to 19 weeks of age) rabbits. The diurnal variation of corneal thickness was also measured at 2 hour intervals for a period of 24 hours on both ...

journal_title：Current eye research

authors： Herse PR

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To explore the in vitro proliferative potential of human limbal epithelial cells after 31 degrees C organ-culture storage and to investigate putative factors influencing it. METHODS:185 cultures of limbal explants were carried-out either from full-thickness explants (n = 102) or from enzymatically dissociated ...

journal_title：Current eye research

authors： Zito-Abbad E,Borderie VM,Baudrimont M,Bourcier T,Laroche L,Chapel C,Uzel JL

更新日期：2006-05-01 00:00:00

abstract：:It has been suggested that the provision of HLA matched tissue for corneal transplantation would be beneficial for graft survival especially in high risk patients. In this study we report the application of a polymerase chain reaction (PCR) based tissue typing procedure to type cadaveric donor material. Using beta-glo...

journal_title：Current eye research

authors： Rakoczy P,Garlepp M,Constable I

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:Hypercarbia has been suggested as a risk factor for retinopathy of prematurity (ROP). We investigated the effect of hypercarbia on the retinal vasculature of the neonatal rat to determine whether hypercarbia alone could induce preretinal neovascularization analogous to ROP. METHODS:In a preliminary blood gas s...

journal_title：Current eye research

authors： Holmes JM,Zhang S,Leske DA,Lanier WL

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:The purpose of these studies is to develop an in vitro model of corneal endothelial aging and to investigate age-related changes in morphology, mitosis, prostaglandin synthesis and prostaglandin response pathways. METHODS:First-passage rabbit corneal endothelial cells were grown in vitro for up to 30 days afte...

journal_title：Current eye research

authors： Jumblatt MM

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:To synthesize and characterize hydrogels with viscoelastic properties comparable to those of the natural lens. METHODS:Hydrogels were synthesized in water by free-radical polymerization of the monomer poly(ethyleneglycol)-monomethacrylate. Three different molecular weights of poly(ethyleneglycol)-dimethacrylat...

journal_title：Current eye research

authors： Murthy SK,Ravi N

更新日期：2001-05-01 00:00:00

abstract：:The efficiency of protein immobilization to provide a hydrogel surface with a high affinity for corneal epithelial cells was investigated. The cell adhesive proteins collagen and fibronectin, and the cell adhesive oligopeptide RGDS (arginine-glycine-aspartic acid-serine) were successfully covalently immobilized on pol...

journal_title：Current eye research

authors： Kobayashi H,Ikada Y

更新日期：1991-10-01 00:00:00

abstract：PURPOSE:To generate toxicology profiles of individual drugs on human corneal epithelial cells (HCEC) and compare their in vitro cytotoxicity. METHODS:Monolayer cultures of HCEC were harvested from two human donor eyes. Sunitinib (0.3-10 µg/mL) and Sorafenib (0.3-100 µg/mL), diluted in culture medium (CnT-BM.1, CELLnTE...

journal_title：Current eye research

authors： Bayyoud T,Hofmann J,Spitzer M,Bartz-Schmidt KU,Yoeruek E

更新日期：2014-02-01 00:00:00

abstract：:Using phosphorus-31 nuclear magnetic resonance (P-31 NMR) spectroscopy the rat crystalline lens was evaluated as a potential animal model for the study of lens metabolic processes relevant to the human. The P-31 NMR spectra of intact rat lenses and rat lens PCA extracts provided comparable qualitative and quantitative...

journal_title：Current eye research

authors： Kopp SJ,Greiner JV,Glonek T

更新日期：1981-01-01 00:00:00

abstract：:Na/K ATPase activity has been determined in normal and cataractous human lenses using labeled ATP as a substrate. The enzyme is distributed throughout the lens with approximately 1/3 of the total activity in the capsule-epithelium and 1/2 of the activity in the cortex. Furthermore, the activity of Na/K ATPase decrease...

journal_title：Current eye research

authors： Kobatashi S,Roy D,Spector A

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection. METHODS:Corneal neovascularization was induced by application of a mixture of 7...

journal_title：Current eye research

authors： Avisar I,Weinberger D,Kremer I

更新日期：2010-02-01 00:00:00

abstract：:Two proteins, with molecular weights of 49 (CP49) and 115 kDa (CP115) as judged by SDS PAGE, have been shown by immunocytochemistry to be components of the beaded filament, a cytoskeletal structure thus far demonstrated only in the lens fiber cell. We have used antibodies reactive with CP49 to screen a mouse lens cDNA...

journal_title：Current eye research

authors： Hess JF,Casselman JT,FitzGerald PG

更新日期：1993-01-01 00:00:00

abstract：:It has been shown that illumination of rod outer segment suspension in the presence of photosensitizers (methylene blue lambda greater than or equal to 620 nm; retinal 370 less than or equal to lambda less than or equal to 390 nm) results in chemical modification of the lipid and protein components of the photo-recept...

journal_title：Current eye research

authors： Shvedova AA,Alekseeva OM,Kuliev IYa,Muranov KO,Kozlov YuP,Kagan VE

更新日期：1982-01-01 00:00:00

abstract：:Lenses from normal Wistar rats and those from a Wistar strain with X-ray-induced cataract mutation were examined electron microscopically for morphological characterization and acid phosphatase (AcPase) localization. Ocular anlages of 11 through 18 days of gestation were included in the study. A late-separating or per...

journal_title：Current eye research

authors： Anderson JW,Gorthy WC

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:Pseudoexfoliation (PXF) is a microfibrillopathy involving disordered elastogenesis. Abnormal extracellular matrix (ECM) production underlies the pathophysiology of PXF. The enzyme Lysyl oxidase (LOX) and its isoforms are known to cross-link the elastin and collagen. Though the etiopathogensis of PXF is not well...

journal_title：Current eye research

authors： Gayathri R,Coral K,Sharmila F,Sripriya S,Sripriya K,Manish P,Shantha B,Ronnie G,Vijaya L,Narayanasamy A

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To report the presence of hyper-reflective dots in the vitreous cavity using spectral-domain optical coherence tomography (SD-OCT) in patients with acute symptomatic posterior vitreous detachment (PVD) and investigate their association with the presence of retinal tear. METHODS:The medical records of 77 patien...

journal_title：Current eye research

authors： Oh JH,Oh J,Roh HC

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To compare the differences in higher-order aberrations (HOAs) after laser subepithelial keratomileusis (LASEK) between two different laser platforms. METHODS:One hundred and seven eyes of 107 patients were included in this study. Fifty-six eyes underwent LASEK with the Triple-A profile (an ablation profile of ...

journal_title：Current eye research

authors： Liu L,Li M,Shi YH,Sun LN,Wang F,Zou J

更新日期：2020-09-01 00:00:00